Zdhhc15 (zinc finger DHHC-type palmitoyltransferase 15) - Rat Genome Database

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Gene: Zdhhc15 (zinc finger DHHC-type palmitoyltransferase 15) Rattus norvegicus
Analyze
Symbol: Zdhhc15
Name: zinc finger DHHC-type palmitoyltransferase 15
RGD ID: 1562075
Description: Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in positive regulation of dendrite development; protein localization to postsynapse; and regulation of dendritic spine morphogenesis. Located in Golgi membrane and postsynapse. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyltransferase ZDHHC15; DHHC-15; LOC317235; membrane-associated DHHC15 zinc finger protein; palmitoyltransferase ZDHHC15; zinc finger DHHC domain-containing protein 15; zinc finger, DHHC domain containing 15; zinc finger, DHHC-type containing 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X73,633,977 - 73,767,451 (-)NCBIGRCr8
mRatBN7.2X69,568,086 - 69,701,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX69,574,124 - 69,701,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX71,083,209 - 71,210,844 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X74,583,502 - 74,711,138 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X72,144,696 - 72,272,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X75,433,957 - 75,566,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX75,439,778 - 75,566,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,236,346 - 76,364,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,568,201 - 92,700,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX70,927,489 - 71,054,488 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Regulation of dendrite morphology and excitatory synapse formation by zDHHC15. Shah BS, etal., J Cell Sci. 2019 Jul 5;132(13). pii: jcs.230052. doi: 10.1242/jcs.230052.
Additional References at PubMed
PMID:12477932   PMID:15603741   PMID:16647879   PMID:18596047   PMID:18817523   PMID:23034182   PMID:23376485  


Genomics

Comparative Map Data
Zdhhc15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X73,633,977 - 73,767,451 (-)NCBIGRCr8
mRatBN7.2X69,568,086 - 69,701,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX69,574,124 - 69,701,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX71,083,209 - 71,210,844 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X74,583,502 - 74,711,138 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X72,144,696 - 72,272,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X75,433,957 - 75,566,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX75,439,778 - 75,566,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,236,346 - 76,364,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X92,568,201 - 92,700,448 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX70,927,489 - 71,054,488 (-)NCBICelera
Cytogenetic MapXq22NCBI
ZDHHC15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X75,368,427 - 75,523,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX75,368,427 - 75,523,502 (-)EnsemblGRCh38hg38GRCh38
GRCh37X74,588,262 - 74,742,872 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X74,508,786 - 74,659,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X74,375,081 - 74,525,896NCBI
CeleraX74,871,681 - 75,026,653 (-)NCBICelera
Cytogenetic MapXq13.3NCBI
HuRefX68,222,539 - 68,377,209 (-)NCBIHuRef
CHM1_1X74,481,166 - 74,636,183 (-)NCBICHM1_1
T2T-CHM13v2.0X73,802,127 - 73,956,714 (-)NCBIT2T-CHM13v2.0
Zdhhc15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X103,580,575 - 103,714,696 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX103,580,575 - 103,714,670 (-)EnsemblGRCm39 Ensembl
GRCm38X104,536,969 - 104,671,090 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX104,536,969 - 104,671,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X101,732,308 - 101,866,403 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X100,741,269 - 100,873,522 (-)NCBIMGSCv36mm8
CeleraX91,429,683 - 91,504,947 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX46.69NCBI
Zdhhc15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555621,466,897 - 1,588,681 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555621,468,373 - 1,588,298 (-)NCBIChiLan1.0ChiLan1.0
ZDHHC15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X75,059,201 - 75,176,004 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X75,090,493 - 75,179,609 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X64,624,908 - 64,777,305 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X74,737,281 - 74,889,055 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX74,737,281 - 74,889,055 (-)Ensemblpanpan1.1panPan2
ZDHHC15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X58,641,182 - 58,812,671 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX58,645,650 - 58,812,671 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX49,814,504 - 49,985,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X59,874,198 - 60,045,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX59,876,028 - 60,046,358 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X57,562,022 - 57,733,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X59,181,791 - 59,353,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X58,780,612 - 58,951,992 (-)NCBIUU_Cfam_GSD_1.0
Zdhhc15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X43,370,733 - 43,464,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366831,482,950 - 1,577,702 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366831,482,968 - 1,576,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZDHHC15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX60,485,565 - 60,584,784 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X60,485,559 - 60,585,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X68,861,681 - 68,944,080 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZDHHC15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X64,906,439 - 65,063,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606716,553,342 - 16,793,539 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zdhhc15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248365,194,177 - 5,400,516 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248365,193,710 - 5,404,547 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zdhhc15
354 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:258
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000003714
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 16 16 12 22 26
Low 3 42 41 25 19 25 7 7 62 13 9 11 7
Below cutoff 1 1 4 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003714   ⟹   ENSRNOP00000003714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX69,574,124 - 69,701,756 (-)Ensembl
Rnor_6.0 EnsemblX75,439,778 - 75,566,481 (-)Ensembl
RefSeq Acc Id: NM_001039101   ⟹   NP_001034190
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X73,639,818 - 73,767,451 (-)NCBI
mRatBN7.2X69,574,123 - 69,701,756 (-)NCBI
Rnor_6.0X75,439,777 - 75,566,481 (-)NCBI
Rnor_5.0X76,236,346 - 76,364,662 (-)NCBI
RGSC_v3.4X92,568,201 - 92,700,448 (-)RGD
CeleraX70,927,489 - 71,054,488 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257145   ⟹   XP_006257207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X73,633,977 - 73,767,399 (-)NCBI
mRatBN7.2X69,568,086 - 69,701,556 (-)NCBI
Rnor_6.0X75,433,957 - 75,566,531 (-)NCBI
Rnor_5.0X76,236,346 - 76,364,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099740   ⟹   XP_038955668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X73,637,301 - 73,745,307 (-)NCBI
mRatBN7.2X69,571,606 - 69,701,547 (-)NCBI
RefSeq Acc Id: XM_063280025   ⟹   XP_063136095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X73,637,301 - 73,745,075 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001034190   ⟸   NM_001039101
- UniProtKB: Q2TGJ4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257207   ⟸   XM_006257145
- Peptide Label: isoform X1
- UniProtKB: Q2TGJ4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003714   ⟸   ENSRNOT00000003714
RefSeq Acc Id: XP_038955668   ⟸   XM_039099740
- Peptide Label: isoform X2
- UniProtKB: A6IV19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136095   ⟸   XM_063280025
- Peptide Label: isoform X2
- UniProtKB: A6IV19 (UniProtKB/TrEMBL)
Protein Domains
DHHC   Palmitoyltransferase DHHC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TGJ4-F1-model_v2 AlphaFold Q2TGJ4 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562075 AgrOrtholog
BioCyc Gene G2FUF-1987 BioCyc
Ensembl Genes ENSRNOG00000002751 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027528 UniProtKB/Swiss-Prot
  ENSRNOG00060021319 UniProtKB/Swiss-Prot
  ENSRNOG00065024430 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003714 ENTREZGENE
  ENSRNOT00000003714.6 UniProtKB/Swiss-Prot
  ENSRNOT00055047694 UniProtKB/Swiss-Prot
  ENSRNOT00060036981 UniProtKB/Swiss-Prot
  ENSRNOT00065041894 UniProtKB/Swiss-Prot
InterPro Palmitoyltrfase_DHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:317235 UniProtKB/Swiss-Prot
NCBI Gene 317235 ENTREZGENE
PANTHER PALMITOYLTRANSFERASE ZDHHC16 UniProtKB/Swiss-Prot
  PALMITOYLTRANSFERASE ZDHHC16 UniProtKB/Swiss-Prot
  PALMITOYLTRANSFERASE ZDHHC16 UniProtKB/TrEMBL
  PALMITOYLTRANSFERASE ZDHHC16 UniProtKB/TrEMBL
Pfam DHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zdhhc15 PhenoGen
PROSITE DHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002751 RatGTEx
  ENSRNOG00055027528 RatGTEx
  ENSRNOG00060021319 RatGTEx
  ENSRNOG00065024430 RatGTEx
UniProt A6IV19 ENTREZGENE, UniProtKB/TrEMBL
  Q2TGJ4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Zdhhc15  zinc finger DHHC-type palmitoyltransferase 15  Zdhhc15  zinc finger, DHHC-type containing 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Zdhhc15  zinc finger, DHHC-type containing 15  Zdhhc15  zinc finger, DHHC domain containing 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Zdhhc15  zinc finger, DHHC domain containing 15  LOC317235  membrane-associated DHHC15 zinc finger protein  Symbol and Name updated 1299863 APPROVED
2006-02-09 LOC317235  membrane-associated DHHC15 zinc finger protein      Symbol and Name status set to provisional 70820 PROVISIONAL