Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2) Rattus norvegicus
Analyze
Symbol: Lamtor2
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
RGD ID: 1562501
Description: Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and regulation of cell growth. Predicted to act upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Predicted to be located in late endosome. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295234; Mapbpip; mitogen activated protein binding protein interacting protein; mitogen-activated protein binding protein interacting protein; mitogen-activated protein-binding protein-interacting protein; ragulator complex protein LAMTOR2; RGD1562501; roadblock domain containing 3; Robld3; similar to Late endosomal/lysosomal Mp1 interacting protein (p14)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Robld3-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,306,353 - 176,310,617 (-)NCBIGRCr8
mRatBN7.22174,008,556 - 174,011,950 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,008,548 - 174,013,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,152,706 - 181,156,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,175,071 - 179,178,454 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,775,155 - 173,778,545 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,911,530 - 187,914,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,911,533 - 187,915,596 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,313,930 - 207,317,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,665,354 - 180,668,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2167,952,942 - 167,956,317 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of mTORC1 by amino acids. Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15263099   PMID:17897319   PMID:19177150   PMID:20381137   PMID:22980980   PMID:23376485   PMID:24841562  


Genomics

Comparative Map Data
Lamtor2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,306,353 - 176,310,617 (-)NCBIGRCr8
mRatBN7.22174,008,556 - 174,011,950 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,008,548 - 174,013,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,152,706 - 181,156,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,175,071 - 179,178,454 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,775,155 - 173,778,545 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,911,530 - 187,914,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,911,533 - 187,915,596 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,313,930 - 207,317,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,665,354 - 180,668,729 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2167,952,942 - 167,956,317 (-)NCBICelera
Cytogenetic Map2q34NCBI
LAMTOR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,054,782 - 156,058,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,054,782 - 156,058,506 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,024,573 - 156,028,297 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,291,229 - 154,294,923 (+)NCBINCBI36Build 36hg18NCBI36
Celera1129,097,578 - 129,101,362 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,387,097 - 127,390,882 (+)NCBIHuRef
CHM1_11157,420,604 - 157,424,391 (+)NCBICHM1_1
T2T-CHM13v2.01155,193,248 - 155,196,972 (+)NCBIT2T-CHM13v2.0
Lamtor2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,457,126 - 88,460,258 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,457,126 - 88,460,381 (-)EnsemblGRCm39 Ensembl
GRCm38388,549,819 - 88,552,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,549,819 - 88,553,074 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,353,741 - 88,356,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,635,746 - 88,638,854 (-)NCBIMGSCv36mm8
Celera388,589,626 - 88,592,744 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.87NCBI
Lamtor2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,236,868 - 2,242,137 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,237,506 - 2,242,070 (+)NCBIChiLan1.0ChiLan1.0
LAMTOR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,787,756 - 93,791,536 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,519,704 - 93,523,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,396,937 - 131,400,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,226,400 - 135,230,167 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,226,400 - 135,230,167 (+)Ensemblpanpan1.1panPan2
LAMTOR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,760,632 - 41,764,926 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,760,638 - 41,763,299 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,250,160 - 41,252,889 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,627,377 - 41,630,107 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,627,383 - 41,630,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,408,225 - 41,410,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,461,577 - 41,464,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,746,005 - 41,748,735 (-)NCBIUU_Cfam_GSD_1.0
Lamtor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,286,374 - 26,289,979 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,316,616 - 5,322,158 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,316,748 - 5,320,364 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMTOR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,971,819 - 93,976,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,972,112 - 93,975,561 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,714,889 - 102,718,338 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMTOR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,806,509 - 7,810,296 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,806,510 - 7,810,456 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,102,867 - 7,106,653 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamtor2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,398,505 - 1,403,789 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,399,235 - 1,403,669 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lamtor2
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:46
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000026974
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat

Markers in Region
RH125318  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01190,555,404 - 90,555,590NCBIRnor5.0
RGSC_v3.41185,397,389 - 85,397,574UniSTSRGSC3.4
Celera1182,176,907 - 82,177,092UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026974   ⟹   ENSRNOP00000026974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,911,533 - 187,914,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,911,534 - 187,912,872 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093008   ⟹   ENSRNOP00000076016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,008,556 - 174,013,013 (-)Ensembl
Rnor_6.0 Ensembl2187,911,536 - 187,915,596 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,912,435 - 187,914,749 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,008,548 - 174,011,946 (-)Ensembl
Rnor_6.0 Ensembl2187,911,534 - 187,912,264 (-)Ensembl
RefSeq Acc Id: NM_001106441   ⟹   NP_001099911
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,306,353 - 176,309,728 (-)NCBI
mRatBN7.22174,008,556 - 174,011,932 (-)NCBI
Rnor_6.02187,911,530 - 187,914,905 (-)NCBI
Rnor_5.02207,313,930 - 207,317,305 (-)NCBI
RGSC_v3.42180,665,354 - 180,668,729 (-)RGD
Celera2167,952,942 - 167,956,317 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761134   ⟹   XP_008759356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,306,357 - 176,309,744 (-)NCBI
mRatBN7.22174,008,559 - 174,011,950 (-)NCBI
Rnor_6.02187,911,533 - 187,914,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281607   ⟹   XP_063137677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,306,357 - 176,309,748 (-)NCBI
RefSeq Acc Id: XM_063281608   ⟹   XP_063137678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,307,898 - 176,310,617 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099911 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759356 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137677 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00701 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076016.2
  ENSRNOP00000094702.1
Reference Protein Sequences
RefSeq Acc Id: NP_001099911   ⟸   NM_001106441
- UniProtKB: A6J687 (UniProtKB/TrEMBL),   A6KSI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759356   ⟸   XM_008761134
- Peptide Label: isoform X1
- UniProtKB: A6KSI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026974   ⟸   ENSRNOT00000026974
RefSeq Acc Id: ENSRNOP00000076016   ⟸   ENSRNOT00000093008
RefSeq Acc Id: XP_063137677   ⟸   XM_063281607
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137678   ⟸   XM_063281608
- Peptide Label: isoform X3
Protein Domains
Roadblock/LAMTOR2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A465-F1-model_v2 AlphaFold D4A465 1-125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691445
Promoter ID:EPDNEW_R1969
Type:initiation region
Name:Lamtor2_1
Description:late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1970  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,914,868 - 187,914,928EPDNEW
RGD ID:13691449
Promoter ID:EPDNEW_R1970
Type:multiple initiation site
Name:Lamtor2_2
Description:late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1969  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,915,563 - 187,915,623EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562501 AgrOrtholog
BioCyc Gene G2FUF-52476 BioCyc
Ensembl Genes ENSRNOG00000019908 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093008.2 UniProtKB/TrEMBL
  ENSRNOT00000093121.2 UniProtKB/TrEMBL
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/TrEMBL
InterPro LAMTOR2-like UniProtKB/TrEMBL
  Roadblock/LAMTOR2_dom UniProtKB/TrEMBL
KEGG Report rno:295234 UniProtKB/TrEMBL
NCBI Gene 295234 ENTREZGENE
PANTHER PTHR13323 UniProtKB/TrEMBL
  RAGULATOR COMPLEX PROTEIN LAMTOR2 UniProtKB/TrEMBL
Pfam Robl_LC7 UniProtKB/TrEMBL
PhenoGen Lamtor2 PhenoGen
RatGTEx ENSRNOG00000019908 RatGTEx
SMART Robl_LC7 UniProtKB/TrEMBL
Superfamily-SCOP Roadblock/LC7 domain UniProtKB/TrEMBL
UniProt A0A1B0GWT7_RAT UniProtKB/TrEMBL
  A0A8I6ALB3_RAT UniProtKB/TrEMBL
  A6J687 ENTREZGENE, UniProtKB/TrEMBL
  A6KSI4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Lamtor2  late endosomal/lysosomal adaptor, MAPK and MTOR activator 2  Robld3  roadblock domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Robld3  roadblock domain containing 3  Mapbpip  mitogen-activated protein binding protein interacting protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Mapbpip  mitogen-activated protein binding protein interacting protein  RGD1562501_predicted  similar to Late endosomal/lysosomal Mp1 interacting protein (p14) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562501_predicted  similar to Late endosomal/lysosomal Mp1 interacting protein (p14) (predicted)  LOC295234  similar to Late endosomal/lysosomal Mp1 interacting protein (p14)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC295234  similar to Late endosomal/lysosomal Mp1 interacting protein (p14)      Symbol and Name status set to provisional 70820 PROVISIONAL