Rnase2 (ribonuclease A family member 2) - Rat Genome Database

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Gene: Rnase2 (ribonuclease A family member 2) Rattus norvegicus
Analyze
Symbol: Rnase2
Name: ribonuclease A family member 2
RGD ID: 1359432
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2); INTERACTS WITH acrylamide; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ear4; eosinophil-associated, ribonuclease A family, member 4; LOC474169; pre-eosinophil-associated ribonuclease-2; R14; R15; R5; Raf1; ribonuclease 14; ribonuclease 15; ribonuclease 5; ribonuclease A f1; ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,923,125 - 26,923,934 (-)NCBIGRCr8
mRatBN7.21524,449,618 - 24,450,427 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,449,611 - 24,450,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,220,768 - 27,221,577 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,182,202 - 28,183,011 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,429,330 - 26,430,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,154,482 - 28,155,291 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,154,482 - 28,155,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,984,003 - 31,984,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,209,877 - 27,210,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,225,576 - 27,226,386 (-)NCBI
Celera1524,766,498 - 24,767,307 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Preparation of recombinant rat eosinophil-associated ribonuclease-1 and -2 and analysis of their biological activities. Ishihara K, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):164-72.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9758888   PMID:9826755   PMID:10594173   PMID:11490157   PMID:12855582   PMID:15676279   PMID:23376485   PMID:23533145   PMID:23992292   PMID:24270810   PMID:24337645  


Genomics

Comparative Map Data
Rnase2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,923,125 - 26,923,934 (-)NCBIGRCr8
mRatBN7.21524,449,618 - 24,450,427 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,449,611 - 24,450,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,220,768 - 27,221,577 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,182,202 - 28,183,011 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,429,330 - 26,430,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,154,482 - 28,155,291 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,154,482 - 28,155,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,984,003 - 31,984,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,209,877 - 27,210,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,225,576 - 27,226,386 (-)NCBI
Celera1524,766,498 - 24,767,307 (-)NCBICelera
Cytogenetic Map15p14NCBI
RNASE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,955,487 - 20,956,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,955,487 - 20,956,436 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,423,646 - 21,424,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,493,470 - 20,494,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,493,469 - 20,494,434NCBI
Celera141,284,485 - 1,285,449 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,544,743 - 1,545,707 (+)NCBIHuRef
CHM1_11421,425,751 - 21,426,715 (+)NCBICHM1_1
T2T-CHM13v2.01415,152,872 - 15,153,821 (+)NCBIT2T-CHM13v2.0
Rnase2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,492,718 - 51,493,569 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,492,719 - 51,493,569 (-)EnsemblGRCm39 Ensembl
GRCm381451,255,261 - 51,256,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,255,262 - 51,256,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv371451,874,936 - 51,875,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,177,212 - 50,178,063 (-)NCBIMGSCv36mm8
Celera1447,567,524 - 47,568,375 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.44NCBI
LOC100981889
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,394,999 - 22,396,712 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,611,486 - 21,613,199 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,759,482 - 1,760,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,841,044 - 19,842,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,841,364 - 19,841,849 (+)Ensemblpanpan1.1panPan2
RNASE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,411,633 - 21,412,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,412,062 - 21,412,544 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,023,402 - 25,024,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Rnase2
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000050820
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
D15Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21524,449,348 - 24,449,638 (+)MAPPERmRatBN7.2
Rnor_6.01528,154,213 - 28,154,502NCBIRnor6.0
Rnor_5.01531,983,734 - 31,984,023UniSTSRnor5.0
RGSC_v3.41527,209,607 - 27,209,897RGDRGSC3.4
RGSC_v3.41527,209,608 - 27,209,897UniSTSRGSC3.4
RGSC_v3.11527,225,307 - 27,225,597RGD
Celera1524,766,237 - 24,766,518UniSTS
RH 2.0 Map15137.8RGD
Cytogenetic Map15p14UniSTS
RH133047  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1524,766,542 - 24,766,758UniSTS
Celera1524,864,784 - 24,865,001UniSTS
Cytogenetic Map15p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 30 18 16 18 6 9 1 1 7 6
Below cutoff 2 5 6 4 2 4 1 1 1 13 13 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050820   ⟹   ENSRNOP00000039262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,449,611 - 24,450,479 (-)Ensembl
Rnor_6.0 Ensembl1528,154,482 - 28,155,291 (-)Ensembl
RefSeq Acc Id: NM_001007015   ⟹   NP_001007016
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,923,125 - 26,923,934 (-)NCBI
mRatBN7.21524,449,618 - 24,450,427 (-)NCBI
Rnor_6.01528,154,482 - 28,155,291 (-)NCBI
Rnor_5.01531,984,003 - 31,984,812 (-)NCBI
RGSC_v3.41527,209,877 - 27,210,686 (-)RGD
Celera1524,766,498 - 24,767,307 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001007016   ⟸   NM_001007015
- Peptide Label: precursor
- UniProtKB: Q5WN11 (UniProtKB/TrEMBL),   Q9R132 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000039262   ⟸   ENSRNOT00000050820
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5WN11-F1-model_v2 AlphaFold Q5WN11 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359432 AgrOrtholog
BioCyc Gene G2FUF-14013 BioCyc
Ensembl Genes ENSRNOG00000032133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050820 ENTREZGENE
  ENSRNOT00000050820.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:474169 UniProtKB/TrEMBL
NCBI Gene 474169 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PharmGKB RNASE3 RGD
PhenoGen Rnase2 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032133 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt Q5WN11 ENTREZGENE, UniProtKB/TrEMBL
  Q9R132 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Rnase2  ribonuclease A family member 2  Rnase2  ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Rnase2  ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)  Ear4  eosinophil-associated, ribonuclease A family, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ear4  eosinophil-associated, ribonuclease A family, member 4  LOC474169  pre-eosinophil-associated ribonuclease-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC474169  pre-eosinophil-associated ribonuclease-2      Symbol and Name status set to provisional 70820 PROVISIONAL