Ppial4g (peptidylprolyl isomerase A like 4G) - Rat Genome Database

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Gene: Ppial4g (peptidylprolyl isomerase A like 4G) Rattus norvegicus
Analyze
Symbol: Ppial4g
Name: peptidylprolyl isomerase A like 4G
RGD ID: 1559682
Description: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in extracellular region and nucleus. Predicted to be active in cytoplasm. Orthologous to human PPIAL4C (peptidylprolyl isomerase A like 4C) and PPIAL4G (peptidylprolyl isomerase A like 4G); INTERACTS WITH ammonium chloride; trichloroethene; (-)-epigallocatechin 3-gallate (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC361080; peptidyl-prolyl cis-trans isomerase A-like; peptidylprolyl isomerase A (cyclophilin A)-like 4G; RGD1559682; similar to Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase) (Cyclophilin A) (Cyclosporin A-binding protein) (P31); similar to peptidylprolyl isomerase A (cyclophilin A))
RGD Orthologs
Human
Dog
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81579,601,128 - 80,424,184 (-)NCBIGRCr8
mRatBN7.21574,015,628 - 74,016,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1574,015,628 - 74,016,215 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01581,576,690 - 81,577,379 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1581,576,888 - 81,577,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01585,116,093 - 85,116,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41580,674,328 - 80,674,915 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1573,274,951 - 73,275,646 (-)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ppial4g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81579,601,128 - 80,424,184 (-)NCBIGRCr8
mRatBN7.21574,015,628 - 74,016,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1574,015,628 - 74,016,215 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01581,576,690 - 81,577,379 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1581,576,888 - 81,577,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01585,116,093 - 85,116,680 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41580,674,328 - 80,674,915 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1573,274,951 - 73,275,646 (-)NCBICelera
Cytogenetic Map15q21NCBI
PPIAL4G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381148,482,548 - 148,483,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1148,482,548 - 148,483,302 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,954,635 - 147,955,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361142,555,943 - 142,559,798 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map1q21.2NCBI
CHM1_11149,850,674 - 149,851,411 (-)NCBICHM1_1
T2T-CHM13v2.01146,324,062 - 146,324,816 (+)NCBIT2T-CHM13v2.0
LOC483905
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11942,982,979 - 42,983,440 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1943,236,241 - 43,236,702 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01944,421,496 - 44,421,957 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11943,087,113 - 43,087,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01943,234,924 - 43,235,385 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01944,543,961 - 44,544,422 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Ppial4g
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:20
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000037377
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 15 6 14 6 1 9 2 6 2
Below cutoff 2 16 21 14 4 14 4 5 10 14 16 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037377   ⟹   ENSRNOP00000067488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1574,015,628 - 74,016,215 (-)Ensembl
Rnor_6.0 Ensembl1581,576,888 - 81,577,379 (-)Ensembl
RefSeq Acc Id: XM_341363   ⟹   XP_341364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81579,601,128 - 80,424,184 (-)NCBI
mRatBN7.21574,015,628 - 74,016,215 (-)NCBI
Rnor_6.01581,576,690 - 81,577,379 (-)NCBI
Rnor_5.01585,116,093 - 85,116,680 (-)NCBI
RGSC_v3.41580,674,328 - 80,674,915 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_341364 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067488
  ENSRNOP00000067488.3
Reference Protein Sequences
RefSeq Acc Id: XP_341364   ⟸   XM_341363
- UniProtKB: M0RCZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067488   ⟸   ENSRNOT00000037377
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCZ9-F1-model_v2 AlphaFold M0RCZ9 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559682 AgrOrtholog
BioCyc Gene G2FUF-12807 BioCyc
Ensembl Genes ENSRNOG00000022492 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037377.7 UniProtKB/TrEMBL
Gene3D-CATH 2.40.100.10 UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom UniProtKB/TrEMBL
  Cyclophilin-like_PPIase_dom UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/TrEMBL
KEGG Report rno:361080 UniProtKB/TrEMBL
NCBI Gene 361080 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/TrEMBL
PhenoGen Ppial4g PhenoGen
PIRSF Peptidylpro_ismrse UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022492 RatGTEx
Superfamily-SCOP SSF50891 UniProtKB/TrEMBL
UniProt M0RCZ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Ppial4g  peptidylprolyl isomerase A like 4G  Ppial4g  peptidylprolyl isomerase A (cyclophilin A)-like 4G  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Ppial4g  peptidylprolyl isomerase A (cyclophilin A)-like 4G  RGD1559682  similar to peptidylprolyl isomerase A (cyclophilin A))  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559682  similar to peptidylprolyl isomerase A (cyclophilin A))   RGD1559682_predicted  similar to peptidylprolyl isomerase A (cyclophilin A)) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1559682_predicted  similar to peptidylprolyl isomerase A (cyclophilin A)) (predicted)    similar to Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase) (Cyclophilin A) (Cyclosporin A-binding protein) (P31) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1559682_predicted  similar to Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase) (Cyclophilin A) (Cyclosporin A-binding protein) (P31) (predicted)  LOC361080  similar to Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase) (Cyclophilin A) (Cyclosporin A-binding protein) (P31)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361080  similar to Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase) (Cyclophilin A) (Cyclosporin A-binding protein) (P31)      Symbol and Name status set to provisional 70820 PROVISIONAL