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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1343920 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDHB mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1552486 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDHB mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1552486 | 6480464 | Ethinyl Estradiol results in increased expression of PDHB mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1552486 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDHB mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDHB mRNA | CTD | PMID:20959002 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDHB mRNA | CTD | PMID:21215274 PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552486 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDHB mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDHB mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDHB mRNA | CTD | PMID:21215274 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of PDHB mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1552486 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of PDHB mRNA | CTD | PMID:18648102 | aflatoxin B1 | decreases expression | ISO | RGD:1552486 | 6480464 | Aflatoxin B1 results in decreased expression of PDHB mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PDHB mRNA | CTD | PMID:21839799 | benzo[a]pyrene | increases expression | ISO | RGD:1552486 | 6480464 | Benzo(a)pyrene results in increased expression of PDHB mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:1552486 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PDHB mRNA] | CTD | PMID:22228805 | bisphenol A | increases expression | ISO | RGD:1552486 | 6480464 | bisphenol A results in increased expression of PDHB mRNA | CTD | PMID:21932408 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of PDHB promoter | CTD | PMID:22457795 | cobalt dichloride | decreases expression | ISO | RGD:1343920 | 6480464 | cobaltous chloride results in decreased expression of PDHB mRNA | CTD | PMID:19376846 | copper(2+) sulfate | decreases expression | ISO | RGD:1343920 | 6480464 | Copper Sulfate results in decreased expression of PDHB mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1343920 | 6480464 | Cyclosporine results in decreased expression of PDHB mRNA | CTD | PMID:20106945 | desferrioxamine B | increases expression | ISO | RGD:1343920 | 6480464 | Deferoxamine results in increased expression of PDHB protein | CTD | PMID:19515424 | desferrioxamine B | multiple interactions | ISO | RGD:1343920 | 6480464 | ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] | CTD | PMID:19515424 | doxorubicin | multiple interactions | ISO | RGD:1552486 | 6480464 | [Doxorubicin co-treated with MT2A protein] results in decreased expression of PDHB protein | CTD | PMID:16144979 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of PDHB mRNA | CTD | PMID:19915844 | ferric ammonium citrate | multiple interactions | ISO | RGD:1343920 | 6480464 | ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] | CTD | PMID:19515424 | imatinib | decreases expression | ISO | RGD:1343920 | 6480464 | imatinib results in decreased expression of PDHB mRNA | CTD | PMID:19208803 | imatinib | multiple interactions | ISO | RGD:1343920 | 6480464 | [imatinib co-treated with tetraarsenic tetrasulfide] results in decreased expression of PDHB mRNA | CTD | PMID:19208803 | isotretinoin | decreases expression | ISO | RGD:1343920 | 6480464 | Isotretinoin results in decreased expression of PDHB mRNA | CTD | PMID:20436886 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of PDHB protein | CTD | PMID:19826936 | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of PDHB protein | CTD | PMID:23056601 | morphine | multiple interactions | EXP | | 6480464 | Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein] | CTD | PMID:23056601 | ochratoxin A | increases expression | ISO | RGD:1552486 | 6480464 | ochratoxin A results in increased expression of PDHB protein | CTD | PMID:19445961 | paracetamol | affects expression | ISO | RGD:1552486 | 6480464 | Acetaminophen affects the expression of PDHB mRNA | CTD | PMID:17562736 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of PDHB mRNA | CTD | PMID:16940010 | rosiglitazone | increases expression | ISO | RGD:1552486 | 6480464 | rosiglitazone results in increased expression of PDHB mRNA | CTD | PMID:17245590 | rosiglitazone | affects expression | ISO | RGD:1552486 | 6480464 | rosiglitazone affects the expression of PDHB mRNA | CTD | PMID:22013433 | rotenone | increases expression | ISO | RGD:1343920 | 6480464 | Rotenone results in increased expression of PDHB protein | CTD | PMID:19763263 | valproic acid | affects expression | ISO | RGD:1552486 | 6480464 | Valproic Acid affects the expression of PDHB mRNA | CTD | PMID:17963808 | vancomycin | increases expression | ISO | RGD:1552486 | 6480464 | Vancomycin results in increased expression of PDHB mRNA | CTD | PMID:18930951 | vincaleukoblastine | affects response to substance | ISO | RGD:1343920 | 6480464 | PDHB protein affects the susceptibility to Vinblastine | CTD | PMID:16217747 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Butanoate metabolism |
| Citrate cycle (TCA cycle) | |
| Glycolysis / Gluconeogenesis | |
| HIF-1 signaling pathway | |
| Metabolic pathways | |
| Pyruvate metabolism | |
Disease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Butanoate metabolism |
| Citrate cycle (TCA cycle) | |
| Glycolysis / Gluconeogenesis | |
| HIF-1 signaling pathway | |
| Metabolic pathways | |
| Pyruvate metabolism | |
References - curated| 1. |
Brown RM, etal., Hum Genet. 2004 Jul;115(2):123-7. Epub 2004 May 11. |
| 2. |
Huh TL, etal., J Biol Chem 1990 Aug 5;265(22):13320-6. |
| 3. |
Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5. |
| 4. |
MGD data from the GO Consortium |
| 5. |
Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7. |
| 6. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 7. |
RGD automated data pipeline |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD Automated Pipelines |
| 10. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
References - uncuratedRGD Disease Portals| Pdhb has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Pdhb (Rattus norvegicus) |
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| PDHB (Homo sapiens) |
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| Pdhb (Mus musculus) |
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Position Markers| RH127408 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001007620 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06082333 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01082591 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC079137 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474010 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ212778 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ214416 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234205 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001007620 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001007621 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001007621 | (Get FASTA) |
| GenBank Protein | AAH79137 | (Get FASTA) |
| EDL94164 | (Get FASTA) | |
| P49432 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007895 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000010545 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000010545 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 289950 | ENTREZGENE |
| Gene3D-CATH | Transketo_C_like | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000007895 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 712 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7127701 | IMAGE-MGC_LOAD |
| InterPro | PDHB | UniProtKB/Swiss-Prot |
| Transketo_C/Pyr-ferredox_oxred | UniProtKB/Swiss-Prot | |
| Transketolase-like_C | UniProtKB/Swiss-Prot | |
| Transketolase-like_Pyr-bd | UniProtKB/Swiss-Prot | |
| Transketolase_C | UniProtKB/Swiss-Prot | |
| IPI | IPI00194324 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:289950 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:94149 | IMAGE-MGC_LOAD |
| PANTHER | PTHR11624:SF11 | UniProtKB/Swiss-Prot |
| Pfam | Transket_pyr | UniProtKB/Swiss-Prot |
| Transketolase_C | UniProtKB/Swiss-Prot | |
| SMART | Transket_pyr | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Transketo_C_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.102424 | ENTREZGENE |
| UniProt | ODPB_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Pdhb | pyruvate dehydrogenase (lipoamide) beta | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2005-07-29 | Pdhb | pyruvate dehydrogenase (lipoamide) beta | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Pdhb | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1359146 |
| Created: | 2005-07-29 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.