Srsf8 (serine and arginine rich splicing factor 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Srsf8 (serine and arginine rich splicing factor 8) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Srsf8
Name: serine and arginine rich splicing factor 8
RGD ID: 1563383
Description: Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nuclear speck; INTERACTS WITH 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase RLIM-like; LOC317533; RGD1563383; serine/arginine-rich splicing factor 2-like; serine/arginine-rich splicing factor 8; similar to hypothetical protein 4930595M18
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X49,612,410 - 49,658,278 (-)NCBIGRCr8
mRatBN7.2X45,695,314 - 45,741,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX45,695,313 - 45,741,134 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X49,529,525 - 49,530,166 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0X49,644,973 - 49,705,870 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX49,529,318 - 49,530,166 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X49,840,837 - 49,884,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X67,788,640 - 67,834,356 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX46,339,876 - 46,386,018 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nuclear speck  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Srsf8
249 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:48
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000072026
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

reproductive system
High
Medium
Low 7
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072026   ⟹   ENSRNOP00000065352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX45,695,313 - 45,741,134 (-)Ensembl
Rnor_6.0 EnsemblX49,529,318 - 49,530,166 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111207   ⟹   ENSRNOP00000091208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX45,695,322 - 45,741,134 (-)Ensembl
RefSeq Acc Id: XM_006256980   ⟹   XP_006257042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X49,612,410 - 49,658,278 (-)NCBI
mRatBN7.2X45,695,314 - 45,741,153 (-)NCBI
Rnor_6.0X49,644,973 - 49,705,870 (-)NCBI
Rnor_5.0X49,840,837 - 49,884,662 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006257042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065352
  ENSRNOP00000065352.2
  ENSRNOP00000091208.1
Reference Protein Sequences
RefSeq Acc Id: XP_006257042   ⟸   XM_006256980
- UniProtKB: M0RB37 (UniProtKB/TrEMBL),   A0A8I6AB60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065352   ⟸   ENSRNOT00000072026
RefSeq Acc Id: ENSRNOP00000091208   ⟸   ENSRNOT00000111207
Protein Domains
RING-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RB37-F1-model_v2 AlphaFold M0RB37 1-214 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563383 AgrOrtholog
BioCyc Gene G2FUF-2373 BioCyc
Ensembl Genes ENSRNOG00000048925 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072026.2 UniProtKB/TrEMBL
  ENSRNOT00000111207.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:317533 UniProtKB/TrEMBL
NCBI Gene 317533 ENTREZGENE
PANTHER RING FINGER PROTEIN 130 UniProtKB/TrEMBL
  SI:CH211-59O9.10 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PhenoGen Srsf8 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048925 RatGTEx
SMART RING UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6AB60 ENTREZGENE, UniProtKB/TrEMBL
  M0RB37 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srsf8  serine and arginine rich splicing factor 8  Srsf8  serine/arginine-rich splicing factor 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-10 Srsf8  serine/arginine-rich splicing factor 8  RGD1563383  similar to hypothetical protein 4930595M18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563383  similar to hypothetical protein 4930595M18   RGD1563383_predicted  similar to hypothetical protein 4930595M18 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563383_predicted  similar to hypothetical protein 4930595M18 (predicted)  LOC317533  similar to hypothetical protein 4930595M18  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317533  similar to hypothetical protein 4930595M18      Symbol and Name status set to provisional 70820 PROVISIONAL