Irs4 (insulin receptor substrate 4) - Rat Genome Database

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Gene: Irs4 (insulin receptor substrate 4) Rattus norvegicus
Analyze
Symbol: Irs4
Name: insulin receptor substrate 4
RGD ID: 1562442
Description: Enables protein domain specific binding activity. Part of protein-containing complex. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9 and lung cancer. Orthologous to human IRS4 (insulin receptor substrate 4); PARTICIPATES IN insulin signaling pathway; aldosterone signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IRS-4
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,132,490 - 110,148,473 (-)NCBIGRCr8
mRatBN7.2X105,344,020 - 105,360,004 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX107,461,148 - 107,477,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,960,343 - 110,976,334 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X108,532,305 - 108,548,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,003,824 - 113,018,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X111,457,261 - 111,471,505 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,881,414 - 36,885,105 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX104,754,830 - 104,768,446 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: Implications for longevity. Chiba T, etal., Neurobiol Aging. 2007 Aug 24.
2. IRS4 promotes the progression of non-small cell lung cancer and confers resistance to EGFR-TKI through the activation of PI3K/Akt and Ras-MAPK pathways. Hao P, etal., Exp Cell Res. 2021 Jun 15;403(2):112615. doi: 10.1016/j.yexcr.2021.112615. Epub 2021 Apr 21.
3. MicroRNAs: a new ray of hope for diabetes mellitus. Kumar M, etal., Protein Cell. 2012 Oct;3(10):726-38. doi: 10.1007/s13238-012-2055-0. Epub 2012 Oct 11.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer. Sanmartín-Salinas P and Guijarro LG, J Oncol. 2018 Oct 16;2018:3812581. doi: 10.1155/2018/3812581. eCollection 2018.
8. Insulin receptor substrate-4 is overexpressed in colorectal cancer and promotes retinoblastoma-cyclin-dependent kinase activation. Sanmartín-Salinas P, etal., J Gastroenterol. 2018 Aug;53(8):932-944. doi: 10.1007/s00535-018-1432-8. Epub 2018 Jan 20.
9. Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients. Sanmartín-Salinas P, etal., J Mol Histol. 2018 Feb;49(1):39-49. doi: 10.1007/s10735-017-9745-0. Epub 2017 Nov 28.
Additional References at PubMed
PMID:10521603   PMID:12774026   PMID:17993726   PMID:21955513  


Genomics

Comparative Map Data
Irs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,132,490 - 110,148,473 (-)NCBIGRCr8
mRatBN7.2X105,344,020 - 105,360,004 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX107,461,148 - 107,477,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X110,960,343 - 110,976,334 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X108,532,305 - 108,548,287 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,003,824 - 113,018,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X111,457,261 - 111,471,505 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,881,414 - 36,885,105 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX104,754,830 - 104,768,446 (-)NCBICelera
Cytogenetic MapXq33NCBI
IRS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X108,719,946 - 108,736,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX108,719,946 - 108,736,563 (-)EnsemblGRCh38hg38GRCh38
GRCh37X107,963,176 - 107,979,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X107,862,368 - 107,866,307 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X107,781,856 - 107,785,784NCBI
CeleraX108,447,146 - 108,451,026 (-)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX97,599,533 - 97,603,519 (-)NCBIHuRef
CHM1_1X107,886,615 - 107,890,495 (-)NCBICHM1_1
T2T-CHM13v2.0X107,157,529 - 107,174,147 (-)NCBIT2T-CHM13v2.0
Irs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X140,493,994 - 140,508,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX140,493,994 - 140,508,259 (-)EnsemblGRCm39 Ensembl
GRCm38X141,710,998 - 141,725,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX141,710,998 - 141,725,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X138,145,541 - 138,159,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X136,957,366 - 136,971,585 (-)NCBIMGSCv36mm8
CeleraX125,711,653 - 125,725,766 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX62.43NCBI
IRS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX89,204,355 - 89,221,085 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X89,204,348 - 89,221,463 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X104,771,354 - 104,773,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X96,589,292 - 96,605,715 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX96,601,944 - 96,605,699 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606521,705,865 - 21,722,358 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248037,477,142 - 7,480,930 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248037,476,840 - 7,493,109 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irs4
31 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat

Markers in Region
PMC86565P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X105,359,006 - 105,359,301 (+)MAPPERmRatBN7.2
Rnor_6.0X113,017,075 - 113,017,369NCBIRnor6.0
Rnor_5.0X111,470,526 - 111,470,820UniSTSRnor5.0
RGSC_v3.4X36,882,097 - 36,882,391UniSTSRGSC3.4
CeleraX104,767,442 - 104,767,736UniSTS
Cytogenetic MapXq14UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001402280   ⟹   NP_001389209
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,132,490 - 110,148,473 (-)NCBI
mRatBN7.2X105,344,020 - 105,360,004 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389209 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001389209   ⟸   NM_001402280
Protein Domains
IRS-type PTB


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562442 AgrOrtholog
BioCyc Gene G2FUF-1525 BioCyc
Gene3D-CATH Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro IRS UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
NCBI Gene 315350 ENTREZGENE
PANTHER INSULIN RECEPTOR SUBSTRATE UniProtKB/TrEMBL
  INSULIN RECEPTOR SUBSTRATE 4 UniProtKB/TrEMBL
Pfam IRS UniProtKB/TrEMBL
PhenoGen Irs4 PhenoGen
PRINTS INSULINRSI UniProtKB/TrEMBL
PROSITE IRS_PTB UniProtKB/TrEMBL
SMART IRS UniProtKB/TrEMBL
  PTBI UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A6KG66_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irs4  insulin receptor substrate 4   Irs4_predicted  insulin receptor substrate 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Irs4_predicted  insulin receptor substrate 4 (predicted)  IRS-4_predicted    Symbol updated 1299863 APPROVED
2006-03-07 IRS-4_predicted  insulin receptor substrate 4 (predicted)  IRS-4  insulin receptor substrate 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 IRS-4  insulin receptor substrate 4      Symbol and Name status set to provisional 70820 PROVISIONAL