CTSZ (cathepsin Z) - Rat Genome Database

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Gene: CTSZ (cathepsin Z) Homo sapiens
Analyze
Symbol: CTSZ
Name: cathepsin Z
RGD ID: 1352898
HGNC Page HGNC:2547
Description: Enables carboxypeptidase activity. Involved in negative regulation of plasminogen activation and proteolysis. Located in several cellular components, including endoplasmic reticulum; extracellular space; and lysosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: carboxypeptidase LB; cathepsin B2; cathepsin IV; cathepsin P; cathepsin X; cathepsin Y; cathepsin Z1; CTSX; cysteine-type carboxypeptidase; FLJ17088; lysosomal carboxypeptidase B; preprocathepsin P
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,995,185 - 59,007,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,985,686 - 59,008,238 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,570,240 - 57,582,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,003,635 - 57,015,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 342057,003,634 - 57,015,680NCBI
Celera2054,310,657 - 54,322,736 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,357,148 - 54,369,230 (-)NCBIHuRef
CHM1_12057,471,631 - 57,483,697 (-)NCBICHM1_1
T2T-CHM13v2.02060,778,286 - 60,790,364 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. Leichsenring A, etal., BMC Neurosci. 2008 Aug 12;9:80.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:9642240   PMID:9738465   PMID:10653162   PMID:10653163   PMID:10656802   PMID:10745011   PMID:10760573   PMID:11030415   PMID:11076863   PMID:11256614   PMID:11780052   PMID:12477932  
PMID:15489334   PMID:15489336   PMID:15680921   PMID:16381901   PMID:17065156   PMID:17601350   PMID:18420963   PMID:18976975   PMID:18977241   PMID:19433310   PMID:20551380   PMID:21310951  
PMID:21354459   PMID:21368909   PMID:21454358   PMID:21516116   PMID:21616554   PMID:21873635   PMID:21966391   PMID:22139419   PMID:22268729   PMID:22451661   PMID:22632162   PMID:23128233  
PMID:23376485   PMID:23533145   PMID:23827504   PMID:23874603   PMID:24026423   PMID:24725597   PMID:25037231   PMID:25416956   PMID:25433997   PMID:25442015   PMID:26496610   PMID:26760575  
PMID:28344315   PMID:28495172   PMID:28515276   PMID:29795304   PMID:30018008   PMID:30021884   PMID:30046941   PMID:30087368   PMID:31090199   PMID:31515488   PMID:32296183   PMID:33545068  
PMID:33869196   PMID:33961781   PMID:34225486   PMID:34378678   PMID:34709727   PMID:35163706   PMID:35563538   PMID:35696571   PMID:35748872   PMID:35831314   PMID:36114006   PMID:36517590  
PMID:37020415   PMID:37210216   PMID:38113892   PMID:38184627  


Genomics

Comparative Map Data
CTSZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,995,185 - 59,007,254 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,985,686 - 59,008,238 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,570,240 - 57,582,309 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,003,635 - 57,015,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 342057,003,634 - 57,015,680NCBI
Celera2054,310,657 - 54,322,736 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,357,148 - 54,369,230 (-)NCBIHuRef
CHM1_12057,471,631 - 57,483,697 (-)NCBICHM1_1
T2T-CHM13v2.02060,778,286 - 60,790,364 (-)NCBIT2T-CHM13v2.0
Ctsz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,269,287 - 174,280,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,269,286 - 174,280,832 (-)EnsemblGRCm39 Ensembl
GRCm382174,427,494 - 174,439,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,427,493 - 174,439,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,252,995 - 174,264,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362174,070,433 - 174,081,931 (-)NCBIMGSCv36mm8
Celera2180,388,324 - 180,399,730 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.94NCBI
Ctsz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,643,077 - 183,653,847 (-)NCBIGRCr8
mRatBN7.23163,224,875 - 163,235,645 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,224,875 - 163,235,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3167,023,616 - 167,034,386 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,520,073 - 175,530,842 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,264,462 - 173,275,232 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,527,107 - 172,537,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,527,107 - 172,537,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,574,619 - 178,585,389 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,398,362 - 162,409,134 (-)NCBICelera
Cytogenetic Map3q43NCBI
Ctsz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955445586,902 - 597,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955445586,901 - 597,753 (+)NCBIChiLan1.0ChiLan1.0
CTSZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22164,758,586 - 64,770,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12064,751,705 - 64,763,824 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02055,346,241 - 55,358,354 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12056,706,511 - 56,718,941 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2056,706,511 - 56,718,941 (-)Ensemblpanpan1.1panPan2
CTSZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,743,291 - 43,750,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,743,294 - 43,754,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2442,989,417 - 42,996,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02444,609,433 - 44,616,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,609,441 - 44,620,531 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,712,987 - 43,720,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,831,671 - 43,839,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02444,491,470 - 44,498,960 (-)NCBIUU_Cfam_GSD_1.0
Ctsz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,815,540 - 181,824,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365301,482,012 - 1,490,736 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365301,482,007 - 1,490,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1759,138,621 - 59,149,377 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11759,141,497 - 59,149,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21766,511,905 - 66,519,788 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,135,729 - 5,146,063 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,135,770 - 5,145,630 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605053,186,955 - 53,197,273 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474125,280,916 - 25,301,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474125,280,916 - 25,301,724 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSZ
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33		 pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33		 pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:55630597-60941207)x3 copy number gain See cases [RCV000135622] Chr20:55630597..60941207 [GRCh38]
Chr20:54220678..59516263 [GRCh37]
Chr20:53639062..58949658 [NCBI36]
Chr20:20q13.2-13.33		 likely pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:56198032-64277321)x3 copy number gain See cases [RCV000138035] Chr20:56198032..64277321 [GRCh38]
Chr20:54773088..62908674 [GRCh37]
Chr20:54206495..62379118 [NCBI36]
Chr20:20q13.2-13.33		 pathogenic
GRCh38/hg38 20q13.31-13.33(chr20:57229415-64273089)x3 copy number gain See cases [RCV000141347] Chr20:57229415..64273089 [GRCh38]
Chr20:55804471..62904442 [GRCh37]
Chr20:55237878..62374886 [NCBI36]
Chr20:20q13.31-13.33		 pathogenic
GRCh38/hg38 20q13.2-13.33(chr20:53236165-64284202)x3 copy number gain See cases [RCV000143584] Chr20:53236165..64284202 [GRCh38]
Chr20:51852704..62915555 [GRCh37]
Chr20:51286111..62385999 [NCBI36]
Chr20:20q13.2-13.33		 likely pathogenic
GRCh37/hg19 20q13.2-13.33(chr20:51542616-62915555)x3 copy number gain See cases [RCV000511980] Chr20:51542616..62915555 [GRCh37]
Chr20:20q13.2-13.33		 likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33		 pathogenic
NC_000020.10:g.(?_56993257)_(57967907_?)dup duplication Amyotrophic lateral sclerosis type 8 [RCV002254579] Chr20:56993257..57967907 [GRCh37]
Chr20:20q13.32		 uncertain significance
GRCh37/hg19 20q13.2-13.33(chr20:54143747-62194881) copy number gain not provided [RCV000767669] Chr20:54143747..62194881 [GRCh37]
Chr20:20q13.2-13.33		 pathogenic
NM_001336.4(CTSZ):c.587T>C (p.Leu196Pro) single nucleotide variant not provided [RCV000960086] Chr20:58997654 [GRCh38]
Chr20:57572709 [GRCh37]
Chr20:20q13.32		 benign
GRCh37/hg19 20q13.32-13.33(chr20:56788101-62762405)x3 copy number gain not provided [RCV001007098] Chr20:56788101..62762405 [GRCh37]
Chr20:20q13.32-13.33		 pathogenic
NM_001336.4(CTSZ):c.571G>A (p.Gly191Arg) single nucleotide variant not provided [RCV000923051] Chr20:58997670 [GRCh38]
Chr20:57572725 [GRCh37]
Chr20:20q13.32		 benign
NM_001336.4(CTSZ):c.677C>G (p.Thr226Ser) single nucleotide variant not provided [RCV000967562] Chr20:58996763 [GRCh38]
Chr20:57571818 [GRCh37]
Chr20:20q13.32		 benign
GRCh37/hg19 20q13.31-13.33(chr20:55743522-62032989)x3 copy number gain not provided [RCV001007097] Chr20:55743522..62032989 [GRCh37]
Chr20:20q13.31-13.33		 pathogenic
NC_000020.10:g.(?_56993257)_(57967907_?)dup duplication Amyotrophic lateral sclerosis type 8 [RCV001324796] Chr20:56993257..57967907 [GRCh37]
Chr20:20q13.32		 uncertain significance
GRCh37/hg19 20q13.2-13.33(chr20:51799648-62916626)x3 copy number gain not provided [RCV001537917] Chr20:51799648..62916626 [GRCh37]
Chr20:20q13.2-13.33		 pathogenic
GRCh37/hg19 20q13.32-13.33(chr20:56835739-62915555) copy number gain not specified [RCV002052713] Chr20:56835739..62915555 [GRCh37]
Chr20:20q13.32-13.33		 pathogenic
GRCh37/hg19 20q13.31-13.32(chr20:55292205-57866365) copy number loss not specified [RCV002052712] Chr20:55292205..57866365 [GRCh37]
Chr20:20q13.31-13.32		 pathogenic
NC_000020.10:g.(?_54823900)_(57899514_?)del deletion not provided [RCV001900543] Chr20:54823900..57899514 [GRCh37]
Chr20:20q13.2-13.32		 uncertain significance
NM_001336.4(CTSZ):c.70G>A (p.Gly24Ser) single nucleotide variant Inborn genetic diseases [RCV002839880] Chr20:59007059 [GRCh38]
Chr20:57582114 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.805G>A (p.Glu269Lys) single nucleotide variant Inborn genetic diseases [RCV002773451] Chr20:58995756 [GRCh38]
Chr20:57570811 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.53C>T (p.Ala18Val) single nucleotide variant Inborn genetic diseases [RCV003001536] Chr20:59007076 [GRCh38]
Chr20:57582131 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.121G>A (p.Gly41Arg) single nucleotide variant Inborn genetic diseases [RCV002641089] Chr20:59007008 [GRCh38]
Chr20:57582063 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.179C>A (p.Ala60Glu) single nucleotide variant Inborn genetic diseases [RCV002955472] Chr20:59006450 [GRCh38]
Chr20:57581505 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.65A>G (p.Gln22Arg) single nucleotide variant Inborn genetic diseases [RCV002916655] Chr20:59007064 [GRCh38]
Chr20:57582119 [GRCh37]
Chr20:20q13.32		 likely benign
NM_001336.4(CTSZ):c.52G>T (p.Ala18Ser) single nucleotide variant Inborn genetic diseases [RCV002673594] Chr20:59007077 [GRCh38]
Chr20:57582132 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.791G>A (p.Gly264Asp) single nucleotide variant Inborn genetic diseases [RCV002792457] Chr20:58996649 [GRCh38]
Chr20:57571704 [GRCh37]
Chr20:20q13.32		 uncertain significance
NM_001336.4(CTSZ):c.179C>T (p.Ala60Val) single nucleotide variant Inborn genetic diseases [RCV002812670] Chr20:59006450 [GRCh38]
Chr20:57581505 [GRCh37]
Chr20:20q13.32		 uncertain significance
GRCh37/hg19 20q13.2-13.33(chr20:52773668-62965020)x3 copy number gain See cases [RCV003329549] Chr20:52773668..62965020 [GRCh37]
Chr20:20q13.2-13.33		 uncertain significance
NM_001336.4(CTSZ):c.702G>C (p.Gln234His) single nucleotide variant Inborn genetic diseases [RCV003381390] Chr20:58996738 [GRCh38]
Chr20:57571793 [GRCh37]
Chr20:20q13.32		 likely benign
NM_001336.4(CTSZ):c.567G>A (p.Arg189=) single nucleotide variant not provided [RCV003440466] Chr20:58997674 [GRCh38]
Chr20:57572729 [GRCh37]
Chr20:20q13.32		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:872
Count of miRNA genes:609
Interacting mature miRNAs:703
Transcripts:ENST00000217131, ENST00000472025, ENST00000488395, ENST00000503833
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G62034  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,571,708 - 57,571,860UniSTSGRCh37
Build 362057,005,103 - 57,005,255RGDNCBI36
Celera2054,312,123 - 54,312,275RGD
Cytogenetic Map20q13.32UniSTS
HuRef2054,358,614 - 54,358,766UniSTS
CTSZ_1953  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,570,124 - 57,570,782UniSTSGRCh37
Build 362057,003,519 - 57,004,177RGDNCBI36
Celera2054,310,539 - 54,311,197RGD
HuRef2054,357,030 - 54,357,688UniSTS
RH48060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,570,269 - 57,570,458UniSTSGRCh37
Build 362057,003,664 - 57,003,853RGDNCBI36
Celera2054,310,684 - 54,310,873RGD
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map20q13UniSTS
HuRef2054,357,175 - 54,357,364UniSTS
GeneMap99-GB4 RH Map20339.83UniSTS
NCBI RH Map20583.1UniSTS
A004R34  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,569,907 - 57,570,144UniSTSGRCh37
Build 362057,003,302 - 57,003,539RGDNCBI36
Celera2054,310,322 - 54,310,559RGD
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map20q13UniSTS
HuRef2054,356,813 - 54,357,050UniSTS
GeneMap99-GB4 RH Map20339.83UniSTS
SHGC-31778  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372057,570,048 - 57,570,175UniSTSGRCh37
Build 362057,003,443 - 57,003,570RGDNCBI36
Celera2054,310,463 - 54,310,590RGD
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map20q13UniSTS
HuRef2054,356,954 - 54,357,081UniSTS
Stanford-G3 RH Map202817.0UniSTS
GeneMap99-GB4 RH Map20349.81UniSTS
Whitehead-RH Map20355.2UniSTS
NCBI RH Map20583.1UniSTS
GeneMap99-G3 RH Map202850.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4 28 3 2 20 2 21 2 6 44 23 8 2
Medium 2421 2951 1711 615 1887 457 4326 2163 3657 411 1398 1526 171 1196 2786 4
Low 6 7 7 4 29 3 7 11 27 1 4 36 1 1
Below cutoff 6 4 2 2 11 2 1 20 23 1 9 24 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000217131   ⟹   ENSP00000217131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000472025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2059,006,042 - 59,007,111 (-)Ensembl
RefSeq Acc Id: ENST00000488395
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,270 (-)Ensembl
RefSeq Acc Id: ENST00000503833
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,996,579 - 59,007,239 (-)Ensembl
RefSeq Acc Id: ENST00000679391
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,258 - 59,007,236 (-)Ensembl
RefSeq Acc Id: ENST00000679948   ⟹   ENSP00000505895
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,206 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000679991
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,226 - 59,006,648 (-)Ensembl
RefSeq Acc Id: ENST00000680156
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,200 - 58,998,427 (-)Ensembl
RefSeq Acc Id: ENST00000680206   ⟹   ENSP00000505861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,247 (-)Ensembl
RefSeq Acc Id: ENST00000680263   ⟹   ENSP00000506111
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,992,122 - 59,007,241 (-)Ensembl
RefSeq Acc Id: ENST00000680283   ⟹   ENSP00000506675
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000680300   ⟹   ENSP00000505432
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,189 - 59,007,237 (-)Ensembl
RefSeq Acc Id: ENST00000680386   ⟹   ENSP00000506279
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,996,591 - 59,007,807 (-)Ensembl
RefSeq Acc Id: ENST00000680456   ⟹   ENSP00000505693
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,242 (-)Ensembl
RefSeq Acc Id: ENST00000680565   ⟹   ENSP00000505923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,191 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000680628
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,187 - 59,007,825 (-)Ensembl
RefSeq Acc Id: ENST00000680738   ⟹   ENSP00000506672
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000680753   ⟹   ENSP00000505409
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,992,109 - 59,007,237 (-)Ensembl
RefSeq Acc Id: ENST00000680879   ⟹   ENSP00000505285
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,990,611 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000680880   ⟹   ENSP00000506691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,996,583 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000680995   ⟹   ENSP00000505169
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,192 - 59,007,241 (-)Ensembl
RefSeq Acc Id: ENST00000681011   ⟹   ENSP00000505520
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,985,686 - 59,008,238 (-)Ensembl
RefSeq Acc Id: ENST00000681029
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,261 - 58,999,616 (-)Ensembl
RefSeq Acc Id: ENST00000681175   ⟹   ENSP00000505215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,992,117 - 59,007,210 (-)Ensembl
RefSeq Acc Id: ENST00000681360   ⟹   ENSP00000505504
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,192 - 59,007,846 (-)Ensembl
RefSeq Acc Id: ENST00000681366
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,005,311 (-)Ensembl
RefSeq Acc Id: ENST00000681416   ⟹   ENSP00000506588
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,992,911 - 59,007,230 (-)Ensembl
RefSeq Acc Id: ENST00000681427   ⟹   ENSP00000506266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,230 (-)Ensembl
RefSeq Acc Id: ENST00000681457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,992,119 - 59,004,838 (-)Ensembl
RefSeq Acc Id: ENST00000681664   ⟹   ENSP00000506298
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,995,185 - 59,007,254 (-)Ensembl
RefSeq Acc Id: ENST00000681797   ⟹   ENSP00000505647
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,996,580 - 59,007,242 (-)Ensembl
RefSeq Acc Id: ENST00000681877   ⟹   ENSP00000506136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2058,992,117 - 59,007,274 (-)Ensembl
RefSeq Acc Id: NM_001336   ⟹   NP_001327
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382058,995,185 - 59,007,254 (-)NCBI
GRCh372057,570,242 - 57,582,309 (-)ENTREZGENE
Build 362057,003,635 - 57,015,697 (-)NCBI Archive
HuRef2054,357,148 - 54,369,230 (-)ENTREZGENE
CHM1_12057,471,631 - 57,483,697 (-)NCBI
T2T-CHM13v2.02060,778,286 - 60,790,364 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001327   ⟸   NM_001336
- Peptide Label: preproprotein
- UniProtKB: Q9UQV5 (UniProtKB/Swiss-Prot),   O75331 (UniProtKB/Swiss-Prot),   B2RC40 (UniProtKB/Swiss-Prot),   Q9UQV6 (UniProtKB/Swiss-Prot),   Q9UBR2 (UniProtKB/Swiss-Prot),   Q5U000 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000217131   ⟸   ENST00000217131
RefSeq Acc Id: ENSP00000505923   ⟸   ENST00000680565
RefSeq Acc Id: ENSP00000505215   ⟸   ENST00000681175
RefSeq Acc Id: ENSP00000506279   ⟸   ENST00000680386
RefSeq Acc Id: ENSP00000506588   ⟸   ENST00000681416
RefSeq Acc Id: ENSP00000506675   ⟸   ENST00000680283
RefSeq Acc Id: ENSP00000505285   ⟸   ENST00000680879
RefSeq Acc Id: ENSP00000505647   ⟸   ENST00000681797
RefSeq Acc Id: ENSP00000506691   ⟸   ENST00000680880
RefSeq Acc Id: ENSP00000506266   ⟸   ENST00000681427
RefSeq Acc Id: ENSP00000505432   ⟸   ENST00000680300
RefSeq Acc Id: ENSP00000505693   ⟸   ENST00000680456
RefSeq Acc Id: ENSP00000505861   ⟸   ENST00000680206
RefSeq Acc Id: ENSP00000505409   ⟸   ENST00000680753
RefSeq Acc Id: ENSP00000505895   ⟸   ENST00000679948
RefSeq Acc Id: ENSP00000506111   ⟸   ENST00000680263
RefSeq Acc Id: ENSP00000506672   ⟸   ENST00000680738
RefSeq Acc Id: ENSP00000505504   ⟸   ENST00000681360
RefSeq Acc Id: ENSP00000506136   ⟸   ENST00000681877
RefSeq Acc Id: ENSP00000505520   ⟸   ENST00000681011
RefSeq Acc Id: ENSP00000506298   ⟸   ENST00000681664
RefSeq Acc Id: ENSP00000505169   ⟸   ENST00000680995
Protein Domains
Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UBR2-F1-model_v2 AlphaFold Q9UBR2 1-303 view protein structure

Promoters
RGD ID:6798997
Promoter ID:HG_KWN:40004
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000268084,   UC010GJT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362057,005,966 - 57,007,367 (-)MPROMDB
RGD ID:6812026
Promoter ID:HG_ACW:49864
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:CTSZ.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 362057,010,136 - 57,010,636 (-)MPROMDB
RGD ID:6798624
Promoter ID:HG_KWN:40005
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000079900
Position:
Human AssemblyChrPosition (strand)Source
Build 362057,014,551 - 57,015,762 (-)MPROMDB
RGD ID:6798518
Promoter ID:HG_KWN:40006
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000217131,   ENST00000371052,   OTTHUMT00000079901,   UC002YAJ.2
Position:
Human AssemblyChrPosition (strand)Source
Build 362057,015,576 - 57,016,537 (-)MPROMDB
RGD ID:13602258
Promoter ID:EPDNEW_H27313
Type:initiation region
Name:CTSZ_1
Description:cathepsin Z
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382059,007,254 - 59,007,314EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2547 AgrOrtholog
COSMIC CTSZ COSMIC
Ensembl Genes ENSG00000101160 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000217131 ENTREZGENE
  ENST00000217131.6 UniProtKB/Swiss-Prot
  ENST00000503833.7 UniProtKB/TrEMBL
  ENST00000679948.1 UniProtKB/TrEMBL
  ENST00000680206.1 UniProtKB/TrEMBL
  ENST00000680263.1 UniProtKB/TrEMBL
  ENST00000680283.1 UniProtKB/TrEMBL
  ENST00000680300.1 UniProtKB/TrEMBL
  ENST00000680386.1 UniProtKB/TrEMBL
  ENST00000680456.1 UniProtKB/TrEMBL
  ENST00000680565.1 UniProtKB/TrEMBL
  ENST00000680738.1 UniProtKB/TrEMBL
  ENST00000680753.1 UniProtKB/TrEMBL
  ENST00000680879.1 UniProtKB/TrEMBL
  ENST00000680880.1 UniProtKB/TrEMBL
  ENST00000680995.1 UniProtKB/TrEMBL
  ENST00000681011.1 UniProtKB/TrEMBL
  ENST00000681175.1 UniProtKB/TrEMBL
  ENST00000681360.1 UniProtKB/TrEMBL
  ENST00000681416.1 UniProtKB/TrEMBL
  ENST00000681427.1 UniProtKB/TrEMBL
  ENST00000681664.1 UniProtKB/TrEMBL
  ENST00000681797.1 UniProtKB/TrEMBL
  ENST00000681877.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000101160 GTEx
HGNC ID HGNC:2547 ENTREZGENE
Human Proteome Map CTSZ Human Proteome Map
InterPro Cathepsin_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1522 UniProtKB/Swiss-Prot
NCBI Gene 1522 ENTREZGENE
OMIM 603169 OMIM
PANTHER CATHEPSIN Z UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27043 PharmGKB
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7P0T8I6_HUMAN UniProtKB/TrEMBL
  A0A7P0T8X2_HUMAN UniProtKB/TrEMBL
  A0A7P0T900_HUMAN UniProtKB/TrEMBL
  A0A7P0T926_HUMAN UniProtKB/TrEMBL
  A0A7P0T989_HUMAN UniProtKB/TrEMBL
  A0A7P0T9G9_HUMAN UniProtKB/TrEMBL
  A0A7P0T9U1_HUMAN UniProtKB/TrEMBL
  A0A7P0T9U4_HUMAN UniProtKB/TrEMBL
  A0A7P0T9X4_HUMAN UniProtKB/TrEMBL
  A0A7P0TA25_HUMAN UniProtKB/TrEMBL
  A0A7P0TAD4_HUMAN UniProtKB/TrEMBL
  A0A7P0TAT6_HUMAN UniProtKB/TrEMBL
  A0A7P0TB41_HUMAN UniProtKB/TrEMBL
  A0A7P0TBB5_HUMAN UniProtKB/TrEMBL
  A0A7P0TBM7_HUMAN UniProtKB/TrEMBL
  A0A7P0Z469_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4A7_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4L1_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4L7_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4Q4_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4R9_HUMAN UniProtKB/TrEMBL
  B2RC40 ENTREZGENE
  CATZ_HUMAN UniProtKB/Swiss-Prot
  O75331 ENTREZGENE
  Q5U000 ENTREZGENE, UniProtKB/TrEMBL
  Q9UBR2 ENTREZGENE
  Q9UQV5 ENTREZGENE
  Q9UQV6 ENTREZGENE
UniProt Secondary B2RC40 UniProtKB/Swiss-Prot
  O75331 UniProtKB/Swiss-Prot
  Q9UQV5 UniProtKB/Swiss-Prot
  Q9UQV6 UniProtKB/Swiss-Prot