Gene: Pip5k1c (phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma)
Mus musculus |
| Symbol: |
Pip5k1c
|
| Name: |
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
|
| Description: |
ENCODES a protein that exhibits 1-phosphatidylinositol-4-phosphate 5-kinase activity; INVOLVED IN axonogenesis; phosphatidylinositol metabolic process; phosphatidylinositol phosphorylation; PARTICIPATES IN E-cadherin signaling pathway; epidermal growth factor/neuregulin signaling pathway; N-cadherin signaling pathway; ASSOCIATED WITH abnormal cardinal vein morphology; abnormal CNS synaptic transmission; abnormal embryonic neuroepithelium morphology; ASSOCIATED WITH Lethal Congenital Contractural Syndrome 3 (ortholog); FOUND IN cell junction (inferred); cell projection (inferred); cytoplasm (inferred); INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
AI115456; AI835305; OTTMUSP00000045290; OTTMUSP00000045291; OTTMUSP00000045293; phosphatidylinositol 4-phosphate 5-kinase type I gamma; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; PIP5K1-gamma; Pip5kIgamma; ptdIns(4)P-5-kinase 1 gamma
|
| Orthologs: |
Homo sapiens : PIP5K1C
(phosphatidylinositol-4-phosphate 5-kinase, type I, gamma)
HGNC
Rattus norvegicus : Pip5k1c
(phosphatidylinositol-4-phosphate 5-kinase, type I, gamma)
|
| Latest Assembly: |
Mouse Genome Assembly Build 37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Mouse Genome Assembly GRCm38 | 10 | 81,292,972 - 81,319,974 | + | NCBI | Mouse cM Map | 10 | | + | NCBI | Mouse Celera Assembly | 10 | 82,313,321 - 82,340,709 | + | NCBI | Mouse Genome Assembly Build 37 | 10 | 80,755,717 - 80,782,719 | + | NCBI | Mouse Genome Assembly Build 36.1 | 10 | 80,755,725 - 80,780,650 | + | NCBI | Mouse Cytogenetic Map | 10 | C1 | | NCBI |
|
| Model |
|
 Disease Annotations |
 Gene-Chemical Interaction Annotations
| (S)-nicotine | multiple interactions | EXP | | 6480464 | Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA]; more ... | CTD | PMID:20230807 | | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | EXP | | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA | CTD | PMID:20230807 | | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | EXP | | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; more ... | CTD | PMID:20230807 | | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of PIP5K1C mRNA | CTD | PMID:17555576 | | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PIP5K1C mRNA | CTD | PMID:17942748 | | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIP5K1C mRNA | CTD | PMID:17942748 | | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PIP5K1C mRNA | CTD | PMID:17942748 | | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PIP5K1C promoter] | CTD | PMID:19654925 | | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIP5K1C mRNA | CTD | PMID:17942748 | | 2-methylcholine | affects expression | ISO | RGD:1320550 | 6480464 | beta-methylcholine affects the expression of PIP5K1C mRNA | CTD | PMID:21179406 | | caffeine | multiple interactions | EXP | | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; more ... | CTD | PMID:20230807 | | deoxycholic acid | decreases response to substance | ISO | RGD:1320550 | 6480464 | PIP5K1C protein results in decreased susceptibility to Deoxycholic Acid | CTD | PMID:12507930 | | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of PIP5K1C mRNA | CTD | PMID:17562736 | | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of PIP5K1C mRNA | CTD | PMID:17555576 | |
Biological Process
| axonogenesis | | IDA | | 2290270 | MGI:MGI:3037391|PMID:14741049 | MGI | MGI:MGI:3037391 PMID:14741049 |
| cell adhesion | | IEA | UniProtKB-KW:KW-0130 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| chemotaxis | | IEA | UniProtKB-KW:KW-0145 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| endocytosis | | IEA | UniProtKB-KW:KW-0254 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| exocytosis | | IEA | UniProtKB-KW:KW-0268 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| phagocytosis | | IEA | UniProtKB-KW:KW-0581 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| phosphatidylinositol metabolic process | | IDA | | 2290270 | MGI:MGI:1202278|PMID:9535851 | MGI | MGI:MGI:1202278 PMID:9535851 |
| phosphatidylinositol metabolic process | | IDA | | 2290270 | MGI:MGI:3037391|PMID:14741049 | MGI | MGI:MGI:3037391 PMID:14741049 |
| phosphatidylinositol phosphorylation | | IDA | | 2290270 | MGI:MGI:3037391|PMID:14741049 | GOC | MGI:MGI:3037391 PMID:14741049 |
| phosphatidylinositol phosphorylation | | IDA | | 2290270 | MGI:MGI:1202278|PMID:9535851 | GOC | MGI:MGI:1202278 PMID:9535851 |
| phosphorylation | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
Cellular Component
| cell junction | | IEA | UniProtKB-KW:KW-0965 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| cell projection | | IEA | UniProtKB-KW:KW-0966 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| cytoplasm | | IEA | UniProtKB-KW:KW-0963 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| membrane | | IEA | UniProtKB-KW:KW-0472 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| plasma membrane | | IEA | UniProtKB-KW:KW-1003 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
Molecular Function
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | | IDA | | 2290270 | MGI:MGI:1202278|PMID:9535851 | MGI | MGI:MGI:1202278 PMID:9535851 |
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | | IDA | | 2290270 | MGI:MGI:3037391|PMID:14741049 | MGI | MGI:MGI:3037391 PMID:14741049 |
| ATP binding | | IEA | UniProtKB-KW:KW-0067 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| kinase activity | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| nucleotide binding | | IEA | UniProtKB-KW:KW-0547 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| phosphatidylinositol phosphate kinase activity | | IEA | InterPro:IPR002498 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| transferase activity | | IEA | UniProtKB-KW:KW-0808 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| 1302035 | Lmb4_m | lupus in MRL and B6 F2 cross (mouse) | | | Not determined | | 10 | 47906889 | 81907087 | Mouse |
| 1302150 | Bbaa18_m | B.burgdorferi-associated arthritis 18 (mouse) | | | Not determined | | 10 | 48964981 | 82965126 | Mouse |
| 1357784 | Arti2_m | age related thymic involution 2 (mouse) | | | Not determined | | 10 | 49329535 | 83329679 | Mouse |
| 1301561 | Chab2_m | cholesterol absorption 2 (mouse) | | | Not determined | | 10 | 49329535 | 83329679 | Mouse |
| 1301386 | Sysbp1_m | systolic blood pressure 1 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1300597 | Skull14_m | skull morphology 14 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1357742 | Jckm1_m | juvenile cystic kidney modifier 1 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 4142169 | Pbwg16_m | postnatal body weight growth 16 (mouse) | | | Not determined | | 10 | 49475156 | 83475381 | Mouse |
| 1301966 | Lifespan2_m | life span 2 (mouse) | | | Not determined | | 10 | 49475191 | 83475366 | Mouse |
| 1357737 | Hpcr2_m | hepatocarcinogen resistance 2 (mouse) | | | Not determined | | 10 | 49475191 | 83475366 | Mouse |
| 1301502 | Eae17_m | susceptibility to experimental allergic encephalomyelitis 17 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 4141577 | Bmd38_m | bone mineral density 38 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 1300882 | Ath17_m | atherosclerosis 17 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 1301003 | Lmblgq4_m | limb length QTL 4 (mouse) | | | Not determined | | 10 | 50718408 | 84718557 | Mouse |
| 1558776 | Artmd1_m | arthropathy in MRL and DBA/1 mice 1 (mouse) | | | Not determined | | 10 | 55139307 | 89139418 | Mouse |
| 1301380 | Cia8_m | collagen induced arthritis QTL 8 (mouse) | | | Not determined | | 10 | 57337186 | 91337351 | Mouse |
| 1301787 | Bsc1_m | brain size control 1 (mouse) | | | Not determined | | 10 | 58143880 | 92144007 | Mouse |
| 1357860 | Aorls1_m | aortic lesion size 1 (mouse) | | | Not determined | | 10 | 65117849 | 99118032 | Mouse |
| 4142376 | Cmn2_m | cardiac modifier of nmd 2 (mouse) | | | Not determined | | 10 | 65117849 | 99118032 | Mouse |
| 1302060 | El3_m | epilepsy 3 (mouse) | | | Not determined | | 10 | 65117849 | 99118032 | Mouse |
| 1301737 | Insq9_m | insulin QTL 9 (mouse) | | | Not determined | | 10 | 65117849 | 99118032 | Mouse |
| 1300533 | Aem3_m | anti-erythrocyte autoantibody modifier 3 (mouse) | | | Not determined | | 10 | 65117849 | 99118032 | Mouse |
| 1300536 | Daq6_m | directional asymmetry QTL 6 (mouse) | | | Not determined | | 10 | 66706531 | 100706665 | Mouse |
| 4141251 | Secia5_m | small effect CIA locus 5 (mouse) | | | Not determined | | 10 | 68081863 | 102081972 | Mouse |
| 4140987 | Chlq6_m | circulating hormone level QTL 6 (mouse) | | | Not determined | | 10 | 72654985 | 106655099 | Mouse |
| 4142122 | Vmmt15_m | vertebral morphology and mechanical traits 15 (mouse) | | | Not determined | | 10 | 72654985 | 106655099 | Mouse |
| 4141976 | Chlq15_m | circulating hormone level QTL 15 (mouse) | | | Not determined | | 10 | 72654985 | 106655099 | Mouse |
| 4142155 | Lmr19_m | leishmaniasis resistance 19 (mouse) | | | Not determined | | 10 | 73133784 | 107133930 | Mouse |
| 4141693 | Adip15_m | adiposity 15 (mouse) | | | Not determined | | 10 | 74754266 | 108754445 | Mouse |
| 1357564 | Apsic3_m | apomorphine stress induced climbing 3 (mouse) | | | Not determined | | 10 | 74885360 | 108885556 | Mouse |
| 1300975 | Fembrs3_m | femur breaking strength 3 (mouse) | | | Not determined | | 10 | 74965451 | 108965650 | Mouse |
| 1357831 | Igf1sl2_m | IGF-1 serum levels 2 (mouse) | | | Not determined | | 10 | 74965451 | 108965650 | Mouse |
| 1357632 | Vtbt9_m | vertebral trabecular bone trait 9 (mouse) | | | Not determined | | 10 | 74965451 | 108965650 | Mouse |