Lpar4 (lysophosphatidic acid receptor 4) - Rat Genome Database

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Gene: Lpar4 (lysophosphatidic acid receptor 4) Mus musculus
Analyze
Symbol: Lpar4
Name: lysophosphatidic acid receptor 4
RGD ID: 1557960
MGI Page MGI
Description: Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including branchial arch; cardiovascular system; future brain; limb; and sensory organ. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730485F04Rik; G protein-coupled receptor 23; G-protein coupled receptor 23; Gpr; Gpr23; L; LPA receptor 4; LPA-4; LPA4; p2y; P2Y purinoceptor 9; p2y9; purinergic receptor 9
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,964,231 - 105,977,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,964,231 - 105,977,506 (+)EnsemblGRCm39 Ensembl
GRCm38X106,920,625 - 106,933,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,920,625 - 106,933,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X104,115,964 - 104,129,238 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X103,123,375 - 103,135,151 (+)NCBIMGSCv36mm8
CeleraX93,766,647 - 93,780,135 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12679517   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16782887   PMID:16829511  
PMID:17166850   PMID:18625716   PMID:18762810   PMID:18799693   PMID:18843048   PMID:18924241   PMID:20505096   PMID:20713964   PMID:21267068   PMID:21873635   PMID:22465231   PMID:24194600  
PMID:24602016   PMID:26090649   PMID:26714589   PMID:28854359   PMID:30026265   PMID:30796085   PMID:30804442   PMID:30847983   PMID:31335323   PMID:31533471   PMID:31633020   PMID:33317583  
PMID:35151977   PMID:35383201  


Genomics

Comparative Map Data
Lpar4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,964,231 - 105,977,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,964,231 - 105,977,506 (+)EnsemblGRCm39 Ensembl
GRCm38X106,920,625 - 106,933,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,920,625 - 106,933,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X104,115,964 - 104,129,238 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X103,123,375 - 103,135,151 (+)NCBIMGSCv36mm8
CeleraX93,766,647 - 93,780,135 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.39NCBI
LPAR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X78,747,720 - 78,758,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX78,747,709 - 78,758,714 (+)EnsemblGRCh38hg38GRCh38
GRCh37X78,003,217 - 78,014,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,896,957 - 77,899,249 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X77,816,445 - 77,818,733NCBI
CeleraX78,243,611 - 78,252,993 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX71,584,019 - 71,593,185 (+)NCBIHuRef
CHM1_1X77,896,235 - 77,905,616 (+)NCBICHM1_1
T2T-CHM13v2.0X77,184,471 - 77,195,526 (+)NCBIT2T-CHM13v2.0
Lpar4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X76,106,319 - 76,119,807 (+)NCBIGRCr8
mRatBN7.2X72,033,486 - 72,046,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX72,033,486 - 72,046,977 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX73,537,790 - 73,551,269 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X77,049,652 - 77,063,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X74,617,950 - 74,631,433 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X78,042,859 - 78,056,347 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX78,042,859 - 78,056,347 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X78,237,912 - 78,251,631 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X95,180,476 - 95,194,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX73,333,463 - 73,346,943 (+)NCBICelera
Cytogenetic MapXq22NCBI
LPAR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X78,287,373 - 78,298,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X78,290,990 - 78,302,342 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,887,929 - 67,899,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,997,762 - 78,007,810 (+)NCBIpanpan1.1PanPan1.1panPan2
LPAR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,828,462 - 60,840,053 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,838,170 - 60,839,282 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX51,840,269 - 51,852,543 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X62,081,200 - 62,093,456 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX62,091,097 - 62,092,209 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,772,817 - 59,785,084 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X61,377,993 - 61,390,257 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,976,943 - 60,989,213 (+)NCBIUU_Cfam_GSD_1.0
Lpar4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X54,501,599 - 54,514,883 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936547750,947 - 834,069 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936547821,950 - 834,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX62,870,984 - 62,874,422 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X62,862,158 - 62,876,184 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X71,950,203 - 71,962,681 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232244
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X67,755,081 - 67,770,690 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX67,764,914 - 67,766,026 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236679094,274 - 10,125 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Lpar4
353 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1093
Count of miRNA genes:509
Interacting mature miRNAs:664
Transcripts:ENSMUST00000060576
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse

Markers in Region
RH131472  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,931,876 - 106,932,046UniSTSGRCm38
MGSCv37X104,127,215 - 104,127,385UniSTSGRCm37
CeleraX93,778,112 - 93,778,282UniSTS
Cytogenetic MapXDUniSTS
UniSTS:238065  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X106,932,186 - 106,932,423UniSTSGRCm38
MGSCv37X104,127,525 - 104,127,762UniSTSGRCm37
CeleraX93,778,422 - 93,778,659UniSTS
Cytogenetic MapXDUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060576   ⟹   ENSMUSP00000053986
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX105,964,231 - 105,977,506 (+)Ensembl
GRCm38.p6 EnsemblX106,920,625 - 106,933,900 (+)Ensembl
RefSeq Acc Id: NM_175271   ⟹   NP_780480
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X105,964,231 - 105,977,505 (+)NCBI
GRCm38X106,920,625 - 106,933,899 (+)ENTREZGENE
MGSCv37X104,115,964 - 104,129,238 (+)RGD
CeleraX93,766,647 - 93,780,135 (+)RGD
cM MapX ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_780480   ⟸   NM_175271
- UniProtKB: Q8BKK1 (UniProtKB/Swiss-Prot),   A2ADM5 (UniProtKB/Swiss-Prot),   Q8VE54 (UniProtKB/Swiss-Prot),   Q8BLG2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000053986   ⟸   ENSMUST00000060576
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BLG2-F1-model_v2 AlphaFold Q8BLG2 1-370 view protein structure

Promoters
RGD ID:6845918
Promoter ID:MM_KWN:61546
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000044364
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X104,115,729 - 104,116,229 (+)MPROMDB
RGD ID:13681208
Promoter ID:EPDNEW_M24753
Type:initiation region
Name:Lpar4_1
Description:Mus musculus lysophosphatidic acid receptor 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X106,920,675 - 106,920,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925384 AgrOrtholog
Ensembl Genes ENSMUSG00000049929 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060576 ENTREZGENE
  ENSMUST00000060576.8 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78134 UniProtKB/Swiss-Prot
MGD MGI:1925384 ENTREZGENE
NCBI Gene 78134 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSOPHOSPHATIDIC ACID RECEPTOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lpar4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y5ORPHANR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ADM5 ENTREZGENE
  LPAR4_MOUSE UniProtKB/Swiss-Prot
  Q80UD5_MOUSE UniProtKB/TrEMBL
  Q8BKK1 ENTREZGENE
  Q8BLG2 ENTREZGENE
  Q8VE54 ENTREZGENE
UniProt Secondary A2ADM5 UniProtKB/Swiss-Prot
  Q8BKK1 UniProtKB/Swiss-Prot
  Q8VE54 UniProtKB/Swiss-Prot