Ptchd1 (patched domain containing 1)

Gene: Ptchd1 (patched domain containing 1) Rattus norvegicus

Analyze

Symbol:

Ptchd1

Name:

patched domain containing 1

RGD ID:

1564527

Description:

Predicted to be involved in several processes, including smoothened signaling pathway; social behavior; and thalamus development. Predicted to act upstream of or within chemical synaptic transmission and memory. Predicted to be active in plasma membrane and synapse. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human PTCHD1 (patched domain containing 1); INTERACTS WITH bisphenol A; copper atom; copper(0).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC317517; patched domain-containing protein 1; RGD1564527; similar to patched domain containing 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTCHD1 (patched domain containing 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Ptchd1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ptchd1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTCHD1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PTCHD1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ptchd1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTCHD1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTCHD1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ptchd1 (patched domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PTCHD1 (patched domain containing 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ptchd1 (patched domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptchd1 (patched domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ptr	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	ptr-11	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ptr-15	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ptr-16	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ptr-17	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ptr-22	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ptchd1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	43,496,907 - 43,548,413 (+)	NCBI		GRCr8
mRatBN7.2	X	39,681,910 - 39,733,416 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	39,681,910 - 39,733,519 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	40,905,386 - 40,956,900 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	44,372,699 - 44,424,207 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	42,057,286 - 42,108,794 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	42,558,912 - 42,610,430 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	42,558,931 - 42,614,242 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	42,866,040 - 42,917,474 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	61,079,670 - 61,131,155 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	40,277,508 - 40,329,013 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

attention deficit hyperactivity disorder (ISS)

autism spectrum disorder (ISO)

autistic disorder (ISO)

Developmental Disease (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

non-syndromic X-linked intellectual disability (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-Linked Intellectual Developmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

copper atom (EXP)

copper(0) (EXP)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

ketamine (EXP)

lead(0) (ISO)

panobinostat (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (IBA)

cognition (IBA,ISO)

excitatory chemical synaptic transmission (ISO)

inhibitory chemical synaptic transmission (ISO)

long-term memory (ISO)

short-term memory (ISO)

smoothened signaling pathway (ISO)

social behavior (ISO)

thalamus development (ISO)

Cellular Component

plasma membrane (IBA,ISO)

synapse (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20844286	PMID:27007844	PMID:29118110

Genomics

Comparative Map Data

Ptchd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	43,496,907 - 43,548,413 (+)	NCBI		GRCr8
mRatBN7.2	X	39,681,910 - 39,733,416 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	39,681,910 - 39,733,519 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	40,905,386 - 40,956,900 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	44,372,699 - 44,424,207 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	42,057,286 - 42,108,794 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	42,558,912 - 42,610,430 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	42,558,931 - 42,614,242 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	42,866,040 - 42,917,474 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	61,079,670 - 61,131,155 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	40,277,508 - 40,329,013 (+)	NCBI		Celera
Cytogenetic Map	X	q21	NCBI

PTCHD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	23,334,396 - 23,404,374 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	23,334,849 - 23,404,374 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	23,352,966 - 23,422,491 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	23,262,906 - 23,324,839 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	23,112,751 - 23,172,076	NCBI
Celera	X	27,474,669 - 27,536,553 (+)	NCBI		Celera
Cytogenetic Map	X	p22.11	NCBI
HuRef	X	21,094,048 - 21,155,060 (+)	NCBI		HuRef
CHM1_1	X	23,384,049 - 23,445,953 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	22,917,921 - 22,987,936 (+)	NCBI		T2T-CHM13v2.0

Ptchd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	154,352,732 - 154,407,185 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	154,356,451 - 154,406,810 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	155,569,736 - 155,624,170 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	155,573,455 - 155,623,814 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	152,004,279 - 152,057,870 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	150,914,257 - 150,964,043 (-)	NCBI		MGSCv36	mm8
Celera	X	138,872,944 - 138,926,972 (-)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI
cM Map	X	72.38	NCBI

Ptchd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955509	3,715,771 - 3,767,541 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955509	3,716,086 - 3,767,541 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTCHD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	25,131,355 - 25,192,568 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	25,134,743 - 25,195,957 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	15,929,619 - 15,991,194 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	23,305,555 - 23,366,273 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	23,305,555 - 23,366,273 (+)	Ensembl	panpan1.1		panPan2

PTCHD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	19,096,787 - 19,153,367 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	19,096,559 - 19,148,528 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	19,050,277 - 19,105,259 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	19,049,225 - 19,101,569 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	19,089,857 - 19,144,818 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	19,119,773 - 19,174,752 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	19,176,247 - 19,231,008 (+)	NCBI		UU_Cfam_GSD_1.0

Ptchd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	12,031,839 - 12,087,657 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936624	1,072,857 - 1,125,994 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936624	1,072,857 - 1,125,962 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTCHD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	19,507,739 - 19,561,828 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	19,508,501 - 19,563,298 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	20,851,579 - 20,904,599 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTCHD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	21,810,530 - 21,874,109 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	21,810,956 - 21,870,417 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	23,674,097 - 23,736,621 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptchd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	8,458,628 - 8,512,511 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	8,458,430 - 8,513,011 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ptchd1
134 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	78
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000044129
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									24
Low		2	3				1	1	44	27	27	1	1
Below cutoff	3	33	22	10	14	10	7	7	6	8	9	7	7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000044129 ⟹ ENSRNOP00000044293

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	42,558,931 - 42,614,242 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113700 ⟹ ENSRNOP00000085114

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	39,681,910 - 39,733,519 (+)	Ensembl

RefSeq Acc Id:

NM_001191734 ⟹ NP_001178663

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	43,496,907 - 43,548,413 (+)	NCBI
mRatBN7.2	X	39,681,910 - 39,733,416 (+)	NCBI
Rnor_6.0	X	42,558,912 - 42,610,430 (+)	NCBI
Rnor_5.0	X	42,866,040 - 42,917,474 (+)	NCBI
Celera	X	40,277,508 - 40,329,013 (+)	NCBI

Sequence:

show sequence

TGCTCTAGGATGCTGCGGCAGGTTCTGCACAGGGGCTTGAGGACGTGTTTCTCCCGGCTTGGCC
ACTTCATTGCCAGTCACCCGGTCTTCTTCGCTTCGGCGCCGGTGCTCATCTCCATCCTGCTCGG
CGCCAGCTTCAGCCGCTACCAGGTGGAAGAGAGCGTGGAGCACCTGCTGGCGCCCCAGCACAGC
CTAGCCAAGATCGAGCGCAACCTAGTCAACAGCCTATTCCCGGTCAACCGCTCCAAGCACCGGC
TCTACTCGGACCTGCAGACCCCTGGGCGCTACGGCCGGGTCATTGTCACCTCCTACCAGAAAGC
CAACATGCTAGACCAGCATCACACGGACCTGATCTTAAAGTTGCACACTGCTGTAACCAAGATC
CAGGTTCCAAGGCCTGGCTTTAACTATACATTTGCCCACATATGTGTCCTGAATAATGATAAGA
CTTGCATTGTGGATGACATAGTACACGTCCTGGAAGAGCTAAAGAATGCTCGGGCCACCAATCG
GACCAATTTTGCTATCACATATCCGATCACTCACTTAAAGGATGGAAGGGCTGTCTATAATGGG
CACCAACTTGGAGGTGTCACTGTGCACAGCAAGGATCGGGTGAAATCTGCGGAGGCCATTCAGC
TCACCTACTATCTGCAATCAATCAACAGTCTCAATGACATGGTAGCTGAGAGGTGGGAGTCCAG
CTTCTGCGACACTGTCAAATTATTCCAGAAATCCAACAGCAAAGTCAAAATATACCCGTACACA
TCCTCATCACTGAGGGAAGATTTCCAGAAGACCAGCCGTGTGTCAGAACGTTACCTGGTCACCA
GTCTGATCCTTGTAGTCACCATGGCCATTCTGTGCTGCTCTATGCAGGACTGTGTCCGCAGCAA
ACCCTGGTTAGGCCTACTTGGGTTGGTGACCATAAGCCTAGCCACTCTCACTGCAGCTGGAATC
ATCAATCTTACTGGTGGAAAATACAATTCCACCTTCCTGGGAGTCCCTTTCGTCATGCTAGGTC
ATGGATTATACGGGACTTTTGAAATGTTATCCTCGTGGAGAAAAACTAGAGAGGACCAACATGT
TAAAGAGCGAACTGCAGAAGTCTATGCAGACTCCATGCTCTCCTTCTCTCTCACCACTGCCATG
TACTTGGTCACCTTTGGCATAGGGGCCAGCCCTTTCACGAACATTGAGGCAGCCAGGATTTTCT
GCTGCAATTCCTGTATTGCAATCCTCTTCAACTACCTCTATGTACTCTCATTTTACGGTTCCAG
CCTTGTGTTCACTGGCTACATAGAAAACAATTACCAGCATAGTATATTCTGTAGAAAAGTTCCA
AAGCCTGAGGTATTACAGGAGAAGCCAGCATGGTATAGGTTTCTTCTGACAGCTAGATTCAGTG
AGGACACAGCTGAAGGTGAGGAAGCAAACACTTATGAGAGTCATTTATTGGTATGTTTCCTCAA
ACGTTATTACTGTGACTGGATAACCAACACCTATGTCAAGCCTTTTGTAGTCCTCTTTTACCTT
ATTTATATTTCCTTTGCCTTAATGGGCTATCTGCAGGTCAGTGAAGGGTCAGACCTTAGTAACA
TCGTAGCAACTGCAACACAAACCATTGAGTACACTACTGCCCACCAAAAGTACTTTAACAACTA
CAGTCCTGTTATTGGGTTTTACATATATGAGTCCATAGAATATTGGAACTCTAGTGTCCAAGAA
GATGTTCTAGAGTACACTAAGGGTTTTGTGCGGATATCCTGGTTTGAAAGCTATTTAAATTATC
TTCGGAAACTCAATGTGTCCACTGACTTGCCTAAGAAAAATTTCACAGACATGTTGAGAAATTC
CTTCCTGAAAGCTCCTCAATTTTCACATTTTCAAGAGGACATCATCTTCTCTAAAAAATACAAT
GATGAGGTTGACGTAGTGGCCTCTAGAATGTTTTTGGTGGCCAAGACTATGGAAACAAACAGAG
AAGAACTTTATGATCTCTTGGAGACCCTGAGGAGGCTTTCAGTCACCTCCAAGGTGAAGTTCAT
TGTCTTTAATCCGTCTTTTGTGTACATGGATCGATATGCCTCCTCTCTGGGAGCCCCCCTGCAC
AACTCCTGCATCAGTGCTTTGTTCCTGCTCTTCTTCTCGGCATTCCTGGTAGCAGATTCGCTGA
TTAATGTCTGGATCACTCTAACGGTTGTGTCTGTGGAGTTTGGAGTGATAGGCTTCATGACATT
ATGGAAGGTCGAACTGGATTGTATTTCTGTGCTATGCTTAATTTATGGAATTAACTACACAATT
GATAACTGTGCTCCACTGTTATCCACATTTGTCCTAGGCAAGGATTTTACAAGAACTAAATGGG
TAAAAAATGCCCTGGAAGTGCATGGGGTAGCTATTTTACAGAGTTACCTCTGTTATATTGTTGG
TCTATTTCCTCTCGCAGCTGTGCCTTCAAATCTGACCTGTACACTGTTCAGGTGCTTGTTTTTA
ATAGCATTTGTCACCTTCTTTCACTGCTTTGCCATTTTACCTGTGATACTGACTTTCCTGCCAC
CCTCTAAGAAAAAAAGGAAAGAGAAGAAAAATCCTGAAAACCGGGAGGAAATTGAGTGTGTAGA
AATGTTGGATATTGACAGTACTCGAGTGGTTGACCAAATTACCACAGTGTGA

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Protein Sequences


Protein RefSeqs	NP_001178663	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL96105	(Get FASTA)	NCBI Sequence Viewer
	EDL96106	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000085114
	ENSRNOP00000085114.1

RefSeq Acc Id:

NP_001178663 ⟸ NM_001191734

- UniProtKB:

A0A8I5ZYJ0 (UniProtKB/TrEMBL), A6IPQ7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAK
IERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQKANMLDQHHTDLILKLHTAVTKIQVP
RPGFNYTFAHICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAVYNGHQL
GGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQKSNSKVKIYPYTSSS
LREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINL
TGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLV
TFGIGASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPE
VLQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYI
SFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEYWNSSVQEDVL
EYTKGFVRISWFESYLNYLRKLNVSTDLPKKNFTDMLRNSFLKAPQFSHFQEDIIFSKKYNDEV
DVVASRMFLVAKTMETNREELYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSC
ISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNC
APLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAF
VTFFHCFAILPVILTFLPPSKKKRKEKKNPENREEIECVEMLDIDSTRVVDQITTV

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RefSeq Acc Id:

ENSRNOP00000044293 ⟸ ENSRNOT00000044129

RefSeq Acc Id:

ENSRNOP00000085114 ⟸ ENSRNOT00000113700

Protein Domains

SSD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZX73-F1-model_v2	AlphaFold	D3ZX73	1-783	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564527	AgrOrtholog
BioCyc Gene	G2FUF-2446	BioCyc
Ensembl Genes	ENSRNOG00000003675	Ensembl
	ENSRNOG00000069252	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000113700	ENTREZGENE
	ENSRNOT00000113700.1	UniProtKB/TrEMBL
Gene3D-CATH	Multidrug efflux transporter AcrB transmembrane domain	UniProtKB/TrEMBL
InterPro	Ptc/Disp	UniProtKB/TrEMBL
	SSD	UniProtKB/TrEMBL
KEGG Report	rno:317517	UniProtKB/TrEMBL
NCBI Gene	317517	ENTREZGENE
PANTHER	PATCHED DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	PATCHED-RELATED	UniProtKB/TrEMBL
Pfam	Patched	UniProtKB/TrEMBL
PhenoGen	Ptchd1	PhenoGen
PROSITE	SSD	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003675	RatGTEx
	ENSRNOG00000069252	RatGTEx
Superfamily-SCOP	Multidrug efflux transporter AcrB transmembrane domain	UniProtKB/TrEMBL
UniProt	A0A8I5ZYJ0	ENTREZGENE, UniProtKB/TrEMBL
	A6IPQ7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ptchd1	patched domain containing 1	Ptchd1_predicted	patched domain containing 1 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Ptchd1_predicted	patched domain containing 1 (predicted)	RGD1564527_predicted	similar to patched domain containing 1 (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1564527_predicted	similar to patched domain containing 1 (predicted)	LOC317517	similar to patched domain containing 1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC317517	similar to patched domain containing 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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