Tsen34 (tRNA splicing endonuclease subunit 34) - Rat Genome Database

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Gene: Tsen34 (tRNA splicing endonuclease subunit 34) Rattus norvegicus
Analyze
Symbol: Tsen34
Name: tRNA splicing endonuclease subunit 34
RGD ID: 1359564
Description: Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34); PARTICIPATES IN tRNA maturation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; diuron.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LENG5; leukocyte receptor cluster (LRC) member 5; MGC94712; SEN34; tRNA splicing endonuclease 34; tRNA splicing endonuclease 34 homolog; tRNA splicing endonuclease 34 homolog (S. cerevisiae); tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae); tRNA splicing endonuclease subunit 34-like 1; tRNA-splicing endonuclease subunit Sen34; tRNA-splicing endonuclease subunit Sen34-like; TSEN34 tRNA splicing endonuclease subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,432,687 - 74,440,553 (-)NCBIGRCr8
mRatBN7.2165,517,324 - 65,525,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,517,330 - 65,524,412 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx170,965,481 - 70,972,532 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,388,423 - 79,395,474 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0172,715,958 - 72,722,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,023,924 - 64,031,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,024,240 - 64,030,175 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,092,226 - 64,099,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,016,179 - 63,024,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,830,255 - 63,837,306 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1163,906,995 - 63,914,047 (-)NCBI
Celera163,242,430 - 63,249,481 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. Paushkin SV, etal., Cell 2004 Apr 30;117(3):311-21.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Handling tRNA introns, archaeal way and eukaryotic way. Yoshihisa T Front Genet. 2014 Jul 10;5:213. doi: 10.3389/fgene.2014.00213. eCollection 2014.

Genomics

Comparative Map Data
Tsen34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,432,687 - 74,440,553 (-)NCBIGRCr8
mRatBN7.2165,517,324 - 65,525,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,517,330 - 65,524,412 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx170,965,481 - 70,972,532 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,388,423 - 79,395,474 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0172,715,958 - 72,722,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,023,924 - 64,031,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,024,240 - 64,030,175 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,092,226 - 64,099,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,016,179 - 63,024,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,830,255 - 63,837,306 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1163,906,995 - 63,914,047 (-)NCBI
Celera163,242,430 - 63,249,481 (-)NCBICelera
Cytogenetic Map1q12NCBI
TSEN34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,189,441 - 54,194,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,189,938 - 54,194,536 (+)EnsemblGRCh38hg38GRCh38
GRCh371954,694,195 - 54,698,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,386,009 - 59,389,338 (+)NCBINCBI36Build 36hg18NCBI36
Build 341959,386,005 - 59,389,333NCBI
Celera1951,735,803 - 51,740,078 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,009,940 - 51,014,207 (+)NCBIHuRef
CHM1_11954,695,287 - 54,699,555 (+)NCBICHM1_1
T2T-CHM13v2.01957,269,829 - 57,274,920 (+)NCBIT2T-CHM13v2.0
Tsen34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,696,300 - 3,704,033 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,695,862 - 3,704,023 (+)EnsemblGRCm39 Ensembl
GRCm3873,693,087 - 3,701,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,692,863 - 3,701,024 (+)EnsemblGRCm38mm10GRCm38
MGSCv3773,645,212 - 3,652,637 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,297,662 - 3,304,097 (+)NCBIMGSCv36mm8
Celera73,606,434 - 3,614,626 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.13NCBI
Tsen34
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495560484,072 - 89,419 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495560484,072 - 89,419 (-)NCBIChiLan1.0ChiLan1.0
TSEN34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22060,194,054 - 60,198,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,115,407 - 62,119,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,121,560 - 51,125,768 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,963,844 - 59,968,453 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,964,174 - 59,968,453 (+)Ensemblpanpan1.1panPan2
TSEN34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,021,519 - 103,027,460 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1103,021,525 - 103,026,643 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,083,351 - 103,089,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,666,756 - 103,672,740 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,666,760 - 103,672,774 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11103,305,018 - 103,310,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,065,051 - 103,071,028 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,779,940 - 103,785,915 (-)NCBIUU_Cfam_GSD_1.0
Tsen34
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,636,843 - 2,641,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936994295,932 - 303,437 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936994296,012 - 300,958 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSEN34
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,930,737 - 55,939,487 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,930,726 - 55,939,487 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,279,887 - 53,288,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSEN34
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,867,553 - 46,871,704 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl646,868,055 - 46,871,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607326,956,449 - 26,960,729 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsen34
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,401,619 - 2,407,525 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,401,411 - 2,406,896 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tsen34
59 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:410
Count of miRNA genes:216
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000016198, ENSRNOT00000073360
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat

Markers in Region
RH127560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,517,371 - 65,517,565 (+)MAPPERmRatBN7.2
Rnor_6.0164,092,274 - 64,092,467NCBIRnor6.0
Rnor_6.0164,023,974 - 64,024,167NCBIRnor6.0
Rnor_5.0163,084,555 - 63,084,748UniSTSRnor5.0
Rnor_5.0163,016,229 - 63,016,422UniSTSRnor5.0
RGSC_v3.4163,830,303 - 63,830,496UniSTSRGSC3.4
Celera163,242,478 - 63,242,671UniSTS
RH 3.4 Map1740.4UniSTS
Cytogenetic Map1q12UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC103574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP501188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM058048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000084846   ⟹   ENSRNOP00000071330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,517,330 - 65,524,412 (-)Ensembl
Rnor_6.0 Ensembl164,092,226 - 64,099,277 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089950   ⟹   ENSRNOP00000072466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl164,024,240 - 64,030,175 (-)Ensembl
RefSeq Acc Id: NM_001006968   ⟹   NP_001006969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,439,794 (-)NCBI
mRatBN7.2165,517,326 - 65,524,434 (-)NCBI
Rnor_6.0164,023,926 - 64,030,977 (-)NCBI
Rnor_5.0163,016,179 - 63,024,146 (-)NCBI
RGSC_v3.4163,830,255 - 63,837,306 (-)RGD
Celera163,242,430 - 63,249,481 (-)RGD
Sequence:
RefSeq Acc Id: NM_001420039   ⟹   NP_001406968
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,438,990 (-)NCBI
mRatBN7.2165,517,326 - 65,523,630 (-)NCBI
RefSeq Acc Id: XM_006228075   ⟹   XP_006228137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,439,652 (-)NCBI
mRatBN7.2165,517,324 - 65,524,111 (-)NCBI
RefSeq Acc Id: XM_008758839   ⟹   XP_008757061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,433,193 - 74,439,787 (-)NCBI
mRatBN7.2165,518,513 - 65,524,113 (-)NCBI
RefSeq Acc Id: XM_017588639   ⟹   XP_017444128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,439,811 (-)NCBI
mRatBN7.2165,517,324 - 65,524,486 (-)NCBI
RefSeq Acc Id: XM_039103681   ⟹   XP_038959609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,439,625 (-)NCBI
mRatBN7.2165,517,324 - 65,524,257 (-)NCBI
RefSeq Acc Id: XM_039103683   ⟹   XP_038959611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,440,553 (-)NCBI
mRatBN7.2165,517,325 - 65,525,194 (-)NCBI
RefSeq Acc Id: XM_063282935   ⟹   XP_063139005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,432,687 - 74,440,001 (-)NCBI
RefSeq Acc Id: XM_063282936   ⟹   XP_063139006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,433,193 - 74,440,001 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001006969   ⟸   NM_001006968
- UniProtKB: Q5XIB7 (UniProtKB/TrEMBL),   F1LSA6 (UniProtKB/TrEMBL),   A0A0G2K071 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071330   ⟸   ENSRNOT00000084846
RefSeq Acc Id: ENSRNOP00000072466   ⟸   ENSRNOT00000089950
RefSeq Acc Id: XP_017444128   ⟸   XM_017588639
- Peptide Label: isoform X1
- UniProtKB: Q5XIB7 (UniProtKB/TrEMBL),   F1LSA6 (UniProtKB/TrEMBL),   A0A0G2K071 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038959609   ⟸   XM_039103681
- Peptide Label: isoform X1
- UniProtKB: F1LSA6 (UniProtKB/TrEMBL),   Q5XIB7 (UniProtKB/TrEMBL),   A0A0G2K071 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_006228137   ⟸   XM_006228075
- Peptide Label: isoform X1
- UniProtKB: Q5XIB7 (UniProtKB/TrEMBL),   F1LSA6 (UniProtKB/TrEMBL),   A0A0G2K071 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038959611   ⟸   XM_039103683
- Peptide Label: isoform X1
- UniProtKB: F1LSA6 (UniProtKB/TrEMBL),   Q5XIB7 (UniProtKB/TrEMBL),   A0A0G2K071 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008757061   ⟸   XM_008758839
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001406968   ⟸   NM_001420039
- UniProtKB: F1LSA6 (UniProtKB/TrEMBL),   Q5XIB7 (UniProtKB/TrEMBL),   A0A0G2K071 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139005   ⟸   XM_063282935
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139006   ⟸   XM_063282936
- Peptide Label: isoform X2
Protein Domains
tRNA intron endonuclease catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIB7-F1-model_v2 AlphaFold Q5XIB7 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689656
Promoter ID:EPDNEW_R181
Type:initiation region
Name:Tsen34_1
Description:tRNA splicing endonuclease subunit 34
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0164,030,188 - 64,030,248EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359564 AgrOrtholog
BioCyc Gene G2FUF-61042 BioCyc
Ensembl Genes ENSRNOG00000055179 Ensembl
  ENSRNOG00000059572 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084846 ENTREZGENE
  ENSRNOT00000084846.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1350.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193201 IMAGE-MGC_LOAD
InterPro tRNA_endonuc-like_dom_sf UniProtKB/TrEMBL
  tRNA_intron_Endo_cat-like_sf UniProtKB/TrEMBL
  tRNA_intron_Endonuc_cat-like UniProtKB/TrEMBL
  tRNA_splic UniProtKB/TrEMBL
  tRNA_splic_SEN34 UniProtKB/TrEMBL
KEGG Report rno:292534 UniProtKB/TrEMBL
MGC_CLONE MGC:94712 IMAGE-MGC_LOAD
NCBI Gene 292534 ENTREZGENE
PANTHER TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34 UniProtKB/TrEMBL
  TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED UniProtKB/TrEMBL
Pfam tRNA_int_endo UniProtKB/TrEMBL
PhenoGen Tsen34 PhenoGen
PIRSF tRNA_splic_SEN34 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055179 RatGTEx
  ENSRNOG00000059572 RatGTEx
Superfamily-SCOP tRNA_int_endo_C UniProtKB/TrEMBL
UniProt A0A0G2K071 ENTREZGENE, UniProtKB/TrEMBL
  A6KS19_RAT UniProtKB/TrEMBL
  F1LSA6 ENTREZGENE
  Q5XIB7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LSA6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tsen34  tRNA splicing endonuclease subunit 34  Tsen34  TSEN34 tRNA splicing endonuclease subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-09-17 Tsen34  TSEN34 tRNA splicing endonuclease subunit  Tsen34  tRNA splicing endonuclease 34 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Tsen34  tRNA splicing endonuclease 34 homolog (S. cerevisiae)  Tsen34  tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Tsen34  tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae)  TSEN34  tRNA splicing endonuclease 34 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 TSEN34  tRNA splicing endonuclease 34 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL