Znrf4 (zinc and ring finger 4) - Rat Genome Database

Name: Znrf4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Znrf4 (zinc and ring finger 4) Rattus norvegicus

Analyze

Symbol:

Znrf4

Name:

zinc and ring finger 4

RGD ID:

1563631

Description:

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of cell cycle; negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ZNRF4 (zinc and ring finger 4); INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E3 ubiquitin-protein ligase ZNRF4; zinc/RING finger protein 4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZNRF4 (zinc and ring finger 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther
Mus musculus (house mouse):	Znrf4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Znrf4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZNRF4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZNRF4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Znrf4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZNRF4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZNRF4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Znrf4 (zinc and ring finger 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ZNRF4 (zinc and ring finger 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Znrf4 (zinc and ring finger 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,440,444 - 1,441,632 (-)	NCBI		GRCr8
mRatBN7.2	9	1,353,308 - 1,354,496 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,353,306 - 1,354,584 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,787,383 - 1,788,572 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,137,058 - 7,138,246 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,092,586 - 6,093,775 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	10,535,340 - 10,536,528 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	10,535,340 - 10,536,528 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	9,530,159 - 9,531,347 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,158,413 - 7,159,601 (+)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

4,4'-sulfonyldiphenol (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

Cuprizon (EXP)

dextran sulfate (ISO)

epoxiconazole (ISO)

lead nitrate (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

resveratrol (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell cycle (IBA)

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

ubiquitin-dependent protein catabolic process (IBA,ISO)

Cellular Component

cytoplasm (IBA,ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:10191088	PMID:21205830

Genomics

Comparative Map Data

Znrf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,440,444 - 1,441,632 (-)	NCBI		GRCr8
mRatBN7.2	9	1,353,308 - 1,354,496 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,353,306 - 1,354,584 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,787,383 - 1,788,572 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,137,058 - 7,138,246 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,092,586 - 6,093,775 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	10,535,340 - 10,536,528 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	10,535,340 - 10,536,528 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	9,530,159 - 9,531,347 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,158,413 - 7,159,601 (+)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

ZNRF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	5,455,417 - 5,456,856 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	5,455,417 - 5,456,856 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	5,455,428 - 5,456,867 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	5,406,426 - 5,407,867 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	5,406,441 - 5,407,866	NCBI
Celera	19	5,392,967 - 5,394,408 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	5,216,538 - 5,217,979 (+)	NCBI		HuRef
CHM1_1	19	5,455,266 - 5,456,707 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	5,442,067 - 5,443,506 (+)	NCBI		T2T-CHM13v2.0

Znrf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,818,248 - 56,819,483 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,818,248 - 56,819,431 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	56,511,248 - 56,512,483 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	56,511,248 - 56,512,431 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,650,671 - 56,651,906 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	56,144,956 - 56,146,126 (-)	NCBI		MGSCv36	mm8
Celera	17	60,856,819 - 60,858,054 (-)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.37	NCBI

Znrf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955495	3,854,178 - 3,855,556 (+)	NCBI	ChiLan1.0	ChiLan1.0

ZNRF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	9,853,056 - 9,854,719 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	9,079,279 - 9,080,940 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	4,474,001 - 4,475,435 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	5,411,760 - 5,413,198 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ZNRF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	54,498,150 - 54,499,662 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	54,493,227 - 54,499,675 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	54,224,636 - 54,226,343 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,154,135 - 55,155,943 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	55,154,487 - 55,155,578 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	54,215,840 - 54,217,666 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	54,696,650 - 54,698,349 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	54,894,086 - 54,895,895 (+)	NCBI		UU_Cfam_GSD_1.0

Znrf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	214,690,901 - 214,692,096 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	3,142,736 - 3,143,793 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	3,142,687 - 3,143,793 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNRF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	73,481,337 - 73,486,347 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	73,484,904 - 73,486,349 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	74,178,754 - 74,180,546 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNRF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	5,127,332 - 5,129,463 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	5,127,865 - 5,129,154 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	2,988,589 - 2,990,026 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Znrf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	4,633,434 - 4,635,366 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Znrf4
3 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	123
Count of miRNA genes:	100
Interacting mature miRNAs:	108
Transcripts:	ENSRNOT00000075408
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											1
Medium											6
Low			10	1	11	1	1	1	9	4	6	8	1
Below cutoff	3	10	15	10	6	10	6	8	28	9	9	3	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000075408 ⟹ ENSRNOP00000066001

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	1,353,306 - 1,354,584 (-)	Ensembl
Rnor_6.0 Ensembl	9	10,535,340 - 10,536,528 (+)	Ensembl

RefSeq Acc Id:

NM_001024878 ⟹ NP_001020049

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	1,440,444 - 1,441,632 (-)	NCBI
mRatBN7.2	9	1,353,308 - 1,354,496 (-)	NCBI
Rnor_6.0	9	10,535,340 - 10,536,528 (+)	NCBI
Rnor_5.0	9	9,530,159 - 9,531,347 (+)	NCBI
Celera	9	7,158,413 - 7,159,601 (+)	RGD

Sequence:

show sequence

CGGCCACAGCAGGCGCCGCTCCCACCCGGCCACGGGGTCCCCGCGTGGCTCCGGAGATGCCCGA
GGGGCTCCCGTACGGTCCCACAAGGGACTCATCGGAGCTCAGGAGCCGGAGGTAGGGACCGCCA
TGGCGCGGTCGGCGTGGACACGGGTAGCCCCGCTGGCCCTGGTGGCTCTCTGGCTGGTCCTGTC
CCTGTCGCCCACGGACGCTCAGGTTAACCTGAGCTCTGGGGACTTCCTGGACCTCCCAGCGCTG
CTTGGGGTTCCCGTGGACCCCAAGAGGGCACGCGGATACCTGCTGGTGGCCCGGCCGGCCGACG
CCTGCCTCGCCATCGAGGGCCCCGGGCTTGACAACCGCTCACTGGACCCACTGGTGCTGGTCCA
GCCCCTGGGCTGCTCCTGGGAGCACACAGGACGGCGAGCACGGAGAGCCAGAGCCACAGCAGCC
TCAATGGGTTCTGAGGCCCCAGGGCAGCTGCGCGTGTTTGAGGACCTGGAAGTGACCGTGCGCT
GCGACCAGTCAGCACGCGTGCTGCTTCCGCATGGGGAACCCTGTCCCGAACCCGAGTGTCATCC
CGTAGTGGCTGCGTCCTGGGCCCTTGCTCGAGCGCTAGCCCTGGCTGCGTCTACGCTGTTCGTG
CTGCGGCAGCTGTGGCCGTGGGTCCGGGGCTGGGGGAGCCGGGGCACCGCGGTGAAGACGCAGA
CGTGCCAGAAGGCGCAAGTGCGCACATTCACGCGCCTCAGTGACCTGTGCGCCATCTGCCTGGA
CGACTACGAGGAGGGGGAACGGCTCAAGATCCTGCCCTGTGCGCATGCGTACCACTGTCGCTGC
ATAGACCCCTGGTTCTCGCGCGCCGCGCGGCGTTCGTGTCCTCTATGCAAGCAGTCGGTGGCCA
GCACGCACGACGGTTCCACGGACGGCAGCATAGGCGGCGACGAAGCACCCCTGCCCGGACACCG
CCCGCCTATATGGGCCATCCAGGCCCGGCTGCGCTCCCGCAGGCTCGAGTTGCTAGCGCGGACA
GTACCCTGCCGTCGCTGCAACAGCACCACGTCCCTGGGGATGGCTGAGAACGTGGCGCCCTCAG
AAGCGACCCCCGAGCCCTCCTGACCCCAACTGACGCGGGAAGGGGCGGAAACTAGGCAGGGGAG
GTGTGGGGGGGTGCCCAATAAAGCGTGTTTGAATCTGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020049	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98025	(Get FASTA)	NCBI Sequence Viewer
	EDL83632	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066001
	ENSRNOP00000066001.1

RefSeq Acc Id:	NP_001020049 ⟸ NM_001024878
- Peptide Label:	precursor
- UniProtKB:	Q4V7C2 (UniProtKB/TrEMBL), M0R940 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARSAWTRVAPLALVALWLVLSLSPTDAQVNLSSGDFLDLPALLGVPVDPKRARGYLLVARPAD ACLAIEGPGLDNRSLDPLVLVQPLGCSWEHTGRRARRARATAASMGSEAPGQLRVFEDLEVTVR CDQSARVLLPHGEPCPEPECHPVVAASWALARALALAASTLFVLRQLWPWVRGWGSRGTAVKTQ TCQKAQVRTFTRLSDLCAICLDDYEEGERLKILPCAHAYHCRCIDPWFSRAARRSCPLCKQSVA STHDGSTDGSIGGDEAPLPGHRPPIWAIQARLRSRRLELLARTVPCRRCNSTTSLGMAENVAPS EATPEPS hide sequence

RefSeq Acc Id:

ENSRNOP00000066001 ⟸ ENSRNOT00000075408

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V7C2-F1-model_v2	AlphaFold	Q4V7C2	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696458

Promoter ID:

EPDNEW_R6983

Type:

initiation region

Name:

Znrf4_1

Description:

zinc and ring finger 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	10,535,283 - 10,535,343	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563631	AgrOrtholog
BioCyc Gene	G2FUF-28530	BioCyc
Ensembl Genes	ENSRNOG00000048875	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000075408	ENTREZGENE
	ENSRNOT00000075408.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7455918	IMAGE-MGC_LOAD
InterPro	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:301127	UniProtKB/TrEMBL
MGC_CLONE	MGC:116178	IMAGE-MGC_LOAD
NCBI Gene	301127	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE ZNRF4	UniProtKB/TrEMBL
	RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING	UniProtKB/TrEMBL
Pfam	zf-RING_2	UniProtKB/TrEMBL
PhenoGen	Znrf4	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000048875	RatGTEx
SMART	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	M0R940	ENTREZGENE, UniProtKB/TrEMBL
	Q4V7C2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Znrf4	zinc and ring finger 4			Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	Znrf4	zinc and ring finger 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar