Gene: Zic3 (zinc finger protein of the cerebellum 3)
Mus musculus
Symbol:
Zic3
Name:
zinc finger protein of the cerebellum 3
Description:
ENCODES a protein that exhibits sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior pattern specification; determination of left/right asymmetry in nervous system; determination of left/right symmetry; ASSOCIATED WITH abnormal anterior visceral endoderm morphology; abnormal anus morphology; abnormal axial skeleton morphology; ASSOCIATED WITH Cardiovascular Abnormalities (ortholog); Heterotaxy, visceral, X-linked (ortholog); Situs Inversus (ortholog); FOUND IN cytoplasm; nucleus; INTERACTS WITH 4,4'-diaminodiphenylmethane; 5-aza-2'-deoxycytidine; bis(2-chloroethyl) sulfide
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Bn; OTTMUSP00000019133; OTTMUSP00000019134; Zic family member 3 (odd-paired homolog, Drosophila); zinc finger protein ZIC 3
Orthologs:
Homo sapiens : ZIC3
(Zic family member 3)
HGNC
Rattus norvegicus : Zic3
(Zic family member 3)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 X 58,030,628 - 58,036,630 + NCBI Mouse cM Map X 32.56 NCBI Mouse Celera Assembly X 44,504,773 - 44,510,775 + NCBI Mouse Genome Assembly Build 37 X 55,283,805 - 55,289,807 + NCBI Mouse Genome Assembly Build 36.1 X 55,283,805 - 55,289,807 + NCBI Mouse Cytogenetic Map X A6 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of ZIC3 mRNA CTD PMID:18648102 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [decitabine co-treated with trichostatin A] results in increased expression of ZIC3 mRNA CTD PMID:17524140 all-trans-retinoic acid decreases expression ISO RGD:1347201 6480464 Tretinoin results in decreased expression of ZIC3 mRNA CTD PMID:21934132 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of ZIC3 mRNA CTD PMID:15674843 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZIC3 gene CTD PMID:20938992 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZIC3 gene CTD PMID:20938992 fonofos increases methylation ISO RGD:1347201 6480464 Fonofos results in increased methylation of ZIC3 promoter CTD PMID:22847954 furan increases methylation ISO RGD:1561261 6480464 furan results in increased methylation of ZIC3 gene CTD PMID:22079235 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZIC3 gene CTD PMID:20938992 mercaptopurine decreases expression ISO RGD:1561261 6480464 6-Mercaptopurine results in decreased expression of ZIC3 mRNA CTD PMID:23358152 nickel atom affects expression ISO RGD:1347201 6480464 Nickel affects the expression of ZIC3 mRNA CTD PMID:14575637 nickel atom multiple interactions ISO RGD:1347201 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of ZIC3 mRNA] CTD PMID:14575637 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of ZIC3 mRNA CTD PMID:17562736 parathion increases methylation ISO RGD:1347201 6480464 Parathion results in increased methylation of ZIC3 promoter CTD PMID:22847954 purine-6-thiol decreases expression ISO RGD:1561261 6480464 6-Mercaptopurine results in decreased expression of ZIC3 mRNA CTD PMID:23358152 terbufos increases methylation ISO RGD:1347201 6480464 terbufos results in increased methylation of ZIC3 promoter CTD PMID:22847954 trichostatin A multiple interactions EXP 6480464 [decitabine co-treated with trichostatin A] results in increased expression of ZIC3 mRNA CTD PMID:17524140 trichostatin A multiple interactions ISO RGD:1347201 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of ZIC3 mRNA] CTD PMID:14575637 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of ZIC3 mRNA CTD PMID:21427059
Biological Process
anterior/posterior pattern specification IGI MGI:MGI:97359 2290270 MGI:MGI:3624254|PMID:16496285 MGI MGI:MGI:3624254 PMID:16496285 cell differentiation IEA UniProtKB-KW:KW-0221 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 determination of digestive tract left/right asymmetry ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 determination of left/right asymmetry in nervous system IMP 2290270 MGI:MGI:2178095|PMID:11959836 UniProtKB MGI:MGI:2178095 PMID:11959836 determination of left/right symmetry IMP MGI:MGI:2180720 2290270 MGI:MGI:3624254|PMID:16496285 MGI MGI:MGI:3624254 PMID:16496285 determination of left/right symmetry ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 determination of left/right symmetry IGI MGI:MGI:97359 2290270 MGI:MGI:3624254|PMID:16496285 MGI MGI:MGI:3624254 PMID:16496285 determination of liver left/right asymmetry ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 determination of pancreatic left/right asymmetry ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 heart looping IMP MGI:MGI:2180720 2290270 MGI:MGI:3624254|PMID:16496285 MGI MGI:MGI:3624254 PMID:16496285 heart looping ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 heart looping IGI MGI:MGI:97359 2290270 MGI:MGI:3624254|PMID:16496285 MGI MGI:MGI:3624254 PMID:16496285 lung development ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 multicellular organismal development IEA UniProtKB-KW:KW-0217 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nervous system development IEA UniProtKB-KW:KW-0524 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 pattern specification process IMP MGI:MGI:2180720 2290270 MGI:MGI:2178095|PMID:11959836 MGI MGI:MGI:2178095 PMID:11959836 positive regulation of transcription from RNA polymerase II promoter IDA 2290270 MGI:MGI:3624254|PMID:16496285 MGI MGI:MGI:3624254 PMID:16496285 positive regulation of transcription from RNA polymerase II promoter ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of transcription, DNA-dependent IDA 2290270 MGI:MGI:4942260|PMID:11053430 UniProtKB MGI:MGI:4942260 PMID:11053430 regulation of transcription, DNA-dependent IEA UniProtKB-KW:KW-0805 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
cytoplasm IDA 2290270 MGI:MGI:4943413|PMID:15207726 UniProtKB MGI:MGI:4943413 PMID:15207726 nucleus IDA 2290270 MGI:MGI:3688043|PMID:11238441 UniProtKB MGI:MGI:3688043 PMID:11238441 nucleus IDA 2290270 MGI:MGI:4943413|PMID:15207726 UniProtKB MGI:MGI:4943413 PMID:15207726
Molecular Function
DNA binding IEA UniProtKB-KW:KW-0238 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 metal ion binding IEA InterPro:IPR007087 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 nucleic acid binding IEA InterPro:IPR013087 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 protein binding IPI UniProtKB:Q8BX65 2290270 MGI:MGI:4943413|PMID:15207726 UniProtKB MGI:MGI:4943413 PMID:15207726 sequence-specific DNA binding ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 sequence-specific DNA binding transcription factor activity IDA 2290270 MGI:MGI:4942260|PMID:11053430 UniProtKB MGI:MGI:4942260 PMID:11053430 sequence-specific DNA binding transcription factor activity ISO UniProtKB:O60481 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
1302039 Oriq4_m ovulation rate QTL 4 (mouse) Not determined X 33336548 67336791 Mouse 1301537 Ihtw1_m interspecific hybrid testis weight 1 (mouse) Not determined X 36859617 70859765 Mouse 1301460 C10bw6_m castaneus 10 week body weight 6 (mouse) Not determined X 37321531 71321631 Mouse 4141565 Pbwg21_m postnatal body weight growth 21 (mouse) Not determined X 37321531 71321631 Mouse 1301009 Pbwg7_m postnatal body weight growth 7 (mouse) Not determined X 37321531 71321631 Mouse 1300702 Fcsa4_m femoral cross-sectional area 4 (mouse) Not determined X 44237013 78237136 Mouse 1357700 Thyct1_m thymocyte count 1 (mouse) Not determined X 49841038 83841170 Mouse 1558765 Tesw1_m testis weight 1 (mouse) Not determined X 51644150 85644320 Mouse 4141970 Obq22_m obesity QTL 22 (mouse) Not determined X 53273783 87273880 Mouse