Gene: Mgrn1 (mahogunin, ring finger 1)
Mus musculus
Symbol:
Mgrn1
Name:
mahogunin, ring finger 1
Description:
ENCODES a protein that exhibits ubiquitin-protein ligase activity; INVOLVED IN protein polyubiquitination; endosome to lysosome transport (ortholog); negative regulation of cAMP-mediated signaling (ortholog); PARTICIPATES IN melanocortin system pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal coat/hair pigmentation; abnormal coronary sinus morphology; abnormal heart and great artery attachment; ASSOCIATED WITH Hyperglycemia; Hyperinsulinism; Obesity; FOUND IN cytoplasm (ortholog); early endosome (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
2610042J20Rik; E3 ubiquitin-protein ligase MGRN1; mahoganoid; mahogunin RING finger protein 1; md; mKIAA0544; N28182; nc; probable E3 ubiquitin-protein ligase MGRN1
Orthologs:
Homo sapiens : MGRN1
(mahogunin ring finger 1, E3 ubiquitin protein ligase)
HGNC
Rattus norvegicus : Mgrn1
(mahogunin ring finger 1, E3 ubiquitin protein ligase)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 16 4,886,100 - 4,938,296 + NCBI Mouse cM Map 16 2.48 NCBI Mouse Celera Assembly 16 5,500,689 - 5,569,636 + NCBI Mouse Genome Assembly Build 37 16 4,886,252 - 4,938,296 + NCBI Mouse Genome Assembly Build 36.1 16 4,886,252 - 4,938,296 + NCBI Mouse Cytogenetic Map 16 A1 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17beta-estradiol increases expression ISO RGD:1353673 6480464 Estradiol results in increased expression of MGRN1 mRNA CTD PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of MGRN1 mRNA CTD PMID:20702594 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of MGRN1 mRNA CTD PMID:20702594 PMID:21570461 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MGRN1 mRNA CTD PMID:20188158 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of MGRN1 mRNA CTD PMID:22228805 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of MGRN1 mRNA CTD PMID:20061341 fenofibrate increases expression EXP 6480464 Fenofibrate results in increased expression of MGRN1 mRNA CTD PMID:21318169 fenofibrate multiple interactions EXP 6480464 [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MGRN1 mRNA CTD PMID:21318169 furan increases methylation ISO RGD:1311862 6480464 furan results in increased methylation of MGRN1 gene CTD PMID:22079235 paraquat increases expression EXP 6480464 Paraquat results in increased expression of MGRN1 mRNA CTD PMID:21371552
Biological Process
endosome to lysosome transport ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of cAMP-mediated signaling ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 negative regulation of G-protein coupled receptor protein signaling pathway ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein monoubiquitination ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 protein polyubiquitination IDA 2290270 MGI:MGI:2449384|PMID:12560552 MGI MGI:MGI:2449384 PMID:12560552
Cellular Component
cytoplasm ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 early endosome ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 endosome IEA UniProtKB-KW:KW-0967 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleus ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 plasma membrane ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
Molecular Function
ligase activity IEA UniProtKB-KW:KW-0436 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 protein binding IPI UniProtKB:P04273 2290270 MGI:MGI:4359573|PMID:19524515 IntAct MGI:MGI:4359573 PMID:19524515 ubiquitin-protein ligase activity IDA 2290270 MGI:MGI:2449384|PMID:12560552 MGI MGI:MGI:2449384 PMID:12560552 ubiquitin-protein ligase activity ISO UniProtKB:O60291 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 zinc ion binding IEA InterPro:IPR001841 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
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