Acot12 (acyl-CoA thioesterase 12)

Gene: Acot12 (acyl-CoA thioesterase 12) Mus musculus

Analyze

Symbol:

Acot12

Name:

acyl-CoA thioesterase 12

RGD ID:

1557713

MGI Page

MGI

Description:

Enables ATP binding activity and acetyl-CoA hydrolase activity. Acts upstream of or within acetyl-CoA metabolic process. Predicted to be located in intercellular bridge and nucleoplasm. Predicted to be active in cytosol. Is expressed in alimentary system and liver. Orthologous to human ACOT12 (acyl-CoA thioesterase 12).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1300004O04Rik; 4930449F15Rik; acetyl-coenzyme A thioesterase; acyl-CoA thioester hydrolase 12; acyl-coenzyme A thioesterase 12; AV027244; Cac; Cach; CACH-1; cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase; mCACH-1; null

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACOT12 (acyl-CoA thioesterase 12)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Acot12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acot12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACOT12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACOT12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acot12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACOT12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACOT12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acot12 (acyl-CoA thioesterase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Acot12 (acyl-CoA thioesterase 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ACOT12 (acyl-CoA thioesterase 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	acot12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	91,889,635 - 91,934,271 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	91,889,631 - 91,934,267 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	91,741,326 - 91,786,148 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	91,741,512 - 91,786,148 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	91,881,126 - 91,925,753 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	92,215,760 - 92,260,387 (+)	NCBI		MGSCv36	mm8
Celera	13	95,375,248 - 95,419,932 (+)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	47.43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

liver cancer (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1,2-dichloroethane (EXP)

1-naphthyl isothiocyanate (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

3-chloropropane-1,2-diol (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (ISO)

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (ISO)

amiodarone (EXP,ISO)

ammonium chloride (ISO)

benzbromarone (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (EXP)

carbon nanotube (EXP)

chlorpyrifos (EXP)

chromium(6+) (EXP)

clofibrate (EXP,ISO)

cyclosporin A (EXP,ISO)

dichloroacetic acid (EXP)

dimethylarsinic acid (EXP)

farnesol (ISO)

furan (ISO)

glafenine (ISO)

GW 4064 (EXP,ISO)

GW 7647 (ISO)

indometacin (ISO)

L-ethionine (ISO)

methapyrilene (ISO)

methylarsonic acid (EXP)

monosodium L-glutamate (EXP)

Muraglitazar (ISO)

N-Nitrosopyrrolidine (ISO)

nefazodone (ISO)

nitrofen (ISO)

O-methyleugenol (ISO)

oleic acid (ISO)

omeprazole (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP,ISO)

pravastatin (EXP,ISO)

sodium arsenate (EXP)

sodium arsenite (EXP,ISO)

Tesaglitazar (ISO)

tetrachloroethene (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (ISO)

troglitazone (EXP,ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetyl-CoA metabolic process (IBA,IDA)

acyl-CoA metabolic process (ISO)

fatty acid metabolic process (TAS)

lipid metabolic process (IEA)

Cellular Component

cytoplasm (IBA)

cytosol (IBA,ISO,TAS)

intercellular bridge (ISO)

nucleoplasm (ISO)

Molecular Function

acetyl-CoA hydrolase activity (IBA,IDA,ISO)

ATP binding (IDA)

carboxylic ester hydrolase activity (IEA)

hydrolase activity (IEA)

identical protein binding (ISO)

lipid binding (IEA)

protein binding (ISO)

thiolester hydrolase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Leigh disease pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal ion homeostasis (IAGP)

abnormal phospholipid level (IAGP)

abnormal vocalization (IEA)

increased circulating cholesterol level (IAGP)

increased circulating phospholipid level (IAGP)

increased hepatocellular carcinoma incidence (IAGP)

increased incidence of tumors by chemical induction (IAGP)

increased liver cholesterol level (IAGP)

increased liver triglyceride level (IAGP)

increased tumor growth/size (IAGP)

liver fibrosis (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	The biphasic change of cytosolic acetyl-CoA hydrolase in rat liver during 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis.	Ebisuno S, etal., Jpn J Cancer Res. 1989 Feb;80(2):132-5.
2.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12545200	PMID:14681479	PMID:15489334	PMID:16103133	PMID:16141072	PMID:16141073	PMID:21267068	PMID:21677750
PMID:21873635	PMID:34285335	PMID:34987154	PMID:37150501	PMID:37908734

Genomics

Comparative Map Data

Acot12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	91,889,635 - 91,934,271 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	91,889,631 - 91,934,267 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	91,741,326 - 91,786,148 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	91,741,512 - 91,786,148 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	91,881,126 - 91,925,753 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	92,215,760 - 92,260,387 (+)	NCBI		MGSCv36	mm8
Celera	13	95,375,248 - 95,419,932 (+)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	47.43	NCBI

ACOT12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	81,308,609 - 81,394,134 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	81,329,996 - 81,394,179 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	80,625,815 - 80,689,953 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	80,661,839 - 80,725,712 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	80,661,838 - 80,725,712	NCBI
Celera	5	76,530,237 - 76,594,485 (-)	NCBI		Celera
Cytogenetic Map	5	q14.1	NCBI
HuRef	5	75,834,814 - 75,898,818 (-)	NCBI		HuRef
CHM1_1	5	80,058,759 - 80,122,826 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	81,793,197 - 81,878,724 (-)	NCBI		T2T-CHM13v2.0

Acot12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	24,721,648 - 24,763,686 (+)	NCBI		GRCr8
mRatBN7.2	2	22,986,867 - 23,027,538 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	22,986,626 - 23,027,536 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	30,027,186 - 30,067,868 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,127,527 - 28,168,209 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	22,946,811 - 22,987,990 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	20,857,056 - 20,901,656 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	20,857,202 - 20,901,659 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	48,055,053 - 48,096,606 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	21,984,849 - 22,035,224 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	21,905,217 - 21,955,593 (+)	NCBI
Celera	2	19,090,138 - 19,130,693 (+)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Acot12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	28,829,144 - 28,875,486 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	28,829,316 - 28,872,629 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACOT12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	33,906,886 - 33,972,212 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	32,060,511 - 32,125,642 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	33,885,302 - 33,950,075 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	34,196,456 - 34,260,652 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	34,196,504 - 34,260,254 (+)	Ensembl	panpan1.1		panPan2

ACOT12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	25,928,356 - 25,979,688 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	25,928,394 - 25,971,378 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,164,302 - 27,215,764 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	25,842,682 - 25,894,121 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	25,842,690 - 25,885,817 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	25,794,545 - 25,845,903 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	25,763,842 - 25,815,461 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,043,885 - 26,095,246 (+)	NCBI		UU_Cfam_GSD_1.0

Acot12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	181,944,364 - 181,989,976 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	636,315 - 681,376 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	635,663 - 681,373 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACOT12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	89,855,162 - 89,905,111 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	89,855,159 - 89,905,105 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	91,785,951 - 91,815,862 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACOT12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	75,398,361 - 75,543,933 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	75,469,424 - 75,535,267 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	24,343,822 - 24,409,316 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acot12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	1,851,068 - 1,883,255 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	1,849,498 - 1,883,250 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acot12
1719 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	457
Count of miRNA genes:	343
Interacting mature miRNAs:	389
Transcripts:	ENSMUST00000022120, ENSMUST00000159214, ENSMUST00000161337
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301949	Skull20_m	skull morphology 20 (mouse)			Not determined		13	64250821	98250945	Mouse
1300941	Skl6_m	skeletal size (tail length) 6 (mouse)			Not determined		13	64250821	98250945	Mouse
4142147	Mvwf4_m	modifier of von Willebrand factor 4 (mouse)			Not determined			20477612	112898424	Mouse
1301445	Listr2_m	listeriosis resistance 2 (mouse)			Not determined		13	66744601	100744746	Mouse
4141728	Egaq4_m	early growth adjusted QTL 4 (mouse)			Not determined			87901985	112431103	Mouse
10043997	Bw40_m	body weight QTL 40 (mouse)			Not determined		14	79239045	113239162	Mouse
10402414	Sgp5_m	serum gp70 production 5 (mouse)			Not determined		13	56470456	105422186	Mouse
1301610	Dps1_m	delta power in slow-wave sleep 1 (mouse)			Not determined		13	77195862	95730894	Mouse
4142465	Pbwg17_m	postnatal body weight growth 17 (mouse)			Not determined		13	83876060	117876256	Mouse
4140995	Fbtq6_m	femoral bone trait QTL 6 (mouse)			Not determined		13	86341617	120341758	Mouse
4141992	W6q16_m	weight 6 weeks QTL 16 (mouse)			Not determined			55720354	112431103	Mouse
1301593	Heal8_m	wound healing/regeneration 8 (mouse)			Not determined		13	68053999	102054119	Mouse
4141266	Mol3_m	modifier of LPS-response 3 (mouse)			Not determined			76132600	112431103	Mouse
1558741	Ses10_m	salmonella enteritidis susceptibility 10 (mouse)			Not determined		13	82739968	116740106	Mouse
14700691	Cisaq1_m	coxsackieviral infection serum ALT QTL 1 (mouse)					13	86148119	120461536	Mouse
4142241	Tailq3_m	tail length QTL 3 (mouse)			Not determined			55720354	112431103	Mouse
1300939	Hrtfm6_m	heart failure modifier 6 (mouse)			Not determined		13	91383692	120883175	Mouse
1357553	Cia28_m	collagen induced arthritis 28 (mouse)			Not determined		13	56629249	96239162	Mouse
10412163	Wra1_m	wheel running activity 1 (mouse)			Not determined		13	59132600	93132738	Mouse
14747007	Mancz11_m	mandible centroid size 11 (mouse)					13	70111284	104111284	Mouse
12880414	V125Dq10_m	vitamin D active form serum level QTL 10 (mouse)					13	78036508	112036508	Mouse
12880402	Emlq1_m	emotional learning QTL 1 (mouse)					13	78108858	96866553	Mouse
10045623	Heal18_m	wound healing regeneration 18 (mouse)			Not determined		13	79239045	113239162	Mouse
4140959	W10q17_m	weight 10 weeks QTL 17 (mouse)			Not determined			55720354	112431103	Mouse
4142314	Tailaq3_m	tail length adjusted QTL 3 (mouse)			Not determined			55720354	112431103	Mouse
14696726	Kidrq3_m	kidney weight, right QTL 3 (mouse)					13	68217066	102217066	Mouse
12879495	Fexq1_m	fear expression QTL 1 (mouse)					13	78268858	95836553	Mouse
10412235	Scgq5_m	spontaneous crescentic glomerulonephritis QTL 5 (mouse)			Not determined		13	36060908	96239162	Mouse

Markers in Region

MT2492

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	91,781,056 - 91,781,177	UniSTS	GRCm38
MGSCv37	13	91,920,661 - 91,920,782	UniSTS	GRCm37
Celera	13	95,414,838 - 95,414,949	UniSTS
Cytogenetic Map	13	C3	UniSTS
cM Map	13	43.0	UniSTS
Whitehead Genetic	13	32.8	UniSTS

D13Mit193.1

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	91,780,967 - 91,781,078	UniSTS	GRCm38
MGSCv37	13	91,920,572 - 91,920,683	UniSTS	GRCm37
Celera	13	95,414,749 - 95,414,860	UniSTS
Cytogenetic Map	13	C3	UniSTS
cM Map	13	43.0	UniSTS
cM Map	13		UniSTS
Whitehead Genetic	13	32.8	UniSTS

AV027244

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	91,785,991 - 91,786,094	UniSTS	GRCm38
MGSCv37	13	91,925,596 - 91,925,699	UniSTS	GRCm37
Celera	13	95,419,775 - 95,419,878	UniSTS
Cytogenetic Map	13	C3	UniSTS
Whitehead/MRC_RH	13	760.19	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001418677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_028790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB078618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC154413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK015431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK033663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK034622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC132050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC137996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000022120 ⟹ ENSMUSP00000022120

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	91,889,631 - 91,934,267 (+)	Ensembl
GRCm38.p6 Ensembl	13	91,741,512 - 91,786,148 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000159214

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	91,927,447 - 91,933,023 (+)	Ensembl
GRCm38.p6 Ensembl	13	91,779,328 - 91,784,904 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000161337

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	91,889,652 - 91,911,292 (+)	Ensembl
GRCm38.p6 Ensembl	13	91,741,533 - 91,763,173 (+)	Ensembl

RefSeq Acc Id:

NM_001418677 ⟹ NP_001405606

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	91,889,635 - 91,934,271 (+)	NCBI

RefSeq Acc Id:

NM_028790 ⟹ NP_083066

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	91,889,635 - 91,934,271 (+)	NCBI
GRCm38	13	91,741,521 - 91,786,148 (+)	NCBI
MGSCv37	13	91,881,126 - 91,925,753 (+)	RGD
Celera	13	95,375,248 - 95,419,932 (+)	RGD
cM Map	13		ENTREZGENE

Sequence:

show sequence

AGCCAGGACGATGGAGTCGATGGTGGCGCCGGGTGAGGTGCTCATGAGCCAGGCCATCCAGCCG
GCTCATGCCGACTCCCGCGGCGAGCTGAGCGCAGGGCAGCTGCTCAAGTGGATGGACACCACCG
CTTGCCTGGCGGCCGAAAAGCATGCTGGGATTTCCTGTGTCACAGCCTCCATGGATGACATTCT
GTTTGAGGACACAGCGAGAATTGGACAAATTATTACCATCAGAGCAAAAGTGACTAGGGCGTTC
AGCACAAGCATGGAGATCAGTATCAAGGTCATAGTCCAGGACAAGTTCACGGGCATCCAGAAGC
TCCTCTGCGTGGCTTTCTCTACGTTTGTAGCTAAACCAGTTGGCAAAGAAAAGGTTCACTTAAA
ACCTGTCCTGCTTCAAACAGAGCAAGAACAAGTGGAGCACAATCTGGCTTCAGAGAGAAGGAAA
GTCCGACTGCAGCATGAGAACACCTTCAACAACATTATGAAGGAGAGCAGCAGGTTCAGCGATT
CCATTTGTAATGAAGAAGAAGGAACGGCCACCACCATGGGCACCTCTGTCCAGAGCATCGAGCT
TGTCCTTCCGCCCCACGCAAACCATCACGGAAACACATTTGGTGGCCAGATCATGGCATGGATG
GAGACAGTCGCCACCATTTCTGCAAGCCGCCTGTGTCATGGGCATCCCTTTCTGAAGTCTGTGG
ATATGTTTAAATTCCGGGGACCGTCCACAGTTGGAGACCGCCTTGTCTTCAGTGCCATAGTCAA
CAACACCTTTCAGAACAGTGTGGAAGTCGGAGTGCGTGTTGAGGCCTTTGACTGTCAGGAGTGG
GCCGAGGGCCAAGGCCGCCACATCAACAGCGCTTTTCTCATTTACAATGCTGTTGATGACCAGG
AGAAACTCATCACCTTTCCCAGAATCCAACCCATTTCAAAGGACGATTTTCGCCGTTACCAGGG
AGCCATCGCACGGAGGAGAATTCGCCTAGGCAGGAAATATGTTATTTCCCACAAGAAAGAAGTT
CCACTCAGTGCACAGTGGGATATAAGCAAAAAGGGATCCCTAAGTAACACCAATGTGGAAGCTC
TCAAAAATCTGGCATCCAAAAGCGGTTGGGAGATTACCACCACCTTGGAGAAGATAAAAATATA
TACCCTGGAGGAGCAAGATGCCATATCTGTTAAGGTTGAAAAGCTTGTGGGCAGTCCAGCCCAC
ATAGCTTATCATCTCTTGTCTGACCTCACAAAGCGACCTTTATGGGACCCCCATTACATATCTT
GTGAAGTTATAGACCAGGTGAGCGAGGACGATCAGATATATTACATCACTTGCTCGGTGGTAAA
TGGAGACAAACCCAAGGACTTTGTGGTGCTTGTGTCACGAAGAAAGCCCCTCAAAGACAACAAC
ACCTACACCGTGGCACTAAGGTCAGTTGTGCTGCCGTCTGTCCCGTCATCTCCACAGTACATCA
GAAGTGAGGTCATTTGTGCTGGGTTTCTCATCCAGGCTGTCGACAGCAATTCGTGCACCGTAAC
GTACCTGAACCAGATGTCAGACAGCATCCTCCCTTACTTTGCTGGCAATATTGGTGGCTGGTCA
AAATCCATTGAGGAAGCTGCAGCCTCTTGTATAAAATTCATAGAGAATGCTACTCCTGATGGAC
TTAAAAGTGTGTTATAAATGGTCAACTCTCAGCTACCTGTAATTTAATTCCAAATGTGTCCTTA
GCCCTTTTATGTGGCAAGCTTTGGGGCCATACAACGATTTAATATCAGCCTAAGCAAAATGCAG
TTATGAAGAGATGAAAAAACAAAGTGTATTCTGGTGATTTGGAGCCAAACCACAAGATCTCACA
GCCCTACTGTACTGACACTTGGAAATTGCCTGGATACGATATCACATGATCTATAAGATGGCAC
AAAATTAGTCAACACTATCACATCTGGCTCTGGATTACAGAAGCTCGATGTGTATTCTGCAATG
ATGAGTTTATAAAACGTGAAATGGTGGGCTAAAACCTGATGAGTGTTTAATATTAGTCCATGGG
CGGCAGACACCTTTGTCAGGAGTCTTTGAGAAGATATATTCCATGTTTTAGAACTTTAAATTAG
GAAGCGTTAAAACATAATGGAATCCAATCAGTTTTTTAAATATGAACGACTTCACTTTTGTCAT
TTTACATATATTCCAGGTAGATGGCCAATTTAGTATCTATTTCTATACACGCACACGCCAAGCA
CCTGTAAAGTGTGATATTAGAGAGAGAATATTAACTGAGCTCTTCTTCTTCATATCTCTTCCAT
TAGTACTTTATCTCCTAGACGTCTACATTTATCATTCTACACCATGATGTGTCTTAACTCATAA
GACCAAGCAGAATGTGTCAGGTTAGCCTCCTTCAAAGGATGACTTTTACAAATGGAAGAGGACC
TCCATCAGAGTTGAGAGCAGGAGACAGGTTTGGGCTATCCTCACCAGATCTCCTCTGCTCCCCG
GCCTGCTCCCACATGCCCACTCAAATAGTTTGAGGCTGGCTACAGTTTTTATCTTACTTATTTG
TCTCAAGGTTCAGCCGTATGTGAACTTTAGACCACGTTCTAATTTTATAAATTACTATTTATAT
ATCATAAGAGTAATGCATAGCATAGAACATTCTAGAACTAAAAAACAACTTCAGGAAATATTTT
AATTCTACAAGGTAAAAGATTTAGTAATAAGGGGCTTATAAGATGCTGTAACTTAGTGTTATCA
TTTCAGACTTCTGAAATGAAGAGGCTTTTAAGTGCTATATGCGTAGGCTTGGTCTTTGAATTCA
GTTTTTGAAATGTTTTCCTGAACAGAAACAGAAATACTTGAGTAACTTTAGCCAGCTTACTTGA
GACATAGACAGTATGGACTCCAGTTTGCAGGATCTACCTTACCCAGGATGGGTATAAACTCTCA
GAACGTTGTCACTTGTCCTAGGTTTGTTTCCATACTGCCTACTTTGGATGAAGTCTAGTTGATA
AGTTGGAGATTCGCAATAACCTCTAATAAAATTGAACCATC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001405606	(Get FASTA)	NCBI Sequence Viewer
	NP_083066	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH25852	(Get FASTA)	NCBI Sequence Viewer
	AAI32051	(Get FASTA)	NCBI Sequence Viewer
	AAI37997	(Get FASTA)	NCBI Sequence Viewer
	BAB23658	(Get FASTA)	NCBI Sequence Viewer
	BAB84021	(Get FASTA)	NCBI Sequence Viewer
	BAC28775	(Get FASTA)	NCBI Sequence Viewer
	EDL00967	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000022120
	ENSMUSP00000022120.5
GenBank Protein	Q9DBK0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_083066 ⟸ NM_028790
- Peptide Label:	isoform 1
- UniProtKB:	Q544M5 (UniProtKB/Swiss-Prot), Q8R108 (UniProtKB/Swiss-Prot), Q9DBK0 (UniProtKB/Swiss-Prot), A2RSC2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESMVAPGEVLMSQAIQPAHADSRGELSAGQLLKWMDTTACLAAEKHAGISCVTASMDDILFED TARIGQIITIRAKVTRAFSTSMEISIKVIVQDKFTGIQKLLCVAFSTFVAKPVGKEKVHLKPVL LQTEQEQVEHNLASERRKVRLQHENTFNNIMKESSRFSDSICNEEEGTATTMGTSVQSIELVLP PHANHHGNTFGGQIMAWMETVATISASRLCHGHPFLKSVDMFKFRGPSTVGDRLVFSAIVNNTF QNSVEVGVRVEAFDCQEWAEGQGRHINSAFLIYNAVDDQEKLITFPRIQPISKDDFRRYQGAIA RRRIRLGRKYVISHKKEVPLSAQWDISKKGSLSNTNVEALKNLASKSGWEITTTLEKIKIYTLE EQDAISVKVEKLVGSPAHIAYHLLSDLTKRPLWDPHYISCEVIDQVSEDDQIYYITCSVVNGDK PKDFVVLVSRRKPLKDNNTYTVALRSVVLPSVPSSPQYIRSEVICAGFLIQAVDSNSCTVTYLN QMSDSILPYFAGNIGGWSKSIEEAAASCIKFIENATPDGLKSVL hide sequence

RefSeq Acc Id:

ENSMUSP00000022120 ⟸ ENSMUST00000022120

RefSeq Acc Id:	NP_001405606 ⟸ NM_001418677
- Peptide Label:	isoform 2

Protein Domains

HotDog ACOT-type START

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9DBK0-F1-model_v2	AlphaFold	Q9DBK0	1-556	view protein structure

Promoters

RGD ID:

8680964

Promoter ID:

EPDNEW_M18513

Type:

multiple initiation site

Name:

Acot12_1

Description:

Mus musculus acyl-CoA thioesterase 12 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	13	91,741,516 - 91,741,576	EPDNEW

RGD ID:

6823628

Promoter ID:

MM_KWN:14872

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney, Liver

Transcripts:

OTTMUST00000059016, OTTMUST00000059759

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	13	91,880,386 - 91,880,922 (+)	MPROMDB

RGD ID:

6823627

Promoter ID:

MM_KWN:14874

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Liver

Transcripts:

OTTMUST00000059761

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	13	91,918,086 - 91,918,586 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1921406	AgrOrtholog
Ensembl Genes	ENSMUSG00000021620	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000022120	ENTREZGENE
	ENSMUST00000022120.5	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.530.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Hotdog Thioesterase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cytosol_ACT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOTDOG_ACOT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HotDog_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	START-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	START_lipid-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Thioestr_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:74156	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:1921406	ENTREZGENE
NCBI Gene	74156	ENTREZGENE
PANTHER	ACETYL-COENZYME A THIOESTERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11049	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	4HBT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	START	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Acot12	PhenoGen
PROSITE	HOTDOG_ACOT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	START	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	START	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Bet v1-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54637	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A2RSC2	ENTREZGENE, UniProtKB/TrEMBL
	ACO12_MOUSE	UniProtKB/Swiss-Prot
	Q544M5	ENTREZGENE
	Q8R108	ENTREZGENE
	Q9DBK0	ENTREZGENE
UniProt Secondary	Q544M5	UniProtKB/Swiss-Prot
	Q8R108	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-26	Acot12	acyl-CoA thioesterase 12	Cach		Data merged from RGD:736722	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype