Aadacl4fm2 (AADACL4 family member 2)

Gene: Aadacl4fm2 (AADACL4 family member 2) Rattus norvegicus

Analyze

Symbol:

Aadacl4fm2 (Ensembl: RGD1563334)

Name:

AADACL4 family member 2 (Ensembl:similar to novel protein similar to esterases)

RGD ID:

1563334

Description:

Predicted to enable hydrolase activity. Orthologous to human AADACL4 (arylacetamide deacetylase like 4); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

arylacetamide deacetylase-like 4; arylacetamide deacetylase-like 4 family member 1; LOC502999; RGD1563334; similar to novel protein similar to esterases

RGD Orthologs

Mouse

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Aadacl4fm2 (AADACL4 family member 2)	RGD	RGD
Other homologs ²
Homo sapiens (human):	AADACL4 (arylacetamide deacetylase like 4)	HGNC	EggNOG, OrthoDB, Panther
Homo sapiens (human):	AADACL3 (arylacetamide deacetylase like 3)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	AADACL4 (arylacetamide deacetylase like 4)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Aadacl4fm2 (AADACL4 family member 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aadacl4 (arylacetamide deacetylase-like 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	trcs-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T09B9.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aadacl4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aadacl3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	161,707,170 - 161,718,664 (-)	NCBI		GRCr8
mRatBN7.2	5	156,426,706 - 156,435,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	156,426,440 - 156,435,454 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	162,593,460 - 162,602,329 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	162,593,392 - 162,602,339 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	166,277,955 - 166,286,582 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	162,999,269 - 163,007,896 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	154,727,476 - 154,736,345 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4,4'-sulfonyldiphenol (EXP)

bisphenol A (EXP)

bisphenol F (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

hydrolase activity (IEA)

lipase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Aadacl4fm2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	161,707,170 - 161,718,664 (-)	NCBI		GRCr8
mRatBN7.2	5	156,426,706 - 156,435,333 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	156,426,440 - 156,435,454 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	162,593,460 - 162,602,329 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	162,593,392 - 162,602,339 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	166,277,955 - 166,286,582 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	162,999,269 - 163,007,896 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	154,727,476 - 154,736,345 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Aadacl4fm2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	144,281,570 - 144,291,704 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	144,281,570 - 144,291,704 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	144,555,000 - 144,565,134 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	144,555,000 - 144,565,134 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	144,144,903 - 144,155,037 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	143,821,687 - 143,831,821 (-)	NCBI		MGSCv36	mm8
MGSCv36	4	141,877,645 - 141,888,334 (-)	NCBI		MGSCv36	mm8
Celera	4	146,160,678 - 146,170,425 (-)	NCBI		Celera
Cytogenetic Map	4	E1	NCBI
cM Map	4	77.99	NCBI

Variants

Variants in Aadacl4fm2
31 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	10
Count of miRNA genes:	10
Interacting mature miRNAs:	10
Transcripts:	ENSRNOT00000071779
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	151006154	161165494	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	151113452	164465185	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	151113452	166875058	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	154828214	166875058	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low	2	10	26	10	19	10	8	8	11	10	10	10	8
Below cutoff	1	1	1	1		1		3	7	1	3	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001074305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_578509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000071779 ⟹ ENSRNOP00000064868

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	156,426,440 - 156,435,454 (-)	Ensembl
Rnor_6.0 Ensembl	5	162,593,392 - 162,602,339 (-)	Ensembl

RefSeq Acc Id:

XM_578509 ⟹ XP_578509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	161,707,170 - 161,718,664 (-)	NCBI
mRatBN7.2	5	156,426,706 - 156,435,333 (-)	NCBI
Rnor_6.0	5	162,593,460 - 162,602,329 (-)	NCBI
Rnor_5.0	5	166,277,955 - 166,286,582 (-)	NCBI
RGSC_v3.4	5	162,999,269 - 163,007,896 (-)	RGD

Sequence:

show sequence

AGAAGTCACCCTGTGTGTTATAAGGCACCTGGGTCTGTGGAGGAGAGAGCTCTATACACTCTTT
CTGGGAGATAGGTATTCTTCAGCATATTCTAAAGGAATAAGACCATCATGATCTTGGTGATAAT
ACTCTTCACCACTGCAATCTTCCTGGTTCTGGGGGTCAGTGTATGGGTTCTCATAAAAGAGATC
TTCACTGTACGTGTTCCTCCTCCCATCCGCCAACGAGTGAAATTTCACATTCTACACTACTTCT
TCCAGTTGACAATAGCATTGGGGAATGTACTGGAGAAGATGAAACTTTGTTCCATGCCCCGGTT
TTTTTGCTTTTTGCAAGACCTCTTGGTGTCAAAAAATAACTTTGGTGTGTTGGTGAAGAACTTG
CATTTTGGTACAATCCCTGTGAGGTTGTTTCAACCCAAGACAACCTCCTCTGGCCCCCGGAGAG
GCATCATCTTCTACCATGGAGGAGGTTGTATGTTTGGTGGCCTGGATTGTTACCACAACTTATG
CAGTTACCTGGCCTCAGAGACAGATTCAGTACTACTATCAGTGGGGTACCGTAAGCTTCCTGAC
CATCATCACCCTATTGTTTACCAGGATTGCCTGAATGCCACCATCCACTTCTTGAAAGAACTGA
AAACTTATGGGATAGACCCTGAACAGGTGGTGATTAGTGGAGAAAGCATTGGAGCTGGGGCTGC
AGCTATTATTGCCCAGGCATTATTGGACAGAAAAGATCTTCCGAAGTTTCGGGCTCAAGTCCTG
ATTAATCCAGTCATTCAGGGGATCAATTTCCAGTTGCCATCTTACCAGCAGTATCCAAATGCCC
CATTTCTATCTAGGAAATTTTTGGTGACTTGTGTATGTAAGTATTTGGCCATTGACCTGTCCTG
GATGGATGACATGTTGAAAGGTACTTTTATACCTCCAGACAACTGGAAAAAGTATAAGAAATGG
CTCAGCTCTGACAACATCCCCCAAAGATTCAAGAGCCAAGGCCCACAACCTGAGTCTCCTGGGC
CTTTTAATGAGGCCGCTTATTTAGAAATTAATCATATTTTCAATTTAGAAGTGTCACCTCTACT
GGCAGATGACAAGACCATTGCTCAGCTTCCTGAAACCCTCCTGGTGAGCAATGAATATGATGTC
CTCCGTGATGACTCTATACTCTACAAGAAACGATTGGAAGACCAGGGGGTTCCTGTGACTTGGT
GCCATTTAGAAGATGGATTTCATGGATGCATTATGCTATTTGATAAGAAAGCTTTATCTTTTCC
TTGTTCTCATAAGGCTATGAGTTCTACAGTCAGTTTCATAAAGGGCATAAAGAGATCTCAAAAT
TGAAGTCAGTAGTTAAATAATTAAATGCTTTAGTATGGTAAATGAGAAACCCTAAAGAAACAAG
TAAACAAGCAGATTGAAAACAAGCAGAATGGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTA
CCTAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_578509	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064868
	ENSRNOP00000064868.2

RefSeq Acc Id:

XP_578509 ⟸ XM_578509

- UniProtKB:

M0R631 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MILVIILFTTAIFLVLGVSVWVLIKEIFTVRVPPPIRQRVKFHILHYFFQLTIALGNVLEKMKL
CSMPRFFCFLQDLLVSKNNFGVLVKNLHFGTIPVRLFQPKTTSSGPRRGIIFYHGGGCMFGGLD
CYHNLCSYLASETDSVLLSVGYRKLPDHHHPIVYQDCLNATIHFLKELKTYGIDPEQVVISGES
IGAGAAAIIAQALLDRKDLPKFRAQVLINPVIQGINFQLPSYQQYPNAPFLSRKFLVTCVCKYL
AIDLSWMDDMLKGTFIPPDNWKKYKKWLSSDNIPQRFKSQGPQPESPGPFNEAAYLEINHIFNL
EVSPLLADDKTIAQLPETLLVSNEYDVLRDDSILYKKRLEDQGVPVTWCHLEDGFHGCIMLFDK
KALSFPCSHKAMSSTVSFIKGIKRSQN

hide sequence

RefSeq Acc Id:

ENSRNOP00000064868 ⟸ ENSRNOT00000071779

Protein Domains

Alpha/beta hydrolase fold-3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-M0R631-F1-model_v2	AlphaFold	M0R631	1-411	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563334	AgrOrtholog
BioCyc Gene	G2FUF-39266	BioCyc
Ensembl Genes	ENSRNOG00000050089	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000071779.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	AB_hydrolase_3	UniProtKB/TrEMBL
KEGG Report	rno:502999	UniProtKB/TrEMBL
NCBI Gene	502999	ENTREZGENE
PANTHER	AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C	UniProtKB/TrEMBL
	ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	Abhydrolase_3	UniProtKB/TrEMBL
PhenoGen	Aadacl4fm2	PhenoGen
RatGTEx	ENSRNOG00000050089	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	M0R631	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-03-09	Aadacl4fm2	AADACL4 family member 2	RGD1563334	similar to novel protein similar to esterases	Name and Symbol changed	629549	APPROVED
2008-04-30	RGD1563334	similar to novel protein similar to esterases	RGD1563334_predicted	similar to novel protein similar to esterases (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1563334_predicted	similar to novel protein similar to esterases (predicted)	LOC502999	similar to novel protein similar to esterases	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC502999	similar to novel protein similar to esterases			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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