Thnsl1 (threonine synthase-like 1)

Gene: Thnsl1 (threonine synthase-like 1) Rattus norvegicus

Analyze

Symbol:

Thnsl1

Name:

threonine synthase-like 1

RGD ID:

1564213

Description:

Predicted to be active in cytoplasm. Orthologous to human THNSL1 (threonine synthase like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

threonine synthase-like 1 (bacterial); threonine synthase-like 1 (S. cerevisiae)

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	THNSL1 (threonine synthase like 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Thnsl1 (threonine synthase-like 1 (bacterial))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Thnsl1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	THNSL1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	THNSL1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Thnsl1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	THNSL1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	THNSL1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Thnsl1 (threonine synthase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	THNSL1 (threonine synthase like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Thnsl1 (threonine synthase-like 1 (bacterial))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	THR4	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	thnsl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	88,623,054 - 88,630,681 (+)	NCBI		GRCr8
mRatBN7.2	17	83,714,794 - 83,722,190 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	83,714,738 - 83,723,805 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	87,187,359 - 87,193,796 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	91,022,733 - 91,029,170 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	85,039,667 - 85,046,104 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	88,095,830 - 88,102,264 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	88,095,830 - 88,102,262 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	89,783,177 - 89,789,611 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	95,202,232 - 95,208,666 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	82,967,475 - 82,973,909 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

hydroquinone (ISO)

irinotecan (ISO)

iron dichloride (ISO)

L-methionine (ISO)

leflunomide (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium dichromate (EXP)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

Cellular Component

cytoplasm (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data

Thnsl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	88,623,054 - 88,630,681 (+)	NCBI		GRCr8
mRatBN7.2	17	83,714,794 - 83,722,190 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	83,714,738 - 83,723,805 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	87,187,359 - 87,193,796 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	91,022,733 - 91,029,170 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	85,039,667 - 85,046,104 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	88,095,830 - 88,102,264 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	88,095,830 - 88,102,262 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	89,783,177 - 89,789,611 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	95,202,232 - 95,208,666 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	82,967,475 - 82,973,909 (+)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

THNSL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	24,952,364 - 25,026,664 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	25,016,612 - 25,026,664 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	25,305,541 - 25,315,593 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	25,345,514 - 25,355,599 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	25,345,592 - 25,354,458	NCBI
Celera	10	25,006,921 - 25,017,017 (+)	NCBI		Celera
Cytogenetic Map	10	p12.1	NCBI
HuRef	10	24,966,375 - 24,976,469 (+)	NCBI		HuRef
CHM1_1	10	25,306,027 - 25,316,112 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	24,970,612 - 25,044,892 (+)	NCBI		T2T-CHM13v2.0

Thnsl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	21,210,236 - 21,232,948 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	21,210,535 - 21,219,820 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	21,205,425 - 21,228,134 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	21,205,724 - 21,215,009 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	21,127,351 - 21,136,636 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	21,123,478 - 21,132,763 (+)	NCBI		MGSCv36	mm8
Celera	2	21,087,094 - 21,096,380 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	14.83	NCBI

Thnsl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	4,169,176 - 4,182,088 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	4,169,170 - 4,208,097 (-)	NCBI	ChiLan1.0	ChiLan1.0

THNSL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	37,650,135 - 37,724,250 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	37,655,658 - 37,730,721 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	25,132,173 - 25,201,044 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	25,506,170 - 25,571,121 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	25,567,676 - 25,569,907 (+)	Ensembl	panpan1.1		panPan2

THNSL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	8,482,955 - 8,497,217 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	8,478,879 - 8,489,453 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	7,177,848 - 7,191,817 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	6,682,462 - 6,696,434 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	6,683,894 - 6,696,627 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	6,052,391 - 6,066,359 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	6,130,496 - 6,144,461 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	6,297,195 - 6,311,168 (-)	NCBI		UU_Cfam_GSD_1.0

Thnsl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	24,515,502 - 24,544,460 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	701,152 - 708,824 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	680,737 - 709,617 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

THNSL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	50,286,747 - 50,310,591 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	50,298,549 - 50,310,584 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	55,701,262 - 55,705,773 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

THNSL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	24,740,323 - 24,749,512 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	24,747,218 - 24,749,449 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	30,701,208 - 30,710,211 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Thnsl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624796	3,952,916 - 3,960,901 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Thnsl1
37 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	7
Count of miRNA genes:	7
Interacting mature miRNAs:	7
Transcripts:	ENSRNOT00000045984
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358295	Aocep1	Aortic cell protein QTL 1	6.1	0.00000071	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
7411575	Bw140	Body weight QTL 140	30.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
8694181	Bw151	Body weight QTL 151	4.36	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	48560935	86533673	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	49920154	86533673	Rat
2303580	Gluco49	Glucose level QTL 49	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	50040271	86533673	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	50909099	86022412	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	60781426	86533673	Rat
7411577	Bw141	Body weight QTL 141		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	17	62619516	86533673	Rat

Markers in Region

AW531532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	83,721,005 - 83,721,161 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	88,102,042 - 88,102,197	NCBI	Rnor6.0
Rnor_5.0	17	89,789,389 - 89,789,544	UniSTS	Rnor5.0
RGSC_v3.4	17	95,208,444 - 95,208,599	UniSTS	RGSC3.4
Celera	17	82,973,687 - 82,973,842	UniSTS
RH 3.4 Map	17	873.41	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1								53		9	3
Low	2	43	57	41	19	41	8	11	21	35	32	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000045984 ⟹ ENSRNOP00000054444

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	83,715,751 - 83,722,967 (+)	Ensembl
Rnor_6.0 Ensembl	17	88,095,830 - 88,102,262 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105674 ⟹ ENSRNOP00000082979

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	83,714,738 - 83,723,805 (+)	Ensembl

RefSeq Acc Id:

NM_001025035 ⟹ NP_001020206

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	88,623,054 - 88,629,488 (+)	NCBI
mRatBN7.2	17	83,714,794 - 83,721,228 (+)	NCBI
Rnor_6.0	17	88,095,830 - 88,102,264 (+)	NCBI
Rnor_5.0	17	89,783,177 - 89,789,611 (+)	NCBI
RGSC_v3.4	17	95,202,232 - 95,208,666 (+)	RGD
Celera	17	82,967,475 - 82,973,909 (+)	RGD

Sequence:

show sequence

CAGCAGCTCTGGGGCGGGTTTGCCGGCTGAGGCTACCAAGGCGGTGTCGAAGTCGCTTCCCTTT
CCCCTTTCTCTTCCTATTCTTCTCTGGGTGGTTTTCTTGGCTTTGCTTTGCTCCAGAGAGTGTA
TCAGACTACCTGGTGAAATTGTTTGTAATTTGGGACCCTACTTTTTGCAAGTTTGCCTTTGCCT
CAGATCAGTACGCTCTTTGTCTGGGGATCCTGTTCTATTGTGTTTCCACTTCAGTGAGTGAAAC
TGCACCATACAAAGCCAAATAAGGAAATGAAGTTTTTCTCTTGACAGGCCGACTTACTTGGCTA
AAGCCAGTCCCTGGTTGGCTGGTCAGGAGAGTGAAGAGAAATGCTGAGCTTTACCAGATGTCAC
CATCTGAAGCGGATAACACAGAAGTGCTTTTCTAGTGCACTGGTTAAAGTGCAGACCCCCACAC
AGCTCTCGCTTCCACGAGCCTTGGCATGTGCAGAATCAGGGAAGTCATGGCACTCGACCCACTC
CCTCGTTGGAGACAAGAATATTGTCCTGATGGGGCCTCCTGGTGCTGGGAAAACAACAGTCGGC
AGAATATTAGGTGACAAACTAGGCTGCTGTGTCATCGATGTGGATGCTGATGTCCTTGAGAAAA
CCTGGAATATGAGCGTGTCTGAAAAATTGCAGGATGTTGGTAATGAGCGATTTTTAGAAGAGGA
AGGAAAAGCAGTGTTAAACTTGTTTGCATCTGGAAGTGTGATTTCCCTCAGTGGGTCCAATCCC
ATGCATGATGCTAGCATGTGGCATCTGAAGAAAAATGGGATTGTCGTATACCTGGATGTGCCTC
TAACAGATATAATTAGTCGTCTGAAGTCAATGAGAGTTGATAGGATTGTTGGCCGGAACACTGG
CACGTCTCTGAGAGACTTGCTGAAGCATGGGAAACTGCACTATAGGAAGTGGTACGATGCCCGA
GTCTTCTGTGAGAGTGGGGCCTCAGCTGAGGAGGTTGCCGACAAAGTGCTTGATGTGGTTAAAA
GATACCAAGATGTGGACTCAGAGACGTTCATTTCAACAAGGCATGTTTGTCTTAAAGACCACGA
CAAGAAGTTTCCACCAAAATACTTCAGTGAAGCTGTGGTTGAGGGATTAGCTTCTGATGGTGGC
CTCTTTGTTCCCGAGAAGGGATTTCCCAAACCAAGCCTCGGGGAGTGGACTAACCTCATAGGGG
CAACCTACATCGAAAGAGCACAGGTGCTGTTGGAAAGGTGCATTCACCCTGCGGACATTCCTGC
TGCCAAATTAGGAGAAATGATTGAAACTGCTTATGGGGAAAGCTTTGCCTGCTCCAAAGTTGCC
CCTGTCAGGCACCTTTCTGGCAATCAGTTCATCCTGGAGTTGTTCTATGGCCCGACGGGCTCCT
TTAAAGATTTGTCTTTACAGCTTATGCCTCATATTTTTGCCTACTGTATCCCTCCAGGCTGCAA
CTATGTGCTGCTTGTAGCTACTTCAGGAGACACTGGGAGTGCCGTCCTAAATGGGTTTAGCCGG
CTTAACAGAAGTGATAAAGAAAGGATAGCTGTGCTCACGTTCTTTCCAGAGAATGGCGTTAGTG
ATTTCCAGAGAGCAGAGATAGTTGGAAGTCAGAGAGAAAATGGATGGGCAATAGGTGTCAAGTC
AGATTTTGATTTTTGCCAGGCAGCTATTAGAAAAATATTTAATGATTCTGATTTTACTGGCTTT
CTGACTGTGGAATACGGCGTGGTCTTAAGTTCAGCGAACTCTATAAATTGGGCTCGACTACTCC
CGCAGGTAGTGTACCATGCCTCCGCATACCTTGAGCTCGTTAGCCAAGGGTTTATTTCTTTTGG
AAGCCCAGTCGATGTCTGTATCCCCACAGGAAACTTTGGAAACATATTAGCAGCAGTGTATGCC
AAGATGATGGGAATTCCTATTCGAAAATTTATCTGTGCCTCTAATCAGAACCACGTTCTGACTG
ATTTCATAAAAACTGGACATTATGATCTAAGAAATAGGAGATTAGCACAAACCTTCTCACCATC
AATAAACATTCTCAAGTCCTCAAACCTGGAGCGACATTTATACTTGATGGCTAACAAAGACGGG
CAGTTGATGGCGGATTTATATAATCAGCTGGAGAGCCAGCTTCACTTCCAGATTGAGGAGCTGC
TAGTTGAGAAGCTGCAGCAGGATTTTGTTGCTGACTGGTGTTCTGAGGGCGAATGCCTAGAGGC
TATCAGCACTACCTACAACACATCGGGCTATATTTTGGATCCACATACCGCTGTTGCAAAAGTG
GTTGCAGACAAGATGCAAGACAAAAGCTGCCCCGTGGTCATCGCATCGACAGCTCACTACTCCA
AGTTTGCACCTGTCGTCCTGCAGGCACTGAGGATCAAAGAACTCAACCAGACGTCGGCAAGCCA
GCTCTACCTCCTGAGCTCGTACAATGCGTTACCACCTCCTCATGAGGCTCTATTAGAGAGAATG
AAGCAGAAGGGGAAGATGGATTACCAGGCTTGTGTAGCTGATGTGGATGTCCTGAAGAGTCATG
TGGAAAAACTCATCCAAAGTTGGTTTAGGGAAGTCTGAGTAGGGTTGTTTTCTTTTTTTTTTTT
CTTGGTAAGGAGCAATAATAAATCTCGAAAGTGGATTTGGACTACAAAAAAAAAAAAAAAAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

XM_039096029 ⟹ XP_038951957

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	88,623,306 - 88,630,681 (+)	NCBI
mRatBN7.2	17	83,715,164 - 83,722,190 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020206	(Get FASTA)	NCBI Sequence Viewer
	XP_038951957	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91213	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000054444
	ENSRNOP00000054444.2
	ENSRNOP00000082979
	ENSRNOP00000082979.1

RefSeq Acc Id:

NP_001020206 ⟸ NM_001025035

- UniProtKB:

Q5BK42 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLSFTRCHHLKRITQKCFSSALVKVQTPTQLSLPRALACAESGKSWHSTHSLVGDKNIVLMGPP
GAGKTTVGRILGDKLGCCVIDVDADVLEKTWNMSVSEKLQDVGNERFLEEEGKAVLNLFASGSV
ISLSGSNPMHDASMWHLKKNGIVVYLDVPLTDIISRLKSMRVDRIVGRNTGTSLRDLLKHGKLH
YRKWYDARVFCESGASAEEVADKVLDVVKRYQDVDSETFISTRHVCLKDHDKKFPPKYFSEAVV
EGLASDGGLFVPEKGFPKPSLGEWTNLIGATYIERAQVLLERCIHPADIPAAKLGEMIETAYGE
SFACSKVAPVRHLSGNQFILELFYGPTGSFKDLSLQLMPHIFAYCIPPGCNYVLLVATSGDTGS
AVLNGFSRLNRSDKERIAVLTFFPENGVSDFQRAEIVGSQRENGWAIGVKSDFDFCQAAIRKIF
NDSDFTGFLTVEYGVVLSSANSINWARLLPQVVYHASAYLELVSQGFISFGSPVDVCIPTGNFG
NILAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRNRRLAQTFSPSINILKSSNLERHL
YLMANKDGQLMADLYNQLESQLHFQIEELLVEKLQQDFVADWCSEGECLEAISTTYNTSGYILD
PHTAVAKVVADKMQDKSCPVVIASTAHYSKFAPVVLQALRIKELNQTSASQLYLLSSYNALPPP
HEALLERMKQKGKMDYQACVADVDVLKSHVEKLIQSWFREV

hide sequence

RefSeq Acc Id:

ENSRNOP00000054444 ⟸ ENSRNOT00000045984

RefSeq Acc Id:	XP_038951957 ⟸ XM_039096029
- Peptide Label:	isoform X1
- UniProtKB:	E9PTK4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000082979 ⟸ ENSRNOT00000105674

Protein Domains

Threonine synthase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PTK4-F1-model_v2	AlphaFold	E9PTK4	1-745	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700612

Promoter ID:

EPDNEW_R11135

Type:

multiple initiation site

Name:

Thnsl1_1

Description:

threonine synthase-like 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	88,095,823 - 88,095,883	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564213	AgrOrtholog
BioCyc Gene	G2FUF-8500	BioCyc
Ensembl Genes	ENSRNOG00000033076	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045984.5	UniProtKB/TrEMBL
	ENSRNOT00000105674	ENTREZGENE
	ENSRNOT00000105674.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1100	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	3.90.1380.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7382276	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Shikimate/glucono_kinase	UniProtKB/TrEMBL
	Shikimate_kinase	UniProtKB/TrEMBL
	Thr_synth_N	UniProtKB/TrEMBL
	Thr_synth_N_sf	UniProtKB/TrEMBL
	Thr_synthase	UniProtKB/TrEMBL
	Trypto_synt_PLP_dependent	UniProtKB/TrEMBL
KEGG Report	rno:498805	UniProtKB/TrEMBL
MGC_CLONE	MGC:108927	IMAGE-MGC_LOAD
NCBI Gene	498805	ENTREZGENE
PANTHER	THREONINE SYNTHASE-LIKE 1	UniProtKB/TrEMBL
	THREONINE SYNTHASE-LIKE 1	UniProtKB/TrEMBL
Pfam	SKI	UniProtKB/TrEMBL
	Thr_synth_N	UniProtKB/TrEMBL
PhenoGen	Thnsl1	PhenoGen
PRINTS	SHIKIMTKNASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033076	RatGTEx
Superfamily-SCOP	PyrdxlP-dep_enz_bsu	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	E9PTK4	ENTREZGENE, UniProtKB/TrEMBL
	Q5BK42	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-10-01	Thnsl1	threonine synthase-like 1	Thnsl1	threonine synthase-like 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Thnsl1	threonine synthase-like 1 (S. cerevisiae)	Thnsl1	threonine synthase-like 1 (bacterial)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Thnsl1	threonine synthase-like 1 (bacterial)	Thnsl1	threonine synthase-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Thnsl1	threonine synthase-like 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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