Naxd (NAD(P)HX dehydratase) - Rat Genome Database

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Gene: Naxd (NAD(P)HX dehydratase) Rattus norvegicus
Analyze
Symbol: Naxd
Name: NAD(P)HX dehydratase
RGD ID: 1562691
Description: Enables ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrion. Orthologous to human NAXD (NAD(P)HX dehydratase); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-dependent (S)-NAD(P)H-hydrate dehydratase; ATP-dependent NAD(P)HX dehydratase; carbohydrate kinase domain containing; carbohydrate kinase domain-containing protein; Carkd; LOC361185; RGD1562691; similar to RIKEN cDNA 0710008K08
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81684,689,776 - 84,706,256 (-)NCBIGRCr8
mRatBN7.21677,986,148 - 78,004,200 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,987,726 - 78,004,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,268,131 - 83,284,573 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01686,720,788 - 86,737,230 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01681,962,317 - 81,978,848 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,326,228 - 83,342,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,326,301 - 83,342,667 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,793,403 - 82,809,848 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,840,229 - 82,856,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1675,786,608 - 75,803,050 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Occurrence and subcellular distribution of the NADPHX repair system in mammals. Marbaix AY, etal., Biochem J. 2014 May 15;460(1):49-58. doi: 10.1042/BJ20131482.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:30576410  


Genomics

Comparative Map Data
Naxd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81684,689,776 - 84,706,256 (-)NCBIGRCr8
mRatBN7.21677,986,148 - 78,004,200 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1677,987,726 - 78,004,192 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1683,268,131 - 83,284,573 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01686,720,788 - 86,737,230 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01681,962,317 - 81,978,848 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01683,326,228 - 83,342,711 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,326,301 - 83,342,667 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,793,403 - 82,809,848 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,840,229 - 82,856,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1675,786,608 - 75,803,050 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
NAXD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813110,615,460 - 110,639,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13110,615,545 - 110,639,996 (+)EnsemblGRCh38hg38GRCh38
GRCh3713111,267,807 - 111,292,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613110,066,009 - 110,090,344 (+)NCBINCBI36Build 36hg18NCBI36
Celera1392,114,056 - 92,138,392 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1391,867,122 - 91,891,659 (+)NCBIHuRef
CHM1_113111,236,259 - 111,260,790 (+)NCBICHM1_1
T2T-CHM13v2.013109,846,085 - 109,870,437 (+)NCBIT2T-CHM13v2.0
Naxd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,547,506 - 11,563,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl811,547,506 - 11,564,960 (+)EnsemblGRCm39 Ensembl
GRCm38811,497,506 - 11,513,287 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl811,497,506 - 11,514,960 (+)EnsemblGRCm38mm10GRCm38
MGSCv37811,497,506 - 11,513,287 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36811,497,574 - 11,513,256 (+)NCBIMGSCv36mm8
Celera811,672,809 - 11,688,594 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Naxd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554042,029,539 - 2,047,211 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,028,560 - 2,049,638 (-)NCBIChiLan1.0ChiLan1.0
NAXD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214112,108,616 - 112,135,034 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113110,790,823 - 110,817,249 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01391,750,962 - 91,775,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113110,867,144 - 110,891,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13110,867,144 - 110,891,404 (+)Ensemblpanpan1.1panPan2
NAXD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12258,889,324 - 58,901,346 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2258,881,927 - 58,900,382 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2258,591,342 - 58,612,939 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02259,503,624 - 59,525,269 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2259,503,639 - 59,525,266 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12259,005,934 - 59,027,372 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02258,997,609 - 59,019,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02259,033,584 - 59,055,362 (+)NCBIUU_Cfam_GSD_1.0
Naxd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945193,751,798 - 193,770,543 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364722,181,650 - 2,200,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364722,182,444 - 2,200,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAXD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1177,210,228 - 77,230,680 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11177,210,164 - 77,230,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,724,811 - 84,745,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAXD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1388,845,564 - 88,870,176 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl388,845,487 - 88,868,411 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604645,580,962 - 45,606,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naxd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247932,150,798 - 2,165,016 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247932,149,647 - 2,164,928 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Naxd
103 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:158
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000065043
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat

Markers in Region
RH129391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,986,194 - 77,986,374 (+)MAPPERmRatBN7.2
Rnor_6.01683,324,738 - 83,324,917NCBIRnor6.0
Rnor_5.01682,791,913 - 82,792,092UniSTSRnor5.0
RGSC_v3.41682,838,739 - 82,838,918UniSTSRGSC3.4
Celera1675,785,118 - 75,785,297UniSTS
RH 3.4 Map16754.1UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 1 4 74 35 41 11 1
Low 8 7 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000065043   ⟹   ENSRNOP00000060397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,987,726 - 78,004,192 (-)Ensembl
Rnor_6.0 Ensembl1683,326,301 - 83,342,667 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100855   ⟹   ENSRNOP00000091976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,988,001 - 78,004,124 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114070   ⟹   ENSRNOP00000079591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,987,726 - 78,004,192 (-)Ensembl
RefSeq Acc Id: NM_001108402   ⟹   NP_001101872
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,689,776 - 84,706,220 (-)NCBI
mRatBN7.21677,987,685 - 78,004,127 (-)NCBI
Rnor_6.01683,326,228 - 83,342,670 (-)NCBI
Rnor_5.01682,793,403 - 82,809,848 (-)NCBI
RGSC_v3.41682,840,229 - 82,856,671 (-)RGD
Celera1675,786,608 - 75,803,050 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253465   ⟹   XP_006253527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,689,810 - 84,706,212 (-)NCBI
mRatBN7.21677,986,148 - 78,004,104 (-)NCBI
Rnor_6.01683,326,262 - 83,342,678 (-)NCBI
Rnor_5.01682,793,403 - 82,809,848 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771403   ⟹   XP_008769625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,690,092 - 84,706,256 (-)NCBI
mRatBN7.21677,988,001 - 78,004,200 (-)NCBI
Rnor_6.01683,326,544 - 83,342,711 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600189   ⟹   XP_017455678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81684,689,810 - 84,705,977 (-)NCBI
mRatBN7.21677,986,148 - 78,003,874 (-)NCBI
Rnor_6.01683,326,262 - 83,342,487 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001101872   ⟸   NM_001108402
- UniProtKB: D4AAT7 (UniProtKB/Swiss-Prot),   A6IWP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253527   ⟸   XM_006253465
- Peptide Label: isoform X1
- UniProtKB: D3ZLK9 (UniProtKB/TrEMBL),   A6IWP7 (UniProtKB/TrEMBL),   A0A8I5ZNB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769625   ⟸   XM_008771403
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ACT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455678   ⟸   XM_017600189
- Peptide Label: isoform X2
- UniProtKB: D4AAT7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060397   ⟸   ENSRNOT00000065043
RefSeq Acc Id: ENSRNOP00000091976   ⟸   ENSRNOT00000100855
RefSeq Acc Id: ENSRNOP00000079591   ⟸   ENSRNOT00000114070
Protein Domains
YjeF C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAT7-F1-model_v2 AlphaFold D4AAT7 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700245
Promoter ID:EPDNEW_R10768
Type:initiation region
Name:Naxd_1
Description:NADHX dehydratase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,342,604 - 83,342,664EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562691 AgrOrtholog
BioCyc Gene G2FUF-10656 BioCyc
Ensembl Genes ENSRNOG00000015021 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065043.4 UniProtKB/TrEMBL
  ENSRNOT00000100855.1 UniProtKB/TrEMBL
  ENSRNOT00000114070 ENTREZGENE
  ENSRNOT00000114070.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARKD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribokinase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361185 UniProtKB/TrEMBL
NCBI Gene 361185 ENTREZGENE
PANTHER ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Naxd PhenoGen
PROSITE YJEF_C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015021 RatGTEx
Superfamily-SCOP SSF53613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZNB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACT3 ENTREZGENE, UniProtKB/TrEMBL
  A6IWP6 ENTREZGENE, UniProtKB/TrEMBL
  A6IWP7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLK9 ENTREZGENE, UniProtKB/TrEMBL
  D4AAT7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Naxd  NAD(P)HX dehydratase  Carkd  carbohydrate kinase domain containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Carkd  carbohydrate kinase domain containing  RGD1562691  similar to RIKEN cDNA 0710008K08   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562691  similar to RIKEN cDNA 0710008K08   RGD1562691_predicted  similar to RIKEN cDNA 0710008K08 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562691_predicted  similar to RIKEN cDNA 0710008K08 (predicted)  LOC361185  similar to RIKEN cDNA 0710008K08  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361185  similar to RIKEN cDNA 0710008K08      Symbol and Name status set to provisional 70820 PROVISIONAL