Dnajc28 (DnaJ heat shock protein family (Hsp40) member C28) - Rat Genome Database

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Gene: Dnajc28 (DnaJ heat shock protein family (Hsp40) member C28) Rattus norvegicus
Analyze
Symbol: Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
RGD ID: 1359589
Description: Orthologous to human DNAJC28 (DnaJ heat shock protein family (Hsp40) member C28); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DnaJ (Hsp40) homolog, subfamily C, member 28; dnaJ homolog subfamily C member 28; LOC360699; similar to J domain protein C21orf55
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,341,528 - 44,344,348 (-)NCBIGRCr8
mRatBN7.21130,855,566 - 30,858,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,853,526 - 30,858,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,549,461 - 39,552,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,220,897 - 32,223,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,386,144 - 31,388,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,770,164 - 31,772,984 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,770,165 - 31,772,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,378,903 - 35,381,723 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,584,546 - 31,587,366 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,623,609 - 31,626,429 (-)NCBI
Celera1130,522,999 - 30,525,819 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Dnajc28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,341,528 - 44,344,348 (-)NCBIGRCr8
mRatBN7.21130,855,566 - 30,858,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,853,526 - 30,858,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,549,461 - 39,552,283 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,220,897 - 32,223,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,386,144 - 31,388,964 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,770,164 - 31,772,984 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,770,165 - 31,772,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,378,903 - 35,381,723 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,584,546 - 31,587,366 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,623,609 - 31,626,429 (-)NCBI
Celera1130,522,999 - 30,525,819 (-)NCBICelera
Cytogenetic Map11q11NCBI
DNAJC28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382133,488,055 - 33,491,716 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2133,488,055 - 33,491,716 (-)EnsemblGRCh38hg38GRCh38
GRCh372134,860,362 - 34,864,023 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,782,108 - 33,785,893 (-)NCBINCBI36Build 36hg18NCBI36
Build 342133,779,706 - 33,785,650NCBI
Celera2120,059,872 - 20,063,657 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,338,558 - 20,342,237 (-)NCBIHuRef
CHM1_12134,422,926 - 34,426,712 (-)NCBICHM1_1
T2T-CHM13v2.02131,869,887 - 31,873,548 (-)NCBIT2T-CHM13v2.0
Dnajc28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,411,142 - 91,415,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,411,142 - 91,415,914 (-)EnsemblGRCm39 Ensembl
GRCm381691,614,257 - 91,618,999 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,614,254 - 91,619,026 (-)EnsemblGRCm38mm10GRCm38
MGSCv371691,614,502 - 91,619,244 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,504,585 - 91,507,852 (-)NCBIMGSCv36mm8
Celera1692,691,065 - 92,695,807 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1653.17NCBI
Dnajc28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540732,928,663 - 32,929,814 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540732,928,655 - 32,931,331 (-)NCBIChiLan1.0ChiLan1.0
DNAJC28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22229,600,313 - 29,610,429 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12124,459,721 - 24,472,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02119,855,277 - 19,859,734 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12133,228,657 - 33,232,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,228,694 - 33,229,860 (-)Ensemblpanpan1.1panPan2
DNAJC28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13128,113,339 - 28,117,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,101,274 - 28,115,460 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03128,308,485 - 28,322,743 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,318,372 - 28,322,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,185,232 - 28,189,613 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,189,061 - 28,203,254 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,689,189 - 28,703,416 (-)NCBIUU_Cfam_GSD_1.0
Dnajc28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,664,722 - 28,668,968 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,800,298 - 8,801,458 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365008,798,884 - 8,802,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJC28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,108,383 - 197,114,455 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113197,104,842 - 197,114,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213206,920,530 - 206,924,916 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJC28
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,690,499 - 58,695,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,693,679 - 58,694,848 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660711,192,277 - 1,196,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajc28
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,717,745 - 21,718,902 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474521,715,732 - 21,720,373 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnajc28
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:28
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000002771
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 2 2 2 5 7 3 10 7 5
Low 3 32 55 39 19 39 3 4 71 25 34 11 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000002771   ⟹   ENSRNOP00000002771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,853,743 - 30,858,417 (-)Ensembl
Rnor_6.0 Ensembl1131,770,165 - 31,772,984 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118466   ⟹   ENSRNOP00000089995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,853,526 - 30,858,441 (-)Ensembl
RefSeq Acc Id: NM_001014124   ⟹   NP_001014146
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,341,528 - 44,344,348 (-)NCBI
mRatBN7.21130,855,566 - 30,858,386 (-)NCBI
Rnor_6.01131,770,164 - 31,772,984 (-)NCBI
Rnor_5.01135,378,903 - 35,381,723 (-)NCBI
RGSC_v3.41131,584,546 - 31,587,366 (-)RGD
Celera1130,522,999 - 30,525,819 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014146 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79055 (Get FASTA)   NCBI Sequence Viewer  
  EDM10732 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002771.4
  ENSRNOP00000089995
  ENSRNOP00000089995.1
RefSeq Acc Id: NP_001014146   ⟸   NM_001014124
- UniProtKB: Q6AYG2 (UniProtKB/TrEMBL),   A0A8I6ACY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002771   ⟸   ENSRNOT00000002771
RefSeq Acc Id: ENSRNOP00000089995   ⟸   ENSRNOT00000118466
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYG2-F1-model_v2 AlphaFold Q6AYG2 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698058
Promoter ID:EPDNEW_R8583
Type:single initiation site
Name:Dnajc28_1
Description:DnaJ heat shock protein family member C28
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01131,773,012 - 31,773,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359589 AgrOrtholog
BioCyc Gene G2FUF-21878 BioCyc
Ensembl Genes ENSRNOG00000002026 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002771.5 UniProtKB/TrEMBL
  ENSRNOT00000118466 ENTREZGENE
  ENSRNOT00000118466.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115421 IMAGE-MGC_LOAD
InterPro DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_homolog_subfam-C_membr-28 UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
KEGG Report rno:360699 UniProtKB/TrEMBL
MGC_CLONE MGC:93998 IMAGE-MGC_LOAD
NCBI Gene 360699 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY C MEMBER 28 UniProtKB/TrEMBL
  OS08G0560600 PROTEIN UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/TrEMBL
  DUF1992 UniProtKB/TrEMBL
PhenoGen Dnajc28 PhenoGen
PROSITE DNAJ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002026 RatGTEx
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP DnaJ_N UniProtKB/TrEMBL
UniProt A0A8I6ACY5 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYG2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajc28  DnaJ heat shock protein family (Hsp40) member C28  Dnajc28  DnaJ (Hsp40) homolog, subfamily C, member 28  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-17 Dnajc28  DnaJ (Hsp40) homolog, subfamily C, member 28  LOC360699  similar to J domain protein C21orf55  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC360699  similar to J domain protein C21orf55      Symbol and Name status set to provisional 70820 PROVISIONAL