Hnrnpa0 (heterogeneous nuclear ribonucleoprotein A0) - Rat Genome Database

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Gene: Hnrnpa0 (heterogeneous nuclear ribonucleoprotein A0) Rattus norvegicus
Analyze
Symbol: Hnrnpa0
Name: heterogeneous nuclear ribonucleoprotein A0
RGD ID: 1563684
Description: Predicted to enable mRNA 3'-UTR AU-rich region binding activity and protein kinase binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization; inflammatory response; and response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in synapse. Orthologous to human HNRNPA0 (heterogeneous nuclear ribonucleoprotein A0); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; methapyrilene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hnrpa0; hypothetical protein LOC681410; LOC498696; LOC681410; RGD1563684; similar to heterogeneous nuclear ribonucleoprotein A0
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,513,129 - 6,515,786 (+)NCBIGRCr8
mRatBN7.2176,507,728 - 6,510,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,507,275 - 6,509,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,531,408 - 6,534,065 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0178,062,954 - 8,065,610 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,527,780 - 6,530,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,909,166 - 6,912,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,909,728 - 6,910,630 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,112,278 - 9,114,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,452,030 - 12,452,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.41712,447,411 - 12,452,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera176,617,417 - 6,619,591 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Identification of recurrence-related genes by integrating microRNA and gene expression profiling of gastric cancer. Yan Z, etal., Int J Oncol. 2012 Dec;41(6):2166-74. doi: 10.3892/ijo.2012.1637. Epub 2012 Sep 24.
Additional References at PubMed
PMID:12456657   PMID:20932473   PMID:22082260   PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Hnrnpa0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,513,129 - 6,515,786 (+)NCBIGRCr8
mRatBN7.2176,507,728 - 6,510,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,507,275 - 6,509,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx176,531,408 - 6,534,065 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0178,062,954 - 8,065,610 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,527,780 - 6,530,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0176,909,166 - 6,912,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl176,909,728 - 6,910,630 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,112,278 - 9,114,786 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41712,452,030 - 12,452,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.41712,447,411 - 12,452,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera176,617,417 - 6,619,591 (+)NCBICelera
Cytogenetic Map17p14NCBI
HNRNPA0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385137,745,651 - 137,754,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5137,745,651 - 137,754,363 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,081,340 - 137,090,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,114,972 - 137,117,938 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,114,973 - 137,117,938NCBI
Celera5133,208,508 - 133,211,474 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,277,733 - 132,280,699 (-)NCBIHuRef
CHM1_15136,519,671 - 136,522,637 (-)NCBICHM1_1
T2T-CHM13v2.05138,271,491 - 138,280,204 (-)NCBIT2T-CHM13v2.0
Hnrnpa0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,273,693 - 58,276,370 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,273,693 - 58,276,370 (-)EnsemblGRCm39 Ensembl
GRCm381358,125,879 - 58,128,556 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,125,879 - 58,128,556 (-)EnsemblGRCm38mm10GRCm38
MGSCv371358,227,240 - 58,229,917 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361358,135,497 - 58,138,179 (-)NCBIMGSCv36mm8
Celera1359,188,312 - 59,191,005 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.95NCBI
Hnrnpa0
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540832,718,736 - 32,719,409 (-)NCBIChiLan1.0ChiLan1.0
HNRNPA0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,033,434 - 133,039,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,172,992 - 131,178,704 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,132,030 - 133,140,771 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,275,249 - 139,278,250 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,277,004 - 139,277,939 (-)Ensemblpanpan1.1panPan2
HNRNPA0
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,464,601 - 25,467,460 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,466,185 - 25,467,117 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,221,624 - 24,224,449 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,307,823 - 26,310,665 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11125,015,201 - 25,018,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01124,839,048 - 24,841,888 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,501,674 - 25,504,531 (-)NCBIUU_Cfam_GSD_1.0
Hnrnpa0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213125,687,294 - 125,690,045 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365974,712,201 - 4,714,949 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPA0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2139,779,867 - 139,783,159 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12139,779,865 - 139,783,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,501,462 - 145,504,543 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPA0
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,433,429 - 40,436,188 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,435,002 - 40,435,913 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603437,455,662 - 37,458,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpa0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247339,266,607 - 9,267,527 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247339,265,784 - 9,271,559 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnrnpa0
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000061231
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat

Markers in Region
RH79130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,509,140 - 6,509,273 (+)MAPPERmRatBN7.2
Rnor_6.0176,910,901 - 6,911,033NCBIRnor6.0
Rnor_5.0179,113,542 - 9,113,674UniSTSRnor5.0
RGSC_v3.41712,453,164 - 12,453,296UniSTSRGSC3.4
Celera176,618,347 - 6,618,479UniSTS
Cytogenetic Map17p14UniSTS
RH127764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,509,984 - 6,510,186 (+)MAPPERmRatBN7.2
Rnor_6.0176,911,745 - 6,911,946NCBIRnor6.0
Rnor_5.0179,114,386 - 9,114,587UniSTSRnor5.0
RGSC_v3.41712,454,008 - 12,454,209UniSTSRGSC3.4
Celera176,619,191 - 6,619,392UniSTS
RH 3.4 Map1767.3UniSTS
Cytogenetic Map17p14UniSTS
AA858784  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,509,091 - 6,509,241 (+)MAPPERmRatBN7.2
Rnor_6.0176,910,852 - 6,911,001NCBIRnor6.0
Rnor_5.0179,113,493 - 9,113,642UniSTSRnor5.0
RGSC_v3.41712,453,115 - 12,453,264UniSTSRGSC3.4
Celera176,618,298 - 6,618,447UniSTS
RH 3.4 Map1771.6UniSTS
Cytogenetic Map17p14UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061231   ⟹   ENSRNOP00000057942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl176,507,275 - 6,509,375 (+)Ensembl
RefSeq Acc Id: NM_001400783   ⟹   NP_001387712
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,513,129 - 6,515,786 (+)NCBI
mRatBN7.2176,507,728 - 6,510,385 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057942.5
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000057942   ⟸   ENSRNOT00000061231
RefSeq Acc Id: NP_001387712   ⟸   NM_001400783
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3H8-F1-model_v2 AlphaFold F1M3H8 1-301 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563684 AgrOrtholog
Ensembl Genes ENSRNOG00000039876 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061231.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro hnRNPA0_RRM1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
NCBI Gene Hnrnpa0 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0,-LIKE UniProtKB/TrEMBL
  HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PhenoGen Hnrnpa0 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039876 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt F1M3H8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-22 Hnrnpa0  heterogeneous nuclear ribonucleoprotein A0  LOC681410  hypothetical protein LOC681410  Data merged from RGD:1595414 737654 PROVISIONAL
2008-04-30 RGD1563684  similar to heterogeneous nuclear ribonucleoprotein A0   RGD1563684_predicted  similar to heterogeneous nuclear ribonucleoprotein A0 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC681410  hypothetical protein LOC681410      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1563684_predicted  similar to heterogeneous nuclear ribonucleoprotein A0 (predicted)  LOC498696  similar to heterogeneous nuclear ribonucleoprotein A0  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498696  similar to heterogeneous nuclear ribonucleoprotein A0      Symbol and Name status set to provisional 70820 PROVISIONAL