H2ap (H2A.P histone) - Rat Genome Database

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Gene: H2ap (H2A.P histone) Rattus norvegicus
Analyze
Symbol: H2ap (Ensembl: Hypm)
Name: H2A.P histone (Ensembl:huntingtin interacting protein M)
RGD ID: 1563155
Description: Predicted to enable nucleosomal DNA binding activity. Predicted to be involved in heterochromatin organization. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AP (H2A.P histone); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: huntingtin interacting protein M; huntingtin-interacting protein M; Hypm; hypothetical protein LOC367734; LOC367734; RGD1563155; similar to RIKEN cDNA 1700054O13; uncharacterized protein LOC367734
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X15,580,476 - 15,581,030 (-)NCBIGRCr8
mRatBN7.2X12,907,962 - 12,908,516 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX13,099,030 - 13,099,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X16,595,967 - 16,596,521 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X12,852,548 - 12,853,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X13,989,401 - 13,989,955 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX13,989,401 - 13,989,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X14,771,915 - 14,772,469 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X25,064,226 - 25,064,780 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX13,517,208 - 13,517,762 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
H2ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X15,580,476 - 15,581,030 (-)NCBIGRCr8
mRatBN7.2X12,907,962 - 12,908,516 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX13,099,030 - 13,099,584 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X16,595,967 - 16,596,521 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X12,852,548 - 12,853,102 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X13,989,401 - 13,989,955 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX13,989,401 - 13,989,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X14,771,915 - 14,772,469 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X25,064,226 - 25,064,780 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX13,517,208 - 13,517,762 (-)NCBICelera
Cytogenetic MapXq12NCBI
H2AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X37,990,779 - 37,991,314 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX37,990,779 - 37,991,314 (+)EnsemblGRCh38hg38GRCh38
GRCh37X37,850,032 - 37,850,567 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,735,014 - 37,735,514 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX41,987,730 - 41,988,230 (+)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX35,595,560 - 35,596,060 (+)NCBIHuRef
CHM1_1X37,880,952 - 37,881,452 (+)NCBICHM1_1
T2T-CHM13v2.0X37,394,369 - 37,394,904 (+)NCBIT2T-CHM13v2.0
H2ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X9,713,186 - 9,713,739 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX9,713,167 - 9,713,747 (+)EnsemblGRCm39 Ensembl
GRCm38X9,846,947 - 9,847,500 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX9,846,928 - 9,847,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X9,424,073 - 9,424,626 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X9,003,906 - 9,004,459 (+)NCBIMGSCv36mm8
CeleraX7,561,130 - 7,561,683 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX4.61NCBI
Hypm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495560138,906 - 39,259 (+)NCBIChiLan1.0ChiLan1.0
LOC100981642
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X39,637,714 - 39,639,358 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,641,090 - 39,642,734 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X30,439,845 - 30,440,842 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X38,148,769 - 38,149,267 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX38,148,790 - 38,149,143 (+)Ensemblpanpan1.1panPan2
H2AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X32,744,935 - 32,745,485 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX20,093,661 - 20,094,210 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X32,791,400 - 32,791,949 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X32,872,988 - 32,873,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X32,844,520 - 32,845,069 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X32,884,731 - 32,885,280 (+)NCBIUU_Cfam_GSD_1.0
LOC120885883
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X24,996,794 - 24,997,623 (+)NCBIHiC_Itri_2
H2AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X33,889,233 - 33,890,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X37,654,671 - 37,655,389 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247462
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605638,455,792 - 38,456,870 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hypm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476217,577,088 - 17,577,662 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000004790
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
BE102379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X12,907,999 - 12,908,169 (-)MAPPERmRatBN7.2
Rnor_6.0X13,989,748 - 13,989,917NCBIRnor6.0
Rnor_5.0X14,772,262 - 14,772,431UniSTSRnor5.0
RGSC_v3.4X25,064,264 - 25,064,433UniSTSRGSC3.4
CeleraX13,517,246 - 13,517,415UniSTS
RH 3.4 MapX116.1UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 2 1 1 5 1 7
Below cutoff 1 12 2 7 2 3 3 6 10 4 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004790   ⟹   ENSRNOP00000004790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX13,989,401 - 13,989,955 (+)Ensembl
RefSeq Acc Id: NM_001134598   ⟹   NP_001128070
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,580,476 - 15,581,030 (-)NCBI
mRatBN7.2X12,907,962 - 12,908,516 (-)NCBI
Rnor_6.0X13,989,401 - 13,989,955 (+)NCBI
Rnor_5.0X14,771,915 - 14,772,469 (+)NCBI
RGSC_v3.4X25,064,226 - 25,064,780 (-)RGD
CeleraX13,517,208 - 13,517,762 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128070 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97609 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001128070   ⟸   NM_001134598
- UniProtKB: A6K026 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004790   ⟸   ENSRNOT00000004790

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZR0-F1-model_v2 AlphaFold D3ZZR0 1-117 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701718
Promoter ID:EPDNEW_R12242
Type:multiple initiation site
Name:Hypm_1
Description:huntingtin interacting protein M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X13,989,411 - 13,989,471EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563155 AgrOrtholog
BioCyc Gene G2FUF-3023 BioCyc
Ensembl Genes ENSRNOG00000021452 Ensembl
Gene3D-CATH Histone, subunit A UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_H2A UniProtKB/TrEMBL
KEGG Report rno:367734 UniProtKB/TrEMBL
NCBI Gene 367734 ENTREZGENE
PhenoGen H2ap PhenoGen
PRINTS HISTONEH2A UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021452 RatGTEx
Superfamily-SCOP Histone-fold UniProtKB/TrEMBL
UniProt A6K026 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-28 H2ap  H2A.P histone  Hypm  huntingtin interacting protein M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-05-28 Hypm  huntingtin interacting protein M  RGD1563155  similar to RIKEN cDNA 1700054O13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563155  similar to RIKEN cDNA 1700054O13   RGD1563155_predicted  similar to RIKEN cDNA 1700054O13 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563155_predicted  similar to RIKEN cDNA 1700054O13 (predicted)  LOC367734  similar to RIKEN cDNA 1700054O13  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367734  similar to RIKEN cDNA 1700054O13      Symbol and Name status set to provisional 70820 PROVISIONAL