Hook3 (hook microtubule-tethering protein 3) - Rat Genome Database

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Gene: Hook3 (hook microtubule-tethering protein 3) Rattus norvegicus
Analyze
Symbol: Hook3 (Ensembl: AABR07026291.1)
Name: hook microtubule-tethering protein 3
RGD ID: 1560960
Description: Predicted to enable several functions, including cytoskeletal protein binding activity; dynein intermediate chain binding activity; and dynein light chain binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within several processes, including interkinetic nuclear migration; microtubule anchoring at centrosome; and neuronal stem cell population maintenance. Predicted to be located in centriolar satellite; cis-Golgi network; and pericentriolar material. Predicted to be part of FHF complex and HOPS complex. Orthologous to human HOOK3 (hook microtubule tethering protein 3); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hook homolog 3; hook homolog 3 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,656,929 - 72,751,696 (+)NCBIGRCr8
mRatBN7.21665,954,293 - 66,058,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1665,954,350 - 66,061,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,237,359 - 71,327,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,643,695 - 74,733,986 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01669,883,875 - 69,974,033 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01670,710,347 - 70,818,789 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,376,538 - 70,483,437 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,338,144 - 70,424,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1663,865,670 - 63,960,092 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. Sano H, etal., J Biol Chem. 2007 Mar 16;282(11):7973-81. Epub 2007 Jan 19.
Additional References at PubMed
PMID:11238449   PMID:18799622   PMID:20152126   PMID:27482052  


Genomics

Comparative Map Data
Hook3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,656,929 - 72,751,696 (+)NCBIGRCr8
mRatBN7.21665,954,293 - 66,058,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1665,954,350 - 66,061,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,237,359 - 71,327,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,643,695 - 74,733,986 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01669,883,875 - 69,974,033 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01670,710,347 - 70,818,789 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,376,538 - 70,483,437 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,338,144 - 70,424,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1663,865,670 - 63,960,092 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
HOOK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,896,978 - 43,030,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,896,946 - 43,030,535 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,752,121 - 42,885,678 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,871,190 - 42,994,084 (+)NCBINCBI36Build 36hg18NCBI36
Build 34842,871,189 - 42,994,084NCBI
Celera841,700,858 - 41,834,504 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef841,275,201 - 41,408,559 (+)NCBIHuRef
CHM1_1842,798,954 - 42,932,603 (+)NCBICHM1_1
T2T-CHM13v2.0843,165,918 - 43,299,475 (+)NCBIT2T-CHM13v2.0
Hook3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,511,449 - 26,609,646 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,511,449 - 26,609,252 (-)EnsemblGRCm39 Ensembl
GRCm38826,021,421 - 26,119,618 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl826,021,421 - 26,119,224 (-)EnsemblGRCm38mm10GRCm38
MGSCv37827,131,893 - 27,229,696 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,497,435 - 27,584,559 (-)NCBIMGSCv36mm8
Celera827,491,977 - 27,589,321 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.29NCBI
Hook3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,149,013 - 13,249,321 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545713,149,013 - 13,249,524 (+)NCBIChiLan1.0ChiLan1.0
HOOK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2761,354,487 - 61,487,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1837,070,523 - 37,203,836 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0842,145,427 - 42,278,727 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,589,942 - 39,720,341 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,595,762 - 39,711,043 (+)Ensemblpanpan1.1panPan2
HOOK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11622,791,198 - 22,940,168 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1622,784,267 - 22,901,991 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,296,402 - 23,406,210 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01624,542,973 - 24,652,642 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1624,491,022 - 24,652,650 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11622,911,279 - 23,020,972 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,476,174 - 23,585,989 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01623,527,294 - 23,636,812 (-)NCBIUU_Cfam_GSD_1.0
Hook3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494345,815,977 - 45,936,880 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493710860 - 110,939 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937108873 - 110,949 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOOK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,818,031 - 11,923,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,817,963 - 11,919,152 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HOOK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,897,108 - 41,023,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,897,209 - 41,021,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666052746,378 - 872,950 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hook3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780127,090 - 235,648 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624780127,718 - 237,701 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hook3
432 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:187
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000019281, ENSRNOT00000019356
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
BF396677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,049,926 - 66,050,110 (+)MAPPERmRatBN7.2
Rnor_6.01670,819,755 - 70,819,938NCBIRnor6.0
Rnor_5.01670,484,403 - 70,484,586UniSTSRnor5.0
RGSC_v3.41670,425,139 - 70,425,322UniSTSRGSC3.4
Celera1663,961,058 - 63,961,241UniSTS
RH 3.4 Map5992.7UniSTS
Cytogenetic Map16q12.4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019281   ⟹   ENSRNOP00000019281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,009,485 - 66,061,338 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097055   ⟹   ENSRNOP00000091293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1665,954,350 - 66,049,636 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100260   ⟹   ENSRNOP00000085710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1665,954,350 - 66,049,636 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107751   ⟹   ENSRNOP00000082084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,009,485 - 66,060,195 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117895   ⟹   ENSRNOP00000083319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1665,954,350 - 66,053,329 (+)Ensembl
RefSeq Acc Id: NM_001136098   ⟹   NP_001129570
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,657,097 - 72,751,696 (+)NCBI
mRatBN7.21665,954,352 - 66,048,961 (+)NCBI
Rnor_6.01670,710,347 - 70,818,789 (+)NCBI
Rnor_5.01670,376,538 - 70,483,437 (+)NCBI
RGSC_v3.41670,338,144 - 70,424,173 (+)RGD
Celera1663,865,670 - 63,960,092 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094555   ⟹   XP_038950483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,656,929 - 72,735,966 (+)NCBI
mRatBN7.21665,954,294 - 66,032,467 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001129570   ⟸   NM_001136098
- UniProtKB: A0A8I6AQA0 (UniProtKB/TrEMBL),   A6IVZ4 (UniProtKB/TrEMBL),   A0A8I5ZWS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038950483   ⟸   XM_039094555
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000091293   ⟸   ENSRNOT00000097055
RefSeq Acc Id: ENSRNOP00000083319   ⟸   ENSRNOT00000117895
RefSeq Acc Id: ENSRNOP00000085710   ⟸   ENSRNOT00000100260
RefSeq Acc Id: ENSRNOP00000082084   ⟸   ENSRNOT00000107751
RefSeq Acc Id: ENSRNOP00000019281   ⟸   ENSRNOT00000019281
Protein Domains
Calponin-homology (CH)   Hook C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQ77-F1-model_v2 AlphaFold Q7TQ77 1-709 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560960 AgrOrtholog
BioCyc Gene G2FUF-10988 BioCyc
Ensembl Genes ENSRNOG00000014275 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019281.8 UniProtKB/TrEMBL
  ENSRNOT00000097055 ENTREZGENE
  ENSRNOT00000097055.1 UniProtKB/TrEMBL
  ENSRNOT00000100260.1 UniProtKB/TrEMBL
  ENSRNOT00000107751.1 UniProtKB/TrEMBL
  ENSRNOT00000117895.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  Hook_C UniProtKB/TrEMBL
  HOOK_N UniProtKB/TrEMBL
KEGG Report rno:306548 UniProtKB/TrEMBL
NCBI Gene 306548 ENTREZGENE
PANTHER HOOK PROTEINS UniProtKB/TrEMBL
  PROTEIN HOOK HOMOLOG 3 UniProtKB/TrEMBL
Pfam HOOK UniProtKB/TrEMBL
  HOOK_N UniProtKB/TrEMBL
PhenoGen Hook3 PhenoGen
PROSITE PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014275 RatGTEx
Superfamily-SCOP Hook domain UniProtKB/TrEMBL
UniProt A0A8I5ZUA0_RAT UniProtKB/TrEMBL
  A0A8I5ZWS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0R7_RAT UniProtKB/TrEMBL
  A0A8I6AQA0 ENTREZGENE, UniProtKB/TrEMBL
  A6IVZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQ77_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Hook3  hook microtubule-tethering protein 3  Hook3  hook homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hook3  hook homolog 3 (Drosophila)    hook homolog 3  Name updated 1299863 APPROVED
2006-02-09 Hook3  hook homolog 3      Symbol and Name status set to provisional 70820 PROVISIONAL