Gsap (gamma-secretase activating protein)

Gene: Gsap (gamma-secretase activating protein) Rattus norvegicus

Analyze

Symbol:

Gsap

Name:

gamma-secretase activating protein

RGD ID:

1563271

Description:

Predicted to enable amyloid-beta binding activity. Predicted to be involved in positive regulation of amyloid-beta formation and regulation of proteolysis. Predicted to be active in trans-Golgi network. Orthologous to human GSAP (gamma-secretase activating protein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC311984; pigeon homolog; pigeon homolog (Drosophila); Pion; similar to RIKEN cDNA A530088I07 gene

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GSAP (gamma-secretase activating protein)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gsap (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gsap (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GSAP (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GSAP (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gsap (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GSAP (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GSAP (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gsap (gamma-secretase activating protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Gsap (gamma-secretase activating protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GSAP (gamma-secretase activating protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gsap (gamma-secretase activating protein)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	pigeon	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,705,237 - 14,800,057 (-)	NCBI		GRCr8
mRatBN7.2	4	13,813,046 - 13,907,875 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	13,813,046 - 13,907,814 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	18,943,769 - 19,038,121 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,745,804 - 14,840,142 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,129,415 - 13,223,765 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,423,090 - 10,517,887 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,423,139 - 10,517,848 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	10,416,312 - 10,511,062 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	9,306,309 - 9,401,421 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	9,376,588 - 9,469,734 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

diallyl trisulfide (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

glafenine (EXP)

leflunomide (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

paracetamol (ISO)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

trichostatin A (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of amyloid-beta formation (IBA,ISO)

regulation of proteolysis (ISO)

Cellular Component

trans-Golgi network (IBA,ISO)

Molecular Function

amyloid-beta binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:20811458	PMID:23209290

Genomics

Comparative Map Data

Gsap
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,705,237 - 14,800,057 (-)	NCBI		GRCr8
mRatBN7.2	4	13,813,046 - 13,907,875 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	13,813,046 - 13,907,814 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	18,943,769 - 19,038,121 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,745,804 - 14,840,142 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,129,415 - 13,223,765 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,423,090 - 10,517,887 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,423,139 - 10,517,848 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	10,416,312 - 10,511,062 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	9,306,309 - 9,401,421 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	9,376,588 - 9,469,734 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

GSAP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	77,310,751 - 77,416,630 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	77,310,751 - 77,416,349 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	76,940,068 - 77,045,666 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	76,778,004 - 76,883,653 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	71,640,697 - 71,746,347 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	71,542,397 - 71,647,114 (-)	NCBI		HuRef
CHM1_1	7	76,870,032 - 76,975,785 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	78,561,812 - 78,667,706 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	76,273,131 - 76,378,780 (-)	NCBI

Gsap
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	21,380,767 - 21,518,423 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	21,391,253 - 21,520,130 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	21,176,019 - 21,291,737 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	21,186,255 - 21,315,132 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	20,692,085 - 20,797,519 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	20,698,113 - 20,803,540 (+)	NCBI		MGSCv36	mm8
Celera	5	18,145,351 - 18,255,075 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	9.83	NCBI

Gsap
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955410	7,740,548 - 7,810,563 (+)	NCBI	ChiLan1.0	ChiLan1.0

GSAP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	95,158,112 - 95,270,356 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	143,422,751 - 143,534,989 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	69,231,374 - 69,340,215 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	83,043,121 - 83,141,931 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	83,043,730 - 83,146,026 (-)	Ensembl	panpan1.1		panPan2

GSAP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	17,406,903 - 17,479,429 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	17,407,532 - 17,484,688 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	17,065,522 - 17,150,068 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	17,728,145 - 17,811,342 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	17,727,492 - 17,811,913 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	17,478,408 - 17,561,728 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	17,417,391 - 17,501,091 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	17,686,332 - 17,770,275 (-)	NCBI		UU_Cfam_GSD_1.0

Gsap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	59,581,805 - 59,676,195 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	20,705,585 - 20,800,020 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	20,705,596 - 20,800,026 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSAP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	102,694,861 - 102,787,536 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	102,694,846 - 102,785,208 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	113,150,670 - 113,180,218 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSAP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	71,513,271 - 71,735,228 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666042	32,356,683 - 32,409,852 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gsap
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624739	26,582,689 - 26,657,097 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gsap
804 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	264
Count of miRNA genes:	171
Interacting mature miRNAs:	201
Transcripts:	ENSRNOT00000039953
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat

Markers in Region

RH132514

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	13,813,244 - 13,813,424 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	10,423,359 - 10,423,538	NCBI	Rnor6.0
Rnor_5.0	4	10,416,581 - 10,416,760	UniSTS	Rnor5.0
RGSC_v3.4	4	9,306,485 - 9,306,664	UniSTS	RGSC3.4
Celera	4	9,376,764 - 9,376,943	UniSTS
RH 3.4 Map	4	47.8	UniSTS
Cytogenetic Map	4	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		23	21	13	21				13	4	11
Low	1	43	34	20	6	20	8	11	63	22	30		8
Below cutoff									11		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001395028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005503209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005503210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010065636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC090018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000039953 ⟹ ENSRNOP00000039097

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	13,813,069 - 13,907,814 (-)	Ensembl
Rnor_6.0 Ensembl	4	10,423,183 - 10,517,832 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083964 ⟹ ENSRNOP00000070072

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	13,813,046 - 13,907,793 (-)	Ensembl
Rnor_6.0 Ensembl	4	10,423,139 - 10,517,848 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119706 ⟹ ENSRNOP00000084970

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	13,813,046 - 13,907,793 (-)	Ensembl

RefSeq Acc Id:

NM_001395028 ⟹ NP_001381957

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,705,237 - 14,800,005 (-)	NCBI
mRatBN7.2	4	13,813,046 - 13,907,818 (-)	NCBI

RefSeq Acc Id:

XM_008762649 ⟹ XP_008760871

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,706,794 - 14,800,054 (-)	NCBI
mRatBN7.2	4	13,814,601 - 13,907,873 (-)	NCBI
Rnor_6.0	4	10,424,735 - 10,517,886 (-)	NCBI

Sequence:

show sequence

GGGCCGCCCAGAACCCTGAACCGAAAGCAGCAGCGGGAGGCGGGGAGGAAGAGAGGCGGCTGCA
GGCTGGGAGGTGTGAGCCTGCCCGGAATGTCCGCCCCGCCGCTGTTTGCGAGCCATGGCTCTGC
GGCTGGTCACCCACTTCGACGTGCTGGCGGACGTGCTCCCGAGTCTGCTCGTCCAGGCAGCGAC
AGCAGATGAAGGAGACGAAGGCGCAGAAACAACTCTTGGGAGCTTACGTGTACTAAACATCGAA
AGAAATGGAGACATTATTTATACCTATAAGGACAACAAAGGAAATGCGGTCTTCGGAATATTTG
ACTGCCAAACCAGAGAAAATGAGCATCTGTACACCTTCGAGAAGGACATGCAAGCTGTCAGTTG
CTCAGTCAACAGCGAGAGGACAGTGCTTGCTGCAAGCTTCATTCAGTACACGGAAGGAGTAAGG
AGTGAGCTTCAGCCAGGATCGAAGTGTCTAACTTTGCTGGTTGAAATCCACCCTGTCAACAACG
TGACGGTTCTGAAAGCTGTGGATAGCTGCGTTTGGGTACAGTTCCTCTACCCACAAGCTGAAAG
TCATCTTCTTGCACAGAACCACCTGTTACTGATTTCAGAAGAGAAATATATTGAACGGTTTCAT
ATCCAGATCACCAGAGAAGATGGAAACAGAGTGGTAATTAGAAATTCTAGCCATCTCCCAAGAG
AAAGAATAGCTGAAGACTTCGTTTGGGCTCAGTGGGATGTGTCAGAGCAGAGAATCCACTACAT
TGAACTGCAGGAGTCAAGGAGTATCTTGAAATGCGTCCAGTTCTGGGCAGATGAAAGCTTTACC
ATAATGTTTGAAATGCCCTTGGACATATCATTAAGTGGCTTGAGATTTAAACTCGTCAACTTCG
GCTATGATTATCGTCAAGACCAAGCCAAGCTTTGCCATCAGCCATCCCTCTGCATTTTTACCAA
CCACACAGGGAGTTTGTGTGTGTGTTACAGCCCGAAGTCTGACTCTTGGAAAGAAATCACGTAT
TCAGTGTTTTACCTCCATAAAGGGTACAGAAAGACCTTCACCGTAGCTCCTGGAAGCACTGACT
CGCAGGTCGCCAACGGCGTCACCTTTCTCAACCTTGGCTACTTTGTGGCTGTTTATTCCCCCTG
CCGTTTCCTTCATTTACTTAACATTCGGCATCCAGACTTGATCTGCCACAGTCTGTTTCTCACA
GGAAACAACAAAACGGCCGCTGTGCTACCTCCGAGTCCTTTGCAGTCCCTGCCGGGGTCCCTCA
TTCTGGACTGCTCTTCTGGAAAGGTCTATAGAGCAACTCTTGACCAGTCATACTTGATGGGTTT
CCTGTGGAACGCCCAGCTAGACTGTGAGAAAATGGCTGCGCTGCATTGTGCACTGTCCTGTGAT
TCAGACCCAGGTTTCCCAGAACAGATCGTTCAGTGGGTTTCTGAGCGTGTCTCTGCCTGCCATT
CATTTGACCTCATTCAAGAATTCCTAATTGCGTCCTCCTATTGGAGTGTGTATCCAGGGCTGGA
TGACGTGGACCTGCTCTTACCCTACTCCTCTGTGCTGACATGGGACACAGAAATTCCTGGAATG
AAGCTTGTGACAGAAGAGCTCCCGTTACCTCTTATGAAGGTCTACAGCTTGAAGGGGTACTGGG
CAAAGCTGAACTCCAACCTCGAGTATATTAAGTACACCAAGCCTCACCTGCACTACCACAACAG
CGTCGTGAGGAGAGAGTGGCATAACCTGATCTCTGAAGAGAGAACGGGAAAAAGGAGGTCCACA
ATGTACGTGAGGAACATTCTTGACAACGCTGTGAAGGTGATTTCTAACATGGAAATGAAAACAT
TCGAGCCAAGGTTAATACCCCTCTTACAAGAGGAAGACAGGCACCAGAGGCTGCTCATGGGCCT
GATGGTGTCTGAGCTAAGAGACCATCTACTGAGACACCTGCAGGGTGTAGAAAAGAAGAAAATT
GAACAGATGGTTCTGGACTACATTTCAAAACTGCTGGATCTCGTTTGGTGCTTGCTGGAAACCA
GTTGGAGGAAACACAGTGTGCACCCCTGGGTTCTCCACCTTAATGAGCACGGCAGCCCCGCAGA
TTTCGAAGTCTTTCATCTCATGACCAGGATTTTGGATGCCGCTAGCAGTTTGTGTTTCCCTCTG
CCTCCTGGTTTCCACTCTCTGCACACAATCCTTGGGGTCCACTGTCTCCCTTTGTACAACCTTC
TGCACTACATTGATAACGGCGTGCTGCTGCTCACCGAGACTGTGGTCACGAGGCTTATGAAAGA
TCTGGATAATTCAGAGAAAAATGAAAAACTGAAATTTAGCATCATTGTCCGGCTTCCTCCGCTT
ATTGGCCAGAAGGTCTGTCGGCTTTGGGACCATCCCATGAGTTCCAACATCATTTCACGGAACC
ACGTGGCCCAGCTTCTGAAGAACTACAAGAAAGAGTGTTTTCCCTTTTAGCCTCAGAGCTCTAT
GATTGACAAGTCATCATTTCCAGTAGAATTTCTTCCTCTGAACTACTTCATTGAAATTCTGATG

hide sequence

RefSeq Acc Id:

XM_039107498 ⟹ XP_038963426

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,723,229 - 14,800,057 (-)	NCBI
mRatBN7.2	4	13,831,040 - 13,907,875 (-)	NCBI

RefSeq Acc Id:

XM_063285956 ⟹ XP_063142026

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,708,045 - 14,800,055 (-)	NCBI

RefSeq Acc Id:

XR_005503209

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,706,842 - 14,800,055 (-)	NCBI
mRatBN7.2	4	13,814,653 - 13,907,874 (-)	NCBI

RefSeq Acc Id:

XR_005503210

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,706,339 - 14,800,055 (-)	NCBI
mRatBN7.2	4	13,813,046 - 13,907,873 (-)	NCBI

RefSeq Acc Id:

XR_010065635

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,707,071 - 14,800,055 (-)	NCBI

RefSeq Acc Id:

XR_010065636

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,708,170 - 14,800,055 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001381957	(Get FASTA)	NCBI Sequence Viewer
	XP_008760871	(Get FASTA)	NCBI Sequence Viewer
	XP_038963426	(Get FASTA)	NCBI Sequence Viewer
	XP_063142026	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL99431	(Get FASTA)	NCBI Sequence Viewer
	EDL99432	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039097.3
	ENSRNOP00000070072
	ENSRNOP00000070072.1
	ENSRNOP00000084970.1

RefSeq Acc Id:	XP_008760871 ⟸ XM_008762649
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A0P7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALRLVTHFDVLADVLPSLLVQAATADEGDEGAETTLGSLRVLNIERNGDIIYTYKDNKGNAVF GIFDCQTRENEHLYTFEKDMQAVSCSVNSERTVLAASFIQYTEGVRSELQPGSKCLTLLVEIHP VNNVTVLKAVDSCVWVQFLYPQAESHLLAQNHLLLISEEKYIERFHIQITREDGNRVVIRNSSH LPRERIAEDFVWAQWDVSEQRIHYIELQESRSILKCVQFWADESFTIMFEMPLDISLSGLRFKL VNFGYDYRQDQAKLCHQPSLCIFTNHTGSLCVCYSPKSDSWKEITYSVFYLHKGYRKTFTVAPG STDSQVANGVTFLNLGYFVAVYSPCRFLHLLNIRHPDLICHSLFLTGNNKTAAVLPPSPLQSLP GSLILDCSSGKVYRATLDQSYLMGFLWNAQLDCEKMAALHCALSCDSDPGFPEQIVQWVSERVS ACHSFDLIQEFLIASSYWSVYPGLDDVDLLLPYSSVLTWDTEIPGMKLVTEELPLPLMKVYSLK GYWAKLNSNLEYIKYTKPHLHYHNSVVRREWHNLISEERTGKRRSTMYVRNILDNAVKVISNME MKTFEPRLIPLLQEEDRHQRLLMGLMVSELRDHLLRHLQGVEKKKIEQMVLDYISKLLDLVWCL LETSWRKHSVHPWVLHLNEHGSPADFEVFHLMTRILDAASSLCFPLPPGFHSLHTILGVHCLPL YNLLHYIDNGVLLLTETVVTRLMKDLDNSEKNEKLKFSIIVRLPPLIGQKVCRLWDHPMSSNII SRNHVAQLLKNYKKECFPF hide sequence

RefSeq Acc Id:

ENSRNOP00000070072 ⟸ ENSRNOT00000083964

RefSeq Acc Id:

ENSRNOP00000039097 ⟸ ENSRNOT00000039953

RefSeq Acc Id:	XP_038963426 ⟸ XM_039107498
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000084970 ⟸ ENSRNOT00000119706

RefSeq Acc Id:	NP_001381957 ⟸ NM_001395028
- Peptide Label:	precursor
- UniProtKB:	A0A0G2JWZ3 (UniProtKB/TrEMBL), A6K5C2 (UniProtKB/TrEMBL), A0A8I6A0P7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063142026 ⟸ XM_063285956
- Peptide Label:	isoform X2

Protein Domains

Gamma-secretase-activating protein C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JWZ3-F1-model_v2	AlphaFold	A0A0G2JWZ3	1-846	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692812

Promoter ID:

EPDNEW_R3336

Type:

initiation region

Name:

Gsap_1

Description:

gamma-secretase activating protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	10,517,837 - 10,517,897	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563271	AgrOrtholog
BioCyc Gene	G2FUF-45969	BioCyc
Ensembl Genes	ENSRNOG00000028801	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039953.4	UniProtKB/TrEMBL
	ENSRNOT00000083964	ENTREZGENE
	ENSRNOT00000083964.2	UniProtKB/TrEMBL
	ENSRNOT00000119706.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7325279	IMAGE-MGC_LOAD
InterPro	GSAP_C_dom	UniProtKB/TrEMBL
	GSAP_fam	UniProtKB/TrEMBL
KEGG Report	rno:311984	UniProtKB/TrEMBL
MGC_CLONE	MGC:109549	IMAGE-MGC_LOAD
NCBI Gene	311984	ENTREZGENE
PANTHER	GAMMA-SECRETASE-ACTIVATING PROTEIN	UniProtKB/TrEMBL
	PTHR13630	UniProtKB/TrEMBL
Pfam	GSAP-16	UniProtKB/TrEMBL
PhenoGen	Gsap	PhenoGen
RatGTEx	ENSRNOG00000028801	RatGTEx
UniProt	A0A0G2JWZ3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A0P7	ENTREZGENE, UniProtKB/TrEMBL
	A6K5C2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZPQ9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-04-10	Gsap	gamma-secretase activating protein	Pion	pigeon homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Pion	pigeon homolog (Drosophila)	LOC311984	similar to RIKEN cDNA A530088I07 gene	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC311984	similar to RIKEN cDNA A530088I07 gene			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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