Gene: EOMES (eomesodermin)
Homo sapiens
Symbol:
EOMES
Name:
eomesodermin
Description:
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
eomesodermin homolog; OTTHUMP00000161129; OTTHUMP00000208392; t box, brain, 2; T-box brain protein 2; T-box brain2; T-brain-2; TBR-2; TBR2
Orthologs:
Mus musculus : Eomes
(eomesodermin homolog (Xenopus laevis))
MGI
Eomes
(eomesodermin)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 3 27,696,092 - 27,702,008 - NCBI Human Genome Assembly HuRef 3 27,700,247 - 27,706,154 - NCBI Human Genome Assembly GRCh37 3 27,757,868 - 27,763,785 - NCBI Human Genome Assembly Build 36 3 27,732,872 - 27,738,789 - NCBI Human Cytogenetic Map 3 p24.1 NCBI Human Genome Assembly 3 27,732,890 - 27,738,789 NCBI
Model
Gene Ontology Annotations
Biological Process brain development IMP 2290271 PMID:17353897 UniProtKB PMID:17353897 CD8-positive, alpha-beta T cell differentiation involved in immune response IMP 2290271 PMID:17566017 UniProtKB PMID:17566017 cell differentiation involved in embryonic placenta development ISS UniProtKB:O54839 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 cerebral cortex neuron differentiation IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 endoderm formation ISS UniProtKB:O54839 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 endodermal cell fate specification IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 interferon-gamma production IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 mesoderm formation ISS UniProtKB:O54839 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 mesodermal to mesenchymal transition involved in gastrulation ISS UniProtKB:O54839 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of transcription from RNA polymerase II promoter ISS UniProtKB:O54839 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 olfactory bulb development IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of cell differentiation IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of transcription from RNA polymerase II promoter IDA 2290271 PMID:20713518 MGI PMID:20713518 positive regulation of transcription, DNA-dependent ISS UniProtKB:P79944 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of neuron differentiation IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 stem cell maintenance IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 trophectodermal cell differentiation IEA Ensembl:ENSMUSP00000035020 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019
1298439 BP30_H Blood pressure QTL 30 (human) 2.03 Blood pressure systolic 3 1 32165375 Human 1643090 BW152_H Body weight QTL 152 (human) .0112 Body fat amount percent body fat 3 2819327 28819327 Human 1298511 RA3_H Rheumatoid arthritis QTL 3 (human) .0139 Joint/bone inflammation rheumatoid arthritis 3 8949604 34949604 Human 1643540 GLUCO17_H Glucose level QTL 17 (human) .007 Glucose level non-insulin-dependent 3 8949604 34949604 Human 1559370 BW78_H Body weight QTL 78 (human) 1.77 .0065 Body weight body mass index 3 10668524 32165375 Human 1357318 AASTH43_H Allergic/atopic asthma related QTL 43 (human) .001 Reversible airflow obstruction 3 19165307 45165307 Human 1643472 SLIPL8_H Serum lipid level QTL 8 (human) 2.02 .001 Lipid level 3 19165307 45165307 Human 2289188 BW349_H Body weight QTL 349 (human) .0015 Body fat amount percent fat 3 19165307 45165307 Human 2289205 BW370_H Body weight QTL 370 (human) 1.9 Body fat amount percent fat 3 19165307 45165307 Human 2292867 PRSTS92_H Prostate tumor susceptibility QTL 92 (human) Prostate tumor susceptibility 3 19165307 45165307 Human 1357322 AASTH44_H Allergic/atopic asthma related QTL 44 (human) .0012 Reversible airflow obstruction 3 21624497 47624497 Human 2316061 GLUCO194_H Glucose level QTL 194 (human) .02 Glucose level 3 21949504 51018984 Human 2314752 GLUCO73_H Glucose level QTL 73 (human) .97 .005 Glucose level non-insulin dependent 3 25869836 51869836 Human
Gene Ontology Annotations
