C20h21orf58 (similar to human chromosome 21 open reading frame 58) - Rat Genome Database

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Gene: C20h21orf58 (similar to human chromosome 21 open reading frame 58) Rattus norvegicus
Analyze
Symbol: C20h21orf58 (Ensembl: RGD1564149)
Name: similar to human chromosome 21 open reading frame 58 (Ensembl:similar to Protein C21orf58)
RGD ID: 1564149
Description: Orthologous to human C21orf58 (chromosome 21 open reading frame 58); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC499419; LOC499419; MGC156707; RGD1564149; similar to Protein C21orf58; uncharacterized protein C21orf58 homolog; uncharacterized protein LOC499419
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,165,853 - 12,187,271 (-)NCBIGRCr8
mRatBN7.22012,167,279 - 12,188,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,175,442 - 12,187,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2012,870,964 - 12,882,529 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,231,887 - 12,243,458 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,703,666 - 12,715,231 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,927,310 - 12,938,891 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,927,320 - 12,938,891 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,085,285 - 15,096,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,591,067 - 12,602,648 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2013,673,278 - 13,684,859 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
C20h21orf58
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,165,853 - 12,187,271 (-)NCBIGRCr8
mRatBN7.22012,167,279 - 12,188,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,175,442 - 12,187,017 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2012,870,964 - 12,882,529 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,231,887 - 12,243,458 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02012,703,666 - 12,715,231 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02012,927,310 - 12,938,891 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,927,320 - 12,938,891 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,085,285 - 15,096,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,591,067 - 12,602,648 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2013,673,278 - 13,684,859 (-)NCBICelera
Cytogenetic Map20p12NCBI
C21orf58
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382146,300,430 - 46,323,870 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2146,300,181 - 46,323,875 (-)EnsemblGRCh38hg38GRCh38
GRCh372147,720,344 - 47,743,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362146,545,475 - 46,568,213 (-)NCBINCBI36Build 36hg18NCBI36
Build 342146,545,474 - 46,568,213NCBI
Celera2132,834,819 - 32,857,559 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2133,104,411 - 33,126,619 (-)NCBIHuRef
CHM1_12147,281,792 - 47,304,522 (-)NCBICHM1_1
T2T-CHM13v2.02144,685,809 - 44,709,216 (-)NCBIT2T-CHM13v2.0
2610028H24Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391076,284,883 - 76,297,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1076,284,915 - 76,296,944 (+)EnsemblGRCm39 Ensembl
GRCm381076,449,049 - 76,461,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1076,449,081 - 76,461,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,911,826 - 75,923,963 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,892,860 - 75,904,821 (+)NCBIMGSCv36mm8
Celera1077,493,470 - 77,505,607 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.84NCBI
CUNH21orf58
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540742,712,152 - 42,728,690 (-)NCBIChiLan1.0ChiLan1.0
C22H21orf58
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22242,397,567 - 42,421,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12137,270,598 - 37,295,168 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02132,641,582 - 32,665,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12145,892,145 - 45,914,445 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2145,892,145 - 45,914,445 (-)Ensemblpanpan1.1panPan2
C31H21orf58
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13139,567,515 - 39,576,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3139,567,614 - 39,574,285 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3138,793,270 - 38,804,879 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03139,206,700 - 39,218,311 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13139,068,308 - 39,079,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03139,031,474 - 39,037,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03139,547,127 - 39,558,737 (-)NCBIUU_Cfam_GSD_1.0
CUNH21orf58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497138,866,114 - 38,877,736 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936778252,866 - 264,677 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUNH21orf58
(Sus scrofa - pig)		 No map positions available.
CUNH21orf58
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,916,904 - 89,934,889 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605418,304,431 - 18,328,329 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH21orf58
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474531,383,509 - 31,399,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C20h21orf58
152 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:71
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000017141
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 3 11
Low 2 22 25 9 18 9 7 8 39 26 28 7
Below cutoff 1 21 9 9 1 9 1 3 19 2 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017141   ⟹   ENSRNOP00000017141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,175,442 - 12,187,017 (-)Ensembl
Rnor_6.0 Ensembl2012,927,320 - 12,938,891 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095238   ⟹   ENSRNOP00000091635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,175,442 - 12,186,838 (-)Ensembl
RefSeq Acc Id: NM_001079708   ⟹   NP_001073176
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,174,922 - 12,186,503 (-)NCBI
mRatBN7.22012,175,436 - 12,187,017 (-)NCBI
Rnor_6.02012,927,310 - 12,938,891 (-)NCBI
Rnor_5.02015,085,285 - 15,096,866 (-)NCBI
RGSC_v3.42012,591,067 - 12,602,648 (-)RGD
Celera2013,673,278 - 13,684,859 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099005   ⟹   XP_038954933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,165,853 - 12,186,577 (-)NCBI
mRatBN7.22012,167,279 - 12,187,092 (-)NCBI
RefSeq Acc Id: XM_039099006   ⟹   XP_038954934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,172,158 - 12,186,577 (-)NCBI
mRatBN7.22012,173,293 - 12,187,092 (-)NCBI
RefSeq Acc Id: XM_039099008   ⟹   XP_038954936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,174,922 - 12,187,271 (-)NCBI
mRatBN7.22012,175,809 - 12,187,716 (-)NCBI
RefSeq Acc Id: XM_063279460   ⟹   XP_063135530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,172,158 - 12,186,577 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001073176   ⟸   NM_001079708
- UniProtKB: A1A5P8 (UniProtKB/TrEMBL),   A6JKD2 (UniProtKB/TrEMBL),   A0A8I6AGI1 (UniProtKB/TrEMBL),   F7ESR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017141   ⟸   ENSRNOT00000017141
RefSeq Acc Id: XP_038954933   ⟸   XM_039099005
- Peptide Label: isoform X1
- UniProtKB: A1A5P8 (UniProtKB/TrEMBL),   A6JKD2 (UniProtKB/TrEMBL),   A0A8I6AGI1 (UniProtKB/TrEMBL),   F7ESR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954934   ⟸   XM_039099006
- Peptide Label: isoform X1
- UniProtKB: A1A5P8 (UniProtKB/TrEMBL),   A6JKD2 (UniProtKB/TrEMBL),   A0A8I6AGI1 (UniProtKB/TrEMBL),   F7ESR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954936   ⟸   XM_039099008
- Peptide Label: isoform X1
- UniProtKB: A1A5P8 (UniProtKB/TrEMBL),   A6JKD2 (UniProtKB/TrEMBL),   A0A8I6AGI1 (UniProtKB/TrEMBL),   F7ESR2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000091635   ⟸   ENSRNOT00000095238
RefSeq Acc Id: XP_063135530   ⟸   XM_063279460
- Peptide Label: isoform X1
- UniProtKB: A1A5P8 (UniProtKB/TrEMBL),   A6JKD2 (UniProtKB/TrEMBL),   F7ESR2 (UniProtKB/TrEMBL)
Protein Domains
DUF4587

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1A5P8-F1-model_v2 AlphaFold A1A5P8 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564149 AgrOrtholog
BioCyc Gene G2FUF-4188 BioCyc
Ensembl Genes ENSRNOG00000012714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017141 ENTREZGENE
  ENSRNOT00000017141.6 UniProtKB/TrEMBL
  ENSRNOT00000095238.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100076 IMAGE-MGC_LOAD
InterPro DUF4587 UniProtKB/TrEMBL
  PRR29-like UniProtKB/TrEMBL
KEGG Report rno:499419 UniProtKB/TrEMBL
MGC_CLONE MGC:156707 IMAGE-MGC_LOAD
NCBI Gene 499419 ENTREZGENE
PANTHER PTHR28604 UniProtKB/TrEMBL
  RIKEN CDNA 2610028H24 GENE UniProtKB/TrEMBL
Pfam DUF4587 UniProtKB/TrEMBL
PhenoGen C20h21orf58 PhenoGen
RatGTEx ENSRNOG00000012714 RatGTEx
UniProt A0A8I6AGI1 ENTREZGENE, UniProtKB/TrEMBL
  A1A5P8 ENTREZGENE
  A6JKD2 ENTREZGENE, UniProtKB/TrEMBL
  F7ESR2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A1A5P8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C20h21orf58  similar to human chromosome 21 open reading frame 58  RGD1564149  similar to Protein C21orf58  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1564149  similar to Protein C21orf58   RGD1564149_predicted  similar to Protein C21orf58 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564149_predicted  similar to Protein C21orf58 (predicted)  LOC499419  similar to Protein C21orf58  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499419  similar to Protein C21orf58      Symbol and Name status set to provisional 70820 PROVISIONAL