Apol9a (apolipoprotein L9a) - Rat Genome Database

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Gene: Apol9a (apolipoprotein L9a) Rattus norvegicus
Analyze
Symbol: Apol9a
Name: apolipoprotein L9a (Ensembl:apolipoprotein L 9a)
RGD ID: 1562332
Description: Predicted to enable lipid binding activity. Predicted to be involved in lipid transport and lipoprotein metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human APOL1 (apolipoprotein L1) and APOL2 (apolipoprotein L2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apolipoprotein L 9a; hypothetical protein LOC503164; LOC503164
RGD Orthologs
Human
Mouse
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,021,452 - 111,030,380 (-)NCBIGRCr8
mRatBN7.27109,140,871 - 109,149,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,140,871 - 109,147,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,896,421 - 110,903,180 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,120,004 - 113,126,763 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,081,441 - 113,088,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,927,013 - 118,933,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,927,008 - 118,933,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,924,869 - 118,931,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,472,725 - 115,479,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7105,488,312 - 105,495,073 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chloroprene  (EXP)
chrysene  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Apol9a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,021,452 - 111,030,380 (-)NCBIGRCr8
mRatBN7.27109,140,871 - 109,149,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,140,871 - 109,147,649 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,896,421 - 110,903,180 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,120,004 - 113,126,763 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,081,441 - 113,088,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07118,927,013 - 118,933,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7118,927,008 - 118,933,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07118,924,869 - 118,931,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,472,725 - 115,479,486 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7105,488,312 - 105,495,073 (-)NCBICelera
Cytogenetic Map7q34NCBI
APOL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,189,128 - 36,204,833 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,189,124 - 36,204,840 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,585,176 - 36,600,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,915,122 - 34,930,825 (-)NCBINCBI36Build 36hg18NCBI36
Build 342234,909,675 - 34,925,379NCBI
Celera2220,387,749 - 20,403,452 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2219,553,303 - 19,569,009 (-)NCBIHuRef
CHM1_12236,544,308 - 36,559,997 (-)NCBICHM1_1
T2T-CHM13v2.02236,649,310 - 36,664,999 (-)NCBIT2T-CHM13v2.0
Apol9a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,287,989 - 77,295,280 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1577,287,989 - 77,295,335 (-)EnsemblGRCm39 Ensembl
GRCm381577,403,789 - 77,411,080 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,403,789 - 77,411,135 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,234,219 - 77,241,510 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361577,231,044 - 77,238,382 (-)NCBIMGSCv36mm8
Celera1578,892,749 - 78,894,701 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.4NCBI
APOL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,907,967 - 18,917,968 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045106,981,189 - 106,991,930 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Apol9a
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:157
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000031951
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH137445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,140,932 - 109,141,149 (+)MAPPERmRatBN7.2
Rnor_6.07118,927,079 - 118,927,295NCBIRnor6.0
Rnor_5.07118,924,935 - 118,925,151UniSTSRnor5.0
RGSC_v3.47115,472,787 - 115,473,003UniSTSRGSC3.4
Celera7105,488,374 - 105,488,590UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 23 16 16 16 8 11 2 6 10 8
Low 1 20 23 7 19 7 27 19 17 1
Below cutoff 10 10 10 19 12 9

Sequence


RefSeq Acc Id: ENSRNOT00000031951   ⟹   ENSRNOP00000036679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,140,871 - 109,147,649 (-)Ensembl
Rnor_6.0 Ensembl7118,927,008 - 118,933,812 (-)Ensembl
RefSeq Acc Id: NM_001025066   ⟹   NP_001020237
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,021,452 - 111,028,213 (-)NCBI
mRatBN7.27109,140,871 - 109,147,632 (-)NCBI
Rnor_6.07118,927,017 - 118,933,778 (-)NCBI
Rnor_5.07118,924,869 - 118,931,634 (-)NCBI
RGSC_v3.47115,472,725 - 115,479,486 (-)RGD
Celera7105,488,312 - 105,495,073 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765642   ⟹   XP_008763864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,021,452 - 111,030,338 (-)NCBI
mRatBN7.27109,140,871 - 109,142,627 (-)NCBI
Rnor_6.07118,927,013 - 118,928,870 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079781   ⟹   XP_038935709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,021,452 - 111,030,380 (-)NCBI
mRatBN7.27109,140,871 - 109,149,799 (-)NCBI
RefSeq Acc Id: XM_063264153   ⟹   XP_063120223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,021,452 - 111,028,208 (-)NCBI
RefSeq Acc Id: NP_001020237   ⟸   NM_001025066
- UniProtKB: Q5XIB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763864   ⟸   XM_008765642
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000036679   ⟸   ENSRNOT00000031951
RefSeq Acc Id: XP_038935709   ⟸   XM_039079781
- Peptide Label: isoform X1
- UniProtKB: Q5XIB6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120223   ⟸   XM_063264153
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIB6-F1-model_v2 AlphaFold Q5XIB6 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695452
Promoter ID:EPDNEW_R5976
Type:multiple initiation site
Name:Apol9a_1
Description:apolipoprotein L 9a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07118,933,795 - 118,933,855EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562332 AgrOrtholog
BioCyc Gene G2FUF-32881 BioCyc
Ensembl Genes ENSRNOG00000023410 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031951 ENTREZGENE
  ENSRNOT00000031951.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193209 IMAGE-MGC_LOAD
InterPro ApoL UniProtKB/TrEMBL
KEGG Report rno:503164 UniProtKB/TrEMBL
MGC_CLONE MGC:94714 IMAGE-MGC_LOAD
NCBI Gene 503164 ENTREZGENE
PANTHER ApoL UniProtKB/TrEMBL
  APOL9A PROTEIN-RELATED UniProtKB/TrEMBL
Pfam ApoL UniProtKB/TrEMBL
PhenoGen Apol9a PhenoGen
RatGTEx ENSRNOG00000023410 RatGTEx
UniProt Q5XIB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-29 Apol9a  apolipoprotein L9a  Apol9a  apolipoprotein L 9a  Name changed 629549 APPROVED
2008-03-17 Apol9a  apolipoprotein L 9a  LOC503164  hypothetical protein LOC503164  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC503164  hypothetical protein LOC503164      Symbol and Name status set to provisional 70820 PROVISIONAL