Magebl1 (MAGE family member B-like 1) - Rat Genome Database

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Gene: Magebl1 (MAGE family member B-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Magebl1
Name: MAGE family member B-like 1
RGD ID: 1559523
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human MAGEB6 (MAGE family member B6) and MAGEB6B (MAGE family member B6B); INTERACTS WITH bisphenol A; rotenone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC302438; melanoma antigen, family B; melanoma antigen, family B-like 1; MGC187533; RGD1559523; similar to Smage-1 protein
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X60,543,044 - 60,546,629 (-)NCBIGRCr8
mRatBN7.2X56,567,844 - 56,571,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX56,567,844 - 56,571,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX57,927,500 - 57,931,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X61,427,853 - 61,431,438 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X59,045,964 - 59,049,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X60,939,260 - 60,942,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX60,939,260 - 60,942,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X61,522,522 - 61,526,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X79,131,896 - 79,135,481 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX57,057,158 - 57,060,743 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
rotenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Magebl1
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000067446
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hepatobiliary system reproductive system
High
Medium
Low 7
Below cutoff 1 1 1 6

Sequence


RefSeq Acc Id: ENSRNOT00000067446   ⟹   ENSRNOP00000059861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX56,567,844 - 56,571,429 (-)Ensembl
Rnor_6.0 EnsemblX60,939,260 - 60,942,845 (-)Ensembl
RefSeq Acc Id: NM_001128493   ⟹   NP_001121965
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X60,543,044 - 60,546,629 (-)NCBI
mRatBN7.2X56,567,844 - 56,571,429 (-)NCBI
Rnor_6.0X60,939,260 - 60,942,845 (-)NCBI
Rnor_5.0X61,522,522 - 61,526,107 (-)NCBI
RGSC_v3.4X79,131,896 - 79,135,481 (-)RGD
CeleraX57,057,158 - 57,060,743 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001121965 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58629 (Get FASTA)   NCBI Sequence Viewer  
  EDL96024 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059861
  ENSRNOP00000059861.1
RefSeq Acc Id: NP_001121965   ⟸   NM_001128493
- UniProtKB: B0BMZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059861   ⟸   ENSRNOT00000067446
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BMZ9-F1-model_v2 AlphaFold B0BMZ9 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701835
Promoter ID:EPDNEW_R12359
Type:single initiation site
Name:Magebl1_1
Description:melanoma antigen, family B-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X60,942,859 - 60,942,919EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559523 AgrOrtholog
BioCyc Gene G2FUF-2291 BioCyc
Ensembl Genes ENSRNOG00000043508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067446 ENTREZGENE
  ENSRNOT00000067446.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455432 IMAGE-MGC_LOAD
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
KEGG Report rno:302438 UniProtKB/TrEMBL
MGC_CLONE MGC:187533 IMAGE-MGC_LOAD
NCBI Gene 302438 ENTREZGENE
PANTHER MAGE FAMILY MEMBER B6B UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
PhenoGen Magebl1 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043508 RatGTEx
SMART MAGE UniProtKB/TrEMBL
  MAGE_N UniProtKB/TrEMBL
UniProt B0BMZ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-18 Magebl1  MAGE family member B-like 1  Magebl1  melanoma antigen, family B-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Magebl1  melanoma antigen, family B-like 1  RGD1559523  similar to Smage-1 protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559523  similar to Smage-1 protein   RGD1559523_predicted  similar to Smage-1 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559523_predicted  similar to Smage-1 protein (predicted)  LOC302438  similar to Smage-1 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302438  similar to Smage-1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL