CFD (complement factor D) - Rat Genome Database

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Gene: CFD (complement factor D) Sus scrofa
Analyze
Symbol: CFD
Name: complement factor D
RGD ID: 14060957
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN complement activation, alternative pathway (ortholog); Notch signaling pathway (ortholog); response to bacterium (ortholog); ASSOCIATED WITH Arterial Occlusive Diseases (ortholog); arthus reaction (ortholog); asbestosis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adipsin; C3 convertase activator; complement factor D preproprotein; DF; properdin factor D
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,509,795 - 77,511,974 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,509,792 - 77,511,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,485,653 - 77,487,849 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11570841   PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
CFD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,509,795 - 77,511,974 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,509,792 - 77,511,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,485,653 - 77,487,849 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819859,664 - 863,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19859,453 - 867,884 (+)EnsemblGRCh38hg38GRCh38
GRCh3719859,664 - 863,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619810,665 - 814,624 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419810,664 - 814,608NCBI
Celera19784,591 - 789,264 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19628,736 - 632,629 (+)NCBIHuRef
CHM1_119859,248 - 863,166 (+)NCBICHM1_1
T2T-CHM13v2.019815,769 - 819,749 (+)NCBIT2T-CHM13v2.0
Cfd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,726,687 - 79,728,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,726,687 - 79,728,489 (+)EnsemblGRCm39 Ensembl
GRCm381079,890,853 - 79,892,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,890,853 - 79,892,655 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,353,598 - 79,355,401 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,294,041 - 79,295,783 (+)NCBIMGSCv36mm8
Celera1080,905,663 - 80,907,466 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Cfd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,463,773 - 10,465,496 (-)NCBIGRCr8
mRatBN7.279,813,148 - 9,814,871 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,813,150 - 9,815,053 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,695,134 - 12,696,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,570,451 - 14,572,174 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,431,649 - 12,433,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,634,216 - 12,635,939 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,634,216 - 12,635,943 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,803,938 - 12,805,661 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,325,538 - 11,327,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,325,546 - 11,327,251 (-)NCBI
Celera77,987,896 - 7,989,620 (-)NCBICelera
RH 3.4 Map741.1RGD
Cytogenetic Map7q11NCBI
Cfd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554956,955,612 - 6,961,317 (-)NCBIChiLan1.0ChiLan1.0
CFD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,189,361 - 5,195,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,428,069 - 4,432,881 (+)NCBINHGRI_mPanPan1
CFD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,785,297 - 57,787,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,657,154 - 57,787,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,587,313 - 57,589,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,527,568 - 58,530,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,527,625 - 58,529,997 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,582,382 - 57,584,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,062,090 - 58,064,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,265,041 - 58,267,518 (-)NCBIUU_Cfam_GSD_1.0
Cfd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,482,051 - 217,483,972 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588350,921 - 355,582 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588350,925 - 352,732 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16608,821 - 612,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6608,800 - 613,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,304,252 - 8,308,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,711,537 - 7,717,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,714,926 - 7,717,139 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CFD
30 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000014662   ⟹   ENSSSCP00000014267
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl277,509,795 - 77,511,974 (-)Ensembl
RefSeq Acc Id: XM_013994801   ⟹   XP_013850255
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1277,509,792 - 77,511,988 (-)NCBI
Sequence:
RefSeq Acc Id: XP_013850255   ⟸   XM_013994801
- UniProtKB: P51779 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSSSCP00000014267   ⟸   ENSSSCT00000014662
Protein Domains
Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013418 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015081206 UniProtKB/Swiss-Prot
  ENSSSCG00025007659 UniProtKB/Swiss-Prot
  ENSSSCG00030017276 UniProtKB/Swiss-Prot
  ENSSSCG00035073930 UniProtKB/Swiss-Prot
  ENSSSCG00040064392 UniProtKB/Swiss-Prot
  ENSSSCG00045031770 UniProtKB/Swiss-Prot
  ENSSSCG00050067127 UniProtKB/Swiss-Prot
  ENSSSCG00055024762 UniProtKB/Swiss-Prot
  ENSSSCG00060010731 UniProtKB/Swiss-Prot
  ENSSSCG00065007012 UniProtKB/Swiss-Prot
  ENSSSCG00070026800 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000014662 ENTREZGENE
  ENSSSCT00000014662.5 UniProtKB/Swiss-Prot
  ENSSSCT00015110733.1 UniProtKB/Swiss-Prot
  ENSSSCT00025010178.1 UniProtKB/Swiss-Prot
  ENSSSCT00030023893.1 UniProtKB/Swiss-Prot
  ENSSSCT00035100272.1 UniProtKB/Swiss-Prot
  ENSSSCT00040088052.1 UniProtKB/Swiss-Prot
  ENSSSCT00045054307.1 UniProtKB/Swiss-Prot
  ENSSSCT00050091537.1 UniProtKB/Swiss-Prot
  ENSSSCT00055048922.1 UniProtKB/Swiss-Prot
  ENSSSCT00060013955.1 UniProtKB/Swiss-Prot
  ENSSSCT00065009398.1 UniProtKB/Swiss-Prot
  ENSSSCT00070053755.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396877 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CFD ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24271:SF54 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480UQ82 ENTREZGENE, UniProtKB/TrEMBL
  B4F449_PIG UniProtKB/TrEMBL
  CFAD_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:86609 ENTREZGENE