Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1348290 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLD mRNA | CTD | PMID:22079256 | (R)-lipoic acid | multiple interactions | ISO | RGD:735073 | 6480464 | [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] | CTD | PMID:21551353 | 1,3-dinitrobenzene | multiple interactions | ISO | RGD:735073 | 6480464 | [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] | CTD | PMID:21551353 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLD mRNA | CTD | PMID:17942748 | 2,2,2-tetramine | multiple interactions | ISO | RGD:735073 | 6480464 | Trientine inhibits the reaction [Streptozocin results in increased expression of DLD protein] | CTD | PMID:21136691 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLD mRNA | CTD | PMID:17942748 | 2,6-dinitrotoluene | affects expression | ISO | RGD:735073 | 6480464 | 2,6-dinitrotoluene affects the expression of DLD mRNA | CTD | PMID:21346803 | Aroclor 1254 | increases expression | ISO | RGD:735073 | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of DLD protein | CTD | PMID:21791222 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of DLD mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of DLD mRNA | CTD | PMID:22228805 | cadmium atom | increases expression | ISO | RGD:735073 | 6480464 | Cadmium results in increased expression of DLD mRNA | CTD | PMID:17327699 | cadmium dichloride | increases expression | ISO | RGD:735073 | 6480464 | Cadmium Chloride results in increased expression of DLD mRNA | CTD | PMID:17327699 | cadmium dichloride | affects expression | ISO | RGD:735073 | 6480464 | Cadmium Chloride affects the expression of DLD mRNA | CTD | PMID:18636176 | cadmium dichloride | decreases expression | ISO | RGD:735073 | 6480464 | Cadmium Chloride results in decreased expression of DLD mRNA; more ... | CTD | PMID:21699967 | clofibrate | increases expression | ISO | RGD:735073 | 6480464 | Clofibrate results in increased expression of DLD protein | CTD | PMID:16470657 | clofibric acid | affects expression | ISO | RGD:735073 | 6480464 | Clofibric Acid affects the expression of DLD mRNA | CTD | PMID:17602206 | copper atom | increases expression | ISO | RGD:735073 | 6480464 | Copper deficiency results in increased expression of DLD protein | CTD | PMID:18993053 | copper(0) | increases expression | ISO | RGD:735073 | 6480464 | Copper deficiency results in increased expression of DLD protein | CTD | PMID:18993053 | cyclosporin A | decreases expression | ISO | RGD:1348290 | 6480464 | Cyclosporine results in decreased expression of DLD mRNA | CTD | PMID:20106945 | dioxygen | increases abundance | ISO | RGD:735073 | 6480464 | DLD protein results in increased abundance of Oxygen | CTD | PMID:1454754 | dioxygen | multiple interactions | ISO | RGD:735073 | 6480464 | Hydrogen Peroxide promotes the reaction [DLD protein results in increased abundance of Oxygen] | CTD | PMID:1454754 | hyaluronic acid | decreases expression | ISO | RGD:735073 | 6480464 | Hyaluronic Acid analog results in decreased expression of DLD protein | CTD | PMID:23178681 | hydrogen peroxide | multiple interactions | ISO | RGD:735073 | 6480464 | Hydrogen Peroxide promotes the reaction [DLD protein results in increased abundance of Oxygen] | CTD | PMID:1454754 | hydrogen peroxide | decreases expression | ISO | RGD:735073 | 6480464 | Hydrogen Peroxide results in decreased expression of DLD protein | CTD | PMID:23178681 | isotretinoin | decreases expression | ISO | RGD:1348290 | 6480464 | Isotretinoin results in decreased expression of DLD mRNA | CTD | PMID:20436886 | lipoic acid | multiple interactions | ISO | RGD:735073 | 6480464 | [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] | CTD | PMID:21551353 | methamphetamine | increases expression | ISO | RGD:735073 | 6480464 | Methamphetamine results in increased expression of DLD protein | CTD | PMID:19826936 | ozone | decreases expression | EXP | | 6480464 | Ozone results in decreased expression of DLD mRNA | CTD | PMID:16183385 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of DLD protein | CTD | PMID:21329376 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of DLD mRNA | CTD | PMID:21371552 | phlorizin | decreases expression | EXP | | 6480464 | Phlorhizin results in decreased expression of DLD mRNA | CTD | PMID:22538082 | quercetin | decreases expression | ISO | RGD:1348290 | 6480464 | Quercetin results in decreased expression of DLD mRNA | CTD | PMID:21632981 | resveratrol | increases expression | ISO | RGD:1348290 | 6480464 | resveratrol results in increased expression of DLD mRNA | CTD | PMID:15582268 | rosiglitazone | increases expression | EXP | | 6480464 | rosiglitazone results in increased expression of DLD mRNA; more ... | CTD | PMID:15520860 | rosiglitazone | affects expression | EXP | | 6480464 | rosiglitazone affects the expression of DLD mRNA | CTD | PMID:22013433 | rosiglitazone | affects expression | EXP | | 6480464 | rosiglitazone affects the expression of DLD protein | CTD | PMID:21347706 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | RGD:735073 | 6480464 | Aminooxyacetic Acid inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein] | CTD | PMID:2360207 | S-(1,2-dichlorovinyl)-L-cysteine | decreases activity | ISO | RGD:735073 | 6480464 | S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein | CTD | PMID:2360207 | streptozocin | increases expression | ISO | RGD:735073 | 6480464 | Streptozocin results in increased expression of DLD protein | CTD | PMID:21136691 | streptozocin | multiple interactions | ISO | RGD:735073 | 6480464 | Trientine inhibits the reaction [Streptozocin results in increased expression of DLD protein] | CTD | PMID:21136691 | trans-resveratrol | increases expression | ISO | RGD:1348290 | 6480464 | resveratrol results in increased expression of DLD mRNA | CTD | PMID:15582268 | zinc atom | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of DLD protein | CTD | PMID:9573368 | zinc(0) | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of DLD protein | CTD | PMID:9573368 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsPhenotype AnnotationsDisease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Citrate cycle (TCA cycle) |
| Glycine, serine and threonine metabolism | |
| Glycolysis / Gluconeogenesis | |
| Metabolic pathways | |
| Pyruvate metabolism | |
| Valine, leucine and isoleucine degradation | |
Phenotype AnnotationsReferences - curated| 1. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 2. |
MGD data from the GO Consortium |
| 3. |
MGD IEA |
| 4. |
Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40. |
| 5. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 6. |
Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated import pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
RGD Automated Pipelines |
| 11. |
Sheu KF and Blass JP, Ann N Y Acad Sci. 1999;893:61-78. |
| 12. |
Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810. |
References - uncurated| PubMed | 10349636 |
| 10922068 | |
| 11042159 | |
| 11076861 | |
| 12477932 | |
| 12904583 | |
| 14681479 | |
| 15009635 | |
| 15356189 | |
| 15782199 | |
| 15888450 | |
| 16141072 | |
| 16141073 | |
| 17404228 | |
| 17500595 | |
| 17626619 | |
| 18423880 | |
| 18614015 | |
| 19573295 | |
| 21267068 | |
| 8672127 | |
| 8889548 | |
| 9169128 | |
| 9373037 | |
| 9405644 |
RGD Disease Portals| Dld has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Comparative Map Data| Dld (Mus musculus) |
|
||||||||||||||||||||||||||||||||||||||||
| DLD (Homo sapiens) |
|
||||||||||||||||||||||||||||||||||||||||
| Dld (Rattus norvegicus) |
|
Position Markers| AI746344 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| D9Mit34.1 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AI315664 |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dld |
|
QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_007861 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01098917 | (Get FASTA) | Search GEO for Microarray Profiles |
| AI847502 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK014092 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK117104 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK135807 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK136193 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK153399 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK167885 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK168157 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK168875 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK184427 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK193031 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK194314 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK208818 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK209175 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC003368 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BY251665 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466526 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CR974423 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U73445 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U73468 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_007861 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_031887 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_031887 | (Get FASTA) |
| GenBank Protein | AAC53170 | (Get FASTA) |
| AAH03368 | (Get FASTA) | |
| BAE22867 | (Get FASTA) | |
| BAE31961 | (Get FASTA) | |
| BAE39898 | (Get FASTA) | |
| BAE40693 | (Get FASTA) | |
| BAE43405 | (Get FASTA) | |
| EDL36917 | (Get FASTA) | |
| O08749 | (Get FASTA) |
Promoters| RGD ID: | 6822852 | ||||||||||
| Promoter ID: | MM_KWN:11435 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | ENSMUST00000002980, NM_007861 | ||||||||||
| Position: |
|
| RGD ID: | 6886600 | ||||||||||
| Promoter ID: | EPDNEW_M6751 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Dld_1 | ||||||||||
| Description: | dihydrolipoamide dehydrogenase | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000020664 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000106481 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000110857 | ENTREZGENE |
| Entrez Gene | 13382 | ENTREZGENE |
| Gene3D-CATH | Pyr_redox_dim | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000020664 | |
| HomoloGene Group ID | 84 | ENTREZGENE |
| InterPro | FAD/NAD-linked_Rdtase_dimer | UniProtKB/Swiss-Prot |
| FAD_pyr_nucl-diS_OxRdtase | UniProtKB/Swiss-Prot | |
| Lipoamide_DH | UniProtKB/Swiss-Prot | |
| Pyr_nucl-diS_OxRdtase_dimer | UniProtKB/Swiss-Prot | |
| Pyr_nucl-diS_OxRdtase_FAD/NAD | UniProtKB/Swiss-Prot | |
| Pyr_OxRdtase_I_AS | UniProtKB/Swiss-Prot | |
| Pyr_OxRdtase_NAD-bd_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00331564 | UniProtKB/TrEMBL |
| IPI00874456 | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:13382 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:107450 | ENTREZGENE |
| PANTHER | Lipoamide_DH | UniProtKB/Swiss-Prot |
| Pfam | Pyr_redox | UniProtKB/Swiss-Prot |
| Pyr_redox_2 | UniProtKB/Swiss-Prot | |
| Pyr_redox_dim | UniProtKB/Swiss-Prot | |
| PRINTS | FADPNR | UniProtKB/Swiss-Prot |
| PROSITE | PYRIDINE_REDOX_1 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | FAD/NAD-linked_reductase_dimer | UniProtKB/Swiss-Prot |
| TIGRFAMs | Lipoamide_DH | UniProtKB/Swiss-Prot |
| UniGene | Mm.3131 | ENTREZGENE |
| UniProt | DLDH_MOUSE | UniProtKB/Swiss-Prot |
| Q3TIE8_MOUSE | UniProtKB/TrEMBL |
| More on Dld | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
MGI Report |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1552468 |
| Created: | 2005-09-30 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.