Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of IER5L mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | IER5L (Homo sapiens) | 6480464 | Ethinyl Estradiol affects the expression of IER5L mRNA | CTD | PMID:20170705 | 17alpha-ethynylestradiol | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Ethinyl Estradiol results in increased expression of IER5L mRNA | CTD | PMID:18936297 | 17beta-estradiol | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Estradiol results in increased expression of IER5L mRNA | CTD | PMID:23019147 | 17beta-estradiol | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of IER5L mRNA | CTD | PMID:30165855 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Ier5l (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IER5L mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IER5L mRNA | CTD | PMID:33387578 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IER5L mRNA | CTD | PMID:20106945 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ier5l (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of IER5L mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of IER5L mRNA | CTD | PMID:22298810 | 4-hydroxyphenyl retinamide | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | Fenretinide results in increased expression of IER5L mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of IER5L mRNA | CTD | PMID:24780913 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of IER5L mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Acrylamide results in increased expression of IER5L mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | IER5L (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of IER5L gene | CTD | PMID:28458013 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of IER5L mRNA | CTD | PMID:33354967 | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of IER5L mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of IER5L mRNA | CTD | PMID:33212167 | arsenous acid | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of IER5L mRNA | CTD | PMID:20458559 | atrazine | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Atrazine results in increased expression of IER5L mRNA | CTD | PMID:22378314 | azathioprine | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Azathioprine results in increased expression of IER5L mRNA | CTD | PMID:22623647 | benzo[a]pyrene | decreases expression | ISO | Ier5l (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of IER5L mRNA | CTD | PMID:27195522 | benzo[a]pyrene | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of IER5L mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | IER5L (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of IER5L promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of IER5L mRNA | CTD | PMID:22228805 and PMID:22610609 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of IER5L mRNA | CTD | PMID:21839799 | bisphenol A | affects expression | ISO | IER5L (Homo sapiens) | 6480464 | bisphenol A affects the expression of IER5L mRNA | CTD | PMID:20170705 | bisphenol A | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | bisphenol A results in increased expression of IER5L mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | ISO | Ier5l (Mus musculus) | 6480464 | bisphenol A results in decreased expression of IER5L mRNA | CTD | PMID:35598803 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of IER5L mRNA | CTD | PMID:25181051 and PMID:30816183 | butanal | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of IER5L mRNA | CTD | PMID:26079696 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of IER5L mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of IER5L mRNA | CTD | PMID:33453195 | cadmium dichloride | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of IER5L mRNA | CTD | PMID:26472689 | carbon nanotube | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of IER5L mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Ier5l (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IER5L mRNA | CTD | PMID:20938992 | coumestrol | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of IER5L mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of IER5L mRNA | CTD | PMID:27989131 | dexamethasone | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of IER5L mRNA | CTD | PMID:25047013 | diarsenic trioxide | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of IER5L mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of IER5L mRNA | CTD | PMID:21266533 | dimethylarsinous acid | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | dimethylarsinous acid results in decreased expression of IER5L mRNA | CTD | PMID:23487506 | dioxygen | multiple interactions | ISO | Ier5l (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of IER5L mRNA | CTD | PMID:30529165 | diquat | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | Diquat results in increased expression of IER5L mRNA | CTD | PMID:36851058 | dorsomorphin | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IER5L mRNA | CTD | PMID:27188386 | ethyl methanesulfonate | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of IER5L mRNA | CTD | PMID:23649840 | folic acid | multiple interactions | ISO | Ier5l (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IER5L mRNA | CTD | PMID:20938992 | formaldehyde | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of IER5L mRNA | CTD | PMID:23649840 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of IER5L mRNA | CTD | PMID:27387713 | genistein | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Genistein results in increased expression of IER5L mRNA | CTD | PMID:23019147 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of IER5L mRNA | CTD | PMID:33387578 | L-methionine | multiple interactions | ISO | Ier5l (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IER5L mRNA | CTD | PMID:20938992 | Licochalcone B | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | licochalcone B results in increased expression of IER5L mRNA | CTD | PMID:33647349 | lipopolysaccharide | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of IER5L mRNA | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IER5L mRNA | CTD | PMID:35811015 | maneb | multiple interactions | ISO | Ier5l (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] affects the expression of IER5L mRNA | CTD | PMID:22563483 | methyl methanesulfonate | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of IER5L mRNA | CTD | PMID:23649840 | methylisothiazolinone | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of IER5L mRNA | CTD | PMID:31629900 | methylmercury chloride | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of IER5L mRNA | CTD | PMID:28001369 | microcystin-LR | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | cyanoginosin LR results in increased expression of IER5L mRNA | CTD | PMID:27796937 | Muraglitazar | increases expression | EXP | | 6480464 | muraglitazar results in increased expression of IER5L mRNA | CTD | PMID:21515302 | N-methyl-4-phenylpyridinium | decreases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of IER5L mRNA | CTD | PMID:28801915 | niclosamide | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Niclosamide results in increased expression of IER5L mRNA | CTD | PMID:36318118 | paracetamol | affects expression | ISO | Ier5l (Mus musculus) | 6480464 | Acetaminophen affects the expression of IER5L mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of IER5L mRNA | CTD | PMID:33387578 | paraquat | multiple interactions | ISO | Ier5l (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] affects the expression of IER5L mRNA | CTD | PMID:22563483 | phenylmercury acetate | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of IER5L mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IER5L mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | Ier5l (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of IER5L mRNA | CTD | PMID:20813756 | progesterone | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Progesterone results in increased expression of IER5L mRNA | CTD | PMID:18037150 | propanal | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of IER5L mRNA | CTD | PMID:26079696 | quercetin | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Quercetin results in increased expression of IER5L mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of IER5L mRNA | CTD | PMID:23557933 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of IER5L mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | IER5L (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IER5L mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of IER5L mRNA | CTD | PMID:23806026 | sodium arsenite | affects expression | ISO | IER5L (Homo sapiens) | 6480464 | sodium arsenite affects the expression of IER5L mRNA | CTD | PMID:29319823 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of IER5L mRNA | CTD | PMID:19281266 | sunitinib | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Sunitinib results in increased expression of IER5L mRNA | CTD | PMID:31533062 | Tesaglitazar | increases expression | EXP | | 6480464 | tesaglitazar results in increased expression of IER5L mRNA | CTD | PMID:21515302 | tetrachloromethane | affects expression | ISO | Ier5l (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of IER5L mRNA | CTD | PMID:17484886 | thimerosal | decreases expression | ISO | Ier5l (Mus musculus) | 6480464 | Thimerosal results in decreased expression of IER5L mRNA | CTD | PMID:24675092 | thimerosal | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of IER5L mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of IER5L mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Ier5l (Mus musculus) | 6480464 | titanium dioxide results in increased expression of IER5L mRNA | CTD | PMID:27760801 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of IER5L mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | trichostatin A results in increased expression of IER5L mRNA | CTD | PMID:24935251 | trovafloxacin | decreases expression | ISO | Ier5l (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of IER5L mRNA | CTD | PMID:35537566 | urethane | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Urethane results in increased expression of IER5L mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of IER5L mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | IER5L (Homo sapiens) | 6480464 | Valproic Acid affects the expression of IER5L mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | IER5L (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of IER5L mRNA | CTD | PMID:24935251 | valproic acid | increases methylation | ISO | IER5L (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of IER5L gene | CTD | PMID:29154799 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of IER5L mRNA | CTD | PMID:18042343 | vorinostat | decreases expression | ISO | IER5L (Homo sapiens) | 6480464 | vorinostat results in decreased expression of IER5L mRNA | CTD | PMID:27188386 | |