Ark2c (arkadia C-terminal like ring finger ubiquitin ligase 2C) - Rat Genome Database

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Gene: Ark2c (arkadia C-terminal like ring finger ubiquitin ligase 2C) Rattus norvegicus
Analyze
Symbol: Ark2c (Ensembl: Rnf165)
Name: arkadia C-terminal like ring finger ubiquitin ligase 2C (Ensembl:ring finger protein 165)
RGD ID: 1560744
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in motor neuron axon guidance and positive regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including forelimb morphogenesis; nervous system development; and protein polyubiquitination. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human ARK2C (arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase ARK2C; E3 ubiquitin-protein ligase RNF165; LOC307251; RGD1560744; ring finger protein 165; Rnf165; similar to ring finger protein 111
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,259,736 - 73,375,987 (-)NCBIGRCr8
mRatBN7.21870,984,566 - 71,100,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1870,989,731 - 71,100,836 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,092,683 - 73,203,942 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01873,761,890 - 73,873,212 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01871,618,481 - 71,729,797 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01873,831,289 - 73,873,246 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1873,831,326 - 73,873,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,505,861 - 73,553,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,413,654 - 74,530,319 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1869,510,509 - 69,538,262 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23610558  


Genomics

Comparative Map Data
Ark2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,259,736 - 73,375,987 (-)NCBIGRCr8
mRatBN7.21870,984,566 - 71,100,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1870,989,731 - 71,100,836 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,092,683 - 73,203,942 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01873,761,890 - 73,873,212 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01871,618,481 - 71,729,797 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01873,831,289 - 73,873,246 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1873,831,326 - 73,873,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,505,861 - 73,553,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,413,654 - 74,530,319 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1869,510,509 - 69,538,262 (-)NCBICelera
Cytogenetic Map18q12.3NCBI
ARK2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381846,334,018 - 46,463,140 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1846,326,809 - 46,463,140 (+)EnsemblGRCh38hg38GRCh38
GRCh371843,913,981 - 44,043,103 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361842,168,185 - 42,294,781 (+)NCBINCBI36Build 36hg18NCBI36
Build 341842,160,770 - 42,294,335NCBI
Celera1840,721,612 - 40,848,199 (+)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1840,771,821 - 40,898,413 (+)NCBIHuRef
CHM1_11843,841,208 - 43,967,794 (+)NCBICHM1_1
T2T-CHM13v2.01846,524,603 - 46,653,701 (+)NCBIT2T-CHM13v2.0
Ark2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391877,543,806 - 77,652,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1877,543,806 - 77,652,857 (-)EnsemblGRCm39 Ensembl
GRCm381877,456,110 - 77,565,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1877,456,110 - 77,565,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv371877,694,849 - 77,803,875 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361877,660,560 - 77,770,607 (-)NCBIMGSCv36mm8
Celera1878,639,714 - 78,748,970 (-)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1852.28NCBI
Ark2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,867,645 - 31,969,804 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540231,867,651 - 31,975,930 (+)NCBIChiLan1.0ChiLan1.0
ARK2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21763,758,604 - 63,885,385 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11849,451,202 - 49,577,986 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01839,615,759 - 39,742,492 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11843,246,884 - 43,274,212 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1843,244,066 - 43,274,212 (+)Ensemblpanpan1.1panPan2
ARK2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1744,834,006 - 44,939,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl744,840,099 - 44,940,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha744,319,338 - 44,422,175 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0744,788,650 - 44,893,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl744,793,300 - 44,893,783 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1744,489,212 - 44,591,957 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0744,541,376 - 44,645,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0744,825,104 - 44,929,370 (-)NCBIUU_Cfam_GSD_1.0
Ark2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,095,644 - 41,203,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936517429,292 - 531,361 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936517428,689 - 531,360 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARK2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,950,746 - 96,066,928 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1195,951,387 - 96,072,522 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21106,267,178 - 106,280,496 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARK2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11834,446,996 - 34,573,186 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1834,451,095 - 34,474,080 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660508,818,570 - 8,945,258 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ark2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247789,982,936 - 10,086,937 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247789,982,923 - 10,089,204 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ark2c
1187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:638
Count of miRNA genes:287
Interacting mature miRNAs:371
Transcripts:ENSRNOT00000075580
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat

Markers in Region
D18Rat121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21871,019,930 - 71,020,158 (+)MAPPERmRatBN7.2
Rnor_6.01873,875,703 - 73,875,930NCBIRnor6.0
Rnor_5.01873,556,301 - 73,556,528UniSTSRnor5.0
RGSC_v3.41874,449,015 - 74,449,242RGDRGSC3.4
RGSC_v3.41874,449,016 - 74,449,243UniSTSRGSC3.4
RGSC_v3.11874,522,288 - 74,522,515RGD
Celera1869,540,719 - 69,540,946UniSTS
SHRSP x BN Map1844.4299RGD
SHRSP x BN Map1844.4299UniSTS
Cytogenetic Map18q12.3UniSTS
RH133453  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21871,003,142 - 71,003,323 (+)MAPPERmRatBN7.2
Rnor_6.01873,858,604 - 73,858,784NCBIRnor6.0
Rnor_6.01873,844,734 - 73,844,914NCBIRnor6.0
Rnor_5.01873,537,294 - 73,537,474UniSTSRnor5.0
Rnor_5.01873,524,433 - 73,524,613UniSTSRnor5.0
RGSC_v3.41874,432,226 - 74,432,406UniSTSRGSC3.4
Celera1869,523,969 - 69,524,149UniSTS
RH 3.4 Map18763.9UniSTS
Cytogenetic Map18q12.3UniSTS
AI427432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21870,984,763 - 70,984,911 (+)MAPPERmRatBN7.2
Rnor_6.01873,826,360 - 73,826,507NCBIRnor6.0
Rnor_5.01873,506,059 - 73,506,206UniSTSRnor5.0
RGSC_v3.41874,413,852 - 74,413,999UniSTSRGSC3.4
Celera1869,505,564 - 69,505,711UniSTS
Cytogenetic Map18q12.3UniSTS
RH135094  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21870,989,841 - 70,990,040 (+)MAPPERmRatBN7.2
Rnor_6.01873,831,437 - 73,831,635NCBIRnor6.0
Rnor_5.01873,511,136 - 73,511,334UniSTSRnor5.0
RGSC_v3.41874,418,929 - 74,419,127UniSTSRGSC3.4
Celera1869,510,641 - 69,510,839UniSTS
RH 3.4 Map18747.3UniSTS
Cytogenetic Map18q12.3UniSTS
ha3141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21871,052,263 - 71,052,471 (+)MAPPERmRatBN7.2
Rnor_6.01873,908,022 - 73,908,229NCBIRnor6.0
Rnor_5.01873,588,620 - 73,588,827UniSTSRnor5.0
RGSC_v3.41874,481,140 - 74,481,347UniSTSRGSC3.4
Celera1869,572,211 - 69,572,418UniSTS
Cytogenetic Map18q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 2 4
Low 12 7 4 4 10 21 16
Below cutoff 3 14 10 5 2 5 1 2 8 18 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075580   ⟹   ENSRNOP00000067322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,989,731 - 71,100,836 (-)Ensembl
Rnor_6.0 Ensembl1873,831,326 - 73,873,280 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109402   ⟹   ENSRNOP00000081887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,989,731 - 71,100,836 (-)Ensembl
RefSeq Acc Id: NM_001164505   ⟹   NP_001157977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,264,880 - 73,375,987 (-)NCBI
mRatBN7.21870,989,710 - 71,100,836 (-)NCBI
Rnor_6.01873,831,289 - 73,873,246 (-)NCBI
Rnor_5.01873,505,861 - 73,553,844 (-)NCBI
RGSC_v3.41874,413,654 - 74,530,319 (-)RGD
Celera1869,510,509 - 69,538,262 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096778   ⟹   XP_038952706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81873,259,736 - 73,304,231 (-)NCBI
mRatBN7.21870,984,566 - 71,029,075 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001157977 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952706 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66566 (Get FASTA)   NCBI Sequence Viewer  
  EDL84711 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067322
  ENSRNOP00000067322.2
  ENSRNOP00000081887.1
Reference Protein Sequences
RefSeq Acc Id: NP_001157977   ⟸   NM_001164505
- UniProtKB: B2GV81 (UniProtKB/TrEMBL),   M0RCK2 (UniProtKB/TrEMBL),   A0A8I5ZSL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067322   ⟸   ENSRNOT00000075580
RefSeq Acc Id: XP_038952706   ⟸   XM_039096778
- Peptide Label: isoform X1
- UniProtKB: A6KMV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081887   ⟸   ENSRNOT00000109402
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCK2-F1-model_v2 AlphaFold M0RCK2 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560744 AgrOrtholog
BioCyc Gene G2FUF-6940 BioCyc
Ensembl Genes ENSRNOG00000048824 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075580 ENTREZGENE
  ENSRNOT00000075580.3 UniProtKB/TrEMBL
  ENSRNOT00000109402.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317237 IMAGE-MGC_LOAD
InterPro MBR1/2-like UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING-CH UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:307251 UniProtKB/TrEMBL
MGC_CLONE MGC:188196 IMAGE-MGC_LOAD
NCBI Gene 307251 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE RNF165 UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE RNF165 UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/TrEMBL
PhenoGen Ark2c PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048824 RatGTEx
SMART RING UniProtKB/TrEMBL
  RINGv UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I5ZSL4 ENTREZGENE, UniProtKB/TrEMBL
  A6KMV1 ENTREZGENE, UniProtKB/TrEMBL
  B2GV81 ENTREZGENE, UniProtKB/TrEMBL
  M0RCK2 ENTREZGENE
UniProt Secondary M0RCK2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-18 Ark2c  arkadia C-terminal like ring finger ubiquitin ligase 2C  Rnf165  ring finger protein 165  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Rnf165  ring finger protein 165  RGD1560744_predicted  similar to ring finger protein 111 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560744_predicted  similar to ring finger protein 111 (predicted)  LOC307251  similar to ring finger protein 111  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC307251  similar to ring finger protein 111      Symbol and Name status set to provisional 70820 PROVISIONAL