Rup2 (urinary protein 2) - Rat Genome Database

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Gene: Rup2 (urinary protein 2) Rattus norvegicus
Analyze
Symbol: Rup2
Name: urinary protein 2
RGD ID: 1561250
Description: Predicted to be located in extracellular region; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: liver regeneration-related protein LRRG05; RUP-1; UP-1; urinary protein 1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8843,547,875 - 43,551,456 (-)NCBIGRCr8
mRatBN7.2835,336,764 - 35,340,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl835,336,764 - 35,489,103 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx839,362,186 - 39,365,767 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0837,645,238 - 37,648,819 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0835,508,119 - 35,511,700 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0841,657,662 - 41,661,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl841,657,566 - 41,661,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0841,643,250 - 41,646,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4836,680,096 - 36,683,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera838,811,835 - 38,813,381 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11565799   PMID:11840564   PMID:12477932  


Genomics

Variants

.
Variants in Rup2
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000042860
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat

Markers in Region
RH142417  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 12 12
Medium 1 1 1 1 1
Low 6 16 1 17 1 8 9 6 6 13 8 8
Below cutoff 2 2 2 1 1 1 5 5 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042860   ⟹   ENSRNOP00000050106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl835,336,764 - 35,340,345 (-)Ensembl
Rnor_6.0 Ensembl841,657,566 - 41,661,238 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072224   ⟹   ENSRNOP00000065475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl835,485,518 - 35,489,103 (-)Ensembl
RefSeq Acc Id: NM_001034950   ⟹   NP_001030122
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8843,547,875 - 43,551,456 (-)NCBI
mRatBN7.2835,336,764 - 35,340,345 (-)NCBI
Rnor_6.0841,657,662 - 41,661,223 (+)NCBI
Rnor_5.0841,643,250 - 41,646,811 (+)NCBI
RGSC_v3.4836,680,096 - 36,683,657 (+)RGD
Celera838,811,835 - 38,813,381 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001030122   ⟸   NM_001034950
- Peptide Label: precursor
- UniProtKB: P83121 (UniProtKB/Swiss-Prot),   Q53ZD7 (UniProtKB/Swiss-Prot),   P81827 (UniProtKB/Swiss-Prot),   H8Y6J4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050106   ⟸   ENSRNOT00000042860
RefSeq Acc Id: ENSRNOP00000065475   ⟸   ENSRNOT00000072224
Protein Domains
UPAR/Ly6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81827-F1-model_v2 AlphaFold P81827 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695869
Promoter ID:EPDNEW_R6393
Type:initiation region
Name:Rup2_1
Description:urinary protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0841,657,644 - 41,657,704EPDNEW

Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-31138 BioCyc
Ensembl Genes ENSRNOG00000045799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055009215 UniProtKB/Swiss-Prot
  ENSRNOG00055009318 UniProtKB/Swiss-Prot
  ENSRNOG00060011358 UniProtKB/Swiss-Prot
  ENSRNOG00060012175 UniProtKB/Swiss-Prot
  ENSRNOG00065001869 UniProtKB/Swiss-Prot
  ENSRNOG00065017040 UniProtKB/Swiss-Prot
  ENSRNOG00065017041 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042860 ENTREZGENE
  ENSRNOT00000042860.6 UniProtKB/Swiss-Prot
  ENSRNOT00055015591 UniProtKB/Swiss-Prot
  ENSRNOT00055015748 UniProtKB/Swiss-Prot
  ENSRNOT00060019208 UniProtKB/Swiss-Prot
  ENSRNOT00060020658 UniProtKB/Swiss-Prot
  ENSRNOT00065002484 UniProtKB/Swiss-Prot
  ENSRNOT00065028429 UniProtKB/Swiss-Prot
  ENSRNOT00065028437 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323589 IMAGE-MGC_LOAD
KEGG Report rno:619560 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156491 IMAGE-MGC_LOAD
NCBI Gene 619560 ENTREZGENE
PhenoGen Rup2 PhenoGen
RatGTEx ENSRNOG00000045799 RatGTEx
  ENSRNOG00055009215 RatGTEx
  ENSRNOG00055009318 RatGTEx
  ENSRNOG00060011358 RatGTEx
  ENSRNOG00060012175 RatGTEx
  ENSRNOG00065001869 RatGTEx
  ENSRNOG00065017040 RatGTEx
  ENSRNOG00065017041 RatGTEx
UniProt H8Y6J4 ENTREZGENE, UniProtKB/TrEMBL
  P81827 ENTREZGENE
  P83121 ENTREZGENE
  Q53ZD7 ENTREZGENE
  UP1_RAT UniProtKB/Swiss-Prot
  UP3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q53ZD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Rup2  urinary protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL