Epgn (epithelial mitogen) - Rat Genome Database

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Gene: Epgn (epithelial mitogen) Rattus norvegicus
Analyze
Symbol: Epgn
Name: epithelial mitogen
RGD ID: 1560084
Description: Predicted to enable epidermal growth factor receptor binding activity; growth factor activity; and transmembrane receptor protein tyrosine kinase activator activity. Predicted to be involved in several processes, including angiogenesis; epidermal growth factor receptor signaling pathway; and positive regulation of mitotic nuclear division. Predicted to act upstream of or within MAPK cascade. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human EPGN (epithelial mitogen); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: epigen; epithelial mitogen homolog; epithelial mitogen homolog (mouse); LOC289515; RGD1560084; similar to Epigen protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,360,968 - 17,369,000 (-)NCBIGRCr8
mRatBN7.21417,076,774 - 17,084,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,076,774 - 17,084,806 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,077,610 - 17,085,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,396,535 - 18,404,572 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,088,653 - 17,096,690 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,627,103 - 18,635,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,626,644 - 18,634,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,534,970 - 18,543,093 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,573,036 - 18,579,934 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1416,454,534 - 16,462,566 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,ISO)
plasma membrane  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
Additional References at PubMed
PMID:11278323   PMID:15611079  


Genomics

Comparative Map Data
Epgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,360,968 - 17,369,000 (-)NCBIGRCr8
mRatBN7.21417,076,774 - 17,084,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,076,774 - 17,084,806 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,077,610 - 17,085,647 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,396,535 - 18,404,572 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,088,653 - 17,096,690 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,627,103 - 18,635,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,626,644 - 18,634,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,534,970 - 18,543,093 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,573,036 - 18,579,934 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1416,454,534 - 16,462,566 (-)NCBICelera
Cytogenetic Map14p22NCBI
EPGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,308,470 - 74,316,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,308,470 - 74,316,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37475,174,187 - 75,182,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,393,068 - 75,398,171 (+)NCBINCBI36Build 36hg18NCBI36
Celera472,534,457 - 72,539,560 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,985,134 - 70,993,467 (+)NCBIHuRef
CHM1_1475,210,022 - 75,218,355 (+)NCBICHM1_1
T2T-CHM13v2.0477,652,095 - 77,660,414 (+)NCBIT2T-CHM13v2.0
Epgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,175,376 - 91,183,071 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,175,323 - 91,183,074 (+)EnsemblGRCm39 Ensembl
GRCm38591,027,517 - 91,035,212 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,027,464 - 91,035,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,456,543 - 91,464,238 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,102,717 - 92,110,412 (+)NCBIMGSCv36mm8
Celera589,163,266 - 89,170,925 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Epgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474564,329 - 573,014 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474564,329 - 573,014 (+)NCBIChiLan1.0ChiLan1.0
EPGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,743,457 - 55,752,425 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,932,463 - 55,941,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,875,419 - 49,884,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,708,072 - 55,716,868 (-)NCBIpanpan1.1PanPan1.1panPan2
EPGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,803,595 - 62,811,581 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,803,654 - 62,810,274 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,490,822 - 62,498,846 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,632,685 - 63,640,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,630,887 - 63,640,714 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11363,247,466 - 63,255,482 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,729,267 - 62,737,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,872,330 - 63,880,347 (+)NCBIUU_Cfam_GSD_1.0
Epgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,935,639 - 12,944,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,389,100 - 1,396,514 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,389,129 - 1,396,508 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,292,467 - 70,300,149 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,266,867 - 70,301,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,389,477 - 74,395,775 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,842,830 - 22,852,867 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,844,202 - 22,853,104 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660371,132,852 - 1,143,249 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247301,403,915 - 1,412,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epgn
160 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:84
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000003720
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 18
Below cutoff 3 2 2 26 14 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003720   ⟹   ENSRNOP00000003720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,076,774 - 17,084,806 (-)Ensembl
Rnor_6.0 Ensembl1418,626,644 - 18,634,309 (-)Ensembl
RefSeq Acc Id: NM_001305170   ⟹   NP_001292099
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,360,968 - 17,369,000 (-)NCBI
mRatBN7.21417,076,774 - 17,084,806 (-)NCBI
Rnor_6.01418,627,103 - 18,635,135 (-)NCBI
Celera1416,454,534 - 16,462,566 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292099 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88579 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003720
  ENSRNOP00000003720.4
Reference Protein Sequences
RefSeq Acc Id: NP_001292099   ⟸   NM_001305170
- UniProtKB: D3Z9P6 (UniProtKB/TrEMBL),   A6KKD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003720   ⟸   ENSRNOT00000003720
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9P6-F1-model_v2 AlphaFold D3Z9P6 1-138 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560084 AgrOrtholog
BioCyc Gene G2FUF-16214 BioCyc
Ensembl Genes ENSRNOG00000002782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003720 ENTREZGENE
  ENSRNOT00000003720.6 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
KEGG Report rno:289515 UniProtKB/TrEMBL
NCBI Gene 289515 ENTREZGENE
PANTHER EPIGEN UniProtKB/TrEMBL
  PTHR10740 UniProtKB/TrEMBL
PhenoGen Epgn PhenoGen
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002782 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A6KKD1 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9P6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-14 Epgn  epithelial mitogen  Epgn  epithelial mitogen homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Epgn  epithelial mitogen homolog (mouse)  Epgn  epithelial mitogen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Epgn  epithelial mitogen  Epgn  epithelial mitogen homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Epgn  epithelial mitogen homolog (mouse)  RGD1560084_predicted  similar to Epigen protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560084_predicted  similar to Epigen protein (predicted)  LOC289515  similar to Epigen protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289515  similar to Epigen protein      Symbol and Name status set to provisional 70820 PROVISIONAL