Gene: TAC3 (tachykinin 3)
Homo sapiens
Symbol:
TAC3
Name:
tachykinin 3
Description:
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
gamma tachykinin 3; HH10; neurokinin B-like; neuromedin K; NKB; NKNB; OTTHUMP00000211122; OTTHUMP00000211123; OTTHUMP00000211124; OTTHUMP00000211125; OTTHUMP00000211126; OTTHUMP00000211127; OTTHUMP00000211128; OTTHUMP00000211129; OTTHUMP00000211130; preprotachykinin B; preprotachykinin-B; PRO1155; tachykinin-3; ZNEUROK1
Orthologs:
Mus musculus : Tac2
(tachykinin 2)
MGI
Tac3
(tachykinin 3)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 12 57,237,538 - 57,244,102 - NCBI Human Genome Assembly HuRef 12 54,442,327 - 54,448,890 - NCBI Human Genome Assembly GRCh37 12 57,403,781 - 57,410,344 - NCBI Human Genome Assembly Build 36 12 55,690,051 - 55,696,592 - NCBI Human Cytogenetic Map 12 q13-q21 NCBI Human Genome Assembly 12 55,690,052 - 55,696,592 NCBI
Model
Gene-Chemical Interaction Annotations
2,6-dinitrotoluene affects expression ISO RGD:3809 6480464 2,6-dinitrotoluene affects the expression of TAC2 mRNA CTD PMID:21346803 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of TAC3 mRNA CTD PMID:22100608 ammonium chloride affects expression ISO RGD:3809 6480464 Ammonium Chloride affects the expression of TAC2 mRNA CTD PMID:16483693 benzo[a]pyrene multiple interactions ISO RGD:736131 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to TAC2 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:3809 6480464 Benzo(a)pyrene results in increased expression of TAC2 mRNA CTD PMID:22374506 bisphenol A increases expression ISO RGD:3809 6480464 bisphenol A results in increased expression of TAC2 mRNA CTD PMID:12075121 bisphenol A decreases expression ISO RGD:3809 6480464 bisphenol A results in decreased expression of TAC2 mRNA CTD PMID:22957036 capsaicin decreases expression ISO RGD:3809 6480464 Capsaicin results in decreased expression of TAC2 mRNA CTD PMID:16278290 carbamazepine multiple interactions EXP 6480464 Carbamazepine inhibits the reaction [REST protein results in increased expression of TAC3 mRNA] CTD PMID:19539370 cefaloridine increases expression ISO RGD:3809 6480464 Cephaloridine results in increased expression of TAC2 mRNA CTD PMID:18500788 clofibric acid multiple interactions ISO RGD:3809 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TAC2 mRNA CTD PMID:17602206 cytarabine decreases expression EXP 6480464 Cytarabine results in decreased expression of TAC3 mRNA CTD PMID:21198554 ketamine increases expression ISO RGD:3809 6480464 Ketamine results in increased expression of TAC2 mRNA CTD PMID:20080153 mercaptopurine decreases expression ISO RGD:3809 6480464 6-Mercaptopurine results in decreased expression of TAC2 mRNA CTD PMID:23358152 N-nitrosodiethylamine multiple interactions ISO RGD:3809 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TAC2 mRNA CTD PMID:17602206 nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of TAC3 mRNA CTD PMID:16780908 paracetamol affects expression ISO RGD:736131 6480464 Acetaminophen affects the expression of TAC2 mRNA CTD PMID:17562736 purine-6-thiol decreases expression ISO RGD:3809 6480464 6-Mercaptopurine results in decreased expression of TAC2 mRNA CTD PMID:23358152 tetrachloromethane increases expression ISO RGD:3809 6480464 Carbon Tetrachloride results in increased expression of TAC2 mRNA CTD PMID:17805973
Biological Process female pregnancy TAS 2290271 PMID:10866201 PINC PMID:10866201 neuropeptide signaling pathway IEA UniProtKB-KW:KW-0527 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 tachykinin receptor signaling pathway IEA InterPro:IPR003635 2290271 GO_REF:0000002 InterPro GO_REF:0000002 Cellular Component extracellular region TAS 2290271 Reactome:REACT_15291 Reactome Reactome:REACT_15291 extracellular region TAS 2290271 Reactome:REACT_22436 Reactome Reactome:REACT_22436 extracellular region TAS 2290271 Reactome:REACT_22263 Reactome Reactome:REACT_22263 extracellular region TAS 2290271 Reactome:REACT_16953 Reactome Reactome:REACT_16953 extracellular space TAS 2290271 PMID:10866201 PINC PMID:10866201 Molecular Function receptor binding TAS 2290271 PMID:10866201 PINC PMID:10866201
1298509 RA21_H Rheumatoid arthritis QTL 21 (human) .0051 Joint/bone inflammation rheumatoid arthritis 12 40197150 66197150 Human 1357305 AASTH49_H Allergic/atopic asthma related QTL 49 (human) .0081 Reversible airflow obstruction 12 55944839 81944839 Human 1576327 LVC2_H Left ventricular contractility QTL 2 (human) 1.97 Left ventricular contractility 12 40197150 66197150 Human 1559096 SCL18_H Serum cholesterol level QTL 18 (human) 4.06 .000746 Lipid level HDL cholesterol 12 48135413 74135413 Human 1559125 SPSL2_H Serum P-selectin level QTL 2 (human) 2.59 Serum P-selectin level 12 12450154 116082709 Human 2289507 BW448_H Body weight QTL 448 (human) 3.31 Body morphometry waist to hip ratio 12 52613054 67934385 Human 1643456 BW74_H Body weight QTL 74 (human) 1.7 .029 Body weight body mass index 12 29220827 68129789 Human 2289615 BW406_H Body weight QTL 406 (human) 1.79 Body weight lean mass 12 47889528 73889528 Human 2314555 GLUCO53_H Glucose level QTL 53 (human) 1.3 Glucose level 12 40728103 66728103 Human 2316702 GLUCO263_H Glucose level QTL 263 (human) 1.7 .029 Glucose level 12 40197150 66197150 Human
Gene-Chemical Interaction Annotations
