CCL7 (C-C motif chemokine ligand 7) - Rat Genome Database

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Gene: CCL7 (C-C motif chemokine ligand 7) Homo sapiens
Analyze
Symbol: CCL7
Name: C-C motif chemokine ligand 7
RGD ID: 1352377
HGNC Page HGNC:10634
Description: Enables CCR1 chemokine receptor binding activity and chemokine activity. Involved in several processes, including eosinophil chemotaxis; positive regulation of natural killer cell chemotaxis; and regulation of cell shape. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in multiple sclerosis. Biomarker of several diseases, including autoimmune disease (multiple); lung disease (multiple); nose disease (multiple); periapical periodontitis (multiple); and viral infectious disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-C motif chemokine 7; chemokine (C-C motif) ligand 7; FIC; MARC; MCP-3; MCP3; MGC138463; MGC138465; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; NC28; SCYA6; SCYA7; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7
RGD Orthologs
Mouse
Rat
Dog
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,270,221 - 34,272,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,597,240 - 32,599,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,621,353 - 29,623,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,621,352 - 29,623,368NCBI
Celera1729,507,053 - 29,509,069 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,782,528 - 28,784,554 (+)NCBIHuRef
CHM1_11732,661,096 - 32,663,122 (+)NCBICHM1_1
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
apocynin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
asperentin  (ISO)
astemizole  (ISO)
atrazine  (EXP)
barium sulfate  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
Brevianamide A  (ISO)
bromobenzene  (ISO)
butanal  (EXP)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
Calcimycin  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
ceric oxide  (ISO)
CGP 52608  (EXP)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dichlorine  (ISO)
dichromium trioxide  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
ferric oxide  (EXP,ISO)
flumequine  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
Fusarenone X  (ISO)
gadodiamide hydrate  (ISO)
gentamycin  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP,ISO)
iodixanol  (ISO)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP,ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
MeIQx  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
piperidines  (EXP)
polymyxin B2  (ISO)
potassium dichromate  (ISO)
procyanidin B3  (ISO)
propanal  (EXP)
quartz  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Chemokines in the limbal form of vernal keratoconjunctivitis. Abu El-Asrar AM, etal., Br J Ophthalmol. 2000 Dec;84(12):1360-6.
2. Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis. Adarichev VA, etal., Autoimmunity. 2006 Dec;39(8):663-73.
3. Monocyte chemotactic protein (MCP3) promoter polymorphism is associated with atopic asthma in the Indian population. Batra J, etal., J Allergy Clin Immunol. 2011 Mar 8.
4. IL-1beta disrupts postnatal lung morphogenesis in the mouse. Bry K, etal., Am J Respir Cell Mol Biol. 2007 Jan;36(1):32-42. Epub 2006 Aug 3.
5. Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Choi ES, etal., Am J Respir Crit Care Med. 2004 Sep 1;170(5):508-15. Epub 2004 Jun 10.
6. Monocyte chemotactic protein-3: possible involvement in apical periodontitis chemotaxis. Dezerega A, etal., Int Endod J. 2010 Oct;43(10):902-8. doi: 10.1111/j.1365-2591.2010.01764.x. Epub 2010 Jul 15.
7. Chemokine monocyte chemoattractant protein-3 in progressive periodontal lesions in patients with chronic periodontitis. Dezerega A, etal., J Periodontol. 2010 Feb;81(2):267-76.
8. Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma. Dharajiya N, etal., PLoS One. 2009 Dec 21;4(12):e8172.
9. Chemokine expression by small sputum macrophages in COPD. Frankenberger M, etal., Mol Med. 2011;17(7-8):762-70. doi: 10.2119/molmed.2010.00202. Epub 2011 Feb 9.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation. Gu N, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L290-6. Epub 2009 Dec 4.
12. CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity. Huber J, etal., J Clin Endocrinol Metab. 2008 Aug;93(8):3215-21. Epub 2008 May 20.
13. Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis. Langley RJ, etal., J Toxicol Environ Health A. 2011;74(19):1261-79.
14. Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Luesink M, etal., Blood. 2009 Dec 24;114(27):5512-21. Epub 2009 Oct 14.
15. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study. McManus C, etal., J Neuroimmunol. 1998 Jun 1;86(1):20-9.
16. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. Morgan DL, etal., Toxicol Pathol. 2012 Apr;40(3):448-65. Epub 2012 Jan 3.
17. Gelatinase B, PECAM-1 and MCP-3 gene polymorphisms in Belgian multiple sclerosis. Nelissen I, etal., J Neurol Sci. 2002 Aug 15;200(1-2):43-8.
18. Effective methylprednisolone dose in experimental crescentic glomerulonephritis. Ou ZL, etal., Am J Kidney Dis. 2001 Feb;37(2):411-7.
19. Transient and sequential expression of chemokine mRNA in glomeruli in puromycin aminonucleoside nephrosis. Ou ZL, etal., Nephron. 2000 Jul;85(3):254-7.
20. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. Patsouras MD, etal., J Autoimmun. 2015 Dec;65:30-7. doi: 10.1016/j.jaut.2015.08.001. Epub 2015 Aug 15.
21. Biomarkers of acute respiratory allergen exposure: screening for sensitization potential. Pucheu-Haston CM, etal., Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55. Epub 2010 Jan 4.
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Study of plasma protein C and inflammatory pathways: biomarkers for dimethylnitrosamine-induced liver fibrosis in rats. Saha JK, etal., Eur J Pharmacol. 2007 Dec 1;575(1-3):158-67. Epub 2007 Aug 2.
24. Role of monocyte chemotactic protein-3 and -4 in children with virus exacerbation of asthma. Santiago J, etal., Eur Respir J. 2008 Nov;32(5):1243-9. Epub 2008 Jun 25.
25. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
26. The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. Steger-Hartmann T, etal., Exp Toxicol Pathol. 2009 Nov;61(6):537-52. Epub 2009 Jan 7.
27. Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis. Uguccioni M, etal., Am J Pathol. 1999 Aug;155(2):331-6.
28. Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. Walsh ER, etal., J Exp Med. 2008 Jun 9;205(6):1285-92. Epub 2008 May 19.
29. Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy. Westermann D, etal., Circulation. 2011 Nov 8;124(19):2082-93. Epub 2011 Oct 10.
30. Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis. Wright ED, etal., J Otolaryngol. 1998 Oct;27(5):281-7.
31. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
32. Activation of microglia and chemokines in light-induced retinal degeneration. Zhang C, etal., Mol Vis. 2005 Oct 27;11:887-95.
33. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. Zhang RX, etal., J Investig Allergol Clin Immunol. 2007;17(5):329-36.
34. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:1613466   PMID:7545673   PMID:7916328   PMID:8318676   PMID:8461011   PMID:8530354   PMID:8580362   PMID:8642344   PMID:8898111   PMID:9109648   PMID:9346360   PMID:9364936  
PMID:9405404   PMID:9780207   PMID:9789057   PMID:10072545   PMID:10201901   PMID:10205198   PMID:10477718   PMID:10525044   PMID:10570327   PMID:10660125   PMID:10734104   PMID:10770925  
PMID:10947989   PMID:11146155   PMID:11781181   PMID:12098517   PMID:12149192   PMID:12477932   PMID:12539042   PMID:12847692   PMID:13679391   PMID:14571188   PMID:14733956   PMID:15067078  
PMID:15194816   PMID:15340161   PMID:15381085   PMID:15489334   PMID:15715950   PMID:16002730   PMID:16169070   PMID:17023422   PMID:17364026   PMID:17703412   PMID:18469140   PMID:18533557  
PMID:18660381   PMID:19253530   PMID:19258923   PMID:19322201   PMID:19403065   PMID:19423540   PMID:19424580   PMID:19526283   PMID:19865101   PMID:19898927   PMID:19937793   PMID:20056178  
PMID:20237496   PMID:20406964   PMID:20438785   PMID:20503287   PMID:20570966   PMID:20628624   PMID:21072187   PMID:21102463   PMID:21148795   PMID:21279498   PMID:21536288   PMID:21873635  
PMID:22412388   PMID:22468089   PMID:22614322   PMID:23762028   PMID:23764760   PMID:24327013   PMID:24578274   PMID:24727473   PMID:24742347   PMID:25193015   PMID:25261323   PMID:25416956  
PMID:26095031   PMID:26756352   PMID:28381538   PMID:28475003   PMID:30764543   PMID:31034889   PMID:32060844   PMID:32217106   PMID:32296183   PMID:32694731   PMID:33257678   PMID:33318472  
PMID:33876413   PMID:35715847   PMID:36118415   PMID:36274485   PMID:36398464   PMID:36585204   PMID:38316963  


Genomics

Comparative Map Data
CCL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,270,221 - 34,272,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,597,240 - 32,599,261 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,621,353 - 29,623,369 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,621,352 - 29,623,368NCBI
Celera1729,507,053 - 29,509,069 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,782,528 - 28,784,554 (+)NCBIHuRef
CHM1_11732,661,096 - 32,663,122 (+)NCBICHM1_1
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBIT2T-CHM13v2.0
Ccl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,936,538 - 81,938,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,936,538 - 81,938,351 (+)EnsemblGRCm39 Ensembl
GRCm381182,045,712 - 82,047,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,045,712 - 82,047,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,859,214 - 81,861,027 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,861,909 - 81,863,720 (+)NCBIMGSCv36mm8
Celera1191,659,161 - 91,660,974 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1149.83NCBI
Ccl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,514,095 - 67,515,945 (+)NCBIGRCr8
mRatBN7.21067,016,446 - 67,018,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,016,446 - 67,018,303 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,637,651 - 71,639,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,143,000 - 71,144,850 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,604,125 - 66,605,975 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,423,083 - 69,424,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,423,086 - 69,424,979 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,058,109 - 69,059,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,267,281 - 70,269,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11070,280,903 - 70,282,754 (+)NCBI
Celera1065,963,980 - 65,965,830 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,994,638 - 38,996,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,993,911 - 39,010,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,217,925 - 38,219,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,808,818 - 39,810,283 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,808,231 - 39,824,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1938,595,171 - 38,596,636 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,875,478 - 38,879,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,963,214 - 38,964,679 (-)NCBIUU_Cfam_GSD_1.0
CCL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,777,795 - 27,780,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660752,239,664 - 2,241,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCL7
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q12(chr17:33642695-34549211)x3 copy number gain See cases [RCV000054013] Chr17:33642695..34549211 [GRCh38]
Chr17:31969714..32876230 [GRCh37]
Chr17:28993827..29900343 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33670906-34596087)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054042]|See cases [RCV000054042] Chr17:33670906..34596087 [GRCh38]
Chr17:31997925..32923106 [GRCh37]
Chr17:29022038..29947219 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33715517-34301601)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054043]|See cases [RCV000054043] Chr17:33715517..34301601 [GRCh38]
Chr17:32042536..32628620 [GRCh37]
Chr17:29066649..29652733 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33777728-34301601)x3 copy number gain See cases [RCV000135956] Chr17:33777728..34301601 [GRCh38]
Chr17:32104747..32628620 [GRCh37]
Chr17:29128860..29652733 [NCBI36]
Chr17:17q12
uncertain significance
GRCh38/hg38 17q12(chr17:33671097-34595982)x3 copy number gain See cases [RCV000139003] Chr17:33671097..34595982 [GRCh38]
Chr17:31998116..32923001 [GRCh37]
Chr17:29022229..29947114 [NCBI36]
Chr17:17q12
likely benign
GRCh38/hg38 17q12(chr17:33671106-34595887)x3 copy number gain See cases [RCV000140285] Chr17:33671106..34595887 [GRCh38]
Chr17:31998125..32922906 [GRCh37]
Chr17:29022238..29947019 [NCBI36]
Chr17:17q12
likely benign
GRCh37/hg19 17q12(chr17:31982779-32917705)x3 copy number gain See cases [RCV000449299] Chr17:31982779..32917705 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000445952] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:31958240-32937658)x3 copy number gain See cases [RCV000511904] Chr17:31958240..32937658 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:32064314-32643063)x3 copy number gain See cases [RCV000511568] Chr17:32064314..32643063 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_006273.4(CCL7):c.131C>G (p.Pro44Arg) single nucleotide variant Inborn genetic diseases [RCV003254790] Chr17:34271200 [GRCh38]
Chr17:32598219 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:32351496-34455576)x1 copy number loss not provided [RCV000683918] Chr17:32351496..34455576 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_006273.4(CCL7):c.107A>G (p.Tyr36Cys) single nucleotide variant Inborn genetic diseases [RCV003271842] Chr17:34271176 [GRCh38]
Chr17:32598195 [GRCh37]
Chr17:17q12
uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787392] Chr17:31889285..33557612 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
GRCh37/hg19 17q12(chr17:31957257-32944153)x3 copy number gain not provided [RCV000846469] Chr17:31957257..32944153 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:31959226-32937658) copy number gain not specified [RCV002052595] Chr17:31959226..32937658 [GRCh37]
Chr17:17q12
uncertain significance
NM_006273.4(CCL7):c.287C>T (p.Thr96Ile) single nucleotide variant Inborn genetic diseases [RCV002888622] Chr17:34271789 [GRCh38]
Chr17:32598808 [GRCh37]
Chr17:17q12
uncertain significance
NM_006273.4(CCL7):c.226G>A (p.Ala76Thr) single nucleotide variant Inborn genetic diseases [RCV002803025] Chr17:34271728 [GRCh38]
Chr17:32598747 [GRCh37]
Chr17:17q12
uncertain significance
NM_006273.4(CCL7):c.227C>A (p.Ala76Asp) single nucleotide variant Inborn genetic diseases [RCV002803026] Chr17:34271729 [GRCh38]
Chr17:32598748 [GRCh37]
Chr17:17q12
uncertain significance
NM_006273.4(CCL7):c.244T>G (p.Trp82Gly) single nucleotide variant Inborn genetic diseases [RCV002919887] Chr17:34271746 [GRCh38]
Chr17:32598765 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q11.2-12(chr17:30572862-35843988) copy number loss Chromosome 17q12 deletion syndrome [RCV003319594] Chr17:30572862..35843988 [GRCh37]
Chr17:17q11.2-12
pathogenic
NM_006273.4(CCL7):c.253G>C (p.Asp85His) single nucleotide variant Inborn genetic diseases [RCV003348001] Chr17:34271755 [GRCh38]
Chr17:32598774 [GRCh37]
Chr17:17q12
uncertain significance
NM_006273.4(CCL7):c.187G>A (p.Ala63Thr) single nucleotide variant Inborn genetic diseases [RCV003354174] Chr17:34271256 [GRCh38]
Chr17:32598275 [GRCh37]
Chr17:17q12
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:713
Count of miRNA genes:202
Interacting mature miRNAs:216
Transcripts:ENST00000200307, ENST00000378569, ENST00000394627, ENST00000394630
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:607772  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,597,319 - 32,597,613UniSTSGRCh37
Build 361729,621,432 - 29,621,726RGDNCBI36
Celera1729,507,132 - 29,507,426RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,782,612 - 28,782,906UniSTS
PMC115222P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,598,235 - 32,598,778UniSTSGRCh37
Build 361729,622,348 - 29,622,891RGDNCBI36
Celera1729,508,048 - 29,508,591RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,783,528 - 28,784,071UniSTS
D17S2013  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,599,123 - 32,599,236UniSTSGRCh37
Build 361729,623,236 - 29,623,349RGDNCBI36
Celera1729,508,936 - 29,509,049RGD
Cytogenetic Map17q11.2-q12UniSTS
HuRef1728,784,416 - 28,784,529UniSTS
GeneMap99-GB4 RH Map17289.14UniSTS
Whitehead-RH Map17307.0UniSTS
Whitehead-YAC Contig Map17 UniSTS
CCL7_3334  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,598,720 - 32,599,304UniSTSGRCh37
Build 361729,622,833 - 29,623,417RGDNCBI36
Celera1729,508,533 - 29,509,117RGD
HuRef1728,784,013 - 28,784,597UniSTS
UniSTS:480900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371732,597,260 - 32,598,871UniSTSGRCh37
Celera1729,507,073 - 29,508,684UniSTS
HuRef1728,782,553 - 28,784,164UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 8 7 4 3 9 3 4 5 6 1 26 28 10 2
Low 265 311 132 49 96 33 260 78 67 51 195 309 18 317 89
Below cutoff 690 766 611 158 286 105 979 381 407 162 384 573 54 430 509 3

Sequence


RefSeq Acc Id: ENST00000378569   ⟹   ENSP00000367832
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,270,221 - 34,272,242 (+)Ensembl
RefSeq Acc Id: ENST00000394627   ⟹   ENSP00000378124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,270,224 - 34,272,078 (+)Ensembl
RefSeq Acc Id: ENST00000394630   ⟹   ENSP00000378126
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1734,270,224 - 34,272,240 (+)Ensembl
RefSeq Acc Id: NM_006273   ⟹   NP_006264
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,270,221 - 34,272,242 (+)NCBI
GRCh371732,597,235 - 32,599,261 (+)NCBI
Build 361729,621,353 - 29,623,369 (+)NCBI Archive
HuRef1728,782,528 - 28,784,554 (+)NCBI
CHM1_11732,661,096 - 32,663,122 (+)NCBI
T2T-CHM13v2.01735,216,497 - 35,218,518 (+)NCBI
Sequence:
RefSeq Acc Id: NP_006264   ⟸   NM_006273
- Peptide Label: precursor
- UniProtKB: Q569J6 (UniProtKB/Swiss-Prot),   P80098 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000367832   ⟸   ENST00000378569
RefSeq Acc Id: ENSP00000378124   ⟸   ENST00000394627
RefSeq Acc Id: ENSP00000378126   ⟸   ENST00000394630

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80098-F1-model_v2 AlphaFold P80098 1-99 view protein structure

Promoters
RGD ID:7234585
Promoter ID:EPDNEW_H23038
Type:multiple initiation site
Name:CCL7_1
Description:C-C motif chemokine ligand 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381734,270,221 - 34,270,281EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10634 AgrOrtholog
COSMIC CCL7 COSMIC
Ensembl Genes ENSG00000108688 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000378569 ENTREZGENE
  ENST00000378569.2 UniProtKB/Swiss-Prot
  ENST00000394627.5 UniProtKB/TrEMBL
  ENST00000394630.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000108688 GTEx
HGNC ID HGNC:10634 ENTREZGENE
Human Proteome Map CCL7 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:6354 UniProtKB/Swiss-Prot
NCBI Gene 6354 ENTREZGENE
OMIM 158106 OMIM
PANTHER C-C MOTIF CHEMOKINE 7 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35566 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A8MVH1_HUMAN UniProtKB/TrEMBL
  A8MX17_HUMAN UniProtKB/TrEMBL
  CCL7_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q569J6 ENTREZGENE
UniProt Secondary Q569J6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL7  C-C motif chemokine ligand 7  CCL7  chemokine (C-C motif) ligand 7  Symbol and/or name change 5135510 APPROVED