Fthl17fl (ferritin, heavy polypeptide-like 17, member F like) - Rat Genome Database

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Gene: Fthl17fl (ferritin, heavy polypeptide-like 17, member F like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fthl17fl (Ensembl: RGD1563378)
Name: ferritin, heavy polypeptide-like 17, member F like (Ensembl:similar to ferritin heavy polypeptide-like 17)
RGD ID: 1563378
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be active in cytoplasm. Orthologous to human FTH1P19 (ferritin heavy chain 1 pseudogene 19) and FTHL17 (ferritin heavy chain like 17); INTERACTS WITH trichloroethene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ferritin heavy polypeptide-like 17; ferritin heavy polypeptide-like 17E; LOC302719; RGD1563378; similar to ferritin heavy polypeptide-like 17
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X46,318,864 - 46,321,178 (+)NCBIGRCr8
mRatBN7.2X42,433,227 - 42,434,091 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX42,433,429 - 42,433,959 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X45,635,751 - 45,640,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,637,415 - 45,637,945 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X45,820,826 - 45,860,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X64,139,575 - 64,140,105 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX43,079,755 - 43,084,016 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000050544
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 3 1 24
Below cutoff 10 6 4 1 4 3 4 26 4 7 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050544   ⟹   ENSRNOP00000048523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX42,433,429 - 42,433,959 (+)Ensembl
Rnor_6.0 EnsemblX45,637,415 - 45,637,945 (+)Ensembl
RefSeq Acc Id: XM_039100338   ⟹   XP_038956266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,318,864 - 46,321,178 (+)NCBI
mRatBN7.2X42,433,227 - 42,434,091 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038956266 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048523
  ENSRNOP00000048523.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000048523   ⟸   ENSRNOT00000050544
RefSeq Acc Id: XP_038956266   ⟸   XM_039100338
- UniProtKB: D3ZC26 (UniProtKB/TrEMBL),   A6IPU1 (UniProtKB/TrEMBL)
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC26-F1-model_v2 AlphaFold D3ZC26 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563378 AgrOrtholog
BioCyc Gene G2FUF-2394 BioCyc
Ensembl Genes ENSRNOG00000048574 Ensembl
  ENSRNOG00000067596 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050544.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin-like UniProtKB/TrEMBL
  Ferritin/RR-like UniProtKB/TrEMBL
  Ferritin_Dps UniProtKB/TrEMBL
  Ferritin_N UniProtKB/TrEMBL
  Ferritin_rel UniProtKB/TrEMBL
NCBI Gene 302719 ENTREZGENE
PANTHER FERRITIN HEAVY POLYPEPTIDE-LIKE 17-RELATED UniProtKB/TrEMBL
  Ferritin_N UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Fthl17fl PhenoGen
PROSITE FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048574 RatGTEx
  ENSRNOG00000067596 RatGTEx
Superfamily-SCOP Ferritin/RR_like UniProtKB/TrEMBL
UniProt A6IPU1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZC26 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Fthl17fl  ferritin, heavy polypeptide-like 17, member F like  RGD1563378  similar to ferritin heavy polypeptide-like 17  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1563378  similar to ferritin heavy polypeptide-like 17   RGD1563378_predicted  similar to ferritin heavy polypeptide-like 17 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563378_predicted  similar to ferritin heavy polypeptide-like 17 (predicted)  LOC302719  similar to ferritin heavy polypeptide-like 17  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302719  similar to ferritin heavy polypeptide-like 17      Symbol and Name status set to provisional 70820 PROVISIONAL