Gpr161 (G protein-coupled receptor 161) - Rat Genome Database

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Gene: Gpr161 (G protein-coupled receptor 161) Rattus norvegicus
Analyze
Symbol: Gpr161
Name: G protein-coupled receptor 161
RGD ID: 1563245
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in cilium; glial cell projection; and neuron projection. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in medulloblastoma. Orthologous to human GPR161 (G protein-coupled receptor 161); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G-protein coupled receptor 161; LOC289180; RGD1563245; similar to G protein-coupled receptor 161
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,111,271 - 80,156,517 (+)NCBIGRCr8
mRatBN7.21377,578,257 - 77,623,661 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,577,739 - 77,619,613 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01383,530,389 - 83,576,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,531,018 - 83,571,505 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,409,782 - 88,455,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,053,624 - 81,074,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1377,290,655 - 77,336,787 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23332756   PMID:28154160  


Genomics

Comparative Map Data
Gpr161
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,111,271 - 80,156,517 (+)NCBIGRCr8
mRatBN7.21377,578,257 - 77,623,661 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,577,739 - 77,619,613 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01383,530,389 - 83,576,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,531,018 - 83,571,505 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,409,782 - 88,455,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,053,624 - 81,074,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1377,290,655 - 77,336,787 (+)NCBICelera
Cytogenetic Map13q23NCBI
GPR161
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,079,542 - 168,137,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,079,542 - 168,137,667 (-)EnsemblGRCh38hg38GRCh38
GRCh371168,048,780 - 168,106,905 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,320,621 - 166,372,248 (-)NCBINCBI36Build 36hg18NCBI36
Celera1141,162,980 - 141,214,616 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1139,293,385 - 139,351,133 (-)NCBIHuRef
CHM1_11169,470,990 - 169,529,180 (-)NCBICHM1_1
T2T-CHM13v2.01167,431,007 - 167,489,154 (-)NCBIT2T-CHM13v2.0
Gpr161
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,108,760 - 165,154,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,123,358 - 165,154,314 (+)EnsemblGRCm39 Ensembl
GRCm381165,281,184 - 165,326,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,295,789 - 165,326,745 (+)EnsemblGRCm38mm10GRCm38
MGSCv371167,225,897 - 167,251,982 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,132,441 - 167,161,079 (+)NCBIMGSCv36mm8
Celera1167,740,027 - 167,766,443 (+)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map172.64NCBI
Gpr161
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554628,981,157 - 9,028,946 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554628,981,729 - 9,034,009 (+)NCBIChiLan1.0ChiLan1.0
GPR161
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,627,443 - 81,685,495 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1181,295,579 - 81,354,170 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,566,775 - 143,625,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,293,355 - 147,351,510 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,299,350 - 147,350,451 (-)Ensemblpanpan1.1panPan2
GPR161
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,364,999 - 30,411,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,366,068 - 30,407,268 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha729,895,733 - 29,948,158 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0730,176,808 - 30,229,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,182,446 - 30,224,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,016,737 - 30,069,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,047,700 - 30,100,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,285,703 - 30,338,184 (+)NCBIUU_Cfam_GSD_1.0
Gpr161
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,250,949 - 100,284,605 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,097,692 - 18,129,873 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,097,704 - 18,130,023 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR161
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl482,844,941 - 82,905,534 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1482,844,944 - 82,909,329 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2490,518,333 - 90,577,014 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR161
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12560,908,741 - 60,965,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2560,940,047 - 60,959,181 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605562,633,696 - 62,690,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr161
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248266,089,127 - 6,134,127 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248266,089,127 - 6,135,076 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr161
427 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:55
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000004104
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 54 6 12
Low 1 42 24 8 18 8 7 8 20 29 23 11 7
Below cutoff 2 1 32 32 1 32 1 3 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004104   ⟹   ENSRNOP00000004104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1377,577,739 - 77,619,613 (+)Ensembl
Rnor_6.0 Ensembl1383,531,018 - 83,571,505 (+)Ensembl
RefSeq Acc Id: XM_017598995   ⟹   XP_017454484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,111,776 - 80,156,517 (+)NCBI
mRatBN7.21377,578,719 - 77,623,661 (+)NCBI
Rnor_6.01383,530,389 - 83,576,117 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063272753   ⟹   XP_063128823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,111,271 - 80,156,517 (+)NCBI
RefSeq Acc Id: XM_063272754   ⟹   XP_063128824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,111,776 - 80,156,517 (+)NCBI
Protein Sequences
Protein RefSeqs XP_017454484 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128823 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09330 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004104
  ENSRNOP00000004104.6
Reference Protein Sequences
RefSeq Acc Id: XP_017454484   ⟸   XM_017598995
- UniProtKB: F1M5Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004104   ⟸   ENSRNOT00000004104
RefSeq Acc Id: XP_063128823   ⟸   XM_063272753
RefSeq Acc Id: XP_063128824   ⟸   XM_063272754
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5Q2-F1-model_v2 AlphaFold F1M5Q2 1-528 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563245 AgrOrtholog
BioCyc Gene G2FUF-17570 BioCyc
Ensembl Genes ENSRNOG00000003073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004104.7 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report rno:289180 UniProtKB/TrEMBL
NCBI Gene 289180 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 161 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr161 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003073 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt F1M5Q2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Gpr161  G protein-coupled receptor 161  RGD1563245  similar to G protein-coupled receptor 161  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563245  similar to G protein-coupled receptor 161   RGD1563245_predicted  similar to G protein-coupled receptor 161 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563245_predicted  similar to G protein-coupled receptor 161 (predicted)  LOC289180  similar to G protein-coupled receptor 161  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289180  similar to G protein-coupled receptor 161      Symbol and Name status set to provisional 70820 PROVISIONAL