Mat2al1 (methionine adenosyltransferase 2A like 1) - Rat Genome Database

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Gene: Mat2al1 (methionine adenosyltransferase 2A like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mat2al1 (Ensembl: RGD1560523)
Name: methionine adenosyltransferase 2A like 1 (Ensembl:similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase))
RGD ID: 1560523
Description: Predicted to enable ATP binding activity; metal ion binding activity; and methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process and one-carbon metabolic process; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; tetrachloromethane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC498211; RGD1560523; S-adenosylmethionine synthase-like; similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase); similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (AdoMet synthetase) (MAT-II)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81326,602,640 - 26,605,438 (-)NCBIGRCr8
mRatBN7.21326,088,997 - 26,090,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1326,089,606 - 26,090,793 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01330,492,829 - 30,494,481 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1330,493,206 - 30,494,392 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01335,628,752 - 35,630,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41316,276,947 - 16,288,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1325,842,661 - 25,845,424 (-)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mat2al1
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000036417
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 1 2 1 1 2 7 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1326,089,606 - 26,090,793 (-)Ensembl
Rnor_6.0 Ensembl1330,493,206 - 30,494,392 (-)Ensembl
RefSeq Acc Id: XM_039091225   ⟹   XP_038947153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81326,602,640 - 26,605,438 (-)NCBI
mRatBN7.21326,088,997 - 26,090,862 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038947153 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081783
  ENSRNOP00000081783.1
  ENSRNOP00000094572.1
Reference Protein Sequences
RefSeq Acc Id: XP_038947153   ⟸   XM_039091225
- UniProtKB: A0A8I6G8F2 (UniProtKB/TrEMBL),   A0A8I6ALA1 (UniProtKB/TrEMBL),   A6IAC2 (UniProtKB/TrEMBL)
Protein Domains
S-adenosylmethionine synthetase C-terminal   S-adenosylmethionine synthetase central   S-adenosylmethionine synthetase N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-18571 BioCyc
Ensembl Genes ENSRNOG00000013520 UniProtKB/TrEMBL
  ENSRNOG00000028513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036417.4 UniProtKB/TrEMBL
  ENSRNOT00000098451.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.10 UniProtKB/TrEMBL
InterPro ADOMET_SYNTHASE_CS UniProtKB/TrEMBL
  S-AdoMet_synt_C UniProtKB/TrEMBL
  S-AdoMet_synt_central UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/TrEMBL
  S-AdoMet_synthetase UniProtKB/TrEMBL
  S-AdoMet_synthetase_sfam UniProtKB/TrEMBL
NCBI Gene 498211 ENTREZGENE
PANTHER PTHR11964 UniProtKB/TrEMBL
  S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2 UniProtKB/TrEMBL
Pfam S-AdoMet_synt_C UniProtKB/TrEMBL
  S-AdoMet_synt_M UniProtKB/TrEMBL
  S-AdoMet_synt_N UniProtKB/TrEMBL
PhenoGen Mat2al1 PhenoGen
PIRSF MAT UniProtKB/TrEMBL
PROSITE ADOMET_SYNTHASE_1 UniProtKB/TrEMBL
  ADOMET_SYNTHASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013520 RatGTEx
  ENSRNOG00000028513 RatGTEx
Superfamily-SCOP SSF55973 UniProtKB/TrEMBL
UniProt A0A8I6ALA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G8F2 ENTREZGENE, UniProtKB/TrEMBL
  A6IAC2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Mat2al1  methionine adenosyltransferase 2A like 1  RGD1560523  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase)  Symbol and Name Changed 1299863 APPROVED
2008-07-08 RGD1560523  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase)   LOC683283  similar to S-adenosylmethionine synthetase isoform type-2 (Methionine adenosyltransferase 2) (AdoMet synthetase 2) (Methionine adenosyltransferase II) (MAT-II)  Data merged from RGD:1589200 1643240 APPROVED
2008-04-30 RGD1560523  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase)   RGD1560523_predicted  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC683283  similar to S-adenosylmethionine synthetase isoform type-2 (Methionine adenosyltransferase 2) (AdoMet synthetase 2) (Methionine adenosyltransferase II) (MAT-II)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-10 RGD1560523_predicted  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (predicted)    similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (AdoMet synthetase) (MAT-II) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1560523_predicted  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (AdoMet synthetase) (MAT-II) (predicted)  LOC498211  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (AdoMet synthetase) (MAT-II)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498211  similar to S-adenosylmethionine synthetase gamma form (Methionine adenosyltransferase) (AdoMet synthetase) (MAT-II)      Symbol and Name status set to provisional 70820 PROVISIONAL