Lactbl1 (lactamase beta like 1) - Rat Genome Database

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Gene: Lactbl1 (lactamase beta like 1) Rattus norvegicus
Analyze
Symbol: Lactbl1
Name: lactamase beta like 1
RGD ID: 1561426
Description: Predicted to be located in mitochondrion; INTERACTS WITH bisphenol A; 4,4'-sulfonyldiphenol (ortholog); chlorpyrifos (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical LOC362633; LOC362633; putative beta-lactamase-like 1; RGD1561426; RGD1561426
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,146,188 - 154,165,662 (+)NCBIGRCr8
mRatBN7.25148,862,736 - 148,882,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,870,245 - 148,879,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,560,330 - 151,579,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,334,612 - 153,354,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,316,620 - 153,336,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,990,515 - 154,996,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera5147,262,880 - 147,285,630 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lactbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,146,188 - 154,165,662 (+)NCBIGRCr8
mRatBN7.25148,862,736 - 148,882,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5148,870,245 - 148,879,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5151,560,330 - 151,579,843 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05153,334,612 - 153,354,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05153,316,620 - 153,336,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05154,990,515 - 154,996,361 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Celera5147,262,880 - 147,285,630 (+)NCBICelera
Cytogenetic Map5q36NCBI
LACTBL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,953,043 - 22,972,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,953,043 - 22,972,866 (-)EnsemblGRCh38hg38GRCh38
GRCh37123,279,536 - 23,299,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36123,152,123 - 23,172,111 (-)NCBINCBI36Build 36hg18NCBI36
Celera121,601,685 - 21,611,819 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef121,523,785 - 21,547,342 (-)NCBIHuRef
CHM1_1123,392,152 - 23,412,119 (-)NCBICHM1_1
T2T-CHM13v2.0122,778,822 - 22,798,628 (-)NCBIT2T-CHM13v2.0
Lactbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,349,952 - 136,369,385 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4136,349,932 - 136,366,421 (+)EnsemblGRCm39 Ensembl
GRCm384136,622,621 - 136,638,110 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,622,621 - 136,639,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv374136,178,507 - 136,194,202 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364135,898,852 - 135,910,160 (+)NCBIMGSCv36mm8
Celera4134,826,185 - 134,834,492 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.94NCBI
Lactbl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,006,140 - 3,020,699 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,006,140 - 3,023,205 (-)NCBIChiLan1.0ChiLan1.0
LACTBL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21203,973,858 - 203,993,663 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,076,851 - 203,096,668 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,139,345 - 22,159,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1123,086,426 - 23,105,651 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,086,426 - 23,098,782 (-)Ensemblpanpan1.1panPan2
LACTBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,392,492 - 76,410,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,397,773 - 76,410,641 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,892,606 - 72,915,472 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,946,378 - 76,969,508 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,956,623 - 76,969,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,768,058 - 73,790,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,776,278 - 74,799,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0275,779,939 - 75,802,809 (+)NCBIUU_Cfam_GSD_1.0
Lactbl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,395,383 - 42,413,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364748,217,559 - 8,233,680 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364748,220,890 - 8,237,772 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LACTBL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,870,866 - 80,885,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,870,412 - 80,885,030 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,906,668 - 74,920,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LACTBL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,693,003 - 109,715,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660336,600,593 - 6,621,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lactbl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247647,617,597 - 7,633,386 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247647,616,931 - 7,631,519 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lactbl1
71 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat

Markers in Region
RH130585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25148,889,634 - 148,889,814 (+)MAPPERmRatBN7.2
Rnor_6.05155,016,869 - 155,017,048NCBIRnor6.0
Rnor_5.05158,781,583 - 158,781,762UniSTSRnor5.0
RGSC_v3.45155,415,426 - 155,415,605UniSTSRGSC3.4
Celera5147,289,744 - 147,289,923UniSTS
RH 3.4 Map51006.3UniSTS
Cytogenetic Map5q36UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000117178   ⟹   ENSRNOP00000081379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5148,870,245 - 148,879,226 (+)Ensembl
RefSeq Acc Id: NM_001401838   ⟹   NP_001388767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,146,188 - 154,165,560 (+)NCBI
mRatBN7.25148,862,736 - 148,882,108 (+)NCBI
RefSeq Acc Id: XM_063288070   ⟹   XP_063144140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85154,146,815 - 154,165,662 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388767 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144140 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80820 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081379.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000081379   ⟸   ENSRNOT00000117178
RefSeq Acc Id: NP_001388767   ⟸   NM_001401838
- UniProtKB: A0A8I5ZSU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144140   ⟸   XM_063288070
- Peptide Label: isoform X1
Protein Domains
Beta-lactamase-related

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-39491 BioCyc
Ensembl Genes ENSRNOG00000065157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000117178.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.710.10 UniProtKB/TrEMBL
InterPro Beta-lactam-related UniProtKB/TrEMBL
  Beta-lactam/transpept-like UniProtKB/TrEMBL
NCBI Gene 362633 ENTREZGENE
PANTHER BETA-LACTAMASE-LIKE 1-RELATED UniProtKB/TrEMBL
  PENICILLIN-BINDING PROTEIN UniProtKB/TrEMBL
Pfam Beta-lactamase UniProtKB/TrEMBL
PhenoGen Lactbl1 PhenoGen
RatGTEx ENSRNOG00000065157 RatGTEx
Superfamily-SCOP SSF56601 UniProtKB/TrEMBL
UniProt A0A8I5ZSU3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Lactbl1  lactamase beta like 1  RGD1561426  RGD1561426  Data merged from RGD:149736125 737654 PROVISIONAL
2021-08-09 RGD1561426  RGD1561426      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Lactbl1  lactamase beta like 1  RGD1561426  RGD1561426  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561426  RGD1561426   RGD1561426_predicted  RGD1561426 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561426_predicted  RGD1561426 (predicted)  LOC362633  hypothetical LOC362633  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362633  hypothetical LOC362633      Symbol and Name status set to provisional 70820 PROVISIONAL