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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1557517 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GFPT1 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557517 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GFPT1 mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of GFPT1 mRNA | CTD | PMID:21346803 | 2-amino-2-deoxy-D-glucopyranose | multiple interactions | EXP | | 6480464 | [Glucosamine co-treated with INS1 protein] affects the localization of GFPT1 protein | CTD | PMID:9453242 | aflatoxin B1 | decreases expression | ISO | RGD:1557517 | 6480464 | Aflatoxin B1 results in decreased expression of GFPT1 mRNA | CTD | PMID:19770486 | aldehydo-D-glucosamine | multiple interactions | EXP | | 6480464 | [Glucosamine co-treated with INS1 protein] affects the localization of GFPT1 protein | CTD | PMID:9453242 | all-trans-retinoic acid | decreases expression | ISO | RGD:1353383 | 6480464 | Tretinoin results in decreased expression of GFPT1 mRNA | CTD | PMID:15498508 | benzo[a]pyrene | decreases expression | ISO | RGD:1353383 | 6480464 | Benzo(a)pyrene results in decreased expression of GFPT1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | multiple interactions | ISO | RGD:1557517 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of GFPT1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1557517 | 6480464 | Benzo(a)pyrene results in decreased expression of GFPT1 mRNA | CTD | PMID:21715664 | beta-D-glucosamine | multiple interactions | EXP | | 6480464 | [Glucosamine co-treated with INS1 protein] affects the localization of GFPT1 protein | CTD | PMID:9453242 | cisplatin | increases expression | ISO | RGD:1353383 | 6480464 | Cisplatin results in increased expression of GFPT1 mRNA | CTD | PMID:19561079 | copper atom | multiple interactions | ISO | RGD:1353383 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of GFPT1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1353383 | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of GFPT1 mRNA | CTD | PMID:20971185 | cyclosporin A | increases expression | ISO | RGD:1353383 | 6480464 | Cyclosporine results in increased expression of GFPT1 mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:1353383 | 6480464 | Cyclosporine results in increased expression of GFPT1 mRNA | CTD | PMID:20106945 PMID:21632981 | cyclosporin A | increases expression | ISO | RGD:1557517 | 6480464 | Cyclosporine results in increased expression of GFPT1 mRNA | CTD | PMID:19770486 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of GFPT1 mRNA | CTD | PMID:21266533 | paclitaxel | decreases response to substance | ISO | RGD:1353383 | 6480464 | GFPT1 protein results in decreased susceptibility to Paclitaxel | CTD | PMID:16734730 | paracetamol | affects expression | ISO | RGD:1557517 | 6480464 | Acetaminophen affects the expression of GFPT1 mRNA | CTD | PMID:17562736 | pirinixic acid | multiple interactions | ISO | RGD:1557517 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GFPT1 mRNA | CTD | PMID:19710929 | propiconazole | increases expression | ISO | RGD:1557517 | 6480464 | propiconazole results in increased expression of GFPT1 mRNA | CTD | PMID:21278054 | tamibarotene | affects expression | ISO | RGD:1353383 | 6480464 | Am 80 affects the expression of GFPT1 mRNA; more ... | CTD | PMID:15498508 | tamoxifen | increases expression | ISO | RGD:1353383 | 6480464 | Tamoxifen results in increased expression of GFPT1 mRNA | CTD | PMID:15604281 | theophylline | increases expression | ISO | RGD:1353383 | 6480464 | Theophylline results in increased expression of GFPT1 mRNA | CTD | PMID:16083514 | trimellitic anhydride | increases expression | ISO | RGD:1557517 | 6480464 | trimellitic anhydride results in increased expression of GFPT1 mRNA | CTD | PMID:19042947 | zinc atom | multiple interactions | ISO | RGD:1353383 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of GFPT1 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1353383 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of GFPT1 mRNA | CTD | PMID:18593933 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alanine, aspartate and glutamate metabolism |
| Amino sugar and nucleotide sugar metabolism | |
| Metabolic pathways | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alanine, aspartate and glutamate metabolism |
| Amino sugar and nucleotide sugar metabolism | |
| Metabolic pathways | |
References - curated| 1. |
Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30. |
| 2. |
Crook ED, etal., Diabetes. 1993 Sep;42(9):1289-96. |
| 3. |
Ferrer-Martinez A, etal., Lipids. 2006 Jan;41(1):55-62. |
| 4. |
Heptulla RA, etal., J Clin Endocrinol Metab. 2009 May;94(5):1608-11. Epub 2009 Feb 3. |
| 5. |
Huynh QK, etal., Arch Biochem Biophys. 2000 Jul 15;379(2):307-13. |
| 6. |
Nerlich AG, etal., Diabetes. 1998 Feb;47(2):170-8. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated data pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
RGD comprehensive gene curation |
| 11. |
Robinson KA, etal., Diabetes. 1995 Dec;44(12):1438-46. |
| 12. |
Simmons ST, etal., Res Commun Mol Pathol Pharmacol. 1999;104(1):63-72. |
| 13. |
Srinivasan V, etal., Clin Biochem. 2007 Sep;40(13-14):952-7. Epub 2007 May 24. |
| 14. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 15. |
Veerababu G, etal., Diabetes. 2000 Dec;49(12):2070-8. |
References - uncuratedRGD Disease Portals| Gfpt1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Gfpt1 (Rattus norvegicus) |
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| GFPT1 (Homo sapiens) |
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| Gfpt1 (Mus musculus) |
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Position Markers| RH143774 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001005879 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06032185 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01031382 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01031383 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC083889 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473957 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001005879 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001005879 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001005879 | (Get FASTA) |
| GenBank Protein | AAH83889 | (Get FASTA) |
| EDL91267 | (Get FASTA) | |
| EDL91268 | (Get FASTA) | |
| EDL91269 | (Get FASTA) | |
| P82808 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018507 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000025070 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000025070 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 297417 | ENTREZGENE |
| HomoloGene Group ID | 68220 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7132442 | IMAGE-MGC_LOAD |
| InterPro | GATase_2 | UniProtKB/Swiss-Prot |
| GATase_II | UniProtKB/Swiss-Prot | |
| GlmS_trans | UniProtKB/Swiss-Prot | |
| SIS | UniProtKB/Swiss-Prot | |
| IPI | IPI00464911 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:297417 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:95214 | IMAGE-MGC_LOAD |
| Pfam | GATase_2 | UniProtKB/Swiss-Prot |
| SIS | UniProtKB/Swiss-Prot | |
| PROSITE | GATASE_TYPE_2 | UniProtKB/Swiss-Prot |
| SIS | UniProtKB/Swiss-Prot | |
| TIGRFAMs | glmS | UniProtKB/Swiss-Prot |
| UniGene | Rn.229622 | ENTREZGENE |
| UniProt | GFPT1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Gfpt1 | glutamine fructose-6-phosphate transaminase 1 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2005-09-15 | Gfpt1 | glutamine fructose-6-phosphate transaminase 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Gfpt1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1549703 |
| Created: | 2005-09-15 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.