Gene: Pard6a (par-6 (partitioning defective 6,) homolog alpha (C. elegans))
Mus musculus
Symbol:
Pard6a
Name:
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
Description:
ENCODES a protein that exhibits GTP-dependent protein binding; protein kinase C binding; Rho GTPase binding; INVOLVED IN cell-cell junction maintenance; regulation of cellular localization (ortholog); PARTICIPATES IN insulin signaling pathway; protein kinase C (PKC) signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; FOUND IN apical part of cell; cell cortex; cytoplasm; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
0710008C04Rik; 2610010A15Rik; Par-6; PAR-6 alpha; PAR-6A; Par6; PAR6alpha; Par6c; partitioning defective 6 homolog alpha; Tax interaction protein 40; TAX40; Tip-40
Orthologs:
Homo sapiens : PARD6A
(par-6 partitioning defective 6 homolog alpha (C. elegans))
HGNC
Rattus norvegicus : Pard6a
(par-6 (partitioning defective 6,) homolog alpha (C. elegans))
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 8 105,701,154 - 105,703,494 + NCBI Mouse cM Map 8 + NCBI Mouse Celera Assembly 8 109,926,072 - 109,928,412 + NCBI Mouse Genome Assembly Build 37 8 108,225,054 - 108,227,394 + NCBI Mouse Genome Assembly Build 36.1 8 108,225,054 - 108,227,394 + NCBI Mouse Cytogenetic Map 8 D2 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARD6A mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of PARD6A mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARD6A mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PARD6A mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1303273 6480464 2,4-dinitrotoluene affects the expression of PARD6A mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:1303273 6480464 2,6-dinitrotoluene affects the expression of PARD6A mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1345737 6480464 beta-methylcholine affects the expression of PARD6A mRNA CTD PMID:21179406 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PARD6A mRNA CTD PMID:21715664 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PARD6A mRNA CTD PMID:22228805 cisplatin increases expression ISO RGD:1345737 6480464 Cisplatin results in increased expression of PARD6A protein CTD PMID:16803524 copper(2+) sulfate decreases expression ISO RGD:1345737 6480464 Copper Sulfate results in decreased expression of PARD6A mRNA CTD PMID:19549813 cytarabine decreases expression ISO RGD:1345737 6480464 Cytarabine results in decreased expression of PARD6A mRNA CTD PMID:19194470 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of PARD6A mRNA CTD PMID:17942915 N-nitrosodiethylamine multiple interactions EXP 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PARD6A mRNA] CTD PMID:17942915
Gene Ontology Annotations
Biological Process
cell cycle IEA UniProtKB-KW:KW-0131 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 cell division IEA UniProtKB-KW:KW-0132 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 cell-cell junction maintenance IDA 2290270 MGI:MGI:3687818|PMID:10954424 UniProtKB MGI:MGI:3687818 PMID:10954424 establishment of cell polarity TAS 2290270 MGI:MGI:3687818|PMID:10954424 UniProtKB MGI:MGI:3687818 PMID:10954424 regulation of cellular localization ISO UniProtKB:Q6B4M5 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
4140967 Bmd39_m bone mineral density 39 (mouse) Not determined 8 33127016 119762600 Mouse 1300920 Pitm3_m prion incubation time 3 (mouse) Not determined 8 75726394 109726497 Mouse 1558890 Lith18_m lithogenic gene 18 (mouse) Not determined 8 78199416 112199522 Mouse 1357470 Obq16_m obesity QTL 16 (mouse) Not determined 8 78209247 112209396 Mouse 1301808 Nhdlq1_m non-HDL QTL 1 (mouse) Not determined 8 78209247 112209396 Mouse 1301874 Hdlq16_m HDL QTL 16 (mouse) Not determined 8 78209247 112209396 Mouse 1301099 Cbm2_m cerebellum weight 2 (mouse) Not determined 8 81042513 115042603 Mouse 1301581 Char2_m P. chabaudi malaria resistance QTL 2 (mouse) Not determined 8 81606078 115606303 Mouse 1301766 Desp1_m despair 1 (mouse) Not determined 8 87283476 121283641 Mouse 1302049 Heal1_m wound healing/regeneration 1 (mouse) Not determined 8 88240821 122240969 Mouse 4142492 Hfem2_m Hfe modifier 2 (mouse) Not determined 8 88240821 122240969 Mouse 4142469 Mpvq2_m mean platelet volume locus 2 (mouse) Not determined 8 88240821 122240969 Mouse 1301104 Fpdty_m forelimb polydactyly (mouse) Not determined 8 99884022 131707632 Mouse 4141924 Brml2_m bone response to mechanical loading 2 (mouse) Not determined 8 100360795 131707632 Mouse 1300567 Bwq3_m body weight (mouse) Not determined 8 100360795 131707632 Mouse 1301481 Lith11_m lithogenic gene 11 (mouse) Not determined 8 100360795 131707632 Mouse 1302105 Im1_m Immunoregulatory 1 (mouse) Not determined 8 101625692 131707632 Mouse 1301080 Sluc9_m susceptibility to lung cancer 9 (mouse) Not determined 8 101625692 131707632 Mouse 1558884 Nsila7_m novelty/stress induced locomotor activation 7 (mouse) Not determined 8 102052549 131707632 Mouse 4141435 Fbtq3_m femoral bone trait QTL 3 (mouse) Not determined 8 102762470 131707632 Mouse