Gene: Cc2d1a (coiled-coil and C2 domain containing 1A)
Mus musculus
Symbol:
Cc2d1a
Name:
coiled-coil and C2 domain containing 1A
Description:
ENCODES a protein that exhibits RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; signal transducer activity (ortholog); INVOLVED IN negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade (ortholog); signal transduction (ortholog); ASSOCIATED WITH Mental Retardation, Autosomal Recessive 3 (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; aflatoxin B1
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
5-HT1A receptor; BC016188; coiled-coil and C2 domain-containing protein 1A; five prime repressor element under dual repression-binding protein 1; five repressor element under dual repression-binding protein 1; five' repressor element under dual repression binding protein 1; FRE under dual repression-binding protein 1; Freud-1; MGC27560; MGC38983; OTTMUSP00000039748; OTTMUSP00000039749; putative NFkB activating protein; Tape
Orthologs:
Homo sapiens : CC2D1A
(coiled-coil and C2 domain containing 1A)
HGNC
Rattus norvegicus : Cc2d1a
(coiled-coil and C2 domain containing 1A)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 8 84,132,828 - 84,147,753 - NCBI Mouse cM Map 8 - NCBI Mouse Celera Assembly 8 88,433,223 - 88,448,143 - NCBI Mouse Genome Assembly Build 37 8 86,656,727 - 86,671,652 - NCBI Mouse Genome Assembly Build 36.1 8 86,656,727 - 86,671,652 - NCBI Mouse Cytogenetic Map 8 C3 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CC2D1A mRNA CTD PMID:21570461 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CC2D1A mRNA CTD PMID:20188158 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CC2D1A mRNA CTD PMID:19770486 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CC2D1A mRNA CTD PMID:22228805 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of CC2D1A mRNA CTD PMID:17562736 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of CC2D1A mRNA CTD PMID:17426115 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of CC2D1A mRNA CTD PMID:17292431
Biological Process
negative regulation of transcription from RNA polymerase II promoter IDA 2290270 MGI:MGI:5086065|PMID:21155902 MGI MGI:MGI:5086065 PMID:21155902 positive regulation of I-kappaB kinase/NF-kappaB cascade ISO UniProtKB:Q6P1N0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transcription, DNA-dependent IEA UniProtKB-KW:KW-0805 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 signal transduction ISO UniProtKB:Q6P1N0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
cytoplasm IEA UniProtKB-KW:KW-0963 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleus ISO UniProtKB:Q66HA5 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458
Molecular Function
DNA binding IEA UniProtKB-KW:KW-0238 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 2290270 MGI:MGI:5086065|PMID:21155902 MGI MGI:MGI:5086065 PMID:21155902 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 2290270 MGI:MGI:5086065|PMID:21155902 MGI MGI:MGI:5086065 PMID:21155902 signal transducer activity ISO UniProtKB:Q6P1N0 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177
4140967 Bmd39_m bone mineral density 39 (mouse) Not determined 8 33127016 119762600 Mouse 4141082 Raml4_m radiation induced acute myeloid leukemia 4 (mouse) Not determined 8 56569352 90569499 Mouse 1301506 Aevm1_m autoimmune extremity vasculitis in MRL mice 1 (mouse) Not determined 8 56811716 90811892 Mouse 1301952 Im3_m immunoregulatory 3 (mouse) Not determined 8 57230513 91230662 Mouse 4141692 Eeq2_m exercise endurance QTL 2 (mouse) Not determined 8 57716979 91717125 Mouse 4140972 Bpq23_m blood pressure QTL 23 (mouse) Not determined 8 60928397 94928515 Mouse 1301688 Orch6_m autoimmune orchitis resistance 6 (mouse) Not determined 8 63310749 97310875 Mouse 4141797 Skmw16_m skeletal muscle weight 16 (mouse) Not determined 8 66463446 100463595 Mouse 1357531 Ssta6_m susceptibility to Salmonella typhimurium antigens 6 (mouse) Not determined 8 66463446 100463595 Mouse 1301946 Prxsh_m preaxial shift (mouse) Not determined 8 67433952 101434094 Mouse 1558895 Nsila6_m novelty/stress induced locomotor activation 6 (mouse) Not determined 8 67839067 101839184 Mouse 4142283 Imraq2_m immune response to AAV2 QTL 2 (mouse) Not determined 8 72829274 106829394 Mouse 1301767 Fcsa2_m femoral cross-sectional area 2 (mouse) Not determined 8 72829274 106829394 Mouse 1558780 Idd22_m insulin dependent diabetes susceptibility 22 (mouse) Not determined 8 73626802 107626908 Mouse 4141122 Chlq5_m circulating hormone level QTL 5 (mouse) Not determined 8 73920080 107920292 Mouse 4142484 Vmmt8_m vertebral morphology and mechanical traits 8 (mouse) Not determined 8 73920080 107920292 Mouse 1357647 Fmgty7_m femur geometry 7 (mouse) Not determined 8 73920080 107920292 Mouse 1301872 Cd4ts3_m CD4 T cell subset 3 (mouse) Not determined 8 73920080 107920292 Mouse 1300920 Pitm3_m prion incubation time 3 (mouse) Not determined 8 75726394 109726497 Mouse 1558890 Lith18_m lithogenic gene 18 (mouse) Not determined 8 78199416 112199522 Mouse 1357470 Obq16_m obesity QTL 16 (mouse) Not determined 8 78209247 112209396 Mouse 1301808 Nhdlq1_m non-HDL QTL 1 (mouse) Not determined 8 78209247 112209396 Mouse 1301874 Hdlq16_m HDL QTL 16 (mouse) Not determined 8 78209247 112209396 Mouse 1301099 Cbm2_m cerebellum weight 2 (mouse) Not determined 8 81042513 115042603 Mouse 1301581 Char2_m P. chabaudi malaria resistance QTL 2 (mouse) Not determined 8 81606078 115606303 Mouse