Uprt (uracil phosphoribosyltransferase homolog) - Rat Genome Database

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Gene: Uprt (uracil phosphoribosyltransferase homolog) Rattus norvegicus
Analyze
Symbol: Uprt
Name: uracil phosphoribosyltransferase homolog
RGD ID: 1564806
Description: Predicted to enable ribosylnicotinamide kinase activity. Involved in several processes, including UMP biosynthetic process; lactation; and response to insulin. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC317237; RGD1564806; similar to hypothetical protein; uracil phosphoribosyltransferase (FUR1) homolog; uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X73,582,267 - 73,612,488 (+)NCBIGRCr8
mRatBN7.2X69,516,573 - 69,546,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX69,516,738 - 69,546,797 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X75,382,553 - 75,408,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX75,382,598 - 75,407,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,184,934 - 76,210,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,511,044 - 92,535,135 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX70,870,490 - 70,896,599 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Pyrimidine nucleotide synthesis in the rat mammary gland: changes in the lactation cycle and effects of diabetes. Kunjara S, etal., Biochem Med Metab Biol. 1992 Dec;48(3):263-74.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Regulation of purine and pyrimidine metabolism by insulin and by resistance to tiazofurin. Weber G, etal., Adv Enzyme Regul. 1985;23:81-99.

Genomics

Comparative Map Data
Uprt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X73,582,267 - 73,612,488 (+)NCBIGRCr8
mRatBN7.2X69,516,573 - 69,546,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX69,516,738 - 69,546,797 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X75,382,553 - 75,408,541 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX75,382,598 - 75,407,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,184,934 - 76,210,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,511,044 - 92,535,135 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX70,870,490 - 70,896,599 (+)NCBICelera
Cytogenetic MapXq22NCBI
UPRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X75,156,369 - 75,304,897 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX75,156,388 - 75,304,885 (+)EnsemblGRCh38hg38GRCh38
GRCh37X74,376,204 - 74,524,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X74,410,686 - 74,441,159 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX74,777,320 - 74,808,158 (+)NCBICelera
Cytogenetic MapXq13.3NCBI
HuRefX68,128,874 - 68,159,480 (+)NCBIHuRef
CHM1_1X74,386,787 - 74,417,624 (+)NCBICHM1_1
T2T-CHM13v2.0X73,590,029 - 73,738,566 (+)NCBIT2T-CHM13v2.0
Uprt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X103,526,409 - 103,555,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX103,526,424 - 103,551,096 (+)EnsemblGRCm39 Ensembl
GRCm38X104,482,803 - 104,512,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX104,482,818 - 104,507,490 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X101,678,121 - 101,701,601 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X100,685,501 - 100,708,981 (+)NCBIMGSCv36mm8
CeleraX91,375,831 - 91,399,185 (+)NCBICelera
Cytogenetic MapXDNCBI
Uprt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555621,385,611 - 1,415,336 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555621,385,617 - 1,415,277 (+)NCBIChiLan1.0ChiLan1.0
UPRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X74,955,259 - 74,991,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X74,958,796 - 74,995,475 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X64,524,889 - 64,561,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X74,639,179 - 74,675,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX74,639,179 - 74,675,221 (+)Ensemblpanpan1.1panPan2
UPRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X58,570,623 - 58,576,980 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX58,543,425 - 58,575,926 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX49,720,058 - 49,753,658 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X59,779,736 - 59,813,343 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX59,779,753 - 59,813,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X57,467,583 - 57,501,188 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X59,087,324 - 59,120,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X58,686,103 - 58,719,766 (+)NCBIUU_Cfam_GSD_1.0
Uprt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X43,493,769 - 43,515,772 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366831,431,965 - 1,454,991 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366831,432,004 - 1,454,004 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UPRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX60,426,975 - 60,451,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X60,426,955 - 60,448,174 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X68,687,968 - 68,709,136 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UPRT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X64,815,163 - 64,846,198 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX64,815,183 - 64,849,547 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606716,812,530 - 16,843,516 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uprt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248365,471,168 - 5,502,261 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248365,473,129 - 5,502,276 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uprt
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:68
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000033494
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 16 16 2 2 60 27 13 8 2
Low 2 43 40 40 3 40 6 9 14 8 24 3 6
Below cutoff 1 1 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033494   ⟹   ENSRNOP00000038431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX75,382,598 - 75,407,217 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100029   ⟹   ENSRNOP00000078739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX69,516,738 - 69,546,797 (+)Ensembl
RefSeq Acc Id: XM_228538   ⟹   XP_228538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X73,582,267 - 73,612,488 (+)NCBI
mRatBN7.2X69,516,573 - 69,546,811 (+)NCBI
Rnor_6.0X75,382,553 - 75,408,541 (+)NCBI
Rnor_5.0X76,184,934 - 76,210,907 (+)NCBI
RGSC_v3.4X92,511,044 - 92,535,135 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_228538 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07163 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078739
  ENSRNOP00000078739.1
Reference Protein Sequences
RefSeq Acc Id: XP_228538   ⟸   XM_228538
- UniProtKB: A0A8I6G3Q5 (UniProtKB/TrEMBL),   A6IV17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038431   ⟸   ENSRNOT00000033494
RefSeq Acc Id: ENSRNOP00000078739   ⟸   ENSRNOT00000100029

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ABC7-F1-model_v2 AlphaFold D4ABC7 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701898
Promoter ID:EPDNEW_R12419
Type:initiation region
Name:Uprt_1
Description:uracil phosphoribosyltransferase homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X75,382,587 - 75,382,647EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564806 AgrOrtholog
BioCyc Gene G2FUF-1988 BioCyc
Ensembl Genes ENSRNOG00000021552 Ensembl
  ENSRNOG00000063275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000100029.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/TrEMBL
InterPro PRibTrfase_dom UniProtKB/TrEMBL
  PRTase-like UniProtKB/TrEMBL
KEGG Report rno:317237 UniProtKB/TrEMBL
NCBI Gene 317237 ENTREZGENE
PANTHER URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG UniProtKB/TrEMBL
  URIDINE KINASE UniProtKB/TrEMBL
Pfam UPRTase UniProtKB/TrEMBL
PhenoGen Uprt PhenoGen
RatGTEx ENSRNOG00000021552 RatGTEx
  ENSRNOG00000063275 RatGTEx
Superfamily-SCOP SSF53271 UniProtKB/TrEMBL
UniProt A0A8I6G3Q5 ENTREZGENE, UniProtKB/TrEMBL
  A6IV17 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Uprt  uracil phosphoribosyltransferase homolog  Uprt  uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Uprt  uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)  RGD1564806_predicted  similar to hypothetical protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564806_predicted  similar to hypothetical protein (predicted)  LOC317237  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317237  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL