Fat4 (FAT atypical cadherin 4) - Rat Genome Database

Name: Fat4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fat4 (FAT atypical cadherin 4) Rattus norvegicus

Analyze

Symbol:

Fat4

Name:

FAT atypical cadherin 4

RGD ID:

1564291

Description:

Predicted to enable calcium ion binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; hippo signaling; and nervous system development. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; condensed mesenchymal cell proliferation; and ossification involved in bone maturation. Predicted to be located in apical part of cell. Human ortholog(s) of this gene implicated in Hennekam syndrome and Van Maldergem syndrome 2. Orthologous to human FAT4 (FAT atypical cadherin 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

FAT tumor suppressor homolog 4; FAT tumor suppressor homolog 4 (Drosophila); LOC108348049; LOC310341; protocadherin Fat 4; protocadherin Fat 4-like; RGD1564291; similar to FAT tumor suppressor homolog 4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FAT4 (FAT atypical cadherin 4)	HGNC	EggNOG, Ensembl, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fat4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fat4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FAT4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FAT4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fat4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FAT4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FAT4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fat4 (FAT atypical cadherin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FAT4 (FAT atypical cadherin 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fat4 (FAT atypical cadherin 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ft	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fat4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	123,855,289 - 123,984,716 (+)	NCBI		GRCr8
mRatBN7.2	2	121,927,266 - 122,056,700 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	121,927,942 - 122,056,707 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	128,499,081 - 128,627,276 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	126,611,655 - 126,739,826 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	121,240,615 - 121,368,809 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	125,751,818 - 125,879,398 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	125,752,130 - 125,879,387 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	126,267,658 - 126,284,238 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	145,349,239 - 145,477,455 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	145,864,192 - 145,880,594 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	125,847,465 - 125,975,620 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	116,853,380 - 116,981,485 (+)	NCBI		Celera
Cytogenetic Map	2	q25	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Ascites (ISO)

CAKUT (ISO)

cystic kidney disease (ISO)

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

Hennekam Lymphangiectasia-Lymphedema Syndrome 1 (ISO)

Hennekam Lymphangiectasia-Lymphedema Syndrome 2 (ISO)

Hennekam syndrome (ISO)

Infantile Capillary Hemangioma (ISO)

melanoma (ISO)

microcephaly (ISO)

Periventricular Nodular Heterotopia 2 (ISO)

Peters anomaly (ISO)

Stomach Neoplasms (ISO)

syndromic microphthalmia 5 (ISO)

Van Maldergem syndrome (ISO)

Van Maldergem syndrome 1 (ISO)

Van Maldergem syndrome 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrobenzenesulfonic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chromium(6+) (ISO)

coumarin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

gentamycin (EXP)

glycidol (EXP)

ketamine (EXP)

maneb (ISO)

manganese(II) chloride (EXP)

melphalan (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

ozone (ISO)

paracetamol (EXP)

paraquat (ISO)

pentanal (ISO)

pioglitazone (ISO)

potassium chromate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sevoflurane (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

toluene (EXP)

tributylstannane (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching involved in ureteric bud morphogenesis (ISO)

cell-cell adhesion (IBA)

cerebral cortex development (ISO)

condensed mesenchymal cell proliferation (ISO)

digestive tract development (ISO)

fibroblast growth factor receptor signaling pathway (ISO)

heart morphogenesis (ISO)

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (ISO)

hippo signaling (ISO)

homophilic cell adhesion via plasma membrane adhesion molecules (IEA)

inner ear receptor cell stereocilium organization (ISO)

kidney development (ISO)

nephron development (ISO)

neurogenesis (ISO)

Notch signaling pathway (ISO)

ossification involved in bone maturation (ISO)

plasma membrane organization (ISO)

regulation of metanephric nephron tubule epithelial cell differentiation (ISO)

Cellular Component

apical part of cell (ISO)

cell-cell junction (IEA)

plasma membrane (IEA)

Molecular Function

calcium ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19506035	PMID:21303848	PMID:23376485	PMID:23533145	PMID:23974041	PMID:24056717	PMID:26116661

Genomics

Comparative Map Data

Fat4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	123,855,289 - 123,984,716 (+)	NCBI		GRCr8
mRatBN7.2	2	121,927,266 - 122,056,700 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	121,927,942 - 122,056,707 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	128,499,081 - 128,627,276 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	126,611,655 - 126,739,826 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	121,240,615 - 121,368,809 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	125,751,818 - 125,879,398 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	125,752,130 - 125,879,387 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	126,267,658 - 126,284,238 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	145,349,239 - 145,477,455 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	145,864,192 - 145,880,594 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	125,847,465 - 125,975,620 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	116,853,380 - 116,981,485 (+)	NCBI		Celera
Cytogenetic Map	2	q25	NCBI

FAT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	125,314,955 - 125,492,932 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	125,314,918 - 125,492,932 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	126,236,110 - 126,414,087 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	126,457,017 - 126,632,373 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	126,672,695 - 126,770,528	NCBI
Celera	4	123,617,849 - 123,794,372 (+)	NCBI		Celera
Cytogenetic Map	4	q28.1	NCBI
HuRef	4	121,965,923 - 122,142,399 (+)	NCBI		HuRef
CHM1_1	4	126,214,142 - 126,390,638 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	128,617,253 - 128,795,252 (+)	NCBI		T2T-CHM13v2.0

Fat4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	38,939,867 - 39,066,134 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	38,941,089 - 39,066,134 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	38,884,667 - 39,011,992 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	38,886,940 - 39,011,985 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	38,785,862 - 38,910,907 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	39,078,489 - 39,203,530 (+)	NCBI		MGSCv36	mm8
Celera	3	38,729,877 - 38,854,312 (+)	NCBI		Celera
Cytogenetic Map	3	B	NCBI
cM Map	3	18.72	NCBI

Fat4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	15,622,498 - 15,810,896 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955428	15,621,333 - 15,812,167 (-)	NCBI	ChiLan1.0	ChiLan1.0

FAT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	123,095,738 - 123,273,598 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	123,362,918 - 123,540,913 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	117,494,842 - 117,674,382 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	128,637,516 - 128,814,413 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	128,637,516 - 128,814,407 (+)	Ensembl	panpan1.1		panPan2

FAT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	15,157,595 - 15,332,821 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	15,158,922 - 15,332,045 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	15,363,356 - 15,537,231 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	15,259,451 - 15,431,654 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	15,259,604 - 15,430,959 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	15,223,649 - 15,398,514 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	15,500,460 - 15,675,303 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	15,965,180 - 16,139,594 (-)	NCBI		UU_Cfam_GSD_1.0

Fat4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	63,414,526 - 63,583,319 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936662	3,537,925 - 3,690,877 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936662	3,537,917 - 3,704,012 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FAT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	99,148,496 - 99,310,519 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	99,141,967 - 99,312,131 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	105,998,766 - 106,018,349 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FAT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	72,498,182 - 72,686,607 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	72,500,264 - 72,685,546 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	51,514,689 - 51,708,405 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fat4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624777	6,095,643 - 6,292,980 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624777	6,095,166 - 6,293,142 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fat4
418 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	589
Count of miRNA genes:	266
Interacting mature miRNAs:	338
Transcripts:	ENSRNOT00000038703
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	59134147	127460910	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	59324377	141596857	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	72532993	157142209	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	76539322	150540526	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2299162	Iddm32	Insulin dependent diabetes mellitus QTL 32	2.36		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	78665616	143657569	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61392	Bp6	Blood pressure QTL 6	7		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	80270434	125270434	Rat
1598865	Bp296	Blood pressure QTL 296	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	81018907	126018907	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1578772	Stresp14	Stress response QTL 14	5	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	2	82345893	130923501	Rat
7207808	Bmd89	Bone mineral density QTL 89	4.1		femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	2	88862519	133862519	Rat
2300165	Bmd49	Bone mineral density QTL 49	4.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	2	88862519	133862519	Rat
2300170	Bmd45	Bone mineral density QTL 45	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
2300185	Bmd46	Bone mineral density QTL 46	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	88862519	133862519	Rat
1598862	Glom9	Glomerulus QTL 9	3.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	2	92337601	137337601	Rat
1598863	Cm65	Cardiac mass QTL 65	2.3		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	92337601	137337601	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	102803808	147803808	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	104559726	149559726	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	112103657	148076632	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1354594	Despr10	Despair related QTL 10		0.00000249	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	114654253	159654253	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	143657569	Rat
1359035	Bp276	Blood pressure QTL 276			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	143657569	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	118111229	149559726	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	118111229	157142209	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	118189491	163189491	Rat

Markers in Region

D3Mit295

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	121,968,795 - 121,968,881 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	125,792,028 - 125,792,113	NCBI	Rnor6.0
Rnor_5.0	2	145,390,197 - 145,390,282	UniSTS	Rnor5.0
RGSC_v3.4	2	125,887,748 - 125,887,833	UniSTS	RGSC3.4
Celera	2	116,893,663 - 116,893,748	UniSTS
Cytogenetic Map	2	q25	UniSTS

RH133227

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	122,047,969 - 122,048,189 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	126,275,456 - 126,275,675	NCBI	Rnor6.0
Rnor_6.0	2	125,870,661 - 125,870,880	NCBI	Rnor6.0
Rnor_5.0	2	145,871,857 - 145,872,076	UniSTS	Rnor5.0
Rnor_5.0	2	145,468,718 - 145,468,937	UniSTS	Rnor5.0
RGSC_v3.4	2	125,966,883 - 125,967,102	UniSTS	RGSC3.4
Celera	2	116,972,748 - 116,972,967	UniSTS
RH 3.4 Map	2	666.5	UniSTS
Cytogenetic Map	2	q25	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		1	9	2	7	2	2	2	50	18	23	8	2
Low	2	39	29	20	12	20	6	6	24	15	13	3	6
Below cutoff	1	2	17	17		17		3		2	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000038703 ⟹ ENSRNOP00000036219

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	121,927,942 - 122,056,707 (+)	Ensembl
Rnor_6.0 Ensembl	2	125,752,130 - 125,879,387 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083246

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	126,267,658 - 126,284,238 (+)	Ensembl

RefSeq Acc Id:

NM_001415042 ⟹ NP_001401971

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	123,855,289 - 123,984,716 (+)	NCBI
mRatBN7.2	2	121,927,266 - 122,056,700 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001401971	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01323	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000036219
	ENSRNOP00000036219.7

RefSeq Acc Id:

ENSRNOP00000036219 ⟸ ENSRNOT00000038703

RefSeq Acc Id:	NP_001401971 ⟸ NM_001415042
- UniProtKB:	D3ZEH1 (UniProtKB/TrEMBL)

Protein Domains

Cadherin EGF-like Laminin G

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564291	AgrOrtholog
BioCyc Gene	G2FUF-53274	BioCyc
Ensembl Genes	ENSRNOG00000028335	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000057060	Ensembl
Ensembl Transcript	ENSRNOT00000038703	ENTREZGENE
	ENSRNOT00000038703.8	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Cadherins	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	Cadherin	UniProtKB/TrEMBL
	Cadherin-like	UniProtKB/TrEMBL
	Cadherin_CS	UniProtKB/TrEMBL
	ConA-like_subgrp	UniProtKB/TrEMBL
	EGF-like_reg_CS	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_Ca-bd	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Growth_fac_rcpt_N_dom	UniProtKB/TrEMBL
	Laminin_G	UniProtKB/TrEMBL
NCBI Gene	310341	ENTREZGENE
PANTHER	DESMOGLEIN FAMILY MEMBER	UniProtKB/TrEMBL
	FAT ATYPICAL CADHERIN 4	UniProtKB/TrEMBL
Pfam	Cadherin	UniProtKB/TrEMBL
	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	hEGF	UniProtKB/TrEMBL
	Laminin_G_2	UniProtKB/TrEMBL
PhenoGen	Fat4	PhenoGen
PRINTS	CADHERIN	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	CADHERIN_1	UniProtKB/TrEMBL
	CADHERIN_2	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LAM_G_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028335	RatGTEx
	ENSRNOG00000057060	RatGTEx
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LamG	UniProtKB/TrEMBL
	SM00112	UniProtKB/TrEMBL
Superfamily-SCOP	Cadherin	UniProtKB/TrEMBL
	ConA_like_lec_gl	UniProtKB/TrEMBL
	EGF/Laminin	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	D3ZEH1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Fat4	FAT atypical cadherin 4	LOC108348049	protocadherin Fat 4-like	Data merged from RGD:11459080	737654	PROVISIONAL
2016-08-02	LOC108348049	protocadherin Fat 4-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-06-05	Fat4	FAT atypical cadherin 4	Fat4	FAT tumor suppressor homolog 4 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Fat4	FAT tumor suppressor homolog 4 (Drosophila)	RGD1564291_predicted	similar to FAT tumor suppressor homolog 4 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564291_predicted	similar to FAT tumor suppressor homolog 4 (predicted)	LOC310341	similar to FAT tumor suppressor homolog 4	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC310341	similar to FAT tumor suppressor homolog 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM