Bag4 (BAG cochaperone 4) - Rat Genome Database

Name: Bag4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Bag4 (BAG cochaperone 4) Rattus norvegicus

Analyze

Symbol:

Bag4

Name:

BAG cochaperone 4

RGD ID:

1560875

Description:

Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of mRNA modification. Predicted to be located in cytosol; nucleus; and plasma membrane. Orthologous to human BAG4 (BAG cochaperone 4); PARTICIPATES IN ceramide signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

BAG family molecular chaperone regulator 4; BCL2-associated athanogene 4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BAG4 (BAG cochaperone 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Bag4 (BCL2-associated athanogene 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bag4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BAG4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BAG4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bag4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BAG4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BAG4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bag4 (BAG cochaperone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SEC14L2 (SEC14 like lipid binding 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	BAG4 (BAG cochaperone 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bag4 (BCL2-associated athanogene 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bag4 (BCL2 associated athanogene 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	stv	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	bag4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	72,991,407 - 73,008,620 (+)	NCBI		GRCr8
mRatBN7.2	16	66,288,678 - 66,305,893 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	66,288,678 - 66,308,663 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	71,567,319 - 71,584,561 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	74,973,629 - 74,990,873 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	70,213,523 - 70,230,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	71,057,709 - 71,075,874 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	71,058,022 - 71,075,320 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	70,722,385 - 70,737,835 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	70,663,821 - 70,680,671 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	64,198,573 - 64,215,812 (+)	NCBI		Celera
Cytogenetic Map	16	q12.4	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hereditary spastic paraplegia 54 (ISO)

hypogonadotropic hypogonadism 2 with or without anosmia (ISO)

pancreatic cancer (ISO)

paraplegia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

amphotericin B (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

beta-carotene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

calcium dichloride (ISO)

chlorpromazine (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

formaldehyde (ISO)

FR900359 (ISO)

genistein (EXP)

indometacin (ISO)

isoprenaline (EXP)

N-nitrosodiethylamine (ISO)

p-menthan-3-ol (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

piperonyl butoxide (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

progesterone (EXP)

pyrogallol (ISO)

quercetin (ISO)

sodium arsenate (ISO)

staurosporine (ISO)

tetrachloromethane (ISO)

thimerosal (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to epidermal growth factor stimulus (ISO)

cellular response to tumor necrosis factor (ISO)

negative regulation of mRNA modification (IMP)

negative regulation of protein targeting to mitochondrion (ISO)

positive regulation of actin filament polymerization (ISO)

positive regulation of cell adhesion (ISO)

positive regulation of fibroblast migration (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of stress fiber assembly (ISO)

protein localization to plasma membrane (ISO)

protein stabilization (IEA)

ruffle assembly (ISO)

Cellular Component

cytosol (ISO)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

adenyl-nucleotide exchange factor activity (IEA)

protein binding (ISO)

protein-containing complex binding (IPI)

protein-folding chaperone binding (IEA)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ceramide signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.	Lau PP and Chan L, J Biol Chem. 2003 Dec 26;278(52):52988-96. Epub 2003 Oct 13.
3.	Enhanced expression of Silencer of death domains (SODD/BAG-4) in pancreatic cancer.	Ozawa F, etal., Biochem Biophys Res Commun. 2000 May 10;271(2):409-13.
4.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.	Shinoda S, etal., Eur J Neurosci. 2003 May;17(10):2065-76.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	Tumor necrosis factor signaling.	Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.

Additional References at PubMed

PMID:21712384	PMID:22681889	PMID:24270810	PMID:30361391

Genomics

Comparative Map Data

Bag4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	72,991,407 - 73,008,620 (+)	NCBI		GRCr8
mRatBN7.2	16	66,288,678 - 66,305,893 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	66,288,678 - 66,308,663 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	71,567,319 - 71,584,561 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	74,973,629 - 74,990,873 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	70,213,523 - 70,230,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	71,057,709 - 71,075,874 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	71,058,022 - 71,075,320 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	70,722,385 - 70,737,835 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	70,663,821 - 70,680,671 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	16	64,198,573 - 64,215,812 (+)	NCBI		Celera
Cytogenetic Map	16	q12.4	NCBI

BAG4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	38,176,855 - 38,213,301 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	38,176,533 - 38,213,301 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	38,034,373 - 38,070,819 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	38,153,263 - 38,187,694 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	38,153,262 - 38,187,694	NCBI
Celera	8	36,986,642 - 37,021,084 (+)	NCBI		Celera
Cytogenetic Map	8	p11.23	NCBI
HuRef	8	36,568,494 - 36,604,926 (+)	NCBI		HuRef
CHM1_1	8	38,236,107 - 38,272,816 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	38,453,834 - 38,490,242 (+)	NCBI		T2T-CHM13v2.0

Bag4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	26,254,566 - 26,275,237 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	26,254,566 - 26,275,315 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	25,764,538 - 25,785,209 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	25,764,538 - 25,785,287 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	26,875,010 - 26,895,681 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	27,230,083 - 27,250,754 (-)	NCBI		MGSCv36	mm8
Celera	8	27,232,745 - 27,253,427 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	14.17	NCBI

Bag4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	13,788,852 - 13,824,135 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955463	13,788,852 - 13,824,135 (+)	NCBI	ChiLan1.0	ChiLan1.0

BAG4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	56,740,199 - 56,783,574 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	32,457,215 - 32,493,712 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	37,479,231 - 37,515,303 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	34,656,004 - 34,692,666 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	34,656,000 - 34,692,666 (+)	Ensembl	panpan1.1		panPan2

BAG4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	27,270,947 - 27,304,178 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	27,273,848 - 27,303,786 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	27,784,245 - 27,822,280 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	29,166,000 - 29,204,172 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	29,108,082 - 29,203,246 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	27,388,344 - 27,426,480 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	27,965,687 - 28,003,726 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	28,004,912 - 28,042,966 (-)	NCBI		UU_Cfam_GSD_1.0

Bag4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	49,885,805 - 49,909,467 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	1,551,738 - 1,575,393 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936710	1,551,729 - 1,575,393 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BAG4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	48,299,666 - 48,348,527 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	48,299,456 - 48,348,810 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	55,468,510 - 55,479,474 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BAG4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	36,198,547 - 36,231,550 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	36,198,811 - 36,231,828 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	5,758,351 - 5,791,377 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bag4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	5,425,607 - 5,472,849 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624780	5,425,607 - 5,472,916 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bag4
65 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	74
Count of miRNA genes:	57
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000066901
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70215	Niddm29	Non-insulin dependent diabetes mellitus QTL 29	3.54		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	16	19004435	75226532	Rat
2302057	Pia29	Pristane induced arthritis QTL 29	3.6	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	16	21735975	66735975	Rat
8694453	Bw172	Body weight QTL 172	8.33	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	16	24325513	69325513	Rat
6903294	Stl30	Serum triglyceride level QTL 30	2.6	0.0013	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	16	25152793	70152793	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	35288870	80288870	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	37752156	82752156	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	37752156	82752156	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	42396345	84729064	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	52726464	84729064	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	52726464	84729064	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	52726464	84729064	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	55711087	83402471	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	6	18	4	18	4			74	32	39	9
Low	2	37	39	37	1	37	8	11		3	2	2	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000066901 ⟹ ENSRNOP00000061900

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	66,288,678 - 66,305,892 (+)	Ensembl
Rnor_6.0 Ensembl	16	71,058,022 - 71,075,320 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109092 ⟹ ENSRNOP00000095662

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	66,288,991 - 66,308,663 (+)	Ensembl

RefSeq Acc Id:

NM_001025130 ⟹ NP_001020301

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	72,991,407 - 73,008,620 (+)	NCBI
mRatBN7.2	16	66,288,678 - 66,305,893 (+)	NCBI
Rnor_6.0	16	71,057,709 - 71,075,874 (+)	NCBI
Rnor_5.0	16	70,722,385 - 70,737,835 (+)	NCBI
RGSC_v3.4	16	70,663,821 - 70,680,671 (+)	RGD
Celera	16	64,198,573 - 64,215,812 (+)	RGD

Sequence:

show sequence

GGGCGTTCGGTCGCAGACAACGTTTTCTTCCTTTCTAGTCAGTGAAGTGAAGTCCAGGTCGGAA
GGGCGGAGAATAGGCGTTTCCTCACTCGTGACAAGCGCTGTCCCTCGCCTCGCTTTCCTGCTCC
GAGGCCCGGGTTGATCCGTACAGTCCATGACCGCTCGGCACTCGGCGTGCAAGGGGCGGGACCG
GCTCGGGATTGGCTGTAGCCGTCCTAACCCCCTTCGCCGCCCGCCAATACCTGTGGCCCGCAGG
CGCCTGCGCAATGGGACGGCCGTGGGGGGCGGGAAGCGCTTCGCGGCAGCGGAGCCCATGTCGG
CCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGCCCTTCGTACGGCCGCTACTACGGGCCCGG
GGGCGGCGATGTCCCGGTCCACGTACCTCCGCCCTTATACCATCCGCTTCGCCCGGAGCCTCCC
CAGCCTCCGGTTTCCTGGCGAGGGCGCGGGGGCGCCCCGGCCGAGACCACCTGGCCGGGAGAAG
GCGCAGGTGGTGATGGCTACTACCCCTCTGGAGGCGCCTGGGCAGAACCGAGCAGAGCTGGAGG
AGGCCACCAGGAACAGCCACCATATCCTGGTTATAACTCTAACTACTGGAATTCTGTGCGACCC
AGGGCTCCGTACCCAAGCACATACCCTATGAGGCCAGAGTTACAAGGCCAGAGTCTGAATTCTT
ACGCAAATGGAGCATATGGCCCACCTTACCCTCCTGGCCCTGCAACAGCAAGTGCTGCCTCTTA
CTCTGGGGCTTACTACGTACCTGGCTATGCTCAAGGCACTTACTCCACGGACATTCCTAGCACC
TACCGTTCACCTGGTAACAGCCCGACTCCAGTGTCGCGTTGGATGTATCCCCAGCAGGACTGTC
CGACAGAAGCGCCTCCTCTGCGGGGTCAGGTGCCGGGGTATCCTGCTTCACAGAACCCTGCAAT
GACCTTGCCCCATTATCCTTACGGAGATGGCAACCGCACTGTGCCACAGTCTGGAGCAACTGGA
CGACCACAAGATGATGCATGGGCTTCTAGTGCTTACGGGATGGGAGCCCGTTATCCCTGGCCTT
CAGCTGCACCCTCAGCCCCCTCTGGGAACCTGTACATGACGGAAAGTGCTTCACCATGGCCCGG
TAACAGTTCTCCTCAGCCACCTCCTTCACCTCCACCCCAACAGCCTAAGGACTCCTCATATTCC
TATAGCCAATCGGGTCAAGGCATGAACCGGCACAGCTTTCCTTGCAGCGTCCGTCAGTATGAAT
CTCCGGGAGCAGTGAACAATGATGAATCAGACCTTTTGGATTCTCAAGTCCAATATAGTGCTGA
GCCGCAGTTGTATGGGAATACCAGCAGTGAGCATCCAAGCAACCAAGTTCCCAGTAATAATCTC
CCTGAAGAGTGTTTCTCTTCAGATGAAGGCACTCCTCCAAGTATTAAAAAAATCATACATGTGC
TGGAGAAGGTCCAGTATCTTGAGCAAGAAGTAGAGGAGTTTGTGGGGAAAAAGACAGACAAAGC
CTACTGGCTTCTGGAAGAAATGCTGACAAAGGAACTGTTAGAACTGGATTCTGTTGAAACTGGG
GGCCAGGACTCTGTGCGTCAGGCCAGGAAAGAAGCTGTTTGTAAGATCCAGGCCATACTGGAAA
AGTTAGAAAAAAAGGGATTATGAAATAATTCGGAATGCAGCGGAAGCCTGTTAATGATTTGGCC
AAAGAACTCTTTAATTTGGTTAGTTCCCATCTTTTGAAATGCCTGTTGTGACAAGAAGCAACAC
ATTCCAACTTTCTTCTGAGCTAAAACTTGAAAGGAAAAAGAACTGGAAAAGCCAGCAGAGGAAT
GGAATTGCAGCAGTGACAAGATTCTTTTCAGTTTTCAGATGACTGCACATAATAGGAAACTGGA
ATTATCAGTATTGCCAAGTAGACCTACTTCTTACGAAACCCACTGATGTCTGGAGGCTGCTGCT
TATCAGGTCGCAGGAGGGAGATAGACTTATGTAACAGGTTGTCAAAAACCGGATCTGAGACAAG
CAGGCTGTTTTGTAAGCATCTGGACTGTCACATTTTTGTGCATTGTGACTGCATATACTTCATG
TGTATATTATAGCCTAGACTCTTGGACCTCTGTTCTGTTTTCTTACCAGCAGGTCACAGATGTA
ATACTATTCTACTTCTTCGTACATTTTGTAGTAATATGTTTAATATAATCAAATATTGGCAGCC
AAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020301	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83608	(Get FASTA)	NCBI Sequence Viewer
	EDM09068	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061900
	ENSRNOP00000061900.4
	ENSRNOP00000095662.1

RefSeq Acc Id:

NP_001020301 ⟸ NM_001025130

- UniProtKB:

Q5XIR5 (UniProtKB/TrEMBL), F1M3K6 (UniProtKB/TrEMBL), A6IW04 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHVPPPLYHPLRPEPPQPPVSWRGRGGAPAETTWP
GEGAGGDGYYPSGGAWAEPSRAGGGHQEQPPYPGYNSNYWNSVRPRAPYPSTYPMRPELQGQSL
NSYANGAYGPPYPPGPATASAASYSGAYYVPGYAQGTYSTDIPSTYRSPGNSPTPVSRWMYPQQ
DCPTEAPPLRGQVPGYPASQNPAMTLPHYPYGDGNRTVPQSGATGRPQDDAWASSAYGMGARYP
WPSAAPSAPSGNLYMTESASPWPGNSSPQPPPSPPPQQPKDSSYSYSQSGQGMNRHSFPCSVRQ
YESPGAVNNDESDLLDSQVQYSAEPQLYGNTSSEHPSNQVPSNNLPEECFSSDEGTPPSIKKII
HVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAI
LEKLEKKGL

hide sequence

RefSeq Acc Id:

ENSRNOP00000061900 ⟸ ENSRNOT00000066901

RefSeq Acc Id:

ENSRNOP00000095662 ⟸ ENSRNOT00000109092

Protein Domains

BAG

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M3K6-F1-model_v2	AlphaFold	F1M3K6	1-456	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700175

Promoter ID:

EPDNEW_R10691

Type:

initiation region

Name:

Bag4_1

Description:

BAG family molecular chaperone regulator 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	71,057,995 - 71,058,055	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560875	AgrOrtholog
BioCyc Gene	G2FUF-10975	BioCyc
Ensembl Genes	ENSRNOG00000042560	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066901	ENTREZGENE
	ENSRNOT00000066901.4	UniProtKB/TrEMBL
	ENSRNOT00000109092.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.120	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7133487	IMAGE-MGC_LOAD
InterPro	BAG_chaperone_regulator	UniProtKB/TrEMBL
	BAG_dom_sf	UniProtKB/TrEMBL
	BAG_domain	UniProtKB/TrEMBL
KEGG Report	rno:361167	UniProtKB/TrEMBL
MGC_CLONE	MGC:94364	IMAGE-MGC_LOAD
NCBI Gene	361167	ENTREZGENE
PANTHER	BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4	UniProtKB/TrEMBL
	PTHR12329	UniProtKB/TrEMBL
Pfam	BAG	UniProtKB/TrEMBL
PhenoGen	Bag4	PhenoGen
PROSITE	BAG	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000042560	RatGTEx
SMART	BAG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63491	UniProtKB/TrEMBL
UniProt	A0A8I6AP78_RAT	UniProtKB/TrEMBL
	A6IW04	ENTREZGENE, UniProtKB/TrEMBL
	F1M3K6	ENTREZGENE
	Q5XIR5	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1M3K6	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-11-11	Bag4	BAG cochaperone 4	Bag4	BCL2-associated athanogene 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Bag4	BCL2-associated athanogene 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)