TMPRSS2 (transmembrane protease, serine 2)

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Keyword

Gene: TMPRSS2 (transmembrane protease, serine 2) Homo sapiens

Symbol:

TMPRSS2

Name:

transmembrane protease, serine 2

Description:

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

epitheliasin; FLJ41954; OTTHUMP00000109259; OTTHUMP00000207916; OTTHUMP00000207917; PP9284; PRSS10; serine protease 10; transmembrane protease serine 2

Orthologs:

Mus musculus : Tmprss2 (transmembrane protease, serine 2) MGI
Rattus norvegicus : Tmprss2 (transmembrane protease, serine 2)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	21	33,384,528 - 33,427,555	-	NCBI
Human Genome Assembly HuRef	21	28,305,352 - 28,349,365	-	NCBI
Human Genome Assembly GRCh37	21	42,836,478 - 42,880,085	-	NCBI
Human Genome Assembly Build 36	21	41,758,351 - 41,801,948	-	NCBI
Human Cytogenetic Map	21	q22.3		NCBI
Human Genome Assembly	21	41,758,350 - 41,801,948		NCBI