Wrn (Werner syndrome RecQ like helicase) - Rat Genome Database

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Gene: Wrn (Werner syndrome RecQ like helicase) Mus musculus
Analyze
Symbol: Wrn
Name: Werner syndrome RecQ like helicase
RGD ID: 1557552
MGI Page MGI
Description: Enables 3'-5' exonuclease activity. Involved in DNA replication and G-quadruplex DNA unwinding. Acts upstream of or within several processes, including determination of adult lifespan; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI846146; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; exonuclease WRN; Werner syndrome ATP-dependent helicase homolog; Werner syndrome homolog; Werner syndrome homolog (human); Werner syndrome protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39833,724,400 - 33,875,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl833,724,412 - 33,875,555 (-)EnsemblGRCm39 Ensembl
GRCm38833,234,372 - 33,385,543 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,234,384 - 33,385,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37834,344,845 - 34,495,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36834,700,308 - 34,851,437 (-)NCBIMGSCv36mm8
Celera835,829,900 - 36,023,160 (-)NCBICelera
Cytogenetic Map8A3NCBI
cM Map820.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
chromosome  (IBA)
chromosome, telomeric region  (IMP,ISO)
cytoplasm  (IBA)
nuclear speck  (ISO)
nucleolus  (IDA,ISO)
nucleoplasm  (IBA,IDA,ISO)
nucleus  (IBA,IDA)
replication fork  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue distribution  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone trabecula morphology  (IAGP)
abnormal cardiovascular development  (IEA)
abnormal cell physiology  (IAGP)
abnormal chromosome morphology  (IAGP)
abnormal circulating hyaluronic acid level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal osteoid morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal thrombosis  (IAGP)
alopecia  (IAGP)
aortic valve stenosis  (IAGP)
bicuspid aortic valve  (IEA)
bicuspid pulmonary valve  (IEA)
cardiac interstitial fibrosis  (IAGP)
cataract  (IAGP)
cleft palate  (IEA)
decreased body weight  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased compact bone area  (IAGP)
decreased compact bone thickness  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased telomere length  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased tumor latency  (IAGP)
delayed wound healing  (IAGP)
enlarged adrenal glands  (IEA)
fragile skeleton  (IAGP)
heart inflammation  (IAGP)
hyperglycemia  (IAGP)
hyperlipidemia  (IAGP)
impaired glucose tolerance  (IAGP)
impaired wound healing  (IAGP)
increased abdominal adipose tissue amount  (IAGP)
increased bone trabecular spacing  (IAGP)
increased cellular sensitivity to oxidative stress  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased left ventricle systolic pressure  (IAGP)
increased osteoclast cell number  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased sarcoma incidence  (IAGP)
increased susceptibility to age related obesity  (IAGP)
increased susceptibility to infection  (IAGP)
increased tumor incidence  (IAGP)
insulin resistance  (IAGP)
kyphosis  (IAGP)
osteoporosis  (IAGP)
oxidative stress  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
small gonad  (IAGP)
small testis  (IAGP)
thymus hypoplasia  (IEA)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients. Bohr VA, etal., Mech Ageing Dev. 2004 Jul;125(7):491-6.
2. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Castro E, etal., Am J Med Genet. 2000 Dec 11;95(4):374-80.
3. Genetic variation in the premature aging gene WRN: a case-control study on breast cancer susceptibility. Ding SL, etal., Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):263-9.
4. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron M, etal., Genomics 2000 Nov 15;70(1):140-9.
5. Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. Ehrenberg M, etal., Mol Vis. 2010 Aug 28;16:1771-5.
6. Significant elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic sclerosis. Goto M, etal., Mod Rheumatol. 2006;16(4):229-34.
7. The spectrum of WRN mutations in Werner syndrome patients. Huang S, etal., Hum Mutat. 2006 Jun;27(6):558-67.
8. Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population. Jiang S, etal., Age (Dordr). 2013 Dec;35(6):2435-44. doi: 10.1007/s11357-013-9512-4. Epub 2013 Jan 20.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet. Moore G, etal., Mech Ageing Dev. 2008 Apr;129(4):201-6. doi: 10.1016/j.mad.2007.12.009. Epub 2008 Jan 17.
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Werner's syndrome and restrictive cardiomyopathy. Theodoropoulos TA, etal., Int J Cardiol. 2006 Apr 4;108(2):284-5.
18. A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. Wang Z, etal., Breast Cancer Res Treat. 2009 Nov;118(1):169-75. doi: 10.1007/s10549-009-0327-z. Epub 2009 Feb 10.
19. Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Ye L, etal., Am J Med Genet. 1997 Feb 11;68(4):494-8.
Additional References at PubMed
PMID:8602509   PMID:8889548   PMID:9143515   PMID:9618508   PMID:9681877   PMID:9789047   PMID:10349636   PMID:10757074   PMID:10757812   PMID:10782115   PMID:10806190   PMID:10871373  
PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11280729   PMID:11301316   PMID:11420665   PMID:11756244   PMID:11863428   PMID:12242664   PMID:12477932   PMID:12707040  
PMID:12803543   PMID:12944467   PMID:14595844   PMID:14610273   PMID:15235603   PMID:15367665   PMID:15642393   PMID:15743673   PMID:16141072   PMID:16141073   PMID:16195394   PMID:16264192  
PMID:16330174   PMID:16769258   PMID:16785251   PMID:17229737   PMID:18028256   PMID:18588880   PMID:18799693   PMID:19896421   PMID:20708636   PMID:21123451   PMID:21267068   PMID:21464516  
PMID:21873635   PMID:22301954   PMID:22621437   PMID:22753033   PMID:22754337   PMID:23974989   PMID:24608430   PMID:24626990   PMID:25807483   PMID:25921537   PMID:26195664   PMID:26447695  
PMID:26521679   PMID:28119126   PMID:29452565   PMID:29494634   PMID:32325033   PMID:33907225   PMID:34772932  


Genomics

Comparative Map Data
Wrn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39833,724,400 - 33,875,591 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl833,724,412 - 33,875,555 (-)EnsemblGRCm39 Ensembl
GRCm38833,234,372 - 33,385,543 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,234,384 - 33,385,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37834,344,845 - 34,495,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36834,700,308 - 34,851,437 (-)NCBIMGSCv36mm8
Celera835,829,900 - 36,023,160 (-)NCBICelera
Cytogenetic Map8A3NCBI
cM Map820.3NCBI
WRN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38831,033,810 - 31,176,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl831,033,788 - 31,176,138 (+)EnsemblGRCh38hg38GRCh38
GRCh37830,891,326 - 31,033,654 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36831,010,320 - 31,150,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 34831,010,319 - 31,150,818NCBI
Celera829,850,819 - 29,989,925 (+)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,435,610 - 29,576,278 (+)NCBIHuRef
CHM1_1831,092,222 - 31,232,737 (+)NCBICHM1_1
T2T-CHM13v2.0831,314,935 - 31,457,266 (+)NCBIT2T-CHM13v2.0
Wrn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,466,552 - 65,602,951 (+)NCBIGRCr8
mRatBN7.21658,763,517 - 58,898,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,763,504 - 58,895,450 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01662,483,773 - 62,619,018 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,483,761 - 62,615,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01662,148,560 - 62,283,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,535,144 - 62,668,700 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1656,796,927 - 56,929,877 (+)NCBICelera
Cytogenetic Map16q12.3NCBI
Wrn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,525,100 - 7,633,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,495,243 - 7,633,532 (+)NCBIChiLan1.0ChiLan1.0
WRN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,612,933 - 49,764,582 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1825,329,155 - 25,486,021 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0830,353,643 - 30,492,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,541,145 - 27,679,855 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,541,145 - 27,679,855 (+)Ensemblpanpan1.1panPan2
WRN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,164,662 - 33,304,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,167,364 - 33,304,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1633,688,179 - 33,763,508 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,190,440 - 35,330,557 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,190,442 - 35,331,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,288,917 - 33,429,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01633,863,786 - 34,003,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01633,981,929 - 34,122,272 (-)NCBIUU_Cfam_GSD_1.0
Wrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,358,222 - 56,501,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792862,383 - 1,005,755 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792862,659 - 1,005,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WRN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1553,966,986 - 54,094,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11553,966,968 - 54,094,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,329,196 - 61,464,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WRN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1829,150,256 - 29,288,830 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl829,174,229 - 29,289,129 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605212,803,116 - 12,942,546 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wrn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478012,876,093 - 13,025,739 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478012,875,747 - 13,051,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wrn
5520 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:856
Count of miRNA genes:333
Interacting mature miRNAs:362
Transcripts:ENSMUST00000033990, ENSMUST00000033991
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1302173Vent1_mventricular size 1 (mouse)Not determined83183168634743564Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
13801029Gripgtt2_mglucose response to intraperitoneal glucose tolerance test 2, females only (mouse)83251002834987154Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83327701651290537Mouse

Markers in Region
D86526  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,236,124 - 33,236,240UniSTSGRCm38
MGSCv37834,346,596 - 34,346,712UniSTSGRCm37
Celera835,857,169 - 35,857,285UniSTS
Celera835,131,741 - 35,131,856UniSTS
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS
Whitehead/MRC_RH8372.02UniSTS
UniSTS:235864  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,235,797 - 33,236,002UniSTSGRCm38
MGSCv37834,346,269 - 34,346,474UniSTSGRCm37
Celera835,856,844 - 35,857,047UniSTS
Celera835,131,414 - 35,131,619UniSTS
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS
AI846146  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,235,903 - 33,235,990UniSTSGRCm38
MGSCv37834,346,375 - 34,346,462UniSTSGRCm37
Celera835,856,948 - 35,857,035UniSTS
Celera835,131,520 - 35,131,607UniSTS
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS
Whitehead/MRC_RH8371.48UniSTS
Wrn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS
PMC117198P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,387,042 - 33,387,388UniSTSGRCm38
MGSCv37834,497,514 - 34,497,860UniSTSGRCm37
Celera836,024,623 - 36,024,969UniSTS
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS
PMC23722P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,282,512 - 33,282,889UniSTSGRCm38
MGSCv37834,392,984 - 34,393,361UniSTSGRCm37
Celera835,911,327 - 35,911,577UniSTS
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS
UniSTS:481162  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,386,317 - 33,387,640UniSTSGRCm38
MGSCv37834,496,789 - 34,498,112UniSTSGRCm37
Celera836,023,898 - 36,025,221UniSTS
Cytogenetic Map8A4UniSTS
UniSTS:488917  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38833,386,325 - 33,387,388UniSTSGRCm38
MGSCv37834,496,797 - 34,497,860UniSTSGRCm37
Celera836,023,906 - 36,024,969UniSTS
Cytogenetic Map8A4UniSTS
cM Map820.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001122822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF241636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U97045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033990   ⟹   ENSMUSP00000033990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl833,725,710 - 33,875,500 (-)Ensembl
GRCm38.p6 Ensembl833,235,682 - 33,385,472 (-)Ensembl
RefSeq Acc Id: ENSMUST00000033991   ⟹   ENSMUSP00000033991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl833,724,412 - 33,875,555 (-)Ensembl
GRCm38.p6 Ensembl833,234,384 - 33,385,527 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209293
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl833,814,238 - 33,875,536 (-)Ensembl
GRCm38.p6 Ensembl833,324,210 - 33,385,508 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211498   ⟹   ENSMUSP00000147379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl833,725,712 - 33,820,578 (-)Ensembl
GRCm38.p6 Ensembl833,235,684 - 33,330,550 (-)Ensembl
RefSeq Acc Id: NM_001122822   ⟹   NP_001116294
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,401 - 33,875,555 (-)NCBI
GRCm38833,234,373 - 33,385,527 (-)NCBI
MGSCv37834,344,845 - 34,495,999 (-)RGD
Celera835,130,502 - 35,132,077 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011721   ⟹   NP_035851
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,401 - 33,875,555 (-)NCBI
GRCm38833,234,373 - 33,385,527 (-)NCBI
MGSCv37834,344,845 - 34,495,999 (-)RGD
Celera835,130,502 - 35,132,077 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509091   ⟹   XP_006509154
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,400 - 33,875,570 (-)NCBI
GRCm38833,234,372 - 33,385,543 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509093   ⟹   XP_006509156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,400 - 33,875,570 (-)NCBI
GRCm38833,234,372 - 33,385,543 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312662   ⟹   XP_017168151
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,400 - 33,851,549 (-)NCBI
GRCm38833,234,372 - 33,361,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153880   ⟹   XP_036009773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,400 - 33,875,553 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934799
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39833,724,400 - 33,875,591 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035851   ⟸   NM_011721
- UniProtKB: Q9Z241 (UniProtKB/Swiss-Prot),   Q9JKD4 (UniProtKB/Swiss-Prot),   Q80YP9 (UniProtKB/Swiss-Prot),   O09050 (UniProtKB/Swiss-Prot),   Q9Z242 (UniProtKB/Swiss-Prot),   O09053 (UniProtKB/Swiss-Prot),   A0A1B0GR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116294   ⟸   NM_001122822
- UniProtKB: Q9Z241 (UniProtKB/Swiss-Prot),   Q9JKD4 (UniProtKB/Swiss-Prot),   Q80YP9 (UniProtKB/Swiss-Prot),   O09050 (UniProtKB/Swiss-Prot),   Q9Z242 (UniProtKB/Swiss-Prot),   O09053 (UniProtKB/Swiss-Prot),   A0A1B0GR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509156   ⟸   XM_006509093
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509154   ⟸   XM_006509091
- Peptide Label: isoform X1
- UniProtKB: Q9Z241 (UniProtKB/Swiss-Prot),   Q9JKD4 (UniProtKB/Swiss-Prot),   Q80YP9 (UniProtKB/Swiss-Prot),   O09050 (UniProtKB/Swiss-Prot),   Q9Z242 (UniProtKB/Swiss-Prot),   O09053 (UniProtKB/Swiss-Prot),   A0A1B0GR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168151   ⟸   XM_017312662
- Peptide Label: isoform X1
- UniProtKB: Q9Z241 (UniProtKB/Swiss-Prot),   Q9JKD4 (UniProtKB/Swiss-Prot),   Q80YP9 (UniProtKB/Swiss-Prot),   O09050 (UniProtKB/Swiss-Prot),   Q9Z242 (UniProtKB/Swiss-Prot),   O09053 (UniProtKB/Swiss-Prot),   A0A1B0GR54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000147379   ⟸   ENSMUST00000211498
RefSeq Acc Id: ENSMUSP00000033990   ⟸   ENSMUST00000033990
RefSeq Acc Id: ENSMUSP00000033991   ⟸   ENSMUST00000033991
RefSeq Acc Id: XP_036009773   ⟸   XM_036153880
- Peptide Label: isoform X2
- UniProtKB: A0A1B0GR54 (UniProtKB/TrEMBL)
Protein Domains
3'-5' exonuclease   Helicase ATP-binding   Helicase C-terminal   HRDC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09053-F1-model_v2 AlphaFold O09053 1-1401 view protein structure

Promoters
RGD ID:8666845
Promoter ID:EPDNEW_M11453
Type:initiation region
Name:Wrn_1
Description:Mus musculus Werner syndrome RecQ like helicase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38833,385,482 - 33,385,542EPDNEW
RGD ID:6843650
Promoter ID:MM_KWN:54111
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000033991,   ENSMUST00000070340,   NM_001122822,   NM_011721,   UC009LJV.1,   UC009LJW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36834,494,831 - 34,496,032 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109635 AgrOrtholog
Ensembl Genes ENSMUSG00000031583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033990 ENTREZGENE
  ENSMUST00000033990.7 UniProtKB/Swiss-Prot
  ENSMUST00000033991 ENTREZGENE
  ENSMUST00000033991.13 UniProtKB/Swiss-Prot
  ENSMUST00000211498.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.150.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 3'-5'_exonuclease_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_RecQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_HTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRDC-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRDC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRDC_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RecQ_Zn-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RQC_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109635 ENTREZGENE
NCBI Gene 22427 ENTREZGENE
PANTHER 3-5 EXONUCLEASE UniProtKB/TrEMBL
  DNA HELICASE RECQ FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WERNER SYNDROME ATP-DEPENDENT HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WERNER SYNDROME-LIKE EXONUCLEASE UniProtKB/TrEMBL
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_A_exo1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HTH_40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RecQ_Zn_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RQC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wrn PhenoGen
PROSITE HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 35EXOc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RQC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47819 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GR54 ENTREZGENE, UniProtKB/TrEMBL
  O09050 ENTREZGENE
  O09053 ENTREZGENE
  O35948_MOUSE UniProtKB/TrEMBL
  Q3TB25_MOUSE UniProtKB/TrEMBL
  Q3TMV6_MOUSE UniProtKB/TrEMBL
  Q3TZ13_MOUSE UniProtKB/TrEMBL
  Q80YP9 ENTREZGENE
  Q8BWH5_MOUSE UniProtKB/TrEMBL
  Q9JKD4 ENTREZGENE
  Q9Z241 ENTREZGENE
  Q9Z242 ENTREZGENE
  WRN_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O09050 UniProtKB/Swiss-Prot
  Q80YP9 UniProtKB/Swiss-Prot
  Q9JKD4 UniProtKB/Swiss-Prot
  Q9Z241 UniProtKB/Swiss-Prot
  Q9Z242 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Wrn  Werner syndrome RecQ like helicase    Werner syndrome homolog (human)  Symbol and/or name change 5135510 APPROVED