Actrt2 (actin-related protein T2) - Rat Genome Database

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Gene: Actrt2 (actin-related protein T2) Rattus norvegicus
Analyze
Symbol: Actrt2
Name: actin-related protein T2
RGD ID: 1359657
Description: Orthologous to human ACTRT2 (actin related protein T2); INTERACTS WITH (S)-nicotine; 6-propyl-2-thiouracil; acetamiprid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-related protein M2; LOC298671; similar to actin related protein M2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,518,470 - 170,519,870 (-)NCBIGRCr8
mRatBN7.25165,236,092 - 165,237,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,236,086 - 165,237,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,940,981 - 167,942,381 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,762,387 - 169,763,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,724,919 - 169,726,319 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,077,290 - 172,078,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,077,282 - 172,078,760 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,534,186 - 175,535,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,473,765 - 171,475,165 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,484,260 - 171,485,660 (-)NCBI
Celera5163,443,936 - 163,445,336 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Actrt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,518,470 - 170,519,870 (-)NCBIGRCr8
mRatBN7.25165,236,092 - 165,237,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,236,086 - 165,237,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,940,981 - 167,942,381 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,762,387 - 169,763,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,724,919 - 169,726,319 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,077,290 - 172,078,690 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,077,282 - 172,078,760 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,534,186 - 175,535,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,473,765 - 171,475,165 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,484,260 - 171,485,660 (-)NCBI
Celera5163,443,936 - 163,445,336 (-)NCBICelera
Cytogenetic Map5q36NCBI
ACTRT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,021,467 - 3,022,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,021,467 - 3,022,903 (+)EnsemblGRCh38hg38GRCh38
GRCh3712,938,031 - 2,939,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,927,906 - 2,929,327 (+)NCBINCBI36Build 36hg18NCBI36
Celera12,136,394 - 2,137,815 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef12,233,024 - 2,234,445 (+)NCBIHuRef
CHM1_112,925,090 - 2,926,511 (+)NCBICHM1_1
T2T-CHM13v2.012,523,087 - 2,524,523 (+)NCBIT2T-CHM13v2.0
Actrt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,750,885 - 154,752,324 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,750,890 - 154,752,324 (-)EnsemblGRCm39 Ensembl
GRCm384154,666,428 - 154,667,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,666,433 - 154,667,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv374154,040,537 - 154,041,976 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,510,234 - 153,511,533 (-)NCBIMGSCv36mm8
Celera4156,945,512 - 156,946,951 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map484.69NCBI
Actrt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,465,620 - 8,466,744 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,465,523 - 8,466,841 (-)NCBIChiLan1.0ChiLan1.0
ACTRT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,297,615 - 225,299,858 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,942,329 - 223,944,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,680,590 - 1,682,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112,818,691 - 2,820,133 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12,818,917 - 2,820,050 (+)Ensemblpanpan1.1panPan2
ACTRT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,659,055 - 57,660,479 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,659,262 - 57,660,395 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha557,671,258 - 57,672,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0557,861,591 - 57,863,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,861,794 - 57,862,927 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,852,649 - 57,854,072 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,745,180 - 57,746,603 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,135,055 - 58,136,480 (+)NCBIUU_Cfam_GSD_1.0
Actrt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,699,309 - 28,700,931 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936737765,125 - 766,432 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936737765,125 - 766,432 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTRT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,664,641 - 64,665,774 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,664,484 - 64,665,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,253,686 - 59,255,135 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTRT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,660,029 - 128,665,485 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20128,660,121 - 128,661,254 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605432,946,475 - 32,947,937 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actrt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,288,304 - 7,289,434 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,288,206 - 7,289,499 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actrt2
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000016781
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 5
Low 2 3 3 1 2
Below cutoff 1 2 14 5 12 5 1 2 10 4 10 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016781   ⟹   ENSRNOP00000016781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,236,086 - 165,237,629 (-)Ensembl
Rnor_6.0 Ensembl5172,077,282 - 172,078,760 (-)Ensembl
RefSeq Acc Id: NM_001013937   ⟹   NP_001013959
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,518,470 - 170,519,870 (-)NCBI
mRatBN7.25165,236,092 - 165,237,492 (-)NCBI
Rnor_6.05172,077,290 - 172,078,690 (-)NCBI
Rnor_5.05175,534,186 - 175,535,586 (-)NCBI
RGSC_v3.45171,473,765 - 171,475,165 (-)RGD
Celera5163,443,936 - 163,445,336 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013959 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83677 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016781
  ENSRNOP00000016781.1
Reference Protein Sequences
RefSeq Acc Id: NP_001013959   ⟸   NM_001013937
- UniProtKB: Q5XIK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016781   ⟸   ENSRNOT00000016781

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIK3-F1-model_v2 AlphaFold Q5XIK3 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694311
Promoter ID:EPDNEW_R4836
Type:single initiation site
Name:Actrt2_1
Description:actin-related protein T2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05172,078,718 - 172,078,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359657 AgrOrtholog
BioCyc Gene G2FUF-38953 BioCyc
Ensembl Genes ENSRNOG00000012586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016781 ENTREZGENE
  ENSRNOT00000016781.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135827 IMAGE-MGC_LOAD
InterPro Actin-like UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report rno:298671 UniProtKB/TrEMBL
MGC_CLONE MGC:94528 IMAGE-MGC_LOAD
NCBI Gene 298671 ENTREZGENE
PANTHER Actin_like UniProtKB/TrEMBL
  PTHR11937:SF38 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PhenoGen Actrt2 PhenoGen
PRINTS ACTIN UniProtKB/TrEMBL
PROSITE ACTINS_ACT_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012586 RatGTEx
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt Q5XIK3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Actrt2  actin-related protein T2  LOC298671  similar to actin related protein M2  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC298671  similar to actin related protein M2      Symbol and Name status set to provisional 70820 PROVISIONAL