Gene: KISS1 (KiSS-1 metastasis-suppressor)  Homo sapiens
Symbol: KISS1
Name: KiSS-1 metastasis-suppressor
Description: This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HH13; KiSS-1; kisspeptin; kisspeptin-1; malignant melanoma metastasis-suppressor; metastasis-suppressor KiSS-1; METASTIN; metastin; MGC39258; OTTHUMP00000034312; prepro-kisspeptin
Orthologs: Mus musculus : Kiss1 (KiSS-1 metastasis-suppressor)  MGI
Rattus norvegicus : Kiss1 (KiSS-1 metastasis-suppressor)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11210,697,196 - 210,703,344-NCBI
Human Genome Assembly HuRef1175,324,487 - 175,330,608-NCBI
Human Genome Assembly GRCh371204,159,469 - 204,165,619-NCBI
Human Genome Assembly Build 361202,426,092 - 202,432,242-NCBI
Human Cytogenetic Map1q32 NCBI
Human Genome Assembly1200,891,126 - 200,897,271 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on KISS1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1352127
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2013-04-02
Status: ACTIVE



Contact Us |  About Us |  Jobs at RGD